PT1194575E - Factor de estimulacao de colonias de granulocitos humanos modificados e processos para a sua producao - Google Patents
Factor de estimulacao de colonias de granulocitos humanos modificados e processos para a sua producaoInfo
- Publication number
- PT1194575E PT1194575E PT00942494T PT00942494T PT1194575E PT 1194575 E PT1194575 E PT 1194575E PT 00942494 T PT00942494 T PT 00942494T PT 00942494 T PT00942494 T PT 00942494T PT 1194575 E PT1194575 E PT 1194575E
- Authority
- PT
- Portugal
- Prior art keywords
- csf
- modified
- processes
- human granulocyte
- production
- Prior art date
Links
- 210000003714 granulocyte Anatomy 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 210000001322 periplasm Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019990027418A KR100356140B1 (ko) | 1999-07-08 | 1999-07-08 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1194575E true PT1194575E (pt) | 2005-10-31 |
Family
ID=36129291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00942494T PT1194575E (pt) | 1999-07-08 | 2000-07-07 | Factor de estimulacao de colonias de granulocitos humanos modificados e processos para a sua producao |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20040224393A1 (enExample) |
| EP (1) | EP1194575B2 (enExample) |
| JP (1) | JP2003504069A (enExample) |
| KR (1) | KR100356140B1 (enExample) |
| CN (1) | CN1195859C (enExample) |
| AT (1) | ATE299187T1 (enExample) |
| AU (1) | AU757147C (enExample) |
| BR (2) | BRPI0012265B8 (enExample) |
| CA (1) | CA2378543C (enExample) |
| DE (1) | DE60021188T3 (enExample) |
| DK (1) | DK1194575T4 (enExample) |
| ES (1) | ES2243275T5 (enExample) |
| NZ (1) | NZ516476A (enExample) |
| PT (1) | PT1194575E (enExample) |
| RU (1) | RU2232772C2 (enExample) |
| WO (1) | WO2001004329A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| IL159524A0 (en) | 2001-07-11 | 2004-06-01 | Maxygen Holdings Ltd | G-csf conjugates |
| US7611700B2 (en) * | 2002-09-09 | 2009-11-03 | Hanall Pharmaceuticals, Co., Ltd. | Protease resistant modified interferon alpha polypeptides |
| US8338373B2 (en) * | 2003-10-24 | 2012-12-25 | Nora Therapeutics, Inc. | Method for reducing the risk of spontaneous abortion in a human female subject |
| EP2198875A1 (en) | 2003-10-24 | 2010-06-23 | Nora, LLC | A method for reducing the likelihood of preterm labour in a subject in need thereof |
| US20090226397A1 (en) | 2003-10-24 | 2009-09-10 | Nora Therapeutics, Inc. | Compositions and methods for reducing the likelihood of implantation failure or miscarriage in recipients of artificial insemination |
| AU2006254543A1 (en) | 2005-06-01 | 2006-12-07 | Maxygen Holdings Ltd. | PEGylated G-CSF polypeptides and methods of producing same |
| DE102005033250A1 (de) | 2005-07-15 | 2007-01-18 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von G-CSF |
| EP2274325A4 (en) * | 2008-05-13 | 2011-05-25 | Nora Therapeutics Inc | ANALOGUE OF HUMAN G-CSF AND METHOD OF MANUFACTURE AND APPLICATION THEREOF |
| JP5657698B2 (ja) | 2010-01-19 | 2015-01-21 | ハンミ サイエンス カンパニー リミテッドＨａｎｍｉ Ｓｃｉｅｎｃｅｃｏ．，Ｌｔｄ． | 持続型顆粒球コロニー刺激因子結合体の液剤 |
| TWI600759B (zh) | 2010-04-02 | 2017-10-01 | 可娜公司 | 藉由抑制群落刺激因子３（ｃｓｆ３）之天然反義轉錄物以治療ｃｓｆ３相關疾病 |
| KR101831300B1 (ko) | 2010-10-29 | 2018-02-23 | 한미사이언스 주식회사 | 재조합 대장균으로부터 인간 과립구 콜로니 자극인자를 정제하는 방법 |
| RU2467764C2 (ru) * | 2011-01-12 | 2012-11-27 | Государственное бюджетное образовательное учреждение дополнительного профессионального образования "Пензенский институт усовершенствования врачей" Министерства здравоохранения и социального развития Российской Федерации | Способ лечения больных аутоиммунной хронической крапивницей с использованием внутривенного введения препарата "габриглобин" |
| KR101623906B1 (ko) | 2014-07-23 | 2016-05-24 | 주식회사 이큐스앤자루 | 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
| WO2016013725A1 (ko) * | 2014-07-23 | 2016-01-28 | 주식회사 이큐스앤자루 | 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
| KR102645064B1 (ko) | 2017-02-03 | 2024-03-08 | 한미약품 주식회사 | 지속성이 증가된 생리활성 물질의 결합체 및 이의 용도 |
| US11267858B2 (en) | 2019-05-31 | 2022-03-08 | Spectrum Pharmaceuticals, Inc. | Methods of treatment using G-CSF protein complex |
| US11684655B2 (en) | 2019-05-31 | 2023-06-27 | Spectrum Pharmaceuticals, Inc. | Methods of treating neutorpenia using G-CSF protein complex |
| KR102375269B1 (ko) * | 2021-01-27 | 2022-03-17 | 한미약품 주식회사 | 단백질 액상 제제 및 이의 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPH01500483A (ja) * | 1986-08-11 | 1989-02-23 | シタス コーポレイション | Ｇ‐ｃｓｆ及びそのミューテインの発現 |
| US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5714581A (en) * | 1986-12-23 | 1998-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| JPH02104598A (ja) | 1988-04-12 | 1990-04-17 | Kirin Amgen Inc | ヒト顆粒球コロニー刺激因子ポリペプチド誘導体 |
| NZ236819A (en) | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
| GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| EP0626448A3 (de) | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
| US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
| US5451660A (en) * | 1993-12-13 | 1995-09-19 | Genentech, Inc. | Method for purifying polypeptides |
| EP0789776B1 (en) | 1994-11-01 | 2001-06-13 | Winfried Wels | Nucleic acid transfer system |
| US6100070A (en) | 1995-10-05 | 2000-08-08 | G. D. Searle & Co. | G-CSF receptor agonists |
| KR100316347B1 (ko) * | 1998-09-15 | 2002-08-27 | 한미약품(주) | 대장균엔테로톡신ⅱ신호펩티드의변형체와인체성장호르몬의융합단백질을발현하는재조합미생물및그를이용한인체성장호르몬의제조방법 |
| NZ522847A (en) * | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
-
1999
- 1999-07-08 KR KR1019990027418A patent/KR100356140B1/ko not_active Expired - Lifetime
-
2000
- 2000-07-07 DE DE60021188T patent/DE60021188T3/de not_active Expired - Lifetime
- 2000-07-07 RU RU2002103159/13A patent/RU2232772C2/ru active
- 2000-07-07 BR BRPI0012265A patent/BRPI0012265B8/pt unknown
- 2000-07-07 CN CNB008100942A patent/CN1195859C/zh not_active Expired - Lifetime
- 2000-07-07 EP EP00942494A patent/EP1194575B2/en not_active Expired - Lifetime
- 2000-07-07 DK DK00942494T patent/DK1194575T4/da active
- 2000-07-07 PT PT00942494T patent/PT1194575E/pt unknown
- 2000-07-07 CA CA2378543A patent/CA2378543C/en not_active Expired - Lifetime
- 2000-07-07 BR BR0012265-3A patent/BR0012265A/pt not_active IP Right Cessation
- 2000-07-07 ES ES00942494T patent/ES2243275T5/es not_active Expired - Lifetime
- 2000-07-07 NZ NZ516476A patent/NZ516476A/en not_active IP Right Cessation
- 2000-07-07 JP JP2001509533A patent/JP2003504069A/ja active Pending
- 2000-07-07 AU AU57106/00A patent/AU757147C/en not_active Expired
- 2000-07-07 WO PCT/KR2000/000733 patent/WO2001004329A1/en not_active Ceased
- 2000-07-07 AT AT00942494T patent/ATE299187T1/de active
-
2002
- 2002-01-09 US US10/031,123 patent/US20040224393A1/en not_active Abandoned
-
2007
- 2007-10-19 US US11/975,541 patent/US7704709B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2232772C2 (ru) | 2004-07-20 |
| WO2001004329A1 (en) | 2001-01-18 |
| JP2003504069A (ja) | 2003-02-04 |
| KR100356140B1 (ko) | 2002-10-19 |
| ATE299187T1 (de) | 2005-07-15 |
| BRPI0012265B8 (pt) | 2021-05-25 |
| EP1194575A4 (en) | 2002-10-24 |
| DE60021188D1 (de) | 2005-08-11 |
| CN1195859C (zh) | 2005-04-06 |
| ES2243275T3 (es) | 2005-12-01 |
| KR20010009171A (ko) | 2001-02-05 |
| AU5710600A (en) | 2001-01-30 |
| CA2378543A1 (en) | 2001-01-18 |
| EP1194575A1 (en) | 2002-04-10 |
| BR0012265A (pt) | 2002-03-12 |
| ES2243275T5 (es) | 2009-12-02 |
| DK1194575T3 (da) | 2005-10-17 |
| AU757147C (en) | 2005-03-03 |
| EP1194575B1 (en) | 2005-07-06 |
| BRPI0012265B1 (pt) | 2018-11-21 |
| US20040224393A1 (en) | 2004-11-11 |
| NZ516476A (en) | 2003-09-26 |
| US7704709B2 (en) | 2010-04-27 |
| EP1194575B2 (en) | 2009-08-26 |
| DE60021188T2 (de) | 2006-04-27 |
| US20080064066A1 (en) | 2008-03-13 |
| DK1194575T4 (da) | 2009-12-07 |
| DE60021188T3 (de) | 2010-04-01 |
| CN1360636A (zh) | 2002-07-24 |
| CA2378543C (en) | 2010-05-18 |
| AU757147B2 (en) | 2003-02-06 |
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