PT1171132E - Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcool - Google Patents
Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcoolInfo
- Publication number
- PT1171132E PT1171132E PT00921946T PT00921946T PT1171132E PT 1171132 E PT1171132 E PT 1171132E PT 00921946 T PT00921946 T PT 00921946T PT 00921946 T PT00921946 T PT 00921946T PT 1171132 E PT1171132 E PT 1171132E
- Authority
- PT
- Portugal
- Prior art keywords
- naltrexone
- heroin
- reduction
- injectable formulations
- alcohol consumption
- Prior art date
Links
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title abstract 4
- 229960003086 naltrexone Drugs 0.000 title abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 239000007972 injectable composition Substances 0.000 title 1
- 239000004005 microsphere Substances 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 abstract 1
- 229920001244 Poly(D,L-lactide) Polymers 0.000 abstract 1
- 229960002069 diamorphine Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12847799P | 1999-04-09 | 1999-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1171132E true PT1171132E (pt) | 2004-07-30 |
Family
ID=22435553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00921946T PT1171132E (pt) | 1999-04-09 | 2000-04-08 | Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcool |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6306425B1 (enExample) |
| EP (1) | EP1171132B1 (enExample) |
| JP (2) | JP4995371B2 (enExample) |
| KR (1) | KR100621261B1 (enExample) |
| CN (1) | CN1210031C (enExample) |
| AT (1) | ATE262906T1 (enExample) |
| AU (1) | AU780852B2 (enExample) |
| BR (1) | BR0009639A (enExample) |
| CA (1) | CA2369302C (enExample) |
| CZ (1) | CZ20013636A3 (enExample) |
| DE (1) | DE60009477T2 (enExample) |
| DK (1) | DK1171132T3 (enExample) |
| EA (1) | EA004734B1 (enExample) |
| ES (1) | ES2218147T3 (enExample) |
| HK (1) | HK1047245B (enExample) |
| HU (1) | HUP0200838A3 (enExample) |
| IL (2) | IL145802A0 (enExample) |
| MX (1) | MXPA01010185A (enExample) |
| NO (1) | NO328647B1 (enExample) |
| NZ (1) | NZ515359A (enExample) |
| PL (1) | PL196930B1 (enExample) |
| PT (1) | PT1171132E (enExample) |
| TR (1) | TR200102880T2 (enExample) |
| UA (1) | UA79921C2 (enExample) |
| WO (1) | WO2000061147A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
| US7919119B2 (en) | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| AU2001223396A1 (en) * | 2000-02-01 | 2001-08-14 | Disetronic Licensing Ag | Container and device for administering a substance |
| US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| DE60223254T2 (de) | 2001-07-06 | 2008-08-14 | Penwest Pharmaceuticals Co. | Verzögert freisetzende formulierungen von oxymorphon |
| JP2005515966A (ja) | 2001-07-06 | 2005-06-02 | エンドー ファーマシューティカルズ， インコーポレイティド | 鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与 |
| US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
| US7094369B2 (en) | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7131997B2 (en) | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
| US7053134B2 (en) | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
| US7157102B1 (en) | 2002-05-31 | 2007-01-02 | Biotek, Inc. | Multi-layered microcapsules and method of preparing same |
| US7041320B1 (en) | 2002-05-31 | 2006-05-09 | Biotek, Inc. | High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence |
| US6972291B2 (en) * | 2002-07-02 | 2005-12-06 | Bernstein Richard K | Method for reducing food intake |
| US7842377B2 (en) * | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US7449236B2 (en) | 2002-08-09 | 2008-11-11 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US20040109886A1 (en) * | 2002-08-27 | 2004-06-10 | Larry Rigby | Methods and apparatus for transdermal delivery of abusable drugs with a deterrent agent |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| US7588825B2 (en) | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
| MXPA05009803A (es) * | 2003-03-13 | 2006-04-18 | Cheryl M Burgess | Metodos para administrar un material en un paciente para realce dermico. |
| EP1628664A4 (en) * | 2003-06-04 | 2008-11-05 | Alkermes Inc | POLYMORPHIC FORMS OF NALTREXONE |
| US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
| US20050031713A1 (en) * | 2003-08-06 | 2005-02-10 | Elliot Ehrich | Methods for administering active agents to CYP3A4 sensitive patients |
| US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
| EP1667659A1 (en) * | 2003-09-30 | 2006-06-14 | Acusphere, Inc. | Injectable, oral, or topical sustained release pharmaceutical formulations |
| US7901770B2 (en) | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
| LT2351555T (lt) * | 2004-02-23 | 2016-12-27 | Euro-Celtique S.A. | Piktnaudžiavimui atspari priemonė, skirta transderminiam opoido įvedimui |
| US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
| US20050245461A1 (en) * | 2004-03-19 | 2005-11-03 | Elliot Ehrich | Methods for treating alcoholism |
| US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
| US7919499B2 (en) | 2004-04-22 | 2011-04-05 | Alkermes, Inc. | Naltrexone long acting formulations and methods of use |
| US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
| US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
| US7858183B2 (en) | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
| US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| CN1872063B (zh) * | 2005-06-03 | 2011-01-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 纳美芬或其盐的长效注射用微球或组合物及其制备方法 |
| US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
| US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| US7501179B2 (en) | 2005-12-21 | 2009-03-10 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| EP1810714A1 (de) * | 2006-01-19 | 2007-07-25 | Holger Lars Hermann | Verwendung einer Kombination von Heroin und Naloxon zur Drogensubstitution |
| RU2310449C1 (ru) * | 2006-05-17 | 2007-11-20 | Руслан Геннадьевич Нервалев | Способ лечения опиоидной и/или алкогольной зависимости |
| WO2009051824A2 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| RU2010129907A (ru) | 2007-12-17 | 2012-01-27 | Лабофарм Инк. (CA) | Лекарственная форма с контролируемым высвобождением, предотвращающая неправильное употребление |
| US8486449B2 (en) | 2008-12-16 | 2013-07-16 | Paladin Labs Inc. | Misuse preventative, controlled release formulation |
| US20100196436A1 (en) * | 2009-01-30 | 2010-08-05 | Gooberman Lance L | Implants containing disulfiram and an anti-inflammatory agent |
| US8791093B2 (en) * | 2009-05-29 | 2014-07-29 | Lance L. Gooberman | Pharmaceutical delivery systems for treatment of substance abuse and other addictions |
| EP2544667B1 (en) * | 2010-03-09 | 2018-11-14 | Alkermes Pharma Ireland Limited | Alcohol resistant enteric pharmaceutical compositions |
| RU2476209C1 (ru) * | 2012-02-29 | 2013-02-27 | Станислав Анатольевич Кедик | Имплантируемое лекарственное средство на основе налтрексона для лечения пациентов, зависимых от алкоголя или опиатов |
| WO2015020240A1 (ko) | 2013-08-06 | 2015-02-12 | 동국제약 주식회사 | 엔테카비어 미립구 및 이를 포함하는 비경구투여용 약제학적 조성물 |
| WO2016013993A1 (en) * | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Stable preservative free ophthalmic formulations of opioid antagonists |
| WO2020080806A1 (en) | 2018-10-15 | 2020-04-23 | Chong Kun Dang Pharmaceutical Corp. | Injectable long-acting naltrexone microparticle compositions |
| GR1009871B (el) * | 2019-07-30 | 2020-11-12 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει μικροσφαιριδια ναλτρεξονης και μεθοδος παρασκευης αυτου |
| US20210059943A1 (en) * | 2019-09-04 | 2021-03-04 | Buffalo Pacific LLC | Systems and methods addressing multiple aspects to provide a comprehensive recovery program for addictions, chronic conditions and diseases |
| CA3208374A1 (en) * | 2021-03-09 | 2022-09-15 | Ju Hee Kim | Sustained formulation for prevention or treatment of autoimmune disease containing naltrexone and method using same |
| CA3236690A1 (en) * | 2021-11-18 | 2023-05-25 | Ju Hee Kim | Sustained-release injectable composition containing naltrexone and method for preparing same |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887699A (en) | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4981696A (en) | 1986-12-22 | 1991-01-01 | E. I. Du Pont De Nemours And Company | Polylactide compositions |
| DE3710175A1 (de) | 1987-02-12 | 1988-08-25 | Hoechst Ag | Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung |
| FR2618674B1 (fr) | 1987-07-30 | 1990-06-15 | Ire Celltarg Sa | Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| DE3734223A1 (de) * | 1987-10-09 | 1989-04-20 | Boehringer Ingelheim Kg | Implantierbares, biologisch abbaubares wirkstofffreigabesystem |
| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| US4902515A (en) | 1988-04-28 | 1990-02-20 | E. I. Dupont De Nemours And Company | Polylactide compositions |
| DE69024953T3 (de) | 1989-05-04 | 2005-01-27 | Southern Research Institute, Birmingham | Einkapselungsverfahren |
| US5486362A (en) * | 1991-05-07 | 1996-01-23 | Dynagen, Inc. | Controlled, sustained release delivery system for treating drug dependency |
| AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| AU7582498A (en) * | 1997-05-20 | 1998-12-11 | Yale University | Substance dependence treatment using opiate antagonists and serotonin compounds |
| JPH11269094A (ja) * | 1998-01-16 | 1999-10-05 | Takeda Chem Ind Ltd | 徐放性組成物、その製造法および用途 |
-
2000
- 2000-04-07 US US09/545,064 patent/US6306425B1/en not_active Expired - Fee Related
- 2000-04-08 HK HK02108954.5A patent/HK1047245B/zh not_active IP Right Cessation
- 2000-04-08 HU HU0200838A patent/HUP0200838A3/hu unknown
- 2000-04-08 TR TR2001/02880T patent/TR200102880T2/xx unknown
- 2000-04-08 DK DK00921946T patent/DK1171132T3/da active
- 2000-04-08 MX MXPA01010185A patent/MXPA01010185A/es active IP Right Grant
- 2000-04-08 JP JP2000610480A patent/JP4995371B2/ja not_active Expired - Fee Related
- 2000-04-08 ES ES00921946T patent/ES2218147T3/es not_active Expired - Lifetime
- 2000-04-08 PL PL350548A patent/PL196930B1/pl unknown
- 2000-04-08 EA EA200101062A patent/EA004734B1/ru active IP Right Revival
- 2000-04-08 CA CA002369302A patent/CA2369302C/en not_active Expired - Fee Related
- 2000-04-08 KR KR1020017012866A patent/KR100621261B1/ko not_active Expired - Fee Related
- 2000-04-08 PT PT00921946T patent/PT1171132E/pt unknown
- 2000-04-08 AT AT00921946T patent/ATE262906T1/de not_active IP Right Cessation
- 2000-04-08 DE DE60009477T patent/DE60009477T2/de not_active Expired - Lifetime
- 2000-04-08 AU AU42203/00A patent/AU780852B2/en not_active Ceased
- 2000-04-08 IL IL14580200A patent/IL145802A0/xx active IP Right Grant
- 2000-04-08 EP EP00921946A patent/EP1171132B1/en not_active Expired - Lifetime
- 2000-04-08 WO PCT/US2000/009438 patent/WO2000061147A1/en not_active Ceased
- 2000-04-08 CN CNB008085684A patent/CN1210031C/zh not_active Expired - Fee Related
- 2000-04-08 NZ NZ515359A patent/NZ515359A/xx unknown
- 2000-04-08 BR BR0009639-3A patent/BR0009639A/pt not_active Application Discontinuation
- 2000-04-08 CZ CZ20013636A patent/CZ20013636A3/cs unknown
- 2000-08-04 UA UA2001117615A patent/UA79921C2/uk unknown
-
2001
- 2001-10-05 IL IL145802A patent/IL145802A/en unknown
- 2001-10-08 NO NO20014896A patent/NO328647B1/no not_active IP Right Cessation
-
2009
- 2009-11-02 JP JP2009252183A patent/JP2010031036A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1171132E (pt) | Formulacoes injectaveis de microsferas de naltrexona e sua utilizacao na reducao do consumo de heroina e alcool | |
| NZ517997A (en) | Injectable, slow release partial opioid agonist or antagonist compositions and their use | |
| BR9808888A (pt) | Formas de dosagem e método de melhorar disfunção erétil masculina | |
| MY119074A (en) | Pharmaceutical aerosol composition | |
| MXPA03005577A (es) | Inyector de tipo pluma que tiene mecanismo de sujecion para cartucho de medicamento. | |
| BR0206441A (pt) | Composição de revestimento de pelìcula, revestimento de pelìcula cobrindo um núcleo farmacêutico, formulação farmacêutica de liberação modificada, e, processos para preparar uma composição de revestimento de pelìcula, um revestimento de pelìcula e uma formulação | |
| BRPI0409781A (pt) | solução de perfume transparente pulverizável, processo para a ampliação da difusão de um perfume, uso de um polìmero, e, artigo perfumado | |
| BR0214602A (pt) | Método de produção de um tablete detergente, tablete detergente, e, componente de argila adequado para uso em uma formulação detergente | |
| DE60135363D1 (de) | Enthält | |
| DK1171101T3 (da) | Fremgangsmåde til fremstilling af en vanduoplöselig amorf depotmatrix | |
| DE59812964D1 (de) | Waschmittelformkörper mit verbesserten auflöseeigenschaften | |
| WO2001085188A3 (en) | Use of echinacea as a hematinic agent | |
| CH691791A8 (de) | Pharmazeutische komposition gegen alkoholmissbrauch und mit notroper wirkung. | |
| NZ331947A (en) | Slow-release pharmaceutical formulations containing mizolastine | |
| WO1999047105A3 (en) | Liquid antimicrobial, skin moisturizing formulation | |
| EP1555023A3 (en) | Injectable buprenorphine microparticle compositions and their use | |
| GR1002731B (el) | Φαρμακευτικα ενεσιμα διαλυματα περιεχοντα συνδυασμους παρακεταμολης με αλλες δραστικες ουσιες. | |
| GB0115798D0 (en) | Organic anti-reflective coating polymer, anti-reflective coating composition and methods of preparation thereof | |
| KR960020988A (ko) | 피부 외용제 | |
| CN2308600Y (zh) | 多功能火柴 | |
| WO2002045800A3 (en) | Liquid composition comprising an alcohol | |
| Anghelaki-Rooke | The Body Is the Victory and the Defeat of Dreams | |
| Kendall | Remembrance | |
| Straub et al. | Application and Testing of Macrolaminate Technology for Dual-Fuel Lean Premixed Pre-Vaporized Combustion, CRADA 98-F010, Final Report | |
| 张晶 | THE LAWYER and the punk |