KR100621261B1 - 주사용 날트렉손 마이크로스피어 조성물 및 헤로인 및알코올 소비를 감소시키기 위한 이것의 용도 - Google Patents

주사용 날트렉손 마이크로스피어 조성물 및 헤로인 및알코올 소비를 감소시키기 위한 이것의 용도 Download PDF

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Publication number
KR100621261B1
KR100621261B1 KR1020017012866A KR20017012866A KR100621261B1 KR 100621261 B1 KR100621261 B1 KR 100621261B1 KR 1020017012866 A KR1020017012866 A KR 1020017012866A KR 20017012866 A KR20017012866 A KR 20017012866A KR 100621261 B1 KR100621261 B1 KR 100621261B1
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KR
South Korea
Prior art keywords
naltrexone
poly
microspheres
lactide
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020017012866A
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English (en)
Korean (ko)
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KR20020011975A (ko
Inventor
토마스 알. 타이스
제이 케이. 스타아스
테레사 엠. 페렐
Original Assignee
브룩우드 파마슈티컬스, 인코포레이티드
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Publication of KR20020011975A publication Critical patent/KR20020011975A/ko
Application granted granted Critical
Publication of KR100621261B1 publication Critical patent/KR100621261B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020017012866A 1999-04-09 2000-04-08 주사용 날트렉손 마이크로스피어 조성물 및 헤로인 및알코올 소비를 감소시키기 위한 이것의 용도 Expired - Fee Related KR100621261B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12847799P 1999-04-09 1999-04-09
US60/128,477 1999-04-09
PCT/US2000/009438 WO2000061147A1 (en) 1999-04-09 2000-04-08 Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol

Publications (2)

Publication Number Publication Date
KR20020011975A KR20020011975A (ko) 2002-02-09
KR100621261B1 true KR100621261B1 (ko) 2006-09-13

Family

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Family Applications (1)

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KR1020017012866A Expired - Fee Related KR100621261B1 (ko) 1999-04-09 2000-04-08 주사용 날트렉손 마이크로스피어 조성물 및 헤로인 및알코올 소비를 감소시키기 위한 이것의 용도

Country Status (25)

Country Link
US (1) US6306425B1 (enExample)
EP (1) EP1171132B1 (enExample)
JP (2) JP4995371B2 (enExample)
KR (1) KR100621261B1 (enExample)
CN (1) CN1210031C (enExample)
AT (1) ATE262906T1 (enExample)
AU (1) AU780852B2 (enExample)
BR (1) BR0009639A (enExample)
CA (1) CA2369302C (enExample)
CZ (1) CZ20013636A3 (enExample)
DE (1) DE60009477T2 (enExample)
DK (1) DK1171132T3 (enExample)
EA (1) EA004734B1 (enExample)
ES (1) ES2218147T3 (enExample)
HK (1) HK1047245B (enExample)
HU (1) HUP0200838A3 (enExample)
IL (2) IL145802A0 (enExample)
MX (1) MXPA01010185A (enExample)
NO (1) NO328647B1 (enExample)
NZ (1) NZ515359A (enExample)
PL (1) PL196930B1 (enExample)
PT (1) PT1171132E (enExample)
TR (1) TR200102880T2 (enExample)
UA (1) UA79921C2 (enExample)
WO (1) WO2000061147A1 (enExample)

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US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
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Also Published As

Publication number Publication date
ES2218147T3 (es) 2004-11-16
NO20014896L (no) 2001-12-07
PL196930B1 (pl) 2008-02-29
MXPA01010185A (es) 2003-07-21
US6306425B1 (en) 2001-10-23
EA004734B1 (ru) 2004-08-26
EA200101062A1 (ru) 2002-04-25
DE60009477T2 (de) 2005-02-24
WO2000061147A1 (en) 2000-10-19
JP2010031036A (ja) 2010-02-12
NZ515359A (en) 2002-10-25
HK1047245A1 (en) 2003-02-14
HUP0200838A2 (hu) 2002-07-29
CN1210031C (zh) 2005-07-13
CN1354664A (zh) 2002-06-19
EP1171132A1 (en) 2002-01-16
HK1047245B (zh) 2006-03-03
UA79921C2 (en) 2007-08-10
TR200102880T2 (tr) 2002-03-21
DE60009477D1 (de) 2004-05-06
CA2369302A1 (en) 2000-10-19
NO20014896D0 (no) 2001-10-08
BR0009639A (pt) 2002-02-05
JP2002541202A (ja) 2002-12-03
PL350548A1 (en) 2002-12-16
HUP0200838A3 (en) 2005-07-28
ATE262906T1 (de) 2004-04-15
AU780852B2 (en) 2005-04-21
CA2369302C (en) 2007-09-25
JP4995371B2 (ja) 2012-08-08
DK1171132T3 (da) 2004-07-12
EP1171132B1 (en) 2004-03-31
IL145802A0 (en) 2002-07-25
KR20020011975A (ko) 2002-02-09
AU4220300A (en) 2000-11-14
IL145802A (en) 2009-02-11
CZ20013636A3 (cs) 2002-03-13
PT1171132E (pt) 2004-07-30
NO328647B1 (no) 2010-04-19

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