PT1082106E - Comprimido efervescente para administração subligual, bucal e gengival de fentanil - Google Patents

Comprimido efervescente para administração subligual, bucal e gengival de fentanil Download PDF

Info

Publication number
PT1082106E
PT1082106E PT00919523T PT00919523T PT1082106E PT 1082106 E PT1082106 E PT 1082106E PT 00919523 T PT00919523 T PT 00919523T PT 00919523 T PT00919523 T PT 00919523T PT 1082106 E PT1082106 E PT 1082106E
Authority
PT
Portugal
Prior art keywords
tablet
effervescent
amount
present
weight
Prior art date
Application number
PT00919523T
Other languages
English (en)
Portuguese (pt)
Inventor
Sathasivan Indiran Pather
Jonathan D Eichman
Joseph R Robinson
John Hontz
Rajendra K Khankari
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26958475&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1082106(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of PT1082106E publication Critical patent/PT1082106E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4468Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007Effervescent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT00919523T 1999-03-26 2000-03-22 Comprimido efervescente para administração subligual, bucal e gengival de fentanil PT1082106E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27742499A 1999-03-26 1999-03-26
US09/327,814 US6200604B1 (en) 1998-03-27 1999-06-08 Sublingual buccal effervescent

Publications (1)

Publication Number Publication Date
PT1082106E true PT1082106E (pt) 2007-02-28

Family

ID=26958475

Family Applications (3)

Application Number Title Priority Date Filing Date
PT00919523T PT1082106E (pt) 1999-03-26 2000-03-22 Comprimido efervescente para administração subligual, bucal e gengival de fentanil
PT03029877T PT1419765E (pt) 1999-03-26 2000-03-22 Métodos de manufactura de composições farmacêuticas
PT03029911T PT1417959E (pt) 1999-03-26 2000-03-22 Composições farmacêuticas para a administração oral de um medicamento

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT03029877T PT1419765E (pt) 1999-03-26 2000-03-22 Métodos de manufactura de composições farmacêuticas
PT03029911T PT1417959E (pt) 1999-03-26 2000-03-22 Composições farmacêuticas para a administração oral de um medicamento

Country Status (13)

Country Link
US (1) US6200604B1 (de)
EP (4) EP1419765B1 (de)
JP (2) JP4789324B2 (de)
AT (4) ATE350017T1 (de)
AU (1) AU4019400A (de)
CA (2) CA2569674C (de)
CY (3) CY1107592T1 (de)
DE (3) DE60042427D1 (de)
DK (3) DK1417959T3 (de)
ES (3) ES2324908T3 (de)
HK (1) HK1130691A1 (de)
PT (3) PT1082106E (de)
WO (1) WO2000057858A1 (de)

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US20040023948A1 (en) * 1997-03-24 2004-02-05 Green Richard David Fast-dispersing dosage form containing 5-HT1 agonists
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6358060B2 (en) * 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US7163705B2 (en) * 1998-12-15 2007-01-16 Wm. Wrigley Jr. Company Coated chewing gum product and method of making
US6531114B1 (en) 1999-04-06 2003-03-11 Wm. Wrigley Jr. Company Sildenafil citrate chewing gum formulations and methods of using the same
US6627234B1 (en) 1998-12-15 2003-09-30 Wm. Wrigley Jr. Company Method of producing active agent coated chewing gum products
US7935362B2 (en) * 1999-04-06 2011-05-03 Wm. Wrigley Jr. Company Over-coated product including consumable center and medicament
US6773716B2 (en) 1999-04-06 2004-08-10 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
EP1181010A4 (de) * 1999-04-06 2003-03-26 Wrigley W M Jun Co Pharmazeutische kaugummiformulierungen
US6426090B1 (en) * 1999-04-06 2002-07-30 Wm. Wrigley Jr. Company Over-coated product including tableted center and medicament
US20020159956A1 (en) * 1999-04-06 2002-10-31 Ream Ronald L. Over-coated chewing gum formulations
US6355265B1 (en) 1999-04-06 2002-03-12 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
US6663849B1 (en) 2000-09-01 2003-12-16 Wm. Wrigley Jr. Company Antacid chewing gum products coated with high viscosity materials
US6645535B2 (en) 1999-09-02 2003-11-11 Wm. Wrigley Jr. Company Method of making coated chewing gum products containing various antacids
US6541048B2 (en) 1999-09-02 2003-04-01 Wm. Wrigley Jr. Company Coated chewing gum products containing an acid blocker and process of preparing
US6569472B1 (en) 2000-09-01 2003-05-27 Wm. Wrigley Jr. Company Coated chewing gum products containing antacid and method of making
AU3885201A (en) * 1999-09-20 2001-04-24 Mastercare Diet and weight control gum and sucker
US9387168B2 (en) 1999-09-20 2016-07-12 Jack Barreca Chewing gum with tomatidine
US9253991B2 (en) 1999-09-20 2016-02-09 Jack Barreca Chewing gum with B vitamins
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
JP4806507B2 (ja) 1999-10-29 2011-11-02 ユーロ−セルティーク エス.エイ. 制御放出ヒドロコドン処方
AU2001261744A1 (en) * 2000-05-19 2001-12-03 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
US6572900B1 (en) 2000-06-09 2003-06-03 Wm. Wrigley, Jr. Company Method for making coated chewing gum products including a high-intensity sweetener
US7115288B2 (en) * 2000-06-09 2006-10-03 Wm. Wrigley Jr. Company Method for making coated chewing gum products with a coating including an aldehyde flavor and a dipeptide sweetener
BR0115382A (pt) 2000-10-30 2003-09-16 Euro Celtique Sa Formulações para liberação controlada de hidrocodona, método de produzir analgesia efetiva, processo de preparação de uma forma farmacêutica de um sólido oral de liberação controlada, liberação controlada da forma farmacêutica oral e uso da forma farmacêutica
AU2141202A (en) * 2000-12-05 2002-06-18 Alexander Macgregor Hydrostatic delivery system for controlled delivery of agent
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
US6579545B2 (en) 2000-12-22 2003-06-17 Wm. Wrigley Jr. Company Coated chewing gum products containing an antigas agent
US7062312B2 (en) * 2001-01-17 2006-06-13 Pediamed Pharmaceuticals, Inc. Combination and method including a visual marker for determining compliance with a medication regimen
US20030035839A1 (en) * 2001-05-15 2003-02-20 Peirce Management, Llc Pharmaceutical composition for both intraoral and oral administration
US6613346B2 (en) 2001-06-28 2003-09-02 Wm. Wrigley, Jr. Company Chewable product including active ingredient
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030022910A1 (en) * 2001-07-05 2003-01-30 R.T. Alamo Ventures I, Inc. Compositions and methods for sublingual formulations of dihydroergotamine for the treatment of migraine
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
HUP0401022A3 (en) * 2001-08-14 2006-11-28 Biotie Therapies Corp Method for the preparation of pharmaceutical compositions containing opioid antagonist for treating alcoholism or alcohol abuse
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
DE10224607B4 (de) * 2002-06-04 2008-03-13 Lts Lohmann Therapie-Systeme Ag Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung
US20030235613A1 (en) 2002-06-19 2003-12-25 Cts Chemical Industries Ltd. Popping oral administration form
SI21221A (sl) * 2002-06-21 2003-12-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Hitro razpadljive tablete
GB0217056D0 (en) * 2002-07-23 2002-08-28 Ass Octel Use
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
BG730Y1 (bg) * 2003-03-20 2005-04-30 Владимир НАЙДЕНОВ Ефервесцентна лекарствена форма
US20040191345A1 (en) * 2003-03-26 2004-09-30 Fredrik Nicklasson New formulations and use thereof
US20040223921A1 (en) * 2003-05-07 2004-11-11 Rau Allen H. Oral care tablet
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20050065175A1 (en) * 2003-09-24 2005-03-24 Xanodyne Pharmacal, Inc. Oral transmucosal methadone
CA2545194C (en) 2003-11-10 2014-10-21 Seymour H. Fein Pharmaceutical compositions including low dosages of desmopressin
DE20321887U1 (de) 2003-11-10 2012-01-20 Allergan, Inc. Arzneimittel umfassend niedrige Dosierungen von Desmopressin
US20070036853A1 (en) * 2003-12-31 2007-02-15 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
EA010826B1 (ru) * 2003-12-31 2008-12-30 Сайма Лэбс Инк. Лекарственная форма фентанила для перорального применения, способ ее получения и способы лечения
ES2359979T3 (es) * 2003-12-31 2011-05-30 Cima Labs Inc. Forma farmacéutica de fentanillo generalmente lineal, efervescente y oral, y métodos de administración.
US7858121B2 (en) * 2003-12-31 2010-12-28 Cima Labs, Inc. Effervescent oral fentanyl dosage form and methods of administering fentanyl
CA2549642C (en) * 2003-12-31 2012-10-30 Cima Labs Inc. Effervescent oral opiate dosage forms and methods of administering opiates
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ, インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
GB0423800D0 (en) 2004-10-27 2004-12-01 Orexo Ab New pharmaceutical formulations
FR2883179B1 (fr) * 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
AU2006249761A1 (en) * 2005-05-25 2006-11-30 Transcept Pharmaceuticals, Inc. Solid compositions and methods for treating middle-of-the night insomnia
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20070020186A1 (en) * 2005-07-22 2007-01-25 Alpex Pharma S.A. Solid dosage formulations of narcotic drugs having improved buccal adsorption
US20070092586A1 (en) * 2005-10-26 2007-04-26 Alamo Pharmaceuticals Compositions and methods for the administration psychotropic drugs which modulate body weight
US20070093471A1 (en) * 2005-10-26 2007-04-26 Alamo Pharmaceuticals, Llc Compositions and methods for the administration clozapine formulations which modulate body weight
CA2629046C (en) * 2005-12-13 2014-04-08 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US20070260491A1 (en) * 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20080069891A1 (en) * 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
US20100015183A1 (en) 2006-07-21 2010-01-21 Bio Delivery Sciences International ,Inc. Transmucosal delivery devices with enhanced uptake
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US20080090874A1 (en) * 2006-09-20 2008-04-17 Messina John C Jr Treatment of breakthrough pain in patients suffering from chronic low back pain
WO2008067549A2 (en) * 2006-11-30 2008-06-05 Transcept Pharmaceuticals, Inc. Stabilized zolpidem pharmaceutical compositions
US20090214442A1 (en) * 2006-12-01 2009-08-27 Cephalon, Inc. Oral Transmucosal Nicotine Dosage Form
JP2010511611A (ja) * 2006-12-01 2010-04-15 シマ ラブス インク. 口腔経粘膜ニコチン剤形
MX2009006672A (es) 2006-12-19 2009-10-26 Univ Virginia Efectos combinados de topiramato y ondansetron sobre el consumo de alcohol.
US20100028447A1 (en) 2007-01-22 2010-02-04 Targacept, Inc. Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs
US20080287494A1 (en) * 2007-04-24 2008-11-20 Cephalon, Inc. Transmucosal treatment methods in patients with mucositis
CN101674843A (zh) 2007-05-01 2010-03-17 赛福伦公司 多肽的经粘膜递送组合物
FI3782612T3 (fi) 2008-05-15 2024-01-16 Celgene Corp Sytidiinianalogien oraalisia formulaatioita ja menetelmiä niiden käyttämiseksi
CN105833420A (zh) * 2008-06-23 2016-08-10 生物递送科学国际公司 多向粘膜给药装置及使用方法
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
KR101004205B1 (ko) * 2008-12-17 2010-12-24 동아제약주식회사 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물
US20130213393A1 (en) 2009-12-22 2013-08-22 Evoke Pharma, Inc. Nasal formulations of metoclopramide
EP3254676B1 (de) 2009-10-30 2018-11-28 IX Biopharma Ltd Schnell lösliche feste darreichungsform
MX2012012991A (es) 2010-05-11 2012-11-30 Cima Labs Inc Formas de dosificacion oral de liberacion prolongada resistentes al alcohol y que contienen metoprolol.
SI2801625T1 (en) 2010-07-02 2018-04-30 University Of Virginia Patent Foundation Molecular genetic approach to treatment and diagnosis of alcohol and drug addiction
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
EP2646003B1 (de) 2010-12-02 2020-06-03 Adare Pharmaceuticals, Inc. Schnell dispergierendes granulat, im mund zerfallende tabletten und verfahren dafür
WO2012087113A1 (en) * 2010-12-24 2012-06-28 N.V. Nutricia Improved nutritional tablet
US10111831B2 (en) 2011-02-28 2018-10-30 Technologies Khloros Inc. Chewable vehicle for mouth absorption
AU2012253610A1 (en) 2011-05-09 2013-12-12 University Of Virginia Patent Foundation Compositions and methods for treating cancer
AU2012296346A1 (en) 2011-08-18 2014-04-03 Biodelivery Sciences International, Inc. Abuse-resistant mucoadhesive devices for delivery of buprenorphine
EA027743B1 (ru) 2011-09-09 2017-08-31 Юниверсити Оф Вирджиния Пэтент Фаундейшн Молекулярно-генетический подход для лечения и диагностики алкогольной и наркотической зависимости
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US9993422B2 (en) 2012-04-18 2018-06-12 SpecGx LLC Immediate release, abuse deterrent pharmaceutical compositions
JP6441890B2 (ja) 2013-03-15 2018-12-19 ブレインツリー・ラボラトリーズ,インコーポレイテッド 硫酸塩の両用経口薬学的組成物錠剤およびその使用の方法
JP6255474B2 (ja) 2013-03-15 2017-12-27 マリンクロッド エルエルシー 機能的割線を有する即時放出用の乱用抑止性固体剤形
WO2015063602A1 (en) 2013-10-29 2015-05-07 Ferring B.V. Desmopressin and blood glucose
JP2016535794A (ja) 2013-11-11 2016-11-17 インパックス ラボラトリーズ,インコーポレーテッド 急速崩壊性製剤及びその使用法
US20160331693A1 (en) * 2014-02-07 2016-11-17 Scilabs Pharmaceuticals All natural, non-toxic sublingual drug delievery systems
BR112016030648B1 (pt) 2014-07-03 2023-10-03 SpecGx LLC Composições farmacêticas de liberação imediata de impedimento de abuso compreendendo polissacarídeos não celulósicos
WO2016086095A1 (en) 2014-11-25 2016-06-02 Biodelivery Sciences International, Inc. Patches, methods for forming and testing pharmaceutical agent delivery patches
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
GB2537652A (en) 2015-04-22 2016-10-26 Cosmetic Warriors Ltd Composition
JP6523132B2 (ja) * 2015-10-20 2019-05-29 リプリーズ バイオファーマシューティクス,エルエルシー 低用量デスモプレシンを含有する医薬組成物
US9855227B2 (en) 2015-12-18 2018-01-02 The Procter & Gamble Company Quick dissolving diphenhydramine oral dosage form
US11110035B1 (en) 2016-02-05 2021-09-07 Gram Tactical Llc Tactical medicine dispensers
WO2017177037A1 (en) 2016-04-06 2017-10-12 University Of Virginia Patent Foundation Compositions and methods for treating cancer
EP3452023A1 (de) 2016-05-05 2019-03-13 Aquestive Therapeutics, Inc. Epinephrinzusammensetzungen mit verbesserter freisetzung
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US11517545B2 (en) 2016-12-15 2022-12-06 Evoke Pharma, Inc. Treatment of moderate and severe gastroparesis
CN110337290A (zh) 2016-12-31 2019-10-15 比奥克斯塞尔医疗股份有限公司 舌下右旋美托咪啶用于治疗激越的用途
US9901545B1 (en) 2017-04-13 2018-02-27 Richard C. Fuisz Method and composition for making an oral soluble film, containing at least one active agent
US10238600B2 (en) 2017-04-13 2019-03-26 Richard C. Fuisz Package, system and methods for custody and control of drugs, and method and composition for making an oral soluble film, containing at least one active agent
CN114983980A (zh) 2018-06-27 2022-09-02 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
US11478426B2 (en) 2018-09-25 2022-10-25 SpecGx LLC Abuse deterrent immediate release capsule dosage forms
CN109303334B (zh) * 2018-10-17 2021-04-13 汤臣倍健股份有限公司 一种口腔微泡腾片及其制备方法
CA3145388A1 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
US11173114B1 (en) 2020-07-10 2021-11-16 Nova Thin Film Pharmaceuticals Llc Method and system for manufacturing and oral soluble films and oral soluble films made by thereby
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4493848A (en) 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4639368A (en) 1984-08-23 1987-01-27 Farmacon Research Corporation Chewing gum containing a medicament and taste maskers
GB8426152D0 (en) * 1984-10-16 1984-11-21 Reckitt & Colmann Prod Ltd Medicinal compositions
US5135752A (en) * 1988-10-14 1992-08-04 Zetachron, Inc. Buccal dosage form
US5004601A (en) * 1988-10-14 1991-04-02 Zetachron, Inc. Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith
DK0494972T3 (da) 1989-10-02 1997-05-12 Cima Labs Inc Brusedosisform samt fremgangsmåde til administration heraf
US5223264A (en) * 1989-10-02 1993-06-29 Cima Labs, Inc. Pediatric effervescent dosage form
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
JP3170139B2 (ja) * 1994-04-08 2001-05-28 エスエス製薬株式会社 発泡性錠剤
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
EP0765157B1 (de) * 1994-06-15 1999-03-24 Dumex-Alpharma A/S Pellets
FR2732217B1 (fr) * 1995-03-29 1997-06-06 Hesnard Xavier Forme d'administration solide a usage oral
US5656284A (en) * 1995-04-24 1997-08-12 Balkin; Michael S. Oral transmucosal delivery tablet and method of making it
US5607697A (en) 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
CN1207675A (zh) * 1995-11-06 1999-02-10 萨默塞特药品有限公司 丙炔苯丙胺的经颊和舌下给药法
US5958455A (en) * 1996-02-09 1999-09-28 Quadrant Holdings Cambridge Ltd Oral solid dosage forms, methods of making same and compositions thereof
DE19618543C2 (de) 1996-05-08 1998-07-02 Ivoclar Ag Polymerisationsgerät
DE19814257A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
WO2000035418A2 (en) * 1998-12-18 2000-06-22 Bayer Corporation Chewable drug delivery system

Also Published As

Publication number Publication date
CA2333375C (en) 2007-05-29
HK1130691A1 (en) 2010-01-08
CY1109172T1 (el) 2014-07-02
ES2324907T3 (es) 2009-08-19
EP1082106A1 (de) 2001-03-14
ATE434432T1 (de) 2009-07-15
EP2095813A1 (de) 2009-09-02
PT1417959E (pt) 2009-07-02
DE60032691D1 (de) 2007-02-15
CY1107592T1 (el) 2013-03-13
EP1082106A4 (de) 2002-07-03
CY1109176T1 (el) 2014-07-02
EP1417959B1 (de) 2009-06-17
DK1082106T3 (da) 2007-04-10
DK1417959T3 (da) 2009-07-27
PT1419765E (pt) 2009-07-02
CA2333375A1 (en) 2000-10-05
US6200604B1 (en) 2001-03-13
EP1417959A1 (de) 2004-05-12
ATE548028T1 (de) 2012-03-15
EP1419765B1 (de) 2009-06-24
WO2000057858A1 (en) 2000-10-05
JP4954170B2 (ja) 2012-06-13
DK1419765T3 (da) 2009-07-20
EP2095813B1 (de) 2012-03-07
DE60042427D1 (de) 2009-07-30
JP4789324B2 (ja) 2011-10-12
JP2009029829A (ja) 2009-02-12
JP2002540141A (ja) 2002-11-26
ATE433745T1 (de) 2009-07-15
ATE350017T1 (de) 2007-01-15
CA2569674C (en) 2011-11-08
CA2569674A1 (en) 2000-10-05
EP1419765A1 (de) 2004-05-19
ES2324908T3 (es) 2009-08-19
DE60032691T2 (de) 2007-10-18
AU4019400A (en) 2000-10-16
DE60042463D1 (de) 2009-08-06
EP1082106B1 (de) 2007-01-03
ES2276677T3 (es) 2007-07-01

Similar Documents

Publication Publication Date Title
PT1082106E (pt) Comprimido efervescente para administração subligual, bucal e gengival de fentanil
US6974590B2 (en) Sublingual buccal effervescent
US8802130B2 (en) Sublingual buccal effervescent
US8048449B2 (en) Mouth dissolving pharmaceutical composition and process for preparing the same
EP1863443B1 (de) Schweres magnesiumcarbonat enthaltende schnell auflösende dosierform
US20070059361A1 (en) Fast-disintegrating epinephrine tablets for buccal or sublingual administration
PT93877B (pt) Processo para a preparacao de composicoes farmaceuticas para administracao oral de medicamentos, por exemplo antibioticos beta-lactamicos
WO2007096906A2 (en) Novel buccoadhesive compositions and process of preparation thereof
US20080187589A1 (en) Multi-modal delivery via transmucosal and gastro-intestinal absorption of antihistamines and symptom relief
AU2004242477B2 (en) Sublingual buccal effervescent
AU2007203233B2 (en) Sublingual buccal effervescent
ES2383478T3 (es) Comprimido para administración bucal, sublingual o gingival que comprende un aditivo efervescente
Shilpa Medicated chewing gum: a novel drug delivery system for the treatmnet of cough