PT1000027E - Modificacao estavel sob o ponto de vista termodinamico de 1-(4-carbazoililoxi)-3-¬2-(2-metoxifenoxi)etilamino|-2-propanolo processo para a sua preparacao e composicoes farmaceuticas que o contem - Google Patents

Modificacao estavel sob o ponto de vista termodinamico de 1-(4-carbazoililoxi)-3-¬2-(2-metoxifenoxi)etilamino|-2-propanolo processo para a sua preparacao e composicoes farmaceuticas que o contem

Info

Publication number
PT1000027E
PT1000027E PT98937576T PT98937576T PT1000027E PT 1000027 E PT1000027 E PT 1000027E PT 98937576 T PT98937576 T PT 98937576T PT 98937576 T PT98937576 T PT 98937576T PT 1000027 E PT1000027 E PT 1000027E
Authority
PT
Portugal
Prior art keywords
carbazoylyl
methoxyphenoxy
ethylamino
propanol
contain
Prior art date
Application number
PT98937576T
Other languages
English (en)
Inventor
Erhard Reinholz
Peter Beyer
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of PT1000027E publication Critical patent/PT1000027E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PT98937576T 1997-07-22 1998-07-18 Modificacao estavel sob o ponto de vista termodinamico de 1-(4-carbazoililoxi)-3-¬2-(2-metoxifenoxi)etilamino|-2-propanolo processo para a sua preparacao e composicoes farmaceuticas que o contem PT1000027E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97112491A EP0893440A1 (en) 1997-07-22 1997-07-22 Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it

Publications (1)

Publication Number Publication Date
PT1000027E true PT1000027E (pt) 2003-07-31

Family

ID=8227094

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98937576T PT1000027E (pt) 1997-07-22 1998-07-18 Modificacao estavel sob o ponto de vista termodinamico de 1-(4-carbazoililoxi)-3-¬2-(2-metoxifenoxi)etilamino|-2-propanolo processo para a sua preparacao e composicoes farmaceuticas que o contem

Country Status (32)

Country Link
EP (2) EP0893440A1 (pt)
JP (1) JP2001510824A (pt)
KR (1) KR100336229B1 (pt)
CN (1) CN1125047C (pt)
AR (1) AR015133A1 (pt)
AT (1) ATE236123T1 (pt)
AU (1) AU740453B2 (pt)
BR (1) BR9810776A (pt)
CA (1) CA2296637C (pt)
CZ (1) CZ296947B6 (pt)
DE (1) DE69812964T2 (pt)
DK (1) DK1000027T3 (pt)
ES (1) ES2195366T3 (pt)
HK (1) HK1029339A1 (pt)
HR (1) HRP980406A2 (pt)
HU (1) HUP0003198A3 (pt)
IL (1) IL133677A (pt)
MA (1) MA26523A1 (pt)
MY (1) MY117734A (pt)
NO (1) NO313588B1 (pt)
NZ (1) NZ502136A (pt)
PE (1) PE96999A1 (pt)
PL (1) PL191602B1 (pt)
PT (1) PT1000027E (pt)
RU (1) RU2202542C2 (pt)
SI (1) SI1000027T1 (pt)
TR (1) TR200000148T2 (pt)
TW (1) TW505631B (pt)
UY (1) UY25108A1 (pt)
WO (1) WO1999005105A1 (pt)
YU (1) YU2200A (pt)
ZA (1) ZA986475B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402336C (en) * 2000-04-03 2008-03-11 F. Hoffmann-La Roche Ag Concentrated solutions of carvedilol
EP1655285A1 (en) * 2000-06-28 2006-05-10 Teva Pharmaceutical Industries Ltd. Method for preparation of a crystalline form of carvedilol (form II)
KR20080064908A (ko) * 2000-06-28 2008-07-09 테바 파마슈티컬 인더스트리즈 리미티드 카르베딜올
DE60212130D1 (en) * 2001-07-13 2006-07-20 Smithkline Beecham Corp Carvedilolpolymorph
ES2298401T3 (es) 2001-09-21 2008-05-16 Egalet A/S Dispersiones solidas de liberacion controlada de carvedilol.
CN1308307C (zh) * 2001-09-28 2007-04-04 弗·哈夫曼-拉罗切有限公司 假多晶型的卡维地洛
WO2003059807A2 (en) 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
AU2003231283A1 (en) * 2002-04-30 2003-11-17 Sb Pharmco Puerto Rico Inc. Carvedilol monocitrate monohydrate
US20050261355A1 (en) 2002-06-27 2005-11-24 Sb Pharmco Puerto Rico Inc., Carvedilol hydobromide
US7268156B2 (en) * 2002-06-27 2007-09-11 Sb Pharmco Puerto Rico Inc. Carvedilol phosphate salts and/or solvates thereof, corresponding compositions and/or methods of treatment
US20040151772A1 (en) 2002-11-08 2004-08-05 Egalet A/S Controlled release carvedilol compositions
ATE495732T1 (de) 2003-03-26 2011-02-15 Egalet As Morphin-system mit kontrollierter freisetzung
WO2004094378A1 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
SI21616A (sl) * 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
US7750036B2 (en) 2003-11-25 2010-07-06 Sb Pharmco Puerto Rico Inc. Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
EP1838670B1 (en) * 2004-12-09 2009-10-14 ZaCh System S.p.A. Process for the preparation of carvedilol and its enantiomers
WO2006135757A1 (en) * 2005-06-09 2006-12-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of carvedilol and processes for their preparation
WO2008002683A2 (en) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
US20080249317A1 (en) * 2007-04-04 2008-10-09 Apotex Inc. Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
CA2751667C (en) 2009-02-06 2016-12-13 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

Also Published As

Publication number Publication date
PL338432A1 (en) 2000-11-06
CN1264366A (zh) 2000-08-23
AU8631998A (en) 1999-02-16
HUP0003198A2 (en) 2001-03-28
DK1000027T3 (da) 2003-07-21
KR100336229B1 (ko) 2002-05-09
CZ2000221A3 (cs) 2000-05-17
AU740453B2 (en) 2001-11-01
EP0893440A1 (en) 1999-01-27
HRP980406A2 (en) 1999-04-30
YU2200A (sh) 2002-03-18
IL133677A (en) 2004-06-01
UY25108A1 (es) 2000-12-29
ZA986475B (en) 2000-01-21
CZ296947B6 (cs) 2006-08-16
MA26523A1 (fr) 2004-12-20
IL133677A0 (en) 2001-04-30
DE69812964T2 (de) 2004-03-04
WO1999005105A1 (en) 1999-02-04
BR9810776A (pt) 2000-09-19
NZ502136A (en) 2002-05-31
EP1000027A1 (en) 2000-05-17
TW505631B (en) 2002-10-11
MY117734A (en) 2004-07-31
NO313588B1 (no) 2002-10-28
KR20010022097A (ko) 2001-03-15
HUP0003198A3 (en) 2002-10-28
DE69812964D1 (de) 2003-05-08
CA2296637A1 (en) 1999-02-04
HK1029339A1 (en) 2001-03-30
NO20000301D0 (no) 2000-01-21
PE96999A1 (es) 1999-10-12
TR200000148T2 (tr) 2000-07-21
SI1000027T1 (en) 2003-10-31
JP2001510824A (ja) 2001-08-07
NO20000301L (no) 2000-01-21
AR015133A1 (es) 2001-04-18
CN1125047C (zh) 2003-10-22
ES2195366T3 (es) 2003-12-01
PL191602B1 (pl) 2006-06-30
RU2202542C2 (ru) 2003-04-20
EP1000027B1 (en) 2003-04-02
ATE236123T1 (de) 2003-04-15
CA2296637C (en) 2005-11-15

Similar Documents

Publication Publication Date Title
PT1000027E (pt) Modificacao estavel sob o ponto de vista termodinamico de 1-(4-carbazoililoxi)-3-¬2-(2-metoxifenoxi)etilamino|-2-propanolo processo para a sua preparacao e composicoes farmaceuticas que o contem
PT1192122E (pt) Derivados de benzeno processo para a sua preparacao e composicoes farmaceuticas que os contem
PT835246E (pt) Compostos aromaticos e composicoes farmaceuticas que os contem
PT1066049E (pt) Composicoes farmaceuticas para a libertacao prolongada de peptido e processo para a sua libertacao
PT1036794E (pt) Derivados de 2-aril-8-oxodi-hidropurina processo para a sua producao composicoes medicinais que os contem e seus intermediarios
PT102504A (pt) Composicoes farmaceuticas estaveis contendo um inibidor de hmg coa redutase e processo para a sua preparacao
BR9804488B1 (pt) filme para modulação de luz curável por radiação ultravioleta e método para sua obtenção.
ITMI951310A0 (it) Estrattore/raffreddatore di materiali sfusi
PT780390E (pt) Modificacao cristalina do cdch processo para a sua producao e preparacoes farmaceuticas que o contem
EE04262B1 (et) Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt
BR9606328A (pt) Derivado de benzilsulfeto processo para sua preparação e praguicida
PT885204E (pt) Novos derivados de arilglicinamida, processo para a sua preparacao e composicoes farmaceuticas que contem estes compostos
PT996614E (pt) Compostos de acrilonitrilo processos para a sua producao e pesticidas que oc contem
BR9506106A (pt) Composto processo para sua preparação medicamento e composição farmacêutica
PT1122254E (pt) Derivados de 4-sulfonamidas piperidina, processo para a sua preparacao e as composicoes farmaceuticas que os contem
PT1118610E (pt) Novos derivados de benzeno-sulfonamida processo para a sua preparacao e as composicoes farmaceuticas que os contem
PT1049706E (pt) Novos penta-sacaridos os respectivos metodos de producao e as composicoes farmaceuticas que os contem
BR1100524A (pt) Compostos, processo para sua preparação; compostos intermediários para os mesmos, e composições farmacêuticas
PT939083E (pt) Complexos de ferro-succinilcaseina procedimento para sua preparacao e suas composicoes farmaceuticas
DE69810243T2 (de) Härtbare Zusammensetzung und optisches Material daraus
PT1086077E (pt) Novos antiestrogeneos processo para a sua preparacao e sua utilizacao farmaceutica
PT1176148E (pt) Novos derivados de benzotiadiazina processo para a sua preparacao e as composicoes farmaceuticas que os contem
PT1241169E (pt) Derivados de isoindoloindolona processo para a sua preparacao e as composicoes farmaceuticas que os contem
BR9506062A (pt) Compostos processo para sua preparação medicamento e composição farmacêutica
PT1277746E (pt) Novos derivados de n-benzilpiperazina, processo para a sua preparacao e as composicoes farmaceuticas que os contem