PL360027A1 - Substituted-triazolopyrimidines as anticancer agents - Google Patents

Substituted-triazolopyrimidines as anticancer agents

Info

Publication number
PL360027A1
PL360027A1 PL36002701A PL36002701A PL360027A1 PL 360027 A1 PL360027 A1 PL 360027A1 PL 36002701 A PL36002701 A PL 36002701A PL 36002701 A PL36002701 A PL 36002701A PL 360027 A1 PL360027 A1 PL 360027A1
Authority
PL
Poland
Prior art keywords
triazolopyrimidines
substituted
anticancer agents
anticancer
agents
Prior art date
Application number
PL36002701A
Other languages
English (en)
Polish (pl)
Inventor
Mark R. Schmitt
Donald R. Kirsch
Jane E. Harris
Carl F. Beyer
Klaus-Juergen Pees
Paul Carter
Waldemar Pfrengle
Guido Albert
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Publication of PL360027A1 publication Critical patent/PL360027A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL36002701A 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents PL360027A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
PL360027A1 true PL360027A1 (en) 2004-09-06

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
PL36002701A PL360027A1 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Country Status (24)

Country Link
US (1) US7329663B2 (OSRAM)
EP (1) EP1307200A2 (OSRAM)
JP (1) JP2004502691A (OSRAM)
KR (1) KR20030013475A (OSRAM)
CN (1) CN1592624A (OSRAM)
AR (1) AR034553A1 (OSRAM)
AU (2) AU7306201A (OSRAM)
BG (1) BG107277A (OSRAM)
BR (1) BR0112038A (OSRAM)
CA (1) CA2413802A1 (OSRAM)
CZ (1) CZ20024150A3 (OSRAM)
EA (1) EA006483B1 (OSRAM)
GE (1) GEP20053688B (OSRAM)
HK (1) HK1052646A1 (OSRAM)
HU (1) HUP0300798A3 (OSRAM)
IL (1) IL152869A0 (OSRAM)
IN (1) IN2003KO00001A (OSRAM)
MX (1) MXPA02011913A (OSRAM)
NO (1) NO20026195L (OSRAM)
NZ (1) NZ523807A (OSRAM)
PL (1) PL360027A1 (OSRAM)
SK (1) SK18412002A3 (OSRAM)
WO (1) WO2002002563A2 (OSRAM)
ZA (1) ZA200300793B (OSRAM)

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DE10124208A1 (de) † 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
EP1412359A1 (en) * 2001-07-18 2004-04-28 Basf Aktiengesellschaft Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides
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JPWO2004011467A1 (ja) * 2002-07-29 2005-12-15 北興化学工業株式会社 トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
EP1611135A1 (de) * 2003-03-31 2006-01-04 Basf Aktiengesellschaft 7-alkenylamino-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bek mpfung von schadpilzen sowie sie enthaltende mittel
US20070275961A1 (en) * 2003-06-04 2007-11-29 Vernalis (Cambridge) Limited. Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
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US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
JPWO2005037837A1 (ja) * 2003-10-17 2006-12-28 日本化薬株式会社 置換２−アミノ−［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
BRPI0417637A (pt) * 2003-12-17 2007-03-27 Basf Ag compostos, processo para preparar os mesmos, agente, semente, e, processo para combater fungos nocivos fitopatogênicos
BRPI0417628A (pt) * 2003-12-17 2007-03-27 Basf Ag composto, processo para preparar o mesmo, agente, semente, e, processo para combater fungos nocivos fitopatogênicos
US20070208038A1 (en) * 2004-03-30 2007-09-06 Basf Aktiengesellschaft 6-(2-Fluorophenyl)-Triazolopyrimidines, Method for Producing Them, Their use for Controlling Parasitic Fungi and Agents Containing the Same
JP2007538028A (ja) * 2004-05-17 2007-12-27 ビーエーエスエフ　アクチェンゲゼルシャフト トリアゾロピリミジン化合物および病原菌を制御するためのそれらの使用
WO2005120233A1 (de) * 2004-06-09 2005-12-22 Basf Aktiengesellschaft Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
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US8921381B2 (en) * 2010-10-04 2014-12-30 Baruch S. Blumberg Institute Inhibitors of secretion of hepatitis B virus antigens
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CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
CA3178865A1 (en) * 2020-04-14 2021-10-21 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
CA3181922A1 (en) 2020-05-01 2021-11-04 Gilead Sciences, Inc. Cd73 inhibiting 2,4-dioxopyrimidine compounds
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
US12180220B2 (en) 2020-10-14 2024-12-31 Tosk, Inc. Heteroaryl modulators of RAS GTPase
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WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

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Also Published As

Publication number Publication date
HUP0300798A2 (hu) 2003-07-28
IL152869A0 (en) 2003-06-24
NO20026195D0 (no) 2002-12-23
KR20030013475A (ko) 2003-02-14
WO2002002563A3 (en) 2003-01-03
NZ523807A (en) 2004-09-24
GEP20053688B (en) 2005-12-12
AR034553A1 (es) 2004-03-03
AU7306201A (en) 2002-01-14
HK1052646A1 (zh) 2003-09-26
BG107277A (bg) 2004-01-30
HUP0300798A3 (en) 2006-02-28
AU2001273062B2 (en) 2005-11-24
NO20026195L (no) 2003-02-27
IN2003KO00001A (OSRAM) 2005-12-02
WO2002002563A2 (en) 2002-01-10
ZA200300793B (en) 2004-07-20
EA200300091A1 (ru) 2003-08-28
EP1307200A2 (en) 2003-05-07
US7329663B2 (en) 2008-02-12
CZ20024150A3 (cs) 2003-09-17
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
SK18412002A3 (sk) 2003-06-03
BR0112038A (pt) 2003-04-01
MXPA02011913A (es) 2003-04-22
EA006483B1 (ru) 2005-12-29
JP2004502691A (ja) 2004-01-29
US20020068744A1 (en) 2002-06-06

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