PL3590971T3 - Polisiarczan pentozanu, kompozycja farmaceutyczna i antykoagulant - Google Patents

Polisiarczan pentozanu, kompozycja farmaceutyczna i antykoagulant

Info

Publication number
PL3590971T3
PL3590971T3 PL18761900.2T PL18761900T PL3590971T3 PL 3590971 T3 PL3590971 T3 PL 3590971T3 PL 18761900 T PL18761900 T PL 18761900T PL 3590971 T3 PL3590971 T3 PL 3590971T3
Authority
PL
Poland
Prior art keywords
anticoagulant
pharmaceutical composition
pentosan polysulfate
polysulfate
pentosan
Prior art date
Application number
PL18761900.2T
Other languages
English (en)
Inventor
Kotaro Ishikawa
Takuro Kashiwamura
Takuya Kato
Toru Koga
Suguru Ishikawa
Original Assignee
Oji Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oji Holdings Corporation filed Critical Oji Holdings Corporation
Publication of PL3590971T3 publication Critical patent/PL3590971T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0057—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Xylans, i.e. xylosaccharide, e.g. arabinoxylan, arabinofuronan, pentosans; (beta-1,3)(beta-1,4)-D-Xylans, e.g. rhodymenans; Hemicellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/14—Hemicellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/14—Hemicellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L97/00—Compositions of lignin-containing materials
    • C08L97/02—Lignocellulosic material, e.g. wood, straw or bagasse

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Birds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
PL18761900.2T 2017-02-28 2018-02-27 Polisiarczan pentozanu, kompozycja farmaceutyczna i antykoagulant PL3590971T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017035916 2017-02-28
JP2017166559A JP6281659B1 (ja) 2017-02-28 2017-08-31 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
PCT/JP2018/007138 WO2018159580A1 (ja) 2017-02-28 2018-02-27 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤

Publications (1)

Publication Number Publication Date
PL3590971T3 true PL3590971T3 (pl) 2023-01-23

Family

ID=61231477

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18761900.2T PL3590971T3 (pl) 2017-02-28 2018-02-27 Polisiarczan pentozanu, kompozycja farmaceutyczna i antykoagulant

Country Status (16)

Country Link
US (1) US11274165B2 (pl)
EP (1) EP3590971B1 (pl)
JP (1) JP6281659B1 (pl)
KR (1) KR102520754B1 (pl)
CN (1) CN110325553B (pl)
AU (1) AU2018229054B2 (pl)
BR (1) BR112019017527B1 (pl)
CA (1) CA3054533C (pl)
ES (1) ES2929538T3 (pl)
HU (1) HUE060518T2 (pl)
MX (1) MX2019010189A (pl)
MY (1) MY198582A (pl)
PL (1) PL3590971T3 (pl)
PT (1) PT3590971T (pl)
SG (1) SG11201907938RA (pl)
WO (1) WO2018159580A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102559743B1 (ko) 2016-08-31 2023-07-25 오지 홀딩스 가부시키가이샤 산성 자일로올리고당의 제조 방법 및 산성 자일로올리고당
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
BR112019025030A2 (pt) 2017-05-31 2020-06-16 Oji Holdings Corporation Preparação umidificante tópica.
KR102678054B1 (ko) 2017-09-12 2024-06-24 오지 홀딩스 가부시키가이샤 폴리황산펜토산 및 폴리황산펜토산의 제조 방법
JP6662503B2 (ja) * 2017-12-20 2020-03-11 王子ホールディングス株式会社 ポリ硫酸ペントサン及びポリ硫酸ペントサンを含む医薬
EP3842048B1 (en) * 2018-08-20 2024-10-02 ReqMed Company, Ltd. Novel pentosan polysulfate sodium preparation
WO2022026398A1 (en) * 2020-07-31 2022-02-03 The Board Of Trustees Of The Leland Stanford Junior University Combination therapy for cancer

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4843100B1 (pl) * 1969-09-05 1973-12-17
JPS4843100A (pl) * 1971-09-30 1973-06-22
US4168742A (en) 1978-03-27 1979-09-25 Hudson Products Corporation Tube bundle
FR2538404B1 (pl) 1982-12-28 1985-08-23 Anic Spa
FR2543145B1 (fr) 1983-03-24 1986-10-17 Sanofi Sa Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante
JPS60112708A (ja) 1983-11-24 1985-06-19 Maruho Kk 皮膚用保湿剤
FR2572731B1 (fr) * 1984-11-07 1987-03-06 Sanofi Sa Nouveaux sulfates de xylanes de bas poids moleculaires, leur procede de preparation et leur activite antithrombotique et hypolipemiante par voie orale
JPS61130302A (ja) 1984-11-30 1986-06-18 Tokyo Univ 抗凝血活性を有する硫酸化リボフラナン及びその製造法
JPS61130301A (ja) 1984-11-30 1986-06-18 Tokyo Univ 抗凝血活性を有する硫酸化キシロフラナン及びその製造法
US5672334A (en) 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
FR2645745B1 (fr) 1989-04-12 1991-09-27 Anben Ste Civile Compositions therapeutiques pour le traitement ou la prevention du ronflement
DE3917982A1 (de) 1989-06-02 1990-12-06 Behringwerke Ag Verwendung von xylanpolyhydrogensulfaten zur therapie von zellproliferations-bedingten erkrankungen
FR2648463B1 (fr) 1989-06-14 1993-01-22 Inst Fs Rech Expl Mer Polysaccharides sulfates, agent anticoagulant et agent anticomplementaire obtenus a partir de fucanes d'algues brunes et leur procede d'obtention
BR9106377A (pt) 1990-04-26 1993-04-27 Cytrx Corp Composicao e processo para o tratamento topico de tecido lesado ou enfermo
US20010005720A1 (en) 1995-06-07 2001-06-28 U.S.A. As Represented By The Secretary Department Of Health And Human Services Method of treating chronic progressive vascular scarring diseases
DE19632840A1 (de) 1996-08-14 1998-02-19 Landsberger Albert Vitamin A-haltige Zusammensetzung
JPH10195107A (ja) 1997-01-10 1998-07-28 Shiseido Co Ltd オリゴ硫酸化ヒアルロン酸
JP4336905B2 (ja) 1997-12-19 2009-09-30 マルホ株式会社 硫酸化多糖類含有皮膚保湿乳剤性ローション剤
US6593310B1 (en) * 2000-11-21 2003-07-15 Arthropharm Pty. Ltd. Treatment of osteoporosis
DE10141106A1 (de) 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
JP4073661B2 (ja) 2001-12-20 2008-04-09 王子製紙株式会社 酸性キシロオリゴ糖組成物の製造方法
JP3772749B2 (ja) 2002-01-25 2006-05-10 王子製紙株式会社 メラニン生成抑制剤
JP2003221339A (ja) 2002-01-29 2003-08-05 Oji Paper Co Ltd 抗炎症剤
ITMI20031618A1 (it) 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
ES2399277T3 (es) 2004-05-27 2013-03-27 Baxter International Inc. Procedimiento de tratamiento de trastornos hemorrágicos utilizando polisacáridos sulfatados
RU2413734C2 (ru) 2004-08-05 2011-03-10 Ивакс Драг Рисерч Инститьют Лтд Полисульфатированные гликозиды и их соли
US20060194759A1 (en) 2005-02-25 2006-08-31 Eidelson Stewart G Topical compositions and methods for treating pain and inflammation
WO2007014155A2 (en) 2005-07-22 2007-02-01 Trf Pharma, Inc. Method for treating sickle cell disease and sickle cell disease sequelae
US20070243218A1 (en) 2006-04-03 2007-10-18 Ellinghuysen Jerry A Stabilized pentosan polysulfate (PPS) formulations and methods of analyzing them
GB0610350D0 (en) 2006-05-25 2006-07-05 Univ Liverpool prevention and/or treatment of neuodegenerative disorders
JPWO2008066193A1 (ja) 2006-11-27 2010-03-11 チッソ株式会社 化粧料組成物
WO2008107906A1 (en) * 2007-03-06 2008-09-12 Alembic Limited Process for the preparation of pentosan polysulfate or salts thereof
FI121811B (fi) * 2007-06-01 2011-04-29 Upm Kymmene Corp Uudet dispersiot ja menetelmä niiden valmistamiseksi
HUP0900072A2 (hu) 2009-02-06 2010-09-28 Egis Gyogyszergyar Nyilvanosan Transzdermális gyógyszerkészítmények
WO2009087581A1 (en) * 2008-01-04 2009-07-16 Alembic Limited An improved process for the preparation of pentosan polysulfate or salts thereof
JP2009196915A (ja) 2008-02-20 2009-09-03 Ezaki Glico Co Ltd 化粧品用組成物
AU2008100725B4 (en) 2008-07-04 2008-10-02 Parnell Technologies Pty Ltd A sulfated polysaccharide compound for clinical use
FR2935386B1 (fr) 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
US8993536B2 (en) * 2009-02-02 2015-03-31 Otsuka Chemical Co., Ltd. Low-molecular polysulfated hyaluronic acid derivative and medicine containing same
CN102061323B (zh) 2010-11-10 2013-09-25 山东龙力生物科技股份有限公司 一种植物木质纤维素的综合利用工艺
WO2012101544A1 (en) 2011-01-29 2012-08-02 Alembic Pharmaceuticals Limited An improved process for the preparation of pentosan polysulfate or salts thereof
WO2012114349A1 (en) * 2011-02-23 2012-08-30 Cadila Healthcare Limited An improved process for the preparation of pentosan polysulfate sodium
CN102766225B (zh) * 2011-05-06 2015-08-05 上海医药工业研究院 一种戊聚糖聚硫酸钠的制备方法以及一种寡聚木糖
WO2013186857A1 (ja) 2012-06-12 2013-12-19 株式会社リボミック Ｆｇｆ２に対するアプタマー及びその使用
ITMI20130112A1 (it) 2013-01-24 2014-07-25 Chemi Spa Metodo di qualificazione di preparazioni di pentosan polifosfato, sue materie prime e processi di produzione
JO3529B1 (ar) 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
JP6132302B2 (ja) 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
CN103320548A (zh) 2013-06-24 2013-09-25 稼禾生物股份有限公司 一种利用农作物秸秆制备低聚木糖和纤维素的方法
JP6403317B2 (ja) 2013-07-19 2018-10-10 学校法人慶應義塾 抗腫瘍剤
WO2016184887A1 (en) * 2015-05-20 2016-11-24 Chemi Spa Process for the preparation of polysaccharides
BR112017025459A2 (pt) 2015-05-27 2018-08-07 Vanguard Therapeutics Inc composição, método para tratamento de doença falciforme, kit, método para detecção de polissulfato pentosano de sódio (pps)
CN106832020A (zh) 2015-12-04 2017-06-13 长春工业大学 一种玉米秸秆戊聚糖硫酸酯的制备工艺
CN105907896B (zh) 2016-05-16 2019-11-12 中国科学院广州能源研究所 一种利用木质纤维原料联产高浓度木糖和低聚木糖的方法
JP6225321B1 (ja) * 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
KR102559743B1 (ko) * 2016-08-31 2023-07-25 오지 홀딩스 가부시키가이샤 산성 자일로올리고당의 제조 방법 및 산성 자일로올리고당
JP6281659B1 (ja) * 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤

Also Published As

Publication number Publication date
CA3054533A1 (en) 2018-09-07
WO2018159580A1 (ja) 2018-09-07
BR112019017527A2 (pt) 2020-03-31
BR112019017527B1 (pt) 2024-03-12
MX2019010189A (es) 2019-10-09
PT3590971T (pt) 2022-11-29
EP3590971B1 (en) 2022-10-12
EP3590971A4 (en) 2020-12-09
CA3054533C (en) 2024-05-28
US11274165B2 (en) 2022-03-15
AU2018229054A1 (en) 2019-09-12
AU2018229054B2 (en) 2021-09-16
HUE060518T2 (hu) 2023-03-28
JP2018141120A (ja) 2018-09-13
EP3590971A1 (en) 2020-01-08
KR20190120216A (ko) 2019-10-23
CN110325553B (zh) 2021-10-08
JP6281659B1 (ja) 2018-02-21
MY198582A (en) 2023-09-06
SG11201907938RA (en) 2019-09-27
CN110325553A (zh) 2019-10-11
US20200062867A1 (en) 2020-02-27
KR102520754B1 (ko) 2023-04-11
ES2929538T3 (es) 2022-11-30

Similar Documents

Publication Publication Date Title
PL3590971T3 (pl) Polisiarczan pentozanu, kompozycja farmaceutyczna i antykoagulant
IL262432B (en) Modified nanocrystaline cellulose materials and formulations and products made therefrom
DK3297605T3 (da) Topiske, farmaceutiske sammesætninger
EP3633034A4 (en) MODIFIED Cas9 PROTEIN AND USE THEREOF
DK3362445T3 (da) Oxadiazolaminderivatforbindelser som histondeacetylase 6-inhibitor, og den farmaceutiske sammensætning dermed
LT3513809T (lt) Medicininė kompozicija, apimanti tivozanibą
DK2986304T3 (da) Farmaceutisk sammensætning, fremgangsmåder til behandling og anvendelser deraf.
EP3450460A4 (en) MULTI-SPECIFIC BINDING CONJUGATE, CORRESPONDING PHARMACEUTICAL COMPOSITIONS AND USE
IL246837B (en) Antibodies, pharmaceutical compositions and uses thereof
DK3655017T3 (da) Farmaceutisk sammensætning
DK3426294T3 (da) Farmaceutisk formulering omfattende antistof, cyclodextrin og methionin
DK3233111T3 (da) Farmaceutisk sammensætning, der omfatter plasminogen, og anvendelser deraf
EP3685828A4 (en) OPHTHALMIC PHARMACEUTICAL COMPOSITION, OPHTHALMIC KIT, AND PHARMACEUTICAL USE THEREOF
EP3520847A4 (en) CAP, SYRINGE ARRANGEMENT AND PRE-FILLED SYRINGE
PL3135110T3 (pl) Pochodne 1,7-diarylo-1,6-heptadieno-3,5-dionu, sposób ich wytwarzania i ich zastosowanie
DK3236934T3 (da) Farmaceutisk sammensætning, fremstilling og anvendelser deraf
DK3223796T3 (da) Farmaceutiske sammensætninger, fremstilling og anvendelser deraf
EP3003344A4 (en) CONOTOXINPEPTIDES, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
EP3583943A4 (en) PHARMACEUTICAL COMPOSITION
BR112017013012A2 (pt) compostos de indenil, composições farmacêuticas e usos médicos destes
DK3229843T3 (da) Farmaceutisk sammensætning, præparat og anvendelser deraf
HUE057871T2 (hu) Gyógyászati hatóanyagokat tartalmazó hialuronán konjugátumok, eljárások és kompozíciók
DK4023651T3 (da) Optisk aktivt pyranochromenylphenolderivat og farmaceutisk sammensætning, der omfatter samme
DK3383397T3 (da) Farmaceutiske sammensætninger indeholdende doravirin, tenofovirdisoproxilfumarat og lamivudin
PT3486233T (pt) Complexo pouco solúvel ou um seu solvato, composição farmacêutica e sua aplicação