PL351767A1 - Heteroaryl amidines, methylamidines and guanidines as protease inhibitors - Google Patents
Heteroaryl amidines, methylamidines and guanidines as protease inhibitorsInfo
- Publication number
- PL351767A1 PL351767A1 PL99351767A PL35176799A PL351767A1 PL 351767 A1 PL351767 A1 PL 351767A1 PL 99351767 A PL99351767 A PL 99351767A PL 35176799 A PL35176799 A PL 35176799A PL 351767 A1 PL351767 A1 PL 351767A1
- Authority
- PL
- Poland
- Prior art keywords
- methylamidines
- guanidines
- protease inhibitors
- amidines
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24706299A | 1999-02-09 | 1999-02-09 | |
PCT/US1999/018065 WO2000047578A1 (fr) | 1999-02-09 | 1999-08-11 | Amidines, methylamidines et guanidines, heteroaryles, en tant qu'inhibiteurs de proteases |
Publications (1)
Publication Number | Publication Date |
---|---|
PL351767A1 true PL351767A1 (en) | 2003-06-16 |
Family
ID=22933398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL99351767A PL351767A1 (en) | 1999-02-09 | 1999-08-11 | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1150979A1 (fr) |
JP (1) | JP2002536446A (fr) |
KR (1) | KR20010098982A (fr) |
CN (1) | CN1337961A (fr) |
AU (1) | AU5671799A (fr) |
BG (1) | BG105866A (fr) |
BR (1) | BR9917036A (fr) |
CA (1) | CA2362390A1 (fr) |
CZ (1) | CZ20012858A3 (fr) |
EA (1) | EA200100882A1 (fr) |
HU (1) | HUP0201475A2 (fr) |
IL (1) | IL144560A0 (fr) |
MX (1) | MXPA01008084A (fr) |
NO (1) | NO324887B1 (fr) |
NZ (1) | NZ513701A (fr) |
PL (1) | PL351767A1 (fr) |
SK (1) | SK11422001A3 (fr) |
WO (1) | WO2000047578A1 (fr) |
ZA (1) | ZA200106849B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1152759A2 (fr) * | 1999-02-09 | 2001-11-14 | 3-Dimensional Pharmaceuticals, Inc. | METHODES DE TRAITEMENT DE MALADIES ET PATHOLOGIES INDUITES PAR C1s, COMPOSES ET COMPOSITIONS PREPARES A CET EFFET |
US7109354B2 (en) * | 2002-05-28 | 2006-09-19 | 3-Dimensional Pharmaceuticals, Inc. | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
KR20070007759A (ko) * | 2003-07-10 | 2007-01-16 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서 유용한 치환된 아릴티오우레아유도체 |
EP1718342A4 (fr) | 2004-02-12 | 2009-07-22 | Molecular Insight Pharm Inc | Complexes de technetium-bis(heteroaryl) et de rhenium-bis(heteroaryl) et methodes d'utilisation associees |
AU2009303335B2 (en) * | 2008-10-09 | 2016-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
CN102482249B (zh) | 2009-07-08 | 2016-06-08 | 德米拉(加拿大)公司 | 用于治疗皮肤病症或疾病状态的tofa类似物 |
WO2011137089A1 (fr) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activateurs de la pyruvate kinase humaine |
ES2693107T3 (es) * | 2011-01-25 | 2018-12-07 | The Regents Of The University Of Michigan | Inhibidores de Bcl-2/Bcl-xL para su uso en el tratamiento del cáncer |
AR086744A1 (es) * | 2011-06-28 | 2014-01-22 | Nippon Soda Co | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria |
EP2606726A1 (fr) * | 2011-12-21 | 2013-06-26 | Bayer CropScience AG | Dérivés de trifluoroéthylsulfure substitués par du N-arylamidine en tant qu'acaricides et insecticides |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
EP3495359A1 (fr) * | 2013-02-04 | 2019-06-12 | Janssen Pharmaceutica NV | Modulateurs à flap |
JP7301042B2 (ja) * | 2018-03-30 | 2023-06-30 | 住友化学株式会社 | 複素環化合物及びそれを含有する有害節足動物防除組成物 |
CN109020837A (zh) * | 2018-07-27 | 2018-12-18 | 广东省石油与精细化工研究院 | 一种2-取代苯基-乙脒盐酸盐的制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4220654A (en) * | 1979-06-04 | 1980-09-02 | Merck & Co., Inc. | Cyclic imidazole cyanoguanidines |
US4424367A (en) * | 1982-08-19 | 1984-01-03 | Norwich Eaton Pharmaceuticals, Inc. | 5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate |
JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
DE3427865A1 (de) * | 1984-07-27 | 1986-02-06 | Torii & Co., Tokio/Tokyo | Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
EP0724435B1 (fr) * | 1993-10-21 | 2002-08-14 | G.D. Searle & Co. | Derives amidino utiles comme inhibiteurs de l'oxyde nitrique-synthase |
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
US5612353A (en) * | 1995-06-07 | 1997-03-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
TW414795B (en) * | 1996-07-01 | 2000-12-11 | Yamanouchi Pharma Co Ltd | A thiophene derivative and the pharmaceutical composition |
DE19632773A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
HUP0100082A3 (en) * | 1998-01-26 | 2001-12-28 | Abbott Gmbh & Co Kg | Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use |
EP1049673A1 (fr) * | 1998-01-26 | 2000-11-08 | Basf Aktiengesellschaft | Amidines heterocycliques utilisees comme inhibiteurs de la kallicreine |
CA2321025A1 (fr) * | 1998-02-09 | 1999-08-12 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines et guanidines utiles en tant qu'inhibiteurs de protease et plus particulierement en tant qu'inhibiteurs d'urokinase |
NZ506985A (en) * | 1998-03-31 | 2003-10-31 | Warner Lambert Co | Benzoxazinones/benzothiazinones as serine protease inhibitors |
KR20010042287A (ko) * | 1998-03-31 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 세린 프로테아제 억제제로서의 퀴놀론 |
KR20010042298A (ko) * | 1998-03-31 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 인자 Xa 및 트롬빈과 같은 세린 프로테아제억제제로서의 퀴녹살리논 |
-
1999
- 1999-08-11 EP EP99943667A patent/EP1150979A1/fr not_active Withdrawn
- 1999-08-11 CZ CZ20012858A patent/CZ20012858A3/cs unknown
- 1999-08-11 PL PL99351767A patent/PL351767A1/xx not_active Application Discontinuation
- 1999-08-11 CN CN99816415A patent/CN1337961A/zh active Pending
- 1999-08-11 MX MXPA01008084A patent/MXPA01008084A/es unknown
- 1999-08-11 BR BR9917036-1A patent/BR9917036A/pt not_active IP Right Cessation
- 1999-08-11 IL IL14456099A patent/IL144560A0/xx unknown
- 1999-08-11 AU AU56717/99A patent/AU5671799A/en not_active Abandoned
- 1999-08-11 SK SK1142-2001A patent/SK11422001A3/sk unknown
- 1999-08-11 EA EA200100882A patent/EA200100882A1/ru unknown
- 1999-08-11 CA CA002362390A patent/CA2362390A1/fr not_active Abandoned
- 1999-08-11 WO PCT/US1999/018065 patent/WO2000047578A1/fr not_active Application Discontinuation
- 1999-08-11 HU HU0201475A patent/HUP0201475A2/hu unknown
- 1999-08-11 NZ NZ513701A patent/NZ513701A/xx not_active Application Discontinuation
- 1999-08-11 KR KR1020017010094A patent/KR20010098982A/ko not_active Application Discontinuation
- 1999-08-11 JP JP2000598498A patent/JP2002536446A/ja active Pending
-
2001
- 2001-08-07 NO NO20013853A patent/NO324887B1/no not_active IP Right Cessation
- 2001-08-20 ZA ZA200106849A patent/ZA200106849B/en unknown
- 2001-09-01 BG BG105866A patent/BG105866A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BR9917036A (pt) | 2002-07-30 |
EA200100882A1 (ru) | 2002-04-25 |
NZ513701A (en) | 2001-09-28 |
CN1337961A (zh) | 2002-02-27 |
MXPA01008084A (es) | 2004-09-10 |
ZA200106849B (en) | 2002-11-20 |
CA2362390A1 (fr) | 2000-08-17 |
SK11422001A3 (sk) | 2002-04-04 |
KR20010098982A (ko) | 2001-11-08 |
NO324887B1 (no) | 2007-12-27 |
JP2002536446A (ja) | 2002-10-29 |
AU5671799A (en) | 2000-08-29 |
HUP0201475A2 (hu) | 2003-10-28 |
BG105866A (en) | 2002-06-28 |
NO20013853L (no) | 2001-10-09 |
EP1150979A1 (fr) | 2001-11-07 |
NO20013853D0 (no) | 2001-08-07 |
WO2000047578A1 (fr) | 2000-08-17 |
IL144560A0 (en) | 2002-05-23 |
CZ20012858A3 (cs) | 2002-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |