PL3319969T3 - Diarylowe polimorfy makrocykliczne - Google Patents
Diarylowe polimorfy makrocykliczneInfo
- Publication number
- PL3319969T3 PL3319969T3 PL16821872.5T PL16821872T PL3319969T3 PL 3319969 T3 PL3319969 T3 PL 3319969T3 PL 16821872 T PL16821872 T PL 16821872T PL 3319969 T3 PL3319969 T3 PL 3319969T3
- Authority
- PL
- Poland
- Prior art keywords
- polymorph
- macrocycle
- diaryl
- diaryl macrocycle
- macrocycle polymorph
- Prior art date
Links
- -1 Diaryl macrocycle Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188846P | 2015-07-06 | 2015-07-06 | |
| US201562218672P | 2015-09-15 | 2015-09-15 | |
| PCT/US2016/040972 WO2017007759A1 (en) | 2015-07-06 | 2016-07-05 | Diaryl macrocycle polymorph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3319969T3 true PL3319969T3 (pl) | 2024-06-24 |
Family
ID=57685592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16821872.5T PL3319969T3 (pl) | 2015-07-06 | 2016-07-05 | Diarylowe polimorfy makrocykliczne |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US10294242B2 (pl) |
| EP (2) | EP3319969B1 (pl) |
| JP (2) | JP6917974B2 (pl) |
| KR (1) | KR102623734B1 (pl) |
| CN (2) | CN108026108B (pl) |
| AU (1) | AU2016289454B2 (pl) |
| BR (1) | BR112018000297A2 (pl) |
| CA (1) | CA2990020C (pl) |
| DK (1) | DK3319969T3 (pl) |
| ES (1) | ES2979111T3 (pl) |
| FI (1) | FI3319969T3 (pl) |
| HR (1) | HRP20240780T1 (pl) |
| HU (1) | HUE067352T2 (pl) |
| IL (2) | IL256443B (pl) |
| LT (1) | LT3319969T (pl) |
| MX (2) | MX386680B (pl) |
| PL (1) | PL3319969T3 (pl) |
| PT (1) | PT3319969T (pl) |
| RS (1) | RS65593B1 (pl) |
| RU (1) | RU2765181C2 (pl) |
| SI (1) | SI3319969T1 (pl) |
| SM (1) | SMT202400213T1 (pl) |
| WO (1) | WO2017007759A1 (pl) |
| ZA (1) | ZA201708436B (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015209239C1 (en) | 2014-01-24 | 2026-05-07 | Turning Point Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| MX2017017097A (es) | 2015-07-02 | 2018-05-23 | Tp Therapeutics Inc | Macrociclos diarílicos quirales como moduladores de proteínas quinasas. |
| PL3319969T3 (pl) * | 2015-07-06 | 2024-06-24 | Turning Point Therapeutics, Inc. | Diarylowe polimorfy makrocykliczne |
| LT3733187T (lt) * | 2015-07-21 | 2024-12-10 | Turning Point Therapeutics, Inc. | Chiralinis diarilo makrociklas ir jo panaudojimas vėžio gydymui |
| RU2019105587A (ru) | 2016-07-28 | 2020-08-28 | Тёрнинг Поинт Терапьютикс, Инк. | Макроциклические ингибиторы киназ |
| TWI808958B (zh) * | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN107586796B (zh) * | 2017-07-20 | 2021-08-06 | 暨明医药科技（苏州）有限公司 | (r)-2-(1-氨基乙基)-4-氟苯酚的合成方法 |
| CA3069232A1 (en) | 2017-07-28 | 2019-01-31 | Turning Point Therapeutics, Inc. | Macrocyclic compounds and uses thereof |
| HUE060711T2 (hu) | 2017-12-19 | 2023-04-28 | Turning Point Therapeutics Inc | Makrociklusos vegyületek betegségek kezelésére |
| CN110386944B (zh) * | 2018-04-16 | 2021-10-29 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的二(杂)芳基大环化合物 |
| HRP20250048T1 (hr) | 2018-10-22 | 2025-03-28 | Alumis Inc. | Inhibitori tyk2 i njihova uporaba |
| WO2020233645A1 (zh) | 2019-05-21 | 2020-11-26 | 浙江海正药业股份有限公司 | 大环类衍生物、及其制备方法和用途 |
| US20220411439A1 (en) * | 2019-06-19 | 2022-12-29 | Turning Point Therapeutics, Inc. | Polymorphs of a macrocyclic kinase inhibitor |
| TW202133856A (zh) * | 2019-11-27 | 2021-09-16 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| JP7670711B2 (ja) * | 2019-11-27 | 2025-04-30 | ターニング・ポイント・セラピューティクス・インコーポレイテッド | ジアリール大環状化合物を含む併用療法 |
| BR112022017425A2 (pt) * | 2020-03-02 | 2022-11-29 | Turning Point Therapeutics Inc | Usos terapêuticos de compostos macrocíclicos |
| CN113620974B (zh) * | 2020-05-08 | 2023-01-31 | 山东轩竹医药科技有限公司 | 大环类酪氨酸激酶抑制剂的晶型及其制备方法 |
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-
2016
- 2016-07-05 PL PL16821872.5T patent/PL3319969T3/pl unknown
- 2016-07-05 SM SM20240213T patent/SMT202400213T1/it unknown
- 2016-07-05 SI SI201631817T patent/SI3319969T1/sl unknown
- 2016-07-05 HR HRP20240780TT patent/HRP20240780T1/hr unknown
- 2016-07-05 RU RU2018104269A patent/RU2765181C2/ru active
- 2016-07-05 US US15/741,893 patent/US10294242B2/en active Active
- 2016-07-05 ES ES16821872T patent/ES2979111T3/es active Active
- 2016-07-05 DK DK16821872.5T patent/DK3319969T3/da active
- 2016-07-05 CN CN201680051405.5A patent/CN108026108B/zh active Active
- 2016-07-05 MX MX2017017081A patent/MX386680B/es unknown
- 2016-07-05 CN CN202110623105.2A patent/CN113354653B/zh active Active
- 2016-07-05 KR KR1020187002778A patent/KR102623734B1/ko active Active
- 2016-07-05 FI FIEP16821872.5T patent/FI3319969T3/fi active
- 2016-07-05 WO PCT/US2016/040972 patent/WO2017007759A1/en not_active Ceased
- 2016-07-05 BR BR112018000297A patent/BR112018000297A2/pt not_active Application Discontinuation
- 2016-07-05 HU HUE16821872A patent/HUE067352T2/hu unknown
- 2016-07-05 RS RS20240632A patent/RS65593B1/sr unknown
- 2016-07-05 EP EP16821872.5A patent/EP3319969B1/en active Active
- 2016-07-05 LT LTEPPCT/US2016/040972T patent/LT3319969T/lt unknown
- 2016-07-05 JP JP2018500582A patent/JP6917974B2/ja active Active
- 2016-07-05 CA CA2990020A patent/CA2990020C/en active Active
- 2016-07-05 EP EP24158643.7A patent/EP4397665A3/en active Pending
- 2016-07-05 AU AU2016289454A patent/AU2016289454B2/en active Active
- 2016-07-05 PT PT168218725T patent/PT3319969T/pt unknown
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2017
- 2017-12-12 ZA ZA2017/08436A patent/ZA201708436B/en unknown
- 2017-12-20 MX MX2021008145A patent/MX2021008145A/es unknown
- 2017-12-20 IL IL256443A patent/IL256443B/en active IP Right Grant
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2019
- 2019-04-08 US US16/378,095 patent/US20190233437A1/en not_active Abandoned
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2020
- 2020-10-15 US US17/071,569 patent/US20210094974A1/en not_active Abandoned
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2021
- 2021-04-16 JP JP2021069649A patent/JP7212713B2/ja active Active
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2022
- 2022-09-19 US US17/933,434 patent/US12187739B2/en active Active
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2024
- 2024-11-22 US US18/957,501 patent/US20250223298A1/en active Pending
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