DE60112611T2 - Makroheterocyclische verbindungen als kinase inhibitoren - Google Patents

Makroheterocyclische verbindungen als kinase inhibitoren Download PDF

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Publication number
DE60112611T2
DE60112611T2 DE60112611T DE60112611T DE60112611T2 DE 60112611 T2 DE60112611 T2 DE 60112611T2 DE 60112611 T DE60112611 T DE 60112611T DE 60112611 T DE60112611 T DE 60112611T DE 60112611 T2 DE60112611 T2 DE 60112611T2
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Prior art keywords
kinase inhibitors
kinase
compounds
macroheterocyclic compounds
macroheterocyclic
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Expired - Lifetime
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DE60112611T
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DE60112611D1 (de
Inventor
Gee-Hong Kuo
Catherine Prouty
Alan Deangelis
Han-Cheng Zhang
Peter Conolly
William V Murray
R Shah
Bruce E Maryanoff
B White
Lan Shen
Bruce Conway
Keith Demarest
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Janssen Pharmaceuticals Inc
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Ortho McNeil Pharmaceutical Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
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  • Virology (AREA)
  • Obesity (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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DE60112611T 2000-12-08 2001-12-06 Makroheterocyclische verbindungen als kinase inhibitoren Expired - Lifetime DE60112611T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25416100P 2000-12-08 2000-12-08
PCT/US2001/047866 WO2002046197A1 (en) 2000-12-08 2001-12-06 Macroheterocylic compounds useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60112611D1 DE60112611D1 (de) 2005-09-15
DE60112611T2 true DE60112611T2 (de) 2006-06-14

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DE60112611T Expired - Lifetime DE60112611T2 (de) 2000-12-08 2001-12-06 Makroheterocyclische verbindungen als kinase inhibitoren

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US (1) US6828327B2 (de)
EP (1) EP1345946B1 (de)
JP (1) JP2004526676A (de)
AT (1) ATE301661T1 (de)
AU (2) AU2737102A (de)
CA (1) CA2431187A1 (de)
DE (1) DE60112611T2 (de)
ES (1) ES2245994T3 (de)
HK (1) HK1055956A1 (de)
MX (1) MXPA03005139A (de)
RU (1) RU2275373C2 (de)
WO (1) WO2002046197A1 (de)

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US6828327B2 (en) 2004-12-07
ATE301661T1 (de) 2005-08-15
US20030078280A1 (en) 2003-04-24
EP1345946B1 (de) 2005-08-10
MXPA03005139A (es) 2004-01-29
JP2004526676A (ja) 2004-09-02
AU2002227371B2 (en) 2007-05-10
AU2737102A (en) 2002-06-18
ES2245994T3 (es) 2006-02-01
WO2002046197A1 (en) 2002-06-13
RU2275373C2 (ru) 2006-04-27
CA2431187A1 (en) 2002-06-13
DE60112611D1 (de) 2005-09-15
HK1055956A1 (en) 2004-01-30
EP1345946A1 (de) 2003-09-24

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