HN2001000277A - PIRROLO [2,1 - a] DIHIDROISOQUINOLINAS - Google Patents

PIRROLO [2,1 - a] DIHIDROISOQUINOLINAS

Info

Publication number
HN2001000277A
HN2001000277A HN2001000277A HN2001000277A HN2001000277A HN 2001000277 A HN2001000277 A HN 2001000277A HN 2001000277 A HN2001000277 A HN 2001000277A HN 2001000277 A HN2001000277 A HN 2001000277A HN 2001000277 A HN2001000277 A HN 2001000277A
Authority
HN
Honduras
Prior art keywords
pirrolo
dihydroisoquinolins
dihydroisoquinolines
phosphodiesterase
inhibitors
Prior art date
Application number
HN2001000277A
Other languages
English (en)
Inventor
Niewohner Ulrich
Bauser Marcus
Erguden Jens-Kerim
Flubacher Dietmar
Naab Paul
Reep Thorsten-Oliver
Stoltefub Juergen
Burkhardt Nils
Sewing Andrea
Schauer Michael
Schlemmer Karl-Heinz
Weber Olaf
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of HN2001000277A publication Critical patent/HN2001000277A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

LA PRESENTE INVENCION SE REFIERE A PIRROLO [2, 1 - a] DIHIDROISOQUINOLINAS QUE SON INHIBIDORES DE LA FOSFODIESTERASA 10a, A UN PROCEDIMIENTO DE TRATAMIENTO DEL CANCER POR MEDIO DE LA ADMINISTRACION DE ESOS COMPUESTOS.
HN2001000277A 2000-12-13 2001-12-12 PIRROLO [2,1 - a] DIHIDROISOQUINOLINAS HN2001000277A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25520600P 2000-12-13 2000-12-13
US31031201P 2001-08-06 2001-08-06

Publications (1)

Publication Number Publication Date
HN2001000277A true HN2001000277A (es) 2002-01-30

Family

ID=26944520

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2001000277A HN2001000277A (es) 2000-12-13 2001-12-12 PIRROLO [2,1 - a] DIHIDROISOQUINOLINAS

Country Status (10)

Country Link
US (1) US6930114B2 (es)
EP (1) EP1347973A1 (es)
JP (1) JP2004517843A (es)
AU (1) AU2002227985A1 (es)
CA (1) CA2431326A1 (es)
HN (1) HN2001000277A (es)
PE (1) PE20021085A1 (es)
SV (1) SV2002000761A (es)
UY (1) UY27067A1 (es)
WO (1) WO2002048144A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
WO2003014116A1 (en) * 2001-08-06 2003-02-20 Bayer Corporation Pyrrolo[2.1-a]isoquinoline derivatives
WO2003051877A1 (en) * 2001-12-18 2003-06-26 Bayer Corporation 2-substituted pyrrolo[2.1-a]isoquinolines against cancer
DE10230604A1 (de) * 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
US8338420B1 (en) 2002-12-04 2012-12-25 Mitsubishi Tanabe Pharma Corporation Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor
EP1578424A4 (en) * 2002-12-12 2007-08-08 Cytovia Inc 1-BENZOYL-3-CYANO-PYRROLO 1,2-I A / I | SUBSTITUTED QUINOLINES AND THEIR ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
EP1641794A1 (en) * 2003-06-30 2006-04-05 ALTANA Pharma AG Novel pyrrolodihydroisoquinolines useful in the treatment of cancer
WO2005002579A1 (en) * 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
WO2006075012A2 (en) * 2005-01-12 2006-07-20 Nycomed Gmbh Pyrrolodihydroisoquinolines as antiproliferative agents
US20080161338A1 (en) * 2005-01-12 2008-07-03 Altana Pharma Ag Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008001182A1 (en) * 2006-06-26 2008-01-03 Pfizer Products Inc. Tricyclic heteroaryl compounds as pde10 inhibitors
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2507244B1 (en) 2009-12-04 2014-11-05 Nerviano Medical Sciences S.r.l. Tricyclopyrazole derivatives
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2015006689A1 (en) 2013-07-12 2015-01-15 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE690792A (es) 1966-12-07 1967-05-16
FR7348M (es) * 1967-12-07 1969-10-13
US4719216A (en) 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
DE3401018A1 (de) 1984-01-13 1985-07-18 Boehringer Ingelheim KG, 6507 Ingelheim Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen
GB8718980D0 (en) 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
IT1292092B1 (it) 1997-06-05 1999-01-25 Geange Ltd Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali
US6673564B2 (en) 1999-10-18 2004-01-06 Millennium Pharmaceuticals, Inc. Methods for using 22045, a human cyclic nucleotide phosphodiesterase

Also Published As

Publication number Publication date
EP1347973A1 (en) 2003-10-01
US20040138249A1 (en) 2004-07-15
CA2431326A1 (en) 2002-06-20
JP2004517843A (ja) 2004-06-17
WO2002048144A1 (en) 2002-06-20
PE20021085A1 (es) 2003-05-16
SV2002000761A (es) 2002-12-02
US6930114B2 (en) 2005-08-16
AU2002227985A1 (en) 2002-06-24
UY27067A1 (es) 2002-07-31

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