SV2002000761A - Pirrolo [2.1-a]dihidroisoquinolinas ref. lea 35090-sv - Google Patents

Pirrolo [2.1-a]dihidroisoquinolinas ref. lea 35090-sv

Info

Publication number
SV2002000761A
SV2002000761A SV2001000761A SV2001000761A SV2002000761A SV 2002000761 A SV2002000761 A SV 2002000761A SV 2001000761 A SV2001000761 A SV 2001000761A SV 2001000761 A SV2001000761 A SV 2001000761A SV 2002000761 A SV2002000761 A SV 2002000761A
Authority
SV
El Salvador
Prior art keywords
pirrolo
dihydroisoquinolins
ref
read
dihydroisoquinolines
Prior art date
Application number
SV2001000761A
Other languages
English (en)
Inventor
Ulrich Niewohner
Marcus Bauser
Jens-Kerim Erguden
Dietmar Flubacher
Paul Naab
Thorsten-Oliver Repp
Juergen Stoltefuss
Buks Burkhardt
Andrea Sewing
Michael Schauer
Karl-Heinz Schlemmer
Olaf Weber
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SV2002000761A publication Critical patent/SV2002000761A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A PIRROLO[2.1-A] DIHIDROISOQUINOLINAS QUE SON INHIBIDORES DE LA FOSFODIESTERASA 10A Y QUE PUEDEN USARSE PARA COMBATIR EL CANCER.
SV2001000761A 2000-12-13 2001-12-12 Pirrolo [2.1-a]dihidroisoquinolinas ref. lea 35090-sv SV2002000761A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25520600P 2000-12-13 2000-12-13
US31031201P 2001-08-06 2001-08-06

Publications (1)

Publication Number Publication Date
SV2002000761A true SV2002000761A (es) 2002-12-02

Family

ID=26944520

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000761A SV2002000761A (es) 2000-12-13 2001-12-12 Pirrolo [2.1-a]dihidroisoquinolinas ref. lea 35090-sv

Country Status (10)

Country Link
US (1) US6930114B2 (es)
EP (1) EP1347973A1 (es)
JP (1) JP2004517843A (es)
AU (1) AU2002227985A1 (es)
CA (1) CA2431326A1 (es)
HN (1) HN2001000277A (es)
PE (1) PE20021085A1 (es)
SV (1) SV2002000761A (es)
UY (1) UY27067A1 (es)
WO (1) WO2002048144A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030236276A1 (en) * 2001-08-06 2003-12-25 Ulrich Niewohner Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
AU2002366362A1 (en) * 2001-12-18 2003-06-30 Bayer Aktiengesellschaft 2-substituted pyrrolo(2.1-a)isoquinolines against cancer
DE10230604A1 (de) * 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
US8338420B1 (en) 2002-12-04 2012-12-25 Mitsubishi Tanabe Pharma Corporation Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor
US7135480B2 (en) * 2002-12-12 2006-11-14 Cytovia, Inc. Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
CA2530114A1 (en) * 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
UA86591C2 (ru) * 2003-06-30 2009-05-12 Алтана Фарма Аг Пирролодигидроизохинолины как ингибиторы pde10, фармацевтическая композиция на их основе
JP2008526817A (ja) * 2005-01-12 2008-07-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のピロロジヒドロイソキノリン
EP1838707B1 (en) * 2005-01-12 2009-04-29 Nycomed GmbH Novel pyrrolodihydroisoquinolines as pde10 inhibitors
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
CA2654394A1 (en) * 2006-06-26 2008-01-03 Pfizer Products Inc. Tricyclic heteroaryl compounds as pde10 inhibitors
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5730896B2 (ja) * 2009-12-04 2015-06-10 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ トリシクロピラゾール誘導体
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US10039764B2 (en) 2013-07-12 2018-08-07 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE690792A (es) * 1966-12-07 1967-05-16
FR7348M (es) * 1967-12-07 1969-10-13
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
DE3401018A1 (de) * 1984-01-13 1985-07-18 Boehringer Ingelheim KG, 6507 Ingelheim Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
IT1292092B1 (it) 1997-06-05 1999-01-25 Geange Ltd Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali
US6673564B2 (en) 1999-10-18 2004-01-06 Millennium Pharmaceuticals, Inc. Methods for using 22045, a human cyclic nucleotide phosphodiesterase

Also Published As

Publication number Publication date
EP1347973A1 (en) 2003-10-01
UY27067A1 (es) 2002-07-31
HN2001000277A (es) 2002-01-30
WO2002048144A1 (en) 2002-06-20
JP2004517843A (ja) 2004-06-17
US20040138249A1 (en) 2004-07-15
PE20021085A1 (es) 2003-05-16
AU2002227985A1 (en) 2002-06-24
CA2431326A1 (en) 2002-06-20
US6930114B2 (en) 2005-08-16

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