PL3086751T3 - Stabilizowane kompozycje cyny - Google Patents

Stabilizowane kompozycje cyny

Info

Publication number
PL3086751T3
PL3086751T3 PL14873771.1T PL14873771T PL3086751T3 PL 3086751 T3 PL3086751 T3 PL 3086751T3 PL 14873771 T PL14873771 T PL 14873771T PL 3086751 T3 PL3086751 T3 PL 3086751T3
Authority
PL
Poland
Prior art keywords
stabilized stannous
stannous compositions
compositions
stabilized
stannous
Prior art date
Application number
PL14873771.1T
Other languages
English (en)
Inventor
Eric Charles Reynolds
Original Assignee
The University Of Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013905081A external-priority patent/AU2013905081A0/en
Application filed by The University Of Melbourne filed Critical The University Of Melbourne
Publication of PL3086751T3 publication Critical patent/PL3086751T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/32Tin compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/42Phosphorus; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/20Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/70Preparations for dentistry comprising inorganic additives
    • A61K6/71Fillers
    • A61K6/74Fillers comprising phosphorus-containing compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24Phosphorous; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058Chewing gums
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Dairy Products (AREA)
PL14873771.1T 2013-12-24 2014-12-24 Stabilizowane kompozycje cyny PL3086751T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2013905081A AU2013905081A0 (en) 2013-12-24 Stabilized stannous compositions
AU2014901202A AU2014901202A0 (en) 2014-04-03 Stabilized stannous compositions (2)
AU2014903815A AU2014903815A0 (en) 2014-09-24 Stabilized stannous compositions (3)
PCT/AU2014/050447 WO2015095932A1 (en) 2013-12-24 2014-12-24 Stabilized stannous compositions

Publications (1)

Publication Number Publication Date
PL3086751T3 true PL3086751T3 (pl) 2023-12-27

Family

ID=53477224

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14873771.1T PL3086751T3 (pl) 2013-12-24 2014-12-24 Stabilizowane kompozycje cyny

Country Status (14)

Country Link
US (3) US10912722B2 (pl)
EP (1) EP3086751B1 (pl)
JP (2) JP6797020B2 (pl)
KR (1) KR102273906B1 (pl)
CN (1) CN105873561B (pl)
AU (1) AU2014373625B2 (pl)
CA (1) CA2932294C (pl)
ES (1) ES2959412T3 (pl)
MX (1) MX2016008482A (pl)
MY (1) MY176788A (pl)
PH (1) PH12016501218B1 (pl)
PL (1) PL3086751T3 (pl)
RU (1) RU2716134C2 (pl)
WO (1) WO2015095932A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9668945B2 (en) 2006-02-09 2017-06-06 The University Of Melbourne Fluoride composition and methods for dental mineralization
CA2918441C (en) 2013-07-23 2023-03-21 The University Of Melbourne A base and phosphopeptide stabilized amorphous calcium phosphate (acp) and/or amorphous calcium fluoride phosphate (acfp) for use in promoting remineralisation
WO2015095932A1 (en) 2013-12-24 2015-07-02 The University Of Melbourne Stabilized stannous compositions
EP3595615B1 (en) * 2017-03-14 2024-01-10 The University Of Melbourne Treatment for gingivitis
US20200197486A1 (en) * 2017-03-14 2020-06-25 The University Of Melbourne Complexes for treating sensitivity
US11911492B2 (en) 2018-05-14 2024-02-27 The Procter & Gamble Company Oral care compositions comprising metal ions
CN112135600B (zh) * 2018-05-14 2024-01-02 宝洁公司 发泡口腔护理组合物
US20200197267A1 (en) * 2018-12-20 2020-06-25 Colgate-Palmolive Company Dentifrice Containing Sodium Bicarbonate and Stannous Fluoride
US11918675B2 (en) 2019-12-16 2024-03-05 Colgate-Palmolive Company Oral care compositions
US11382852B2 (en) * 2020-09-30 2022-07-12 GC Laboratory America Inc. Oral composition

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864471A (en) 1968-12-20 1975-02-04 Colgate Palmolive Co Stable dentifrices containing a monofluorophosphate, an insoluble metaphosphate, and calcium carbonate
US3966901A (en) 1970-12-29 1976-06-29 Colgate-Palmolive Company Dentifrice preparation
US4080440A (en) 1974-12-13 1978-03-21 The Procter & Gamble Company Method for remineralizing tooth enamel
US4157386A (en) 1978-05-18 1979-06-05 Rochelle Paul J Soft, chewable lozenge forming a sticky coating on teeth when combined with saliva in the mouth which is removable only by brushing
US4588763A (en) 1978-06-01 1986-05-13 Braennstroem Martin Ethyl acetate as solvent in cavity liners
NZ199891A (en) 1981-03-04 1985-07-31 Univ Melbourne Caries-inhibiting compositions containing casein or x-s-casein or phosuitin
US4357318A (en) 1981-07-31 1982-11-02 Richardson-Vicks Inc. Dentifrices with improved soluble fluoride availability
US4522805A (en) 1983-06-08 1985-06-11 Norman Gordon Tooth and gum dentifrice
US4672032A (en) * 1983-11-09 1987-06-09 University Of Southern California Dental enamel production
US5015628A (en) 1986-06-12 1991-05-14 The University Of Melbourne Anticariogenic phosphopeptides
CA1315480C (en) 1986-06-12 1993-03-30 Eric Charles Reynolds Phosphopeptides
US6056930A (en) 1989-05-24 2000-05-02 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
US5227154A (en) 1991-08-22 1993-07-13 The University Of Melbourne Phosphopeptides for the treatment of dental calculus
NZ252959A (en) 1992-06-29 1996-06-25 Univ Melbourne Treating dentinal hypersensitivity with one or more of casein, a phosphoprotein, a phosphopeptide and a phosphatase or peptidase inhibitor
CH684773A5 (fr) 1992-12-28 1994-12-30 Nestle Sa Composition alimentaire anti-cariogène.
JP3471431B2 (ja) 1994-07-18 2003-12-02 株式会社ジーシー 歯科用グラスアイオノマーセメント組成物
JP3340265B2 (ja) 1994-11-21 2002-11-05 一枝 山岸 歯の漂白剤
KR0140248B1 (ko) 1995-03-23 1998-06-15 한상기 신규한 카제인 포스포펩티드, 그것을 포함하는 카제인 및 그 제조방법
EP0748591B1 (fr) 1995-06-16 2001-10-17 Societe Des Produits Nestle S.A. Caséines micellaires fluorées
US6036944A (en) 1995-08-08 2000-03-14 Enamelon, Inc. Processes for the remineralization and mineralization of teeth
JP2974604B2 (ja) 1996-01-23 1999-11-10 雪印乳業株式会社 塩基性タンパク質組成物、塩基性ペプチド組成物及びその利用
JP4040705B2 (ja) 1996-01-24 2008-01-30 株式会社サンギ 口腔組成物
AUPN898296A0 (en) 1996-03-28 1996-04-26 Nulite Systems International Pty Ltd Elastomeric state glass ionomer cement
US5741773A (en) 1996-04-26 1998-04-21 Colgate Palmolive Company Storage stable dentifrice composition containing an antibacterial casein glycomacropeptide adjuvant
JP2975337B2 (ja) 1997-02-20 1999-11-10 雪印乳業株式会社 カルシウム複合体
AUPO566297A0 (en) 1997-03-13 1997-04-10 University Of Melbourne, The Calcium phosphopeptide complexes
JPH11228327A (ja) 1998-02-18 1999-08-24 Gc Corp 歯科用ペースト系グラスアイオノマーセメント組成物
JP3742523B2 (ja) 1998-02-27 2006-02-08 雪印乳業株式会社 高分子型カルシウム・ホスホペプチド複合体
AUPP494798A0 (en) 1998-07-29 1998-08-20 Pacific Biolink Pty Limited Protective protein formulation
DK1176939T3 (da) 1999-03-25 2008-05-05 Cadbury Adams Usa Llc Tyggegummi og konfekt til mundpleje
US6846500B1 (en) 1999-03-25 2005-01-25 Cadbury Adams Usa Llc Oral care chewing gums and method of use
FR2791573B1 (fr) 1999-03-30 2003-04-11 Pf Medicament Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate
US6149894A (en) 1999-05-14 2000-11-21 Colgate Palmolive Company Method for the manufacture of toothpaste
US6521215B2 (en) 1999-05-28 2003-02-18 Devin Okay Compositions and methods for tooth treatment
US6685920B2 (en) * 1999-11-12 2004-02-03 The Procter & Gamble Company Method of protecting teeth against erosion
JP2001144695A (ja) 1999-11-17 2001-05-25 Matsushita Electric Ind Co Ltd 音声処理装置及び音声処理方法
GB9929919D0 (en) 1999-12-17 2000-02-09 Hannah Research Inst The Calcium phosphate nanoclusters and their applications
US7727539B2 (en) 2001-03-14 2010-06-01 Drexel University Polymeric bioresorbable composites containing an amorphous calcium phosphate polymer ceramic for bone repair and replacement
AUPR517701A0 (en) 2001-05-21 2001-06-14 University Of Melbourne, The Dental restorative materials
WO2003059304A1 (en) 2002-01-03 2003-07-24 The Procter & Gamble Company Stable oral compositions comprising casein phosphopeptide complexes and flouride
CA2469498C (en) * 2002-01-03 2009-06-02 The Procter & Gamble Company Stable oral compositions comprising casein phosphopeptide complexes and fluoride
NZ522071A (en) 2002-10-18 2005-07-29 Patrick Joseph Silcock Hydrolysed casein phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation
JP3853785B2 (ja) 2002-12-27 2006-12-06 花王株式会社 口腔用組成物
WO2004060336A1 (en) 2002-12-27 2004-07-22 Kao Corporation Oral preparation system
JP4340069B2 (ja) 2003-01-10 2009-10-07 雪印乳業株式会社 カルシウム複合体の製造法
JP2005014595A (ja) * 2003-05-30 2005-01-20 Canon Inc 画像形成装置およびその制御方法
JP2005145952A (ja) 2003-10-23 2005-06-09 Gc Corp う蝕予防用組成物
US20050089481A1 (en) 2003-10-23 2005-04-28 Gc Corporation Composition for caries prevention
US20050118115A1 (en) 2003-10-24 2005-06-02 Fontenot Mark G. Accelerated tooth whitening method, composition and kit
US20060183081A1 (en) 2004-09-27 2006-08-17 Al Bevilacqua Tooth bleaching system and method
EP3192489A1 (en) 2004-11-25 2017-07-19 The University of Melbourne Stabilized calcium phosphate complexes
CA2611077C (en) 2005-06-07 2014-07-15 The University Of Melbourne Dental mineralization
US8603988B2 (en) 2005-06-24 2013-12-10 The University Of Melbourne Ionic complexes
EP1928265A2 (en) 2005-08-22 2008-06-11 Conagra Foods Packaged Foods Company, Inc. Cryogenic peeling process
US20090016972A1 (en) 2005-11-25 2009-01-15 Tamazi Omarovich Manasherov Oral cavity care curative and prophylactic composition
US20070254260A1 (en) 2005-12-02 2007-11-01 Alden Wayne S Iv Oral care compositions, methods, devices and systems
US9668945B2 (en) 2006-02-09 2017-06-06 The University Of Melbourne Fluoride composition and methods for dental mineralization
US20080171001A1 (en) 2007-01-12 2008-07-17 Engelman Emil E Mineralization toothpaste
GB0807224D0 (en) 2008-04-21 2008-05-28 Univ Dundee Remineralisation of calcified tissue
US9849310B2 (en) 2008-06-24 2017-12-26 Dental Alliance Holdings, Llc Dental appliance, oral care product and method of preventing dental disease
US9226895B2 (en) 2008-07-30 2016-01-05 Ultradent Products, Inc. Methods and kits for cleaning and remineralizing teeth
JP2010047494A (ja) 2008-08-20 2010-03-04 Gc Corp 歯牙塗布用組成物
JP5437692B2 (ja) 2009-04-30 2014-03-12 インターコンチネンタル グレート ブランズ エルエルシー チューインガム組成物、チューインガム製品、及びこれらの製造方法
SG175785A1 (en) 2009-05-18 2011-12-29 Colgate Palmolive Co Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof
JP2011073983A (ja) * 2009-09-29 2011-04-14 Gc Corp 歯牙塗布用組成物
JP2011162470A (ja) * 2010-02-09 2011-08-25 Gc Corp 歯牙用被覆材
SG183277A1 (en) 2010-02-12 2012-09-27 Theocorp Holding Co Llc Methods and compositions to improve mechanical resistance of teeth
US9539445B2 (en) * 2010-11-22 2017-01-10 Taipei Medical University Type of anion-containing calcium phosphate compound for dental remineralization
JP2013163656A (ja) 2012-02-10 2013-08-22 Gc Corp 歯磨剤
GB201202341D0 (en) 2012-02-10 2012-03-28 Periproducts Ltd Multicomponent oral care compostion
CA2918441C (en) 2013-07-23 2023-03-21 The University Of Melbourne A base and phosphopeptide stabilized amorphous calcium phosphate (acp) and/or amorphous calcium fluoride phosphate (acfp) for use in promoting remineralisation
WO2015095932A1 (en) 2013-12-24 2015-07-02 The University Of Melbourne Stabilized stannous compositions
RU2720242C2 (ru) 2014-12-24 2020-04-28 Юниверсити Оф Мельбурн Минерализующие фторсодержащие композиции
EP3595615B1 (en) 2017-03-14 2024-01-10 The University Of Melbourne Treatment for gingivitis
US20200197486A1 (en) 2017-03-14 2020-06-25 The University Of Melbourne Complexes for treating sensitivity
AU2020234723A1 (en) 2019-03-13 2021-10-07 The University Of Melbourne Concealment of hypomineralised lesions

Also Published As

Publication number Publication date
CN105873561B (zh) 2020-02-21
ES2959412T3 (es) 2024-02-26
WO2015095932A1 (en) 2015-07-02
CA2932294A1 (en) 2015-07-02
AU2014373625B2 (en) 2018-07-19
US11564873B2 (en) 2023-01-31
RU2716134C2 (ru) 2020-03-06
RU2016126429A (ru) 2018-01-30
US20230404867A1 (en) 2023-12-21
JP2017505760A (ja) 2017-02-23
AU2014373625A1 (en) 2016-07-14
EP3086751B1 (en) 2023-07-12
NZ721687A (en) 2020-11-27
US10912722B2 (en) 2021-02-09
JP7218934B2 (ja) 2023-02-07
KR20160102294A (ko) 2016-08-29
RU2016126429A3 (pl) 2018-09-17
CA2932294C (en) 2023-08-22
PH12016501218A1 (en) 2016-08-22
JP6797020B2 (ja) 2020-12-09
MY176788A (en) 2020-08-21
KR102273906B1 (ko) 2021-07-06
EP3086751A1 (en) 2016-11-02
EP3086751A4 (en) 2017-08-16
CN105873561A (zh) 2016-08-17
US20160317404A1 (en) 2016-11-03
MX2016008482A (es) 2016-10-26
US20210161778A1 (en) 2021-06-03
JP2020186258A (ja) 2020-11-19
PH12016501218B1 (en) 2016-08-22

Similar Documents

Publication Publication Date Title
IL295091B1 (en) Solid solution mixtures
HK1224218A1 (zh) 穩定的抗體組合物
SG11201602596UA (en) Stabilized efinaconazole compositions
GB201304662D0 (en) Compositions
GB201319525D0 (en) Composition
EP2889350A4 (en) ADHESIVE COMPOSITION
EP2968108A4 (en) COSMETIC COMPOSITIONS
GB201608461D0 (en) Compositions
PL3086751T3 (pl) Stabilizowane kompozycje cyny
GB201319540D0 (en) Composition
GB201318489D0 (en) Composition
GB201317388D0 (en) Composition
EP3066178A4 (en) GREASE COMPOSITION
GB201319538D0 (en) Composition
IL240687A0 (en) Ganglioside preparations
GB201306984D0 (en) Composition
GB201320303D0 (en) Composition
GB201317196D0 (en) Composition
GB201307622D0 (en) Composition
ZA201508677B (en) Stabilized mesembrine compositions
GB201316463D0 (en) Novel compositions
ZA201505650B (en) New compositions
GB201320504D0 (en) Composition
GB201308502D0 (en) Composition
GB201301774D0 (en) Composition