PL2598526T4 - Agoniści i antagoniści receptora typu i chimerycznej interleukiny il-1 - Google Patents
Agoniści i antagoniści receptora typu i chimerycznej interleukiny il-1Info
- Publication number
- PL2598526T4 PL2598526T4 PL11749612T PL11749612T PL2598526T4 PL 2598526 T4 PL2598526 T4 PL 2598526T4 PL 11749612 T PL11749612 T PL 11749612T PL 11749612 T PL11749612 T PL 11749612T PL 2598526 T4 PL2598526 T4 PL 2598526T4
- Authority
- PL
- Poland
- Prior art keywords
- agonists
- antagonists
- chimeric
- receptor type
- receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36879910P | 2010-07-29 | 2010-07-29 | |
US201161436184P | 2011-01-25 | 2011-01-25 | |
US201161436178P | 2011-01-25 | 2011-01-25 | |
US201161493966P | 2011-06-06 | 2011-06-06 | |
US201161493967P | 2011-06-06 | 2011-06-06 | |
EP11749612.5A EP2598526B1 (en) | 2010-07-29 | 2011-07-29 | Chimeric il-1 receptor type i agonists and antagonists |
PCT/US2011/045995 WO2012016203A1 (en) | 2010-07-29 | 2011-07-29 | Chimeric il-1 receptor type i agonists and antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
PL2598526T3 PL2598526T3 (pl) | 2019-02-28 |
PL2598526T4 true PL2598526T4 (pl) | 2019-02-28 |
Family
ID=44533130
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL11749612T PL2598526T4 (pl) | 2010-07-29 | 2011-07-29 | Agoniści i antagoniści receptora typu i chimerycznej interleukiny il-1 |
PL18191564.6T PL3470421T3 (pl) | 2010-07-29 | 2011-07-29 | Chimeryczne antagonisty receptora il-1 typu i |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL18191564.6T PL3470421T3 (pl) | 2010-07-29 | 2011-07-29 | Chimeryczne antagonisty receptora il-1 typu i |
Country Status (23)
Country | Link |
---|---|
US (2) | US8853150B2 (pl) |
EP (3) | EP4219538A3 (pl) |
JP (1) | JP6030554B2 (pl) |
KR (1) | KR102080704B1 (pl) |
CN (2) | CN107337735B (pl) |
AU (3) | AU2011283669A1 (pl) |
BR (1) | BR112013003646B1 (pl) |
CA (1) | CA2806438C (pl) |
DK (1) | DK2598526T3 (pl) |
ES (2) | ES2701405T3 (pl) |
HK (1) | HK1246327A1 (pl) |
HR (2) | HRP20230776T1 (pl) |
HU (2) | HUE041590T2 (pl) |
IL (2) | IL224435B (pl) |
LT (1) | LT2598526T (pl) |
MX (1) | MX360097B (pl) |
NZ (1) | NZ605928A (pl) |
PL (2) | PL2598526T4 (pl) |
RU (2) | RU2013108836A (pl) |
SG (1) | SG187231A1 (pl) |
SI (1) | SI2598526T1 (pl) |
WO (1) | WO2012016203A1 (pl) |
ZA (1) | ZA201505145B (pl) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
CN107337735B (zh) | 2010-07-29 | 2021-06-22 | 巴扎德制药公司 | 嵌合il-1受体i型激动剂和拮抗剂 |
WO2012103240A2 (en) * | 2011-01-25 | 2012-08-02 | Eleven Biotherapeutics, Inc. | Receptor binding agents |
SG10201606218WA (en) * | 2011-07-29 | 2016-09-29 | Eleven Biotherapeutics Inc | Purified Proteins |
WO2013184938A2 (en) * | 2012-06-08 | 2013-12-12 | Alkermes. Inc. | Fusion polypeptides comprising mucin-domain polypeptide linkers |
AU2015268652B2 (en) * | 2012-06-08 | 2017-11-23 | Alkermes Pharma Ireland Limited | Ligands modified by circular permutation as agonists and antagonists |
BR112015022587A2 (pt) | 2013-03-13 | 2017-10-24 | Eleven Biotherapeutics Inc | formulações de citocina quimérica para entrega ocular |
EP3003356B1 (en) * | 2013-05-31 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Il-1 antagonists for use in treating alzheimer's disease |
US9895420B2 (en) | 2013-06-05 | 2018-02-20 | B.G. Negev Technologies And Applications Ltd., At Ben Gurion University | IL-1beta propeptide and IL-1Ra chimera and methods of using the same |
WO2015048526A1 (en) * | 2013-09-27 | 2015-04-02 | Eleven Biotherapeutics, Inc. | Treating ocular pain |
WO2015138844A1 (en) | 2014-03-13 | 2015-09-17 | Eleven Biotherapeutics, Inc. | Methods for production of stable chimeric cytokine protein formulations in blow fill seal containers |
EP3871682A1 (en) * | 2016-10-14 | 2021-09-01 | i.com Medical GmbH | Method for establishing, restoring, and preserving homeostasis of the ocular surface |
CN114480406B (zh) * | 2021-09-16 | 2024-01-30 | 广东翠点生物科技有限公司 | 一种il-1信号通路响应元件及其应用 |
WO2023169686A1 (en) | 2022-03-10 | 2023-09-14 | Buzzard Pharmaceuticals AB | Inhibitor of interleukin-1 receptor type 1 for use in the treatment of cancer |
Family Cites Families (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL188266C (nl) | 1975-07-29 | 1992-05-18 | Merck & Co Inc | Werkwijze ter bereiding van een oogheelkundig inplantaat. |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US5693489A (en) | 1984-03-30 | 1997-12-02 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
EP0569687B1 (en) | 1984-05-18 | 2002-08-21 | New England Medical Center Hospitals, Inc. | Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins |
US5998578A (en) | 1984-05-18 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Biologically active fragments of IL-1β |
US5484887A (en) | 1984-06-19 | 1996-01-16 | Immunex Corporation | Homogeneous interleukin 1 |
DK172052B1 (da) | 1984-12-21 | 1997-09-29 | Otsuka Pharma Co Ltd | Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor |
US6107465A (en) | 1984-12-21 | 2000-08-22 | Otsuka Pharmaceutical Co., Ltd. | IL-1β and derivatives thereof and drugs |
US5122459A (en) | 1984-12-31 | 1992-06-16 | Immunex Corporation | Gene encoding biologically active human interleukin 1 |
US4770781A (en) | 1986-03-03 | 1988-09-13 | Merck & Co., Inc. | Purification of human interleukin-1 species |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4883658A (en) | 1986-04-28 | 1989-11-28 | Holly Frank J | Ophthalmic solution for treatment of dry-eye syndrome |
US4804539A (en) | 1986-07-28 | 1989-02-14 | Liposome Technology, Inc. | Ophthalmic liposomes |
US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
US6858409B1 (en) | 1988-05-27 | 2005-02-22 | Amgen Inc. | Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors |
US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
KR0148009B1 (ko) | 1988-05-27 | 1998-08-01 | 그래고리 비. 아보트 | 인터루킨-1 억제제 |
US6159460A (en) | 1988-05-27 | 2000-12-12 | Amgen Inc. | Method for treating interleukin-1 mediated diseases |
AU4005289A (en) | 1988-08-25 | 1990-03-01 | Smithkline Beecham Corporation | Recombinant saccharomyces |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE69032251T2 (de) | 1989-02-27 | 1998-08-13 | New England Medical Center Inc | Il-1, dessen biologische aktivität inhibiert ist |
US5075104A (en) | 1989-03-31 | 1991-12-24 | Alcon Laboratories, Inc. | Ophthalmic carboxy vinyl polymer gel for dry eye syndrome |
EP0502956B1 (en) | 1989-11-29 | 1997-04-23 | Amgen Boulder Inc. | Production of recombinant human interleukin-1 inhibitor |
WO1991017184A1 (en) | 1990-04-27 | 1991-11-14 | The Upjohn Company | Modified interleukin-1 inhibitors |
ZA912797B (en) | 1990-05-29 | 1992-12-30 | Boston Ocular Res | Dry eye treatment process and solution |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
EP0570462A4 (en) | 1991-02-05 | 1994-11-23 | Univ Maryland | MODIFIED INTERLEUKIN-1BETA. |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
JP3122139B2 (ja) | 1991-10-15 | 2001-01-09 | マラーキー,ミッシェル,エフ. | 後期段階炎症反応の治療用組成物 |
ES2173871T3 (es) | 1991-10-31 | 2002-11-01 | Univ Manchester | Tratamiento de condiciones neurologicas por un compuesto inhibidor de la interleukina-1. |
EP0661992B1 (en) | 1992-09-17 | 2004-01-07 | Amgen Inc. | Pharmaceutical formulations of interleukin-1 inhibitors |
DK0678122T3 (da) | 1993-01-12 | 2000-03-06 | Biogen Inc | Rekombinante anti-VLA4 antistofmolekyler |
US5340572A (en) | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
WO1995010298A1 (en) | 1993-10-12 | 1995-04-20 | Mary Lake Polan | Method of contraception |
US5861476A (en) | 1994-02-02 | 1999-01-19 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
IT1269989B (it) | 1994-09-21 | 1997-04-16 | Dompe Spa | Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria |
US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
US6416753B1 (en) | 1996-03-15 | 2002-07-09 | The General Hospital Corporation | Method for modulating apoptosis |
US6974682B1 (en) | 1996-08-26 | 2005-12-13 | Human Genome Sciences, Inc. | Soluble interleukin-1 receptor accessory molecule |
AU5452798A (en) * | 1996-11-19 | 1998-06-10 | Schepens Eye Research Institute, Inc., The | Local use of il-1ra in corneal transplant rejection or disorders of the eye |
WO1998022130A1 (en) | 1996-11-19 | 1998-05-28 | The Schepens Eye Research Institute, Inc. | Local use of il-1ra in corneal transplant rejection or disorders of the eye |
ATE387495T1 (de) | 1996-12-03 | 2008-03-15 | Amgen Fremont Inc | Vollkommen humane antikörper die egfr binden |
JP4771563B2 (ja) | 1996-12-06 | 2011-09-14 | アムジエン・インコーポレーテツド | Il−1媒介疾患を処置するためにil−1インヒビターを使用する組合せ療法 |
AU7103198A (en) * | 1997-04-21 | 1998-11-13 | Schering Corporation | Mammalian cytokines; related reagents and methods |
US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
US7906481B2 (en) | 1998-09-25 | 2011-03-15 | Sciaticon Ab | Specific TNF-A inhibitors for treating spinal disorders mediated by nucleous pulposus |
US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
US6471961B1 (en) | 1999-02-24 | 2002-10-29 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
US6419944B2 (en) | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
JP3363832B2 (ja) | 1999-05-13 | 2003-01-08 | アルプス電気株式会社 | 薄膜構造体およびその製造方法 |
JP2003516132A (ja) | 1999-12-10 | 2003-05-13 | アムジェン インコーポレイテッド | インターロイキン−1レセプターアンタゴニスト様分子およびその使用 |
CN1433431A (zh) | 1999-12-10 | 2003-07-30 | 安姆根有限公司 | 白介素-1受体拮抗剂样分子及其应用 |
CA2395417A1 (en) | 1999-12-10 | 2001-06-14 | Amgen Inc. | Interleukin-1 receptor antagonist-related molecules and uses thereof |
US20030007971A1 (en) | 2000-01-31 | 2003-01-09 | Hideaki Hara | Remedies for ophthalmic diseases |
US20010041792A1 (en) | 2000-02-03 | 2001-11-15 | Donda Russell S. | Extraction of growth factors from tissue |
US20040026011A1 (en) | 2000-04-17 | 2004-02-12 | Edwards Mark Stephen | Method and apparatus for making bristle subassemblies |
US6623736B2 (en) | 2000-05-02 | 2003-09-23 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
US20010053764A1 (en) | 2000-05-12 | 2001-12-20 | Sims John E. | Interleukin-1 inhibitors in the treatment of diseases |
US20030026806A1 (en) | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
US20030166069A1 (en) | 2000-11-28 | 2003-09-04 | Amgen, Inc. | Interleukin-1 receptor antagonist-like molecules and uses thereof |
EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
CN1549723A (zh) | 2001-02-06 | 2004-11-24 | Ĭ��ר������˾ | 免疫原性减弱的经修饰白介素-1受体拮抗剂(il-1ra) |
US20050143333A1 (en) | 2001-05-18 | 2005-06-30 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
AU2002332931A1 (en) | 2001-09-06 | 2003-03-24 | Board Of Regents, The University Of Texas System | Therapeutic treatments for spinal cord injury via blockade of interleukin-1 receptor |
ATE509032T1 (de) | 2002-02-13 | 2011-05-15 | Ludwig Inst For Cancer Res Ltd | Chimerizierte gm-csf antikörper |
US6890654B2 (en) | 2002-04-18 | 2005-05-10 | Northwestern University | Encapsulation of nanotubes via self-assembled nanostructures |
US7029712B1 (en) | 2002-07-17 | 2006-04-18 | Biosyntrx Inc | Treatment for dry eye syndrome |
CA2511823A1 (en) | 2002-12-30 | 2004-07-22 | Amgen Inc. | Combination therapy with co-stimulatory factors |
US20050033694A1 (en) | 2003-06-03 | 2005-02-10 | United States Postal Service. | System and method for fleet card management |
US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
US20050023872A1 (en) | 2003-07-28 | 2005-02-03 | Hetzel Thomas R. | Modular seat cushion with interlocking human support and base portions and method of creating and using a seat cushion |
KR100543466B1 (ko) | 2003-11-13 | 2006-01-20 | 삼성전자주식회사 | 영상 보간 장치 및 방법 |
US7674464B2 (en) | 2004-03-04 | 2010-03-09 | The University Of Tennessee Research Foundation | Intracellular interleukin-1 receptor antagonists |
US7482323B2 (en) | 2004-03-04 | 2009-01-27 | The University Of Tennessee Research Foundation | Intracellular interleukin-1 receptor antagonist and uses thereof |
TR201816556T4 (tr) | 2004-04-02 | 2018-11-21 | Swedish Orphan Biovitrum Ab Publ | Il-1ra agregasyonunun azaltilmasina yöneli̇k yöntemler |
US8618054B2 (en) | 2004-05-05 | 2013-12-31 | Valorisation-Rechereche Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
JP5022216B2 (ja) | 2004-06-04 | 2012-09-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 自己炎症性疾患を処置するためのil−1アンタゴニストを使用する方法 |
SI1778723T1 (sl) | 2004-08-17 | 2013-02-28 | Regeneron Pharmaceuticals, Inc. | Formulacije IL-1 antagonista |
US7700318B2 (en) * | 2004-08-25 | 2010-04-20 | Amprotein Corporation | Chimeric polypeptide and use thereof |
KR20080016780A (ko) | 2004-11-24 | 2008-02-22 | 테라킨 리미티드 | 안내 약물 전달용 임플란트 |
US20090111745A1 (en) | 2004-12-02 | 2009-04-30 | Domantis Limited | Plad Domain Peptides With Increased Serum Half Life Due To Conjugation To Domain Antibodies |
US7956160B2 (en) | 2005-07-22 | 2011-06-07 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
JP2009507023A (ja) | 2005-09-01 | 2009-02-19 | シェーリング コーポレイション | 自己免疫性眼炎症性疾患を処置するためのil−23およびil−17のアンタゴニストの使用 |
IL172297A (en) | 2005-10-03 | 2016-03-31 | Compugen Ltd | Soluble vegfr-1 variants for the diagnosis of preeclampsia |
AU2006304778B2 (en) | 2005-10-21 | 2011-04-28 | Amgen Inc. | Methods of decreasing vascular calcification using IL-1 inhibitors |
KR20080109093A (ko) | 2006-04-14 | 2008-12-16 | 노파르티스 아게 | 안과 장애 치료를 위한 il-1 항체의 용도 |
EP2008100A4 (en) | 2006-04-18 | 2009-12-16 | Univ Leland Stanford Junior | ESTABLISHING ANTIBODY PROFILES FOR DETERMINING PATIENT SENSITIVITY TO TREATMENT |
BRPI0621761A2 (pt) | 2006-06-12 | 2011-12-20 | Therakine Ltd | solução oftálmica e uso de uma solução salina, e uma quantidade eficaz de pelo menos um agente terapêutico |
US20080095754A1 (en) | 2006-10-18 | 2008-04-24 | Burke Susan E | Ophthalmic compositions comprising diglycine |
US8399421B2 (en) | 2007-03-30 | 2013-03-19 | The Board Of Regents Of The University Of Texas System | Treatment for neuropathic pain due to spinal cord injury |
GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
EP2468301A1 (en) | 2007-05-29 | 2012-06-27 | Novartis AG | New indications for anti-IL-1-beta therapy |
EP2369005B1 (en) | 2007-06-21 | 2013-04-03 | Technische Universität München | Biological active proteins having increased in vivo and/or in vitro stability |
KR101430584B1 (ko) | 2007-07-05 | 2014-08-14 | 삼성전자주식회사 | 이동 통신 시스템에서 심 어플리케이션 툴킷을 제공하는장치 및 방법 |
KR20100058541A (ko) | 2007-08-15 | 2010-06-03 | 아뮤닉스 인코포레이티드 | 생물학적 활성 폴리펩티드의 특성을 변경하기 위한 조성물 및 방법 |
JP5894364B2 (ja) | 2007-08-16 | 2016-03-30 | ザ スキーペンズ アイ リサーチ インスティチュート インコーポレイテッド | 眼および付属器組織の炎症を処置するための治療組成物 |
WO2009048961A1 (en) | 2007-10-08 | 2009-04-16 | Anaphore, Inc. | Trimeric il-1ra |
CA3069576A1 (en) | 2008-01-09 | 2009-07-16 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of ocular inflammatory disorders |
US8298533B2 (en) | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
US20120014970A1 (en) | 2009-01-09 | 2012-01-19 | Reza Dana | Therapeutic Compositions for Treatment of Corneal Disorders |
EP2385839B1 (en) | 2009-01-09 | 2014-11-26 | The Schepens Eye Research Institute, Inc. | Therapeutic compositions for treatment of corneal disorders |
EP2398499B1 (en) | 2009-02-18 | 2017-09-06 | Eyeon Particle Sciences LLC | Bi-functional co-polymer use for ophthalmic and other topical and local applications |
EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
CA2726232A1 (en) | 2009-07-16 | 2010-08-12 | Arecor Limited | Stable formulation of a therapeutic protein |
WO2011011797A2 (en) | 2009-07-24 | 2011-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Cytokine compositions and methods of use thereof |
WO2011028344A2 (en) | 2009-08-25 | 2011-03-10 | Amunix Operating Inc. | Interleukin-1 receptor antagonist compositions and methods of making and using same |
CN102648002A (zh) | 2009-10-10 | 2012-08-22 | 斯坦福大学托管董事会 | Il-17家族细胞因子组合物及用途 |
WO2011063195A2 (en) | 2009-11-20 | 2011-05-26 | Dr. Reddy's Laboratories Ltd. | Purification of modified cytokines |
US9328162B2 (en) | 2010-02-25 | 2016-05-03 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
WO2011123813A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
US20130195868A1 (en) | 2010-06-24 | 2013-08-01 | Eleven Biotherapeutics, Inc. | Treating surface of the eye disorders |
CN107337735B (zh) | 2010-07-29 | 2021-06-22 | 巴扎德制药公司 | 嵌合il-1受体i型激动剂和拮抗剂 |
WO2012103240A2 (en) | 2011-01-25 | 2012-08-02 | Eleven Biotherapeutics, Inc. | Receptor binding agents |
RU2013145283A (ru) | 2011-03-14 | 2015-04-20 | Флого АпС | Новые антагонисты рецептора интерлейкина-1 |
SG10201606218WA (en) | 2011-07-29 | 2016-09-29 | Eleven Biotherapeutics Inc | Purified Proteins |
BR112015022587A2 (pt) | 2013-03-13 | 2017-10-24 | Eleven Biotherapeutics Inc | formulações de citocina quimérica para entrega ocular |
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