PL2595662T3 - Przeciwciało anty-cd19 mające funkcje adcc i cdc oraz poprawiony profil glikozylacji - Google Patents
Przeciwciało anty-cd19 mające funkcje adcc i cdc oraz poprawiony profil glikozylacjiInfo
- Publication number
- PL2595662T3 PL2595662T3 PL11732491T PL11732491T PL2595662T3 PL 2595662 T3 PL2595662 T3 PL 2595662T3 PL 11732491 T PL11732491 T PL 11732491T PL 11732491 T PL11732491 T PL 11732491T PL 2595662 T3 PL2595662 T3 PL 2595662T3
- Authority
- PL
- Poland
- Prior art keywords
- adcc
- antibody
- glycosylation profile
- improved glycosylation
- cdc functions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36554810P | 2010-07-19 | 2010-07-19 | |
| EP10305796A EP2409712A1 (en) | 2010-07-19 | 2010-07-19 | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| PCT/EP2011/062271 WO2012010562A1 (en) | 2010-07-19 | 2011-07-18 | Anti-cd19 antibody having adcc and cdc functions and improved glycosylation profile |
| EP11732491.3A EP2595662B1 (en) | 2010-07-19 | 2011-07-18 | Anti-cd19 antibody having adcc and cdc functions and improved glycosylation profile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2595662T3 true PL2595662T3 (pl) | 2019-02-28 |
Family
ID=43425912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11732491T PL2595662T3 (pl) | 2010-07-19 | 2011-07-18 | Przeciwciało anty-cd19 mające funkcje adcc i cdc oraz poprawiony profil glikozylacji |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | USRE49192E1 (pl) |
| EP (3) | EP2409712A1 (pl) |
| JP (2) | JP6092102B2 (pl) |
| CN (2) | CN103221068B (pl) |
| CA (1) | CA2805994C (pl) |
| DK (1) | DK2595662T3 (pl) |
| ES (1) | ES2700294T3 (pl) |
| HK (1) | HK1217338A1 (pl) |
| IN (1) | IN2013CN01338A (pl) |
| PL (1) | PL2595662T3 (pl) |
| PT (1) | PT2595662T (pl) |
| WO (1) | WO2012010562A1 (pl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2409712A1 (en) * | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| CN102636655B (zh) * | 2012-05-10 | 2014-07-23 | 苏州大学附属第一医院 | 一种荧光原位微量淋巴毒检测方法和试剂盒 |
| CA2950415A1 (en) * | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| WO2016007625A1 (en) * | 2014-07-08 | 2016-01-14 | Tdw Group | Antibodies to argininosuccinate synthase and related methods |
| FR3024453B1 (fr) * | 2014-08-01 | 2018-06-29 | Lab Francais Du Fractionnement | Procede de production de variants ayant un fc presentant une sialylation amelioree |
| EP3048116A1 (en) * | 2015-01-23 | 2016-07-27 | International-Drug-Development-Biotech | Anti-dr5 antibodies with enhanced apoptosis potency |
| CN114601931B (zh) | 2015-05-26 | 2023-09-01 | 莫佛塞斯公司 | 抗-cd19抗体和布鲁顿酪氨酸激酶抑制剂的组合及其用途 |
| US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
| WO2017032679A1 (en) | 2015-08-21 | 2017-03-02 | Morphosys Ag | Combinations and uses thereof |
| SI3465214T1 (sl) | 2016-05-30 | 2021-12-31 | Morphosys Ag | Postopki za napovedovanje terapevtske koristi terapije proti CD19 pri pacientih |
| DK3475303T3 (da) | 2016-06-27 | 2021-05-31 | Morphosys Ag | Anti-cd19-antistofformuleringer |
| CN106191072A (zh) * | 2016-08-04 | 2016-12-07 | 沈沭彤 | 重组人源嵌合GcFc基因片段及融合蛋白 |
| LT3532098T (lt) | 2016-10-28 | 2021-06-25 | Morphosys Ag | Anti cd19 antikūno derinys su bcl-2 inhibitoriumi, ir jo naudojimas |
| CN116120454A (zh) * | 2017-01-05 | 2023-05-16 | 上海煦顼技术有限公司 | 人源化抗cd19抗体及其与嵌合抗原受体的用途 |
| US11634488B2 (en) * | 2017-07-10 | 2023-04-25 | International—Drug—Development—Biotech | Treatment of B cell malignancies using afucosylated pro-apoptotic anti-CD19 antibodies in combination with anti CD20 antibodies or chemotherapeutics |
| WO2020159504A1 (en) | 2019-01-30 | 2020-08-06 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
| AU2018306436A1 (en) | 2017-07-27 | 2020-02-13 | Nomocan Pharmaceuticals Llc | Antibodies to M(H)DM2/4 and their use in diagnosing and treating cancer |
| CN115819588A (zh) * | 2017-09-21 | 2023-03-21 | 上海药明生物技术有限公司 | 新型抗cd19抗体 |
| TWI745615B (zh) * | 2018-08-31 | 2021-11-11 | 聯合生物製藥股份有限公司 | 去岩藻醣基化抗體及表現此抗體的細胞株 |
| TWI748124B (zh) * | 2018-08-31 | 2021-12-01 | 聯合生物製藥股份有限公司 | 去岩藻醣基化抗體的製造方法 |
| SG11202111343TA (en) | 2019-05-03 | 2021-11-29 | Morphosys Ag | Anti-cd19 therapy in patients having a limited number of nk cells |
| JPWO2021015237A1 (pl) * | 2019-07-24 | 2021-01-28 | ||
| KR20220103969A (ko) | 2019-10-31 | 2022-07-25 | 모르포시스 아게 | 백혈병 또는 림프종의 치료를 위해 레날리도마이드와 조합된 항-cd19 요법 |
| EP4051710A1 (en) | 2019-10-31 | 2022-09-07 | MorphoSys AG | Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells |
| CN110845617B (zh) * | 2019-12-05 | 2021-07-09 | 常州费洛斯药业科技有限公司 | 针对cd19的全人源抗体或抗体片段、嵌合抗原受体及应用 |
| CN115485295A (zh) | 2020-03-10 | 2022-12-16 | 麻省理工学院 | NPM1c阳性癌症的免疫疗法的组合物和方法 |
| US20220356266A1 (en) * | 2020-04-17 | 2022-11-10 | Janssen Biotech, Inc. | Biosynthetic glycoprotein populations |
| EP3915641A1 (en) * | 2020-05-27 | 2021-12-01 | International-Drug-Development-Biotech | Anti-cd5 antibodies and methods of use thereof |
| JP2023530499A (ja) | 2020-06-22 | 2023-07-18 | モルフォシス・アーゲー | 抗ＣＤ１９抗体及びＳＩＲＰα－ＣＤ４７自然免疫チェックポイントを遮断するポリペプチドを含む抗腫瘍組み合わせ療法 |
| MX2023003997A (es) | 2020-10-06 | 2023-06-15 | Xencor Inc | Biomarcadores, métodos y composiciones para el tratamiento de la enfermedad autoinmunitaria, que incluye el lupus eritematoso sistémico (les). |
| MX2023006538A (es) | 2020-12-04 | 2023-08-08 | Morphosys Ag | Terapia combinada de anticuerpo anti cúmulo de diferenciación 19 (cd19). |
| WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
| US12077597B2 (en) | 2021-11-24 | 2024-09-03 | International-Drug-Development-Biotech | Anti-CD5 antibodies and methods of use thereof |
| CN114316060B (zh) * | 2021-12-15 | 2023-06-13 | 北京市肿瘤防治研究所 | 抗人cd19与cd206双特异性抗体及其制备方法和应用 |
| CN117304308A (zh) * | 2022-06-20 | 2023-12-29 | 华辉安健（北京）生物科技有限公司 | 抗乙型肝炎病毒的抗体及其制备和应用 |
| WO2024038115A1 (en) | 2022-08-17 | 2024-02-22 | Morphosys Ag | Therapy comprising anti-cd19 antibody and ezh2 modulators |
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| ES2402591T3 (es) | 2006-08-14 | 2013-05-07 | Xencor Inc. | Anticuerpos optimizados que seleccionan como diana CD19 |
| EP2066349B1 (en) | 2006-09-08 | 2012-03-28 | MedImmune, LLC | Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases |
| WO2008140603A2 (en) | 2006-12-08 | 2008-11-20 | Macrogenics, Inc. | METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| LT2211904T (lt) | 2007-10-19 | 2016-11-25 | Seattle Genetics, Inc. | Cd19 surišantys agentai ir jų panaudojimas |
| CA2705289A1 (en) * | 2007-11-13 | 2009-05-22 | The Scripps Research Institute | Production of cytotoxic antibody-toxin fusion in eukaryotic algae |
| TR201804897T4 (tr) | 2009-10-07 | 2018-06-21 | Macrogenics Inc | Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| EP2409712A1 (en) * | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
-
2010
- 2010-07-19 EP EP10305796A patent/EP2409712A1/en not_active Withdrawn
-
2011
- 2011-07-18 US US16/427,106 patent/USRE49192E1/en active Active
- 2011-07-18 DK DK11732491.3T patent/DK2595662T3/en active
- 2011-07-18 CN CN201180044951.3A patent/CN103221068B/zh active Active
- 2011-07-18 PL PL11732491T patent/PL2595662T3/pl unknown
- 2011-07-18 CA CA2805994A patent/CA2805994C/en active Active
- 2011-07-18 CN CN201510532645.4A patent/CN105111312B/zh active Active
- 2011-07-18 PT PT11732491T patent/PT2595662T/pt unknown
- 2011-07-18 EP EP18192521.5A patent/EP3461843B1/en active Active
- 2011-07-18 WO PCT/EP2011/062271 patent/WO2012010562A1/en active Application Filing
- 2011-07-18 IN IN1338CHN2013 patent/IN2013CN01338A/en unknown
- 2011-07-18 JP JP2013520114A patent/JP6092102B2/ja active Active
- 2011-07-18 EP EP11732491.3A patent/EP2595662B1/en active Active
- 2011-07-18 ES ES11732491T patent/ES2700294T3/es active Active
- 2011-07-18 US US13/811,045 patent/US9663583B2/en not_active Ceased
-
2016
- 2016-05-09 HK HK16105263.1A patent/HK1217338A1/zh unknown
- 2016-10-06 JP JP2016198046A patent/JP6371815B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IN2013CN01338A (pl) | 2015-08-07 |
| JP2013535192A (ja) | 2013-09-12 |
| CA2805994A1 (en) | 2012-01-26 |
| CN103221068B (zh) | 2016-08-17 |
| EP2409712A1 (en) | 2012-01-25 |
| EP2595662A1 (en) | 2013-05-29 |
| EP3461843A3 (en) | 2019-04-24 |
| CN105111312A (zh) | 2015-12-02 |
| EP2595662B1 (en) | 2018-09-05 |
| DK2595662T3 (en) | 2018-11-26 |
| HK1217338A1 (zh) | 2017-01-06 |
| EP3461843B1 (en) | 2023-09-06 |
| JP2017008108A (ja) | 2017-01-12 |
| ES2700294T3 (es) | 2019-02-14 |
| WO2012010562A1 (en) | 2012-01-26 |
| US9663583B2 (en) | 2017-05-30 |
| JP6092102B2 (ja) | 2017-03-08 |
| US20130224190A1 (en) | 2013-08-29 |
| CN105111312B (zh) | 2018-12-14 |
| JP6371815B2 (ja) | 2018-08-08 |
| USRE49192E1 (en) | 2022-08-30 |
| PT2595662T (pt) | 2018-12-11 |
| EP3461843A2 (en) | 2019-04-03 |
| CN103221068A (zh) | 2013-07-24 |
| CA2805994C (en) | 2020-05-12 |
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