IN2013CN01338A - - Google Patents
Info
- Publication number
- IN2013CN01338A IN2013CN01338A IN1338CHN2013A IN2013CN01338A IN 2013CN01338 A IN2013CN01338 A IN 2013CN01338A IN 1338CHN2013 A IN1338CHN2013 A IN 1338CHN2013A IN 2013CN01338 A IN2013CN01338 A IN 2013CN01338A
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- India
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- relates
- antibodies
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention relates to an anti CD19 antibody having a variant Fc region having some specific amino acid modifications relative to a wild type Fc region which confer one or several useful effector functions. The present invention relates in particular to chimeric humanized or full human anti CD19 antibodies comprising such a variant Fc region. It relates advantageously to antibodies with an interesting and valuable glycosylation profile especially a low fucose level and/or a high oligomannose level and low level of sialylated glycoform. The present invention also relates to the use of these antibodies in the treatment prevention or management of disease or disorder such as cancer especially a B cell malignancy and auto immune disease.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36554810P | 2010-07-19 | 2010-07-19 | |
EP10305796A EP2409712A1 (en) | 2010-07-19 | 2010-07-19 | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
PCT/EP2011/062271 WO2012010562A1 (en) | 2010-07-19 | 2011-07-18 | Anti-cd19 antibody having adcc and cdc functions and improved glycosylation profile |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013CN01338A true IN2013CN01338A (en) | 2015-08-07 |
Family
ID=43425912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1338CHN2013 IN2013CN01338A (en) | 2010-07-19 | 2011-07-18 |
Country Status (12)
Country | Link |
---|---|
US (2) | US9663583B2 (en) |
EP (3) | EP2409712A1 (en) |
JP (2) | JP6092102B2 (en) |
CN (2) | CN103221068B (en) |
CA (1) | CA2805994C (en) |
DK (1) | DK2595662T3 (en) |
ES (1) | ES2700294T3 (en) |
HK (1) | HK1217338A1 (en) |
IN (1) | IN2013CN01338A (en) |
PL (1) | PL2595662T3 (en) |
PT (1) | PT2595662T (en) |
WO (1) | WO2012010562A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2409712A1 (en) * | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
CN102636655B (en) * | 2012-05-10 | 2014-07-23 | 苏州大学附属第一医院 | Fluorescence in-situ micro-lymphocytotoxicity detection method and kit |
CA2950415A1 (en) * | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
TWI790481B (en) | 2014-07-08 | 2023-01-21 | 開曼群島商瑞華藥業集團 | Antibodies to argininosuccinate synthase and related methods |
FR3024453B1 (en) * | 2014-08-01 | 2018-06-29 | Lab Francais Du Fractionnement | PROCESS FOR PRODUCING VARIANTS HAVING FC HAVING ENHANCED SIALYLATION |
EP3048116A1 (en) * | 2015-01-23 | 2016-07-27 | International-Drug-Development-Biotech | Anti-dr5 antibodies with enhanced apoptosis potency |
CN114601931B (en) | 2015-05-26 | 2023-09-01 | 莫佛塞斯公司 | Combination of anti-CD 19 antibodies and bruton's tyrosine kinase inhibitors and uses thereof |
US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
RS62260B1 (en) | 2015-08-21 | 2021-09-30 | Morphosys Ag | Combinations and uses thereof |
HUE054860T2 (en) | 2016-05-30 | 2021-10-28 | Morphosys Ag | Methods for predicting therapeutic benefit of anti-cd19 therapy in patients |
KR102533875B1 (en) | 2016-06-27 | 2023-05-18 | 모르포시스 아게 | Anti-CD19 Antibody Formulations |
CN106191072A (en) * | 2016-08-04 | 2016-12-07 | 沈沭彤 | Recombination human source is fitted together to GcFc genetic fragment and fusion protein |
PL3532098T3 (en) | 2016-10-28 | 2022-01-31 | Morphosys Ag | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
EP4032550A3 (en) * | 2017-01-05 | 2022-10-19 | Innovative Cellular Therapeutics Holdings, Ltd. | Humanized anti-cd19 antibody and use thereof with chimeric antigen receptor |
US11634488B2 (en) | 2017-07-10 | 2023-04-25 | International—Drug—Development—Biotech | Treatment of B cell malignancies using afucosylated pro-apoptotic anti-CD19 antibodies in combination with anti CD20 antibodies or chemotherapeutics |
US20210032364A1 (en) | 2017-07-27 | 2021-02-04 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
CN109535253B (en) | 2017-09-21 | 2022-11-04 | 上海药明生物技术有限公司 | Novel anti-CD 19 antibodies |
TWI745615B (en) * | 2018-08-31 | 2021-11-11 | 聯合生物製藥股份有限公司 | Afucosylated antibodies and cell lines expressing the afucosylated antibodies |
TWI748124B (en) * | 2018-08-31 | 2021-12-01 | 聯合生物製藥股份有限公司 | Manufacture method of afucosylated antibodies |
AU2019427766A1 (en) | 2019-01-30 | 2021-09-16 | Nomocan Pharmaceuticals Llc | Antibodies to M(H)DM2/4 and their use in diagnosing and treating cancer |
CA3137664A1 (en) | 2019-05-03 | 2020-11-12 | Morphosys Ag | Anti-cd19 therapy in patients having a limited number of nk cells |
WO2021015237A1 (en) * | 2019-07-24 | 2021-01-28 | 国立研究開発法人科学技術振興機構 | Innovative production technique for antibody-enzyme |
IL292181A (en) | 2019-10-31 | 2022-06-01 | Morphosys Ag | Anti-cd19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma |
CN115151565A (en) | 2019-10-31 | 2022-10-04 | 莫佛塞斯公司 | Anti-tumor combination therapy comprising anti-CD 19 antibody and gamma delta T cells |
CN111303286B (en) * | 2019-12-05 | 2022-05-20 | 常州费洛斯药业科技有限公司 | anti-CD19 fully human antibody or antibody fragment, chimeric antigen receptor thereof and application thereof |
JP2023517889A (en) | 2020-03-10 | 2023-04-27 | マサチューセッツ インスティテュート オブ テクノロジー | Compositions and methods for immunotherapy of NPM1c-positive cancers |
WO2021211956A1 (en) * | 2020-04-17 | 2021-10-21 | Janssen Biotech, Inc. | Biosynthetic glycoprotein populations |
EP3915641A1 (en) * | 2020-05-27 | 2021-12-01 | International-Drug-Development-Biotech | Anti-cd5 antibodies and methods of use thereof |
CA3181827A1 (en) | 2020-06-22 | 2021-12-30 | Morphosys Ag | Anti-tumor combination therapy comprising anti-cd19 antibody and polypeptides blocking the sirp?-cd47 innate immune checkpoint |
EP4225794A1 (en) | 2020-10-06 | 2023-08-16 | Xencor, Inc. | Biomarkers, methods, and compositions for treating autoimmune disease including systemic lupus erythematous (sle) |
KR20230131464A (en) | 2020-12-04 | 2023-09-13 | 모르포시스 아게 | Anti-CD19 combination therapy |
WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
CN114316060B (en) * | 2021-12-15 | 2023-06-13 | 北京市肿瘤防治研究所 | Bispecific antibody against human CD19 and CD206, and preparation method and application thereof |
CN117304308A (en) * | 2022-06-20 | 2023-12-29 | 华辉安健(北京)生物科技有限公司 | Anti-hepatitis B virus antibody, preparation and application thereof |
WO2024038115A1 (en) | 2022-08-17 | 2024-02-22 | Morphosys Ag | Therapy comprising anti-cd19 antibody and ezh2 modulators |
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PT2059536E (en) | 2006-08-14 | 2014-04-14 | Xencor Inc | Optimized antibodies that target cd19 |
EP2066349B1 (en) | 2006-09-08 | 2012-03-28 | MedImmune, LLC | Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases |
US8652466B2 (en) | 2006-12-08 | 2014-02-18 | Macrogenics, Inc. | Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting |
CL2007003622A1 (en) | 2006-12-13 | 2009-08-07 | Medarex Inc | Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method. |
US7968687B2 (en) | 2007-10-19 | 2011-06-28 | Seattle Genetics, Inc. | CD19 binding agents and uses thereof |
WO2009064815A1 (en) * | 2007-11-13 | 2009-05-22 | The Scripps Research Institute | Production of cytotoxic antibody-toxin fusion in eukaryotic algae |
RU2583298C2 (en) | 2009-10-07 | 2016-05-10 | Макродженикс, Инк. | POLYPEPTIDES CONTAINING Fc-SECTION THAT DISPLAY INCREASED EFFECTOR FUNCTION OWING TO VARYING FUCOSYLATION LEVEL AND THEIR APPLICATIONS |
EP2409712A1 (en) * | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
-
2010
- 2010-07-19 EP EP10305796A patent/EP2409712A1/en not_active Withdrawn
-
2011
- 2011-07-18 US US13/811,045 patent/US9663583B2/en not_active Ceased
- 2011-07-18 US US16/427,106 patent/USRE49192E1/en active Active
- 2011-07-18 ES ES11732491T patent/ES2700294T3/en active Active
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CN103221068A (en) | 2013-07-24 |
EP3461843A3 (en) | 2019-04-24 |
EP3461843A2 (en) | 2019-04-03 |
US9663583B2 (en) | 2017-05-30 |
USRE49192E1 (en) | 2022-08-30 |
CA2805994A1 (en) | 2012-01-26 |
CN105111312B (en) | 2018-12-14 |
CA2805994C (en) | 2020-05-12 |
CN103221068B (en) | 2016-08-17 |
HK1217338A1 (en) | 2017-01-06 |
WO2012010562A1 (en) | 2012-01-26 |
CN105111312A (en) | 2015-12-02 |
PT2595662T (en) | 2018-12-11 |
JP6092102B2 (en) | 2017-03-08 |
US20130224190A1 (en) | 2013-08-29 |
JP2017008108A (en) | 2017-01-12 |
EP3461843B1 (en) | 2023-09-06 |
EP2595662A1 (en) | 2013-05-29 |
ES2700294T3 (en) | 2019-02-14 |
EP2409712A1 (en) | 2012-01-25 |
DK2595662T3 (en) | 2018-11-26 |
JP2013535192A (en) | 2013-09-12 |
JP6371815B2 (en) | 2018-08-08 |
EP2595662B1 (en) | 2018-09-05 |
PL2595662T3 (en) | 2019-02-28 |
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