PL2463368T3 - Humanizowane przeciwciało anty-oligomer amyloidu B - Google Patents
Humanizowane przeciwciało anty-oligomer amyloidu BInfo
- Publication number
- PL2463368T3 PL2463368T3 PL10806566T PL10806566T PL2463368T3 PL 2463368 T3 PL2463368 T3 PL 2463368T3 PL 10806566 T PL10806566 T PL 10806566T PL 10806566 T PL10806566 T PL 10806566T PL 2463368 T3 PL2463368 T3 PL 2463368T3
- Authority
- PL
- Poland
- Prior art keywords
- amyloid
- humanized anti
- oligomer antibody
- oligomer
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23203809P | 2009-08-07 | 2009-08-07 | |
| EP10806566.5A EP2463368B1 (en) | 2009-08-07 | 2010-08-06 | Humanized anti-amyloid-b oligomer antibody |
| PCT/JP2010/063430 WO2011016567A1 (ja) | 2009-08-07 | 2010-08-06 | 抗アミロイドβオリゴマーヒト化抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2463368T3 true PL2463368T3 (pl) | 2018-07-31 |
Family
ID=43544461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10806566T PL2463368T3 (pl) | 2009-08-07 | 2010-08-06 | Humanizowane przeciwciało anty-oligomer amyloidu B |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8333967B2 (pl) |
| EP (1) | EP2463368B1 (pl) |
| JP (1) | JP5051806B2 (pl) |
| KR (1) | KR101787118B1 (pl) |
| CN (1) | CN102597234B (pl) |
| AU (1) | AU2010279892B8 (pl) |
| BR (1) | BR112012002819B1 (pl) |
| CA (1) | CA2769464C (pl) |
| DK (1) | DK2463368T3 (pl) |
| ES (1) | ES2661601T3 (pl) |
| HU (1) | HUE036392T2 (pl) |
| MX (1) | MX2012001708A (pl) |
| PL (1) | PL2463368T3 (pl) |
| PT (1) | PT2463368T (pl) |
| SG (1) | SG177679A1 (pl) |
| WO (1) | WO2011016567A1 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2921180T3 (es) | 2014-04-16 | 2022-08-19 | Kyowa Kirin Co Ltd | Método para medir la toxicidad del CSF humano |
| AU2017207082B2 (en) * | 2016-01-12 | 2023-07-13 | Eisai Randd Management Co., Ltd. | Anti-Myl9 antibody |
| CN107118260B (zh) * | 2017-05-12 | 2020-10-16 | 中国科学院过程工程研究所 | 一种多肽及其组成的疫苗和应用 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CA3118692A1 (en) * | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| CN117586388A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 改进的β淀粉样蛋白寡聚体特异性结合抗体 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02257891A (ja) | 1989-03-31 | 1990-10-18 | Kyowa Hakko Kogyo Co Ltd | 組換え動物細胞による蛋白質の製造 |
| ES2233974T3 (es) | 1995-09-11 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Anticuerpo contra la cadena alfa del receptor de la interleucina 5 humana. |
| US20030068316A1 (en) | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US20050059591A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
| CA2953239A1 (en) | 2000-10-06 | 2002-04-18 | Kyowa Hakko Kirin Co., Ltd. | Antibody composition-producing cell |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| JPWO2005035586A1 (ja) | 2003-10-08 | 2007-11-22 | 協和醗酵工業株式会社 | 融合蛋白質組成物 |
| SI1674111T1 (sl) * | 2004-07-09 | 2011-02-28 | Chugai Pharmaceutical Co Ltd | Protitelo proti glipikanu 3 |
| JP3806883B2 (ja) | 2004-09-28 | 2006-08-09 | ダイキン工業株式会社 | 空気調和装置 |
| US7811563B2 (en) * | 2004-10-25 | 2010-10-12 | Northwestern University | Anti-addl antibodies and uses thereof |
| CA2790433A1 (en) * | 2004-10-25 | 2006-05-26 | Northwestern University | Anti-addl antibodies and uses thereof |
| US8716451B2 (en) | 2005-01-12 | 2014-05-06 | Kyowa Hakko Kirin Co., Ltd | Stabilized human IgG2 and IgG3 antibodies |
| US7700099B2 (en) | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
| US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
| CN101965365A (zh) | 2007-10-19 | 2011-02-02 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
| CN102936287B (zh) * | 2008-02-08 | 2015-09-09 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
| AU2011262758B8 (en) * | 2010-06-11 | 2014-09-04 | Kyowa Kirin Co., Ltd. | Anti-tim-3 antibody |
-
2010
- 2010-08-06 SG SG2012003208A patent/SG177679A1/en unknown
- 2010-08-06 BR BR112012002819-7A patent/BR112012002819B1/pt active IP Right Grant
- 2010-08-06 HU HUE10806566A patent/HUE036392T2/hu unknown
- 2010-08-06 PT PT108065665T patent/PT2463368T/pt unknown
- 2010-08-06 KR KR1020127003173A patent/KR101787118B1/ko active Active
- 2010-08-06 CA CA2769464A patent/CA2769464C/en active Active
- 2010-08-06 CN CN201080035051.8A patent/CN102597234B/zh active Active
- 2010-08-06 ES ES10806566.5T patent/ES2661601T3/es active Active
- 2010-08-06 JP JP2011525961A patent/JP5051806B2/ja active Active
- 2010-08-06 AU AU2010279892A patent/AU2010279892B8/en active Active
- 2010-08-06 MX MX2012001708A patent/MX2012001708A/es active IP Right Grant
- 2010-08-06 DK DK10806566.5T patent/DK2463368T3/en active
- 2010-08-06 PL PL10806566T patent/PL2463368T3/pl unknown
- 2010-08-06 WO PCT/JP2010/063430 patent/WO2011016567A1/ja not_active Ceased
- 2010-08-06 EP EP10806566.5A patent/EP2463368B1/en active Active
- 2010-08-09 US US12/852,548 patent/US8333967B2/en active Active
-
2012
- 2012-11-15 US US13/678,214 patent/US9181332B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010279892B2 (en) | 2014-05-22 |
| CN102597234B (zh) | 2014-10-29 |
| SG177679A1 (en) | 2012-02-28 |
| JP5051806B2 (ja) | 2012-10-17 |
| ES2661601T3 (es) | 2018-04-02 |
| BR112012002819A2 (pt) | 2017-07-11 |
| US9181332B2 (en) | 2015-11-10 |
| US20130095526A1 (en) | 2013-04-18 |
| PT2463368T (pt) | 2018-02-08 |
| HUE036392T2 (hu) | 2018-07-30 |
| EP2463368B1 (en) | 2018-01-10 |
| KR20120038474A (ko) | 2012-04-23 |
| DK2463368T3 (en) | 2018-01-22 |
| BR112012002819B1 (pt) | 2022-11-22 |
| CA2769464C (en) | 2017-11-21 |
| EP2463368A9 (en) | 2012-11-28 |
| CN102597234A (zh) | 2012-07-18 |
| AU2010279892B8 (en) | 2014-09-25 |
| KR101787118B1 (ko) | 2017-10-18 |
| EP2463368A4 (en) | 2013-09-18 |
| WO2011016567A1 (ja) | 2011-02-10 |
| MX2012001708A (es) | 2012-05-22 |
| AU2010279892A1 (en) | 2012-02-09 |
| RU2012108610A (ru) | 2013-09-20 |
| US20120009179A1 (en) | 2012-01-12 |
| CA2769464A1 (en) | 2011-02-10 |
| US8333967B2 (en) | 2012-12-18 |
| AU2010279892A8 (en) | 2014-09-25 |
| EP2463368A1 (en) | 2012-06-13 |
| JPWO2011016567A1 (ja) | 2013-01-17 |
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