PL2451936T3 - Sposób hodowli komórek eukariotycznych - Google Patents
Sposób hodowli komórek eukariotycznychInfo
- Publication number
- PL2451936T3 PL2451936T3 PL10730960T PL10730960T PL2451936T3 PL 2451936 T3 PL2451936 T3 PL 2451936T3 PL 10730960 T PL10730960 T PL 10730960T PL 10730960 T PL10730960 T PL 10730960T PL 2451936 T3 PL2451936 T3 PL 2451936T3
- Authority
- PL
- Poland
- Prior art keywords
- eukaryotic cells
- culturing eukaryotic
- culturing
- cells
- eukaryotic
- Prior art date
Links
- 238000012258 culturing Methods 0.000 title 1
- 210000003527 eukaryotic cell Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/20—Degassing; Venting; Bubble traps
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Computer Hardware Design (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22331309P | 2009-07-06 | 2009-07-06 | |
| EP10730960.1A EP2451936B1 (en) | 2009-07-06 | 2010-07-06 | Method of culturing eukaryotic cells |
| PCT/US2010/041082 WO2011005773A2 (en) | 2009-07-06 | 2010-07-06 | Method of culturing eukaryotic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2451936T3 true PL2451936T3 (pl) | 2020-02-28 |
Family
ID=43429807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10730960T PL2451936T3 (pl) | 2009-07-06 | 2010-07-06 | Sposób hodowli komórek eukariotycznych |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20120329151A1 (pl) |
| EP (2) | EP2451936B1 (pl) |
| JP (2) | JP2012531930A (pl) |
| KR (1) | KR101838302B1 (pl) |
| CN (2) | CN107043703B (pl) |
| AU (4) | AU2010270726A1 (pl) |
| BR (1) | BR112012000242B1 (pl) |
| CA (2) | CA3118479A1 (pl) |
| ES (1) | ES2752874T3 (pl) |
| IL (3) | IL217223A0 (pl) |
| MX (3) | MX382080B (pl) |
| PL (1) | PL2451936T3 (pl) |
| SG (1) | SG177555A1 (pl) |
| WO (1) | WO2011005773A2 (pl) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2842964A1 (en) | 2006-09-13 | 2008-03-20 | Abbvie Inc. | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| NZ592095A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography |
| AU2009307737B2 (en) | 2008-10-20 | 2015-07-23 | Abbvie Inc. | Viral inactivation during purification of antibodies |
| CN107043703B (zh) | 2009-07-06 | 2020-03-27 | 弗·哈夫曼-拉罗切有限公司 | 真核细胞的培养方法 |
| CN103380210B (zh) * | 2011-02-24 | 2016-11-09 | 通用电气健康护理生物科学股份公司 | 具有通过过滤组件的给料流和收获流的生物反应器 |
| US9376654B2 (en) | 2011-03-03 | 2016-06-28 | Meissner Filtration Products, Inc. | Biocontainer |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CN202786257U (zh) * | 2011-08-31 | 2013-03-13 | 通用电气健康护理生物科学股份公司 | 用于生物反应器的排气过滤装置 |
| WO2013086371A1 (en) * | 2011-12-09 | 2013-06-13 | Atmi Packaging, Inc. | Filtration apparatus for continuous perfusion |
| US9228166B2 (en) * | 2011-12-20 | 2016-01-05 | Pall Corporation | Rockable biocontainer |
| EP2639294A1 (fr) | 2012-03-15 | 2013-09-18 | CellProthera | Automate et procédé automatisé de culture cellulaire |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| JP2013237644A (ja) * | 2012-05-16 | 2013-11-28 | Mitsubishi Gas Chemical Co Inc | 細胞活性化炭酸水 |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| EP2890782A1 (en) | 2012-09-02 | 2015-07-08 | AbbVie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| EP4036208A1 (en) | 2012-10-26 | 2022-08-03 | Massachusetts Institute Of Technology | Humidity control in chemical reactors |
| CN104870629A (zh) * | 2012-10-26 | 2015-08-26 | 麻省理工学院 | 小容积反应器中二氧化碳水平和pH的控制 |
| HK1207960A1 (en) | 2013-03-12 | 2016-02-19 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| KR20210095233A (ko) * | 2013-03-15 | 2021-07-30 | 젠자임 코포레이션 | 고-밀도 세포 뱅킹 방법 |
| US10479973B2 (en) | 2013-08-23 | 2019-11-19 | Massachuesetts Institute Of Technology | Small volume bioreactors with substantially constant working volumes and associated systems and methods |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) * | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| GB201416362D0 (en) * | 2014-07-25 | 2014-10-29 | Ge Healthcare Bio Sciences Ab | Method and system for suspension culture |
| AU2015317530A1 (en) * | 2014-09-18 | 2017-04-13 | Genzyme Corporation | Ultra-high density cell banking methods |
| US10617070B2 (en) | 2014-10-06 | 2020-04-14 | Life Technologies Corporation | Methods and systems for culturing microbial and cellular seed cultures |
| US9944894B2 (en) * | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| KR102427457B1 (ko) * | 2015-03-24 | 2022-08-01 | 메디칸(주) | 연속 세포 배양 증식장치 및 방법 |
| GB201509202D0 (en) | 2015-05-28 | 2015-07-15 | Ge Healthcare Bio Sciences Ab | Semi-static cell culture |
| CN105176815B (zh) * | 2015-10-20 | 2017-03-22 | 哈尔滨工业大学 | 一种用于人工皮肤组织培养的气液界面灌注式生物反应器及其制备方法和使用方法 |
| KR102612135B1 (ko) | 2015-10-30 | 2023-12-08 | 에프. 호프만-라 로슈 아게 | Ph-측정 디바이스들의 교정 편차들의 식별 |
| CN108699502A (zh) | 2016-02-23 | 2018-10-23 | 康宁股份有限公司 | 灌注生物反应器及其用于进行连续细胞培养的方法 |
| CN105802851B (zh) * | 2016-03-25 | 2018-06-19 | 苏州诺普再生医学有限公司 | 一种3d打印皮肤的动态倾斜旋转生物反应器 |
| CN105820948B (zh) * | 2016-03-31 | 2018-06-01 | 上海高机生物工程有限公司 | 一种用于生物反应袋的旋摆平台 |
| EP4325111A3 (en) | 2016-07-12 | 2024-05-01 | Emulate, Inc. | Removing bubbles in a microfluidic device |
| US11359176B2 (en) | 2016-07-12 | 2022-06-14 | Global Life Sciences Solutions Usa Llc | Microfluidic device for cell culture monitoring |
| RU2755725C2 (ru) * | 2016-09-12 | 2021-09-20 | Джуно Терапьютикс, Инк. | Сборочные узлы перфузионных биореакторных мешков |
| CN109952367A (zh) * | 2016-09-14 | 2019-06-28 | Vbc控股有限责任公司 | 用于控制细胞培养物的运动以优化细胞生长的系统、装置和方法 |
| WO2018094235A1 (en) | 2016-11-18 | 2018-05-24 | New York Stem Cell Foundation, Inc. | Microfluidic system and method of use thereof |
| ES2848701T3 (es) * | 2016-12-21 | 2021-08-11 | Hoffmann La Roche | Control de la proliferación de células eucariotas |
| US11525112B2 (en) | 2016-12-29 | 2022-12-13 | Global Life Sciences Solutions Usa Llc | Failure recovery in cell culture bioreactors |
| KR101895195B1 (ko) * | 2017-03-17 | 2018-09-05 | 인제대학교 산학협력단 | 세포 체외 증식을 위한 바이오리액터 |
| IL273549B2 (en) | 2017-10-06 | 2023-10-01 | Lonza Ag | Automated control of cell culture using Raman spectroscopy |
| ES2919850T3 (es) | 2017-10-16 | 2022-07-28 | Regeneron Pharma | Procedimientos de perfusión |
| WO2019131626A1 (ja) * | 2017-12-28 | 2019-07-04 | オリンパス株式会社 | 細胞培養制御方法、細胞培養制御装置、細胞培養装置および細胞培養システム |
| AU2020254733B2 (en) * | 2019-04-03 | 2025-02-20 | Flaskworks, Llc | Cell culture systems and uses thereof |
| US11708555B2 (en) * | 2019-05-30 | 2023-07-25 | Global Life Sciences Solutions Usa Llc | System, method and apparatus for draining a bioreactor vessel |
| JP7580451B2 (ja) * | 2019-09-06 | 2024-11-11 | 浙江金儀盛世生物工程有限公司 | バイオリアクターシステム及びその適用 |
| WO2021069287A1 (en) * | 2019-10-11 | 2021-04-15 | Cytiva Sweden Ab | Bioreactor apparatus and operation method thereof |
| EP3985089A1 (en) * | 2020-10-15 | 2022-04-20 | The Automation Partnership (Cambridge) Ltd. | Bioreactor including probe for electrical or electromagnetic measurements |
| CA3210970A1 (en) * | 2021-02-12 | 2022-08-18 | Bayer Healthcare Llc | Methods of adjusting the ph of a cell culture medium |
| US11299700B1 (en) | 2021-02-19 | 2022-04-12 | Acequia Biotechnology, Llc | Bioreactor containers and methods of growing hairy roots using the same |
| EP4491703A1 (en) * | 2023-07-12 | 2025-01-15 | Imec VZW | A sensor head and a method for manufacturing a sensor head |
| WO2025205600A1 (ja) * | 2024-03-25 | 2025-10-02 | 三菱ケミカル株式会社 | 細胞培養方法及び細胞培養装置 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3941662A (en) * | 1971-06-09 | 1976-03-02 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Apparatus for culturing cells |
| JPS5238082A (en) | 1975-09-13 | 1977-03-24 | Heraeus Gmbh W C | Cultivating container for microorganism * bacterium and tissue |
| JPS60141286A (ja) * | 1983-12-28 | 1985-07-26 | Ajinomoto Co Inc | 動物細胞の培養方法および装置 |
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| DE3515753C2 (de) * | 1985-05-02 | 1987-03-05 | Hans 4156 Willich Preisendanz | Verfahren zur Bestimmung der Wirkung von Chemotherapeutika auf das Wachstum von Mikroorganismen und/oder Zellen und Verwendung einer Vorrichtung mit mehreren Kammern zu seiner Durchführung |
| JPH0310679A (ja) * | 1989-06-09 | 1991-01-18 | Shimadzu Corp | 細胞培養バッグ |
| EP0567738A3 (en) * | 1992-05-01 | 1995-09-06 | American Cyanamid Co | Controlling perfusion rates in continuous bioreactor culture of animal cells |
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| US6544788B2 (en) * | 2001-02-15 | 2003-04-08 | Vijay Singh | Disposable perfusion bioreactor for cell culture |
| MXPA06014099A (es) * | 2004-06-04 | 2007-05-09 | Xcellerex Inc | Sistemas biorreactores desechables y metodos. |
| US7195394B2 (en) * | 2004-07-19 | 2007-03-27 | Vijay Singh | Method for resonant wave mixing in closed containers |
| US20060196501A1 (en) * | 2005-03-02 | 2006-09-07 | Hynetics Llc | Systems and methods for mixing and sparging solutions and/or suspensions |
| US7745209B2 (en) | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
| US9109193B2 (en) * | 2007-07-30 | 2015-08-18 | Ge Healthcare Bio-Sciences Corp. | Continuous perfusion bioreactor system |
| US8215238B2 (en) | 2007-10-10 | 2012-07-10 | The Texas A&M University System | Guideway coupling system |
| CN107043703B (zh) | 2009-07-06 | 2020-03-27 | 弗·哈夫曼-拉罗切有限公司 | 真核细胞的培养方法 |
-
2010
- 2010-07-06 CN CN201611012418.XA patent/CN107043703B/zh active Active
- 2010-07-06 JP JP2012519674A patent/JP2012531930A/ja not_active Withdrawn
- 2010-07-06 BR BR112012000242-2A patent/BR112012000242B1/pt active IP Right Grant
- 2010-07-06 MX MX2019010034A patent/MX382080B/es unknown
- 2010-07-06 EP EP10730960.1A patent/EP2451936B1/en active Active
- 2010-07-06 KR KR1020127003042A patent/KR101838302B1/ko active Active
- 2010-07-06 EP EP19185639.2A patent/EP3643773A1/en active Pending
- 2010-07-06 MX MX2012000354A patent/MX2012000354A/es not_active Application Discontinuation
- 2010-07-06 CA CA3118479A patent/CA3118479A1/en active Pending
- 2010-07-06 MX MX2014010342A patent/MX367489B/es unknown
- 2010-07-06 SG SG2012001202A patent/SG177555A1/en unknown
- 2010-07-06 CA CA2766902A patent/CA2766902C/en active Active
- 2010-07-06 WO PCT/US2010/041082 patent/WO2011005773A2/en not_active Ceased
- 2010-07-06 PL PL10730960T patent/PL2451936T3/pl unknown
- 2010-07-06 CN CN2010800392845A patent/CN102482633A/zh active Pending
- 2010-07-06 ES ES10730960T patent/ES2752874T3/es active Active
- 2010-07-06 US US13/383,829 patent/US20120329151A1/en not_active Abandoned
- 2010-07-06 AU AU2010270726A patent/AU2010270726A1/en not_active Abandoned
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2011
- 2011-12-27 IL IL217223A patent/IL217223A0/en unknown
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2014
- 2014-09-08 US US14/480,366 patent/US10190084B2/en active Active
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2015
- 2015-10-15 IL IL242092A patent/IL242092B/en active IP Right Grant
- 2015-11-02 JP JP2015215899A patent/JP6358999B2/ja active Active
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2016
- 2016-05-10 AU AU2016202997A patent/AU2016202997A1/en not_active Abandoned
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2018
- 2018-10-19 AU AU2018250474A patent/AU2018250474B2/en active Active
- 2018-12-12 US US16/218,323 patent/US10894940B2/en active Active
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2019
- 2019-06-25 IL IL267629A patent/IL267629A/en unknown
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2021
- 2021-01-08 AU AU2021200110A patent/AU2021200110A1/en not_active Abandoned
- 2021-01-13 US US17/148,190 patent/US11939559B2/en active Active
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