MX367489B - Metodo para cultivar celulas eucarionticas. - Google Patents
Metodo para cultivar celulas eucarionticas.Info
- Publication number
- MX367489B MX367489B MX2014010342A MX2014010342A MX367489B MX 367489 B MX367489 B MX 367489B MX 2014010342 A MX2014010342 A MX 2014010342A MX 2014010342 A MX2014010342 A MX 2014010342A MX 367489 B MX367489 B MX 367489B
- Authority
- MX
- Mexico
- Prior art keywords
- eukaryotic cells
- cell culture
- culturing eukaryotic
- culturing
- range
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/20—Degassing; Venting; Bubble traps
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Computer Hardware Design (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un aparato y método para mantener el pH dentro de un intervalo conducente para el crecimiento celular en un sistema de cultivo celular que contiene bicarbonato sin la adición de base. El método depende de las características de transferencia de gas del sistema de bioreactor para modular la transferencia de CO2 a y del cultivo celular, de tal manera que el pH del cultivo celular puede ser mantenido dentro de un intervalo deseado. Un método para el cultivo por lotes de células eucarióticas que comprende: proveer un inoculante de cultivo celular que comprende células eucarióticas en un líquido de cultivo que contiene bicarbonato a un recipiente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22331309P | 2009-07-06 | 2009-07-06 | |
| PCT/US2010/041082 WO2011005773A2 (en) | 2009-07-06 | 2010-07-06 | Method of culturing eukaryotic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX367489B true MX367489B (es) | 2019-08-23 |
Family
ID=43429807
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000354A MX2012000354A (es) | 2009-07-06 | 2010-07-06 | Metodo para cultivar celulas eucarionticas. |
| MX2014010342A MX367489B (es) | 2009-07-06 | 2010-07-06 | Metodo para cultivar celulas eucarionticas. |
| MX2019010034A MX2019010034A (es) | 2009-07-06 | 2012-01-05 | Metodo para cultivar celulas eucarionticas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012000354A MX2012000354A (es) | 2009-07-06 | 2010-07-06 | Metodo para cultivar celulas eucarionticas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010034A MX2019010034A (es) | 2009-07-06 | 2012-01-05 | Metodo para cultivar celulas eucarionticas. |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20120329151A1 (es) |
| EP (2) | EP2451936B1 (es) |
| JP (2) | JP2012531930A (es) |
| KR (1) | KR101838302B1 (es) |
| CN (2) | CN102482633A (es) |
| AU (4) | AU2010270726A1 (es) |
| BR (1) | BR112012000242B1 (es) |
| CA (2) | CA2766902C (es) |
| ES (1) | ES2752874T3 (es) |
| IL (3) | IL217223A0 (es) |
| MX (3) | MX2012000354A (es) |
| PL (1) | PL2451936T3 (es) |
| SG (1) | SG177555A1 (es) |
| WO (1) | WO2011005773A2 (es) |
Families Citing this family (63)
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| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| CN103397065A (zh) | 2006-09-13 | 2013-11-20 | 雅培制药有限公司 | 细胞培养改良 |
| JP5856845B2 (ja) | 2008-10-20 | 2016-02-10 | アッヴィ・インコーポレイテッド | 抗体精製中におけるウイルスの不活性化 |
| BRPI0920027A2 (pt) | 2008-10-20 | 2015-10-06 | Abbott Lab | isolamento e purificação de anticorpos usando cromatografia de afinidade a proteína a |
| KR101838302B1 (ko) | 2009-07-06 | 2018-03-13 | 제넨테크, 인크. | 진핵 세포의 배양 방법 |
| US9428724B2 (en) | 2011-02-24 | 2016-08-30 | Ge Healthcare Bio-Sciences Ab | Bioreactor with feed and harvest flow through filter assembly |
| US9376654B2 (en) | 2011-03-03 | 2016-06-28 | Meissner Filtration Products, Inc. | Biocontainer |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CN202786257U (zh) * | 2011-08-31 | 2013-03-13 | 通用电气健康护理生物科学股份公司 | 用于生物反应器的排气过滤装置 |
| US20140370588A1 (en) * | 2011-12-09 | 2014-12-18 | Atmi Packaging, Inc. | Filtration apparatus for continuous perfusion |
| US9228166B2 (en) * | 2011-12-20 | 2016-01-05 | Pall Corporation | Rockable biocontainer |
| EP2639294A1 (fr) * | 2012-03-15 | 2013-09-18 | CellProthera | Automate et procédé automatisé de culture cellulaire |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| JP2013237644A (ja) * | 2012-05-16 | 2013-11-28 | Mitsubishi Gas Chemical Co Inc | 細胞活性化炭酸水 |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| WO2014035475A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
| SG11201502926TA (en) | 2012-10-26 | 2015-05-28 | Massachusetts Inst Technology | Humidity control in chemical reactors |
| SG11201502917TA (en) * | 2012-10-26 | 2015-05-28 | Massachusetts Inst Technology | Control of carbon dioxide levels and ph in small volume reactors |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| DK2970843T3 (da) * | 2013-03-15 | 2021-11-22 | Genzyme Corp | Fremgangsmåder til frembringelse af cellebank med høj densitet |
| US10479973B2 (en) | 2013-08-23 | 2019-11-19 | Massachuesetts Institute Of Technology | Small volume bioreactors with substantially constant working volumes and associated systems and methods |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
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| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI707949B (zh) * | 2014-06-09 | 2020-10-21 | 美商健臻公司 | 種子罐培養法（ｓｅｅｄ ｔｒａｉｎ ｐｒｏｃｅｓｓｅｓ）及其用途 |
| GB201416362D0 (en) * | 2014-07-25 | 2014-10-29 | Ge Healthcare Bio Sciences Ab | Method and system for suspension culture |
| CN107426990A (zh) * | 2014-09-18 | 2017-12-01 | 建新公司 | 超高密度细胞建库方法 |
| US10617070B2 (en) * | 2014-10-06 | 2020-04-14 | Life Technologies Corporation | Methods and systems for culturing microbial and cellular seed cultures |
| US9944894B2 (en) * | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| KR102427457B1 (ko) * | 2015-03-24 | 2022-08-01 | 메디칸(주) | 연속 세포 배양 증식장치 및 방법 |
| GB201509202D0 (en) | 2015-05-28 | 2015-07-15 | Ge Healthcare Bio Sciences Ab | Semi-static cell culture |
| CN105176815B (zh) * | 2015-10-20 | 2017-03-22 | 哈尔滨工业大学 | 一种用于人工皮肤组织培养的气液界面灌注式生物反应器及其制备方法和使用方法 |
| WO2017072346A1 (en) | 2015-10-30 | 2017-05-04 | F. Hoffmann-La Roche Ag | Identification of calibration deviations of ph-measuring devices |
| CN108699502A (zh) | 2016-02-23 | 2018-10-23 | 康宁股份有限公司 | 灌注生物反应器及其用于进行连续细胞培养的方法 |
| CN105802851B (zh) * | 2016-03-25 | 2018-06-19 | 苏州诺普再生医学有限公司 | 一种3d打印皮肤的动态倾斜旋转生物反应器 |
| CN105820948B (zh) * | 2016-03-31 | 2018-06-01 | 上海高机生物工程有限公司 | 一种用于生物反应袋的旋摆平台 |
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| KR101895195B1 (ko) * | 2017-03-17 | 2018-09-05 | 인제대학교 산학협력단 | 세포 체외 증식을 위한 바이오리액터 |
| IL273549B2 (en) | 2017-10-06 | 2023-10-01 | Lonza Ag | Automated control of cell culture using Raman spectroscopy |
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| WO2019131626A1 (ja) * | 2017-12-28 | 2019-07-04 | オリンパス株式会社 | 細胞培養制御方法、細胞培養制御装置、細胞培養装置および細胞培養システム |
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-
2010
- 2010-07-06 KR KR1020127003042A patent/KR101838302B1/ko active IP Right Grant
- 2010-07-06 US US13/383,829 patent/US20120329151A1/en not_active Abandoned
- 2010-07-06 JP JP2012519674A patent/JP2012531930A/ja not_active Withdrawn
- 2010-07-06 WO PCT/US2010/041082 patent/WO2011005773A2/en active Application Filing
- 2010-07-06 ES ES10730960T patent/ES2752874T3/es active Active
- 2010-07-06 CA CA2766902A patent/CA2766902C/en active Active
- 2010-07-06 CN CN2010800392845A patent/CN102482633A/zh active Pending
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