PL2349238T3 - KOKRYSZTAŁY TRAMADOLU i NLPZ - Google Patents
KOKRYSZTAŁY TRAMADOLU i NLPZInfo
- Publication number
- PL2349238T3 PL2349238T3 PL09736862T PL09736862T PL2349238T3 PL 2349238 T3 PL2349238 T3 PL 2349238T3 PL 09736862 T PL09736862 T PL 09736862T PL 09736862 T PL09736862 T PL 09736862T PL 2349238 T3 PL2349238 T3 PL 2349238T3
- Authority
- PL
- Poland
- Prior art keywords
- tramadol
- nsaids
- crystals
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20080384012 EP2177215A1 (en) | 2008-10-17 | 2008-10-17 | Co-crystals of tramadol and NSAIDs |
| EP09736862.5A EP2349238B1 (en) | 2008-10-17 | 2009-10-16 | Co-crystals of tramadol and nsaids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2349238T3 true PL2349238T3 (pl) | 2017-06-30 |
Family
ID=40673614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09736862T PL2349238T3 (pl) | 2008-10-17 | 2009-10-16 | KOKRYSZTAŁY TRAMADOLU i NLPZ |
Country Status (27)
| Country | Link |
|---|---|
| US (10) | US20110257134A1 (pl) |
| EP (2) | EP2177215A1 (pl) |
| JP (1) | JP5645830B2 (pl) |
| KR (1) | KR101679400B1 (pl) |
| CN (1) | CN102186465B (pl) |
| AU (1) | AU2009304235B2 (pl) |
| BR (1) | BRPI0920358A2 (pl) |
| CA (1) | CA2737754C (pl) |
| CY (1) | CY1118374T1 (pl) |
| DK (1) | DK2349238T3 (pl) |
| ES (1) | ES2603962T3 (pl) |
| HR (1) | HRP20161526T1 (pl) |
| HU (1) | HUE030976T2 (pl) |
| IL (1) | IL211785A (pl) |
| IN (1) | IN2012DN01435A (pl) |
| LT (1) | LT2349238T (pl) |
| MX (1) | MX336318B (pl) |
| MY (1) | MY156285A (pl) |
| NZ (1) | NZ591873A (pl) |
| PL (1) | PL2349238T3 (pl) |
| PT (1) | PT2349238T (pl) |
| RU (1) | RU2599717C2 (pl) |
| SI (1) | SI2349238T1 (pl) |
| SM (1) | SMT201600439B (pl) |
| UA (1) | UA109534C2 (pl) |
| WO (1) | WO2010043412A1 (pl) |
| ZA (1) | ZA201102762B (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| ES2402112T3 (es) * | 2009-10-16 | 2013-04-29 | Laboratorios Del Dr. Esteve, S.A. | Cocristales de tramadol y coxibs |
| EP2392319A1 (en) * | 2010-06-04 | 2011-12-07 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions of co-crystals of tramadol and coxibs |
| SG185642A1 (en) * | 2010-07-12 | 2012-12-28 | Yung Shin Pharm Ind Co Ltd | Diclofenac salt of tramadol |
| DE102010063609A1 (de) * | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure |
| KR101888852B1 (ko) | 2011-12-02 | 2018-09-21 | 삼성전자주식회사 | 휴대용 단말기에서 다이버시티 서비스를 제공하기 위한 장치 및 방법 |
| GB201222287D0 (en) * | 2012-12-11 | 2013-01-23 | Ct For Process Innovation Ltd | Methods for making active crystalline materials |
| ITMI20130210A1 (it) * | 2013-02-14 | 2014-08-15 | Menarini Lab | Composizioni farmaceutiche contenenti dexketoprofene e tramadolo |
| RU2542100C1 (ru) * | 2013-12-24 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) | Сокристаллическая форма теофиллина с дифлунисалом или диклофенаком |
| WO2016116942A1 (en) | 2015-01-20 | 2016-07-28 | Anlon Chemical Research Organization | Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin |
| CN104592009B (zh) * | 2015-02-09 | 2017-02-22 | 黑龙江大学 | 萘普生药物共晶及其制备方法 |
| US9693949B1 (en) * | 2015-12-22 | 2017-07-04 | Revogenex Ireland Ltd | Intravenous administration of tramadol |
| MX2016006464A (es) * | 2016-05-18 | 2017-11-17 | Laboratorios Liomont S A De C V | Composicion farmaceutica de una combinacion de clorhidrato de tramadol-etoricoxib para el tratamiento del dolor. |
| AU2018230350A1 (en) * | 2017-03-08 | 2019-09-26 | Intercept Pharmaceuticals, Inc | Crystalline forms of obeticholic acid |
| MX2018003456A (es) | 2017-12-21 | 2019-09-06 | Gruenenthal Gmbh | Combinacion farmaceutica en la forma de comprimidos en bicapa que comprende ketorolaco trometamina y tramadol clorhidrato, y su uso para el tratamiento del dolor. |
| MX2018013070A (es) | 2017-12-29 | 2019-10-15 | Gruenenthal Gmbh | Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor. |
| US11510926B2 (en) | 2018-05-31 | 2022-11-29 | The Royal Institution For The Advancement Of Learning/Mcgill University | Pharmaceutical salts/co-crystals of pentoxifylline, clonidine and linsidomine with caffeic, protocatechuic or alpha-lipoic acid an use thereof for treatment of pain |
| CA3110155A1 (en) * | 2018-08-20 | 2020-02-27 | Mylan Laboratories Limited | Tramadol hbr-celecoxib co-crystal |
| WO2020121326A1 (en) | 2018-12-13 | 2020-06-18 | Mylan Laboratories Limited | Amorphous (rac)-tramadol.hcl-celecoxib (1:1) |
| CA3137381A1 (en) * | 2019-05-14 | 2020-11-19 | Esteve Pharmaceuticals, S.A. | Use of co-crystals of tramadol and celecoxib for treating pain while reducing the abuse liability of tramadol |
| EP4169903A1 (en) * | 2021-10-25 | 2023-04-26 | Dompe' Farmaceutici S.P.A. | Co-crystals of nonsteroidal anti-inflammatory drugs, lysine and gabapentin, pharmaceutical compositions and their medical use |
| KR20240027436A (ko) * | 2022-08-23 | 2024-03-04 | 대원제약주식회사 | 펠루비프로펜 및 트라마돌의 이온결합 화합물, 이를 포함하는 조성물, 및 이의 제조 방법 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| JP3381190B2 (ja) | 1991-09-06 | 2003-02-24 | マクニーラブ・インコーポレーテツド | トラマドール物質およびアセトアミノフェンを含んでなる組成物並びにそれの使用 |
| AU661723B2 (en) | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| US5516803A (en) | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| WO1995015316A1 (en) | 1993-11-30 | 1995-06-08 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| CA2249009C (en) | 1996-04-12 | 2003-09-16 | G.D. Searle & Co. | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors |
| US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| BRPI9710372B8 (pt) | 1996-07-18 | 2021-05-25 | Merck Canada Inc | composto, e, composição farmacêutica. |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| CA2364127A1 (en) * | 1999-03-01 | 2000-09-08 | Ortho-Mcneil Pharmaceutical, Inc. | Composition comprising a tramadol material and a selective cox-2 inhibitor drug |
| DE19927688A1 (de) | 1999-06-17 | 2000-12-21 | Gruenenthal Gmbh | Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac |
| DE10108122A1 (de) | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
| CA2419089A1 (en) * | 2001-07-27 | 2003-03-05 | Tatsuki Shinoda | Composition comprises sustained-release fine particles for quick-disintegrating tablets in the buccal cavity and manufacturing method thereof |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US20050090517A1 (en) | 2002-02-19 | 2005-04-28 | Norris Michael C. | Pharmaceutical combinations of cox-2 inhibitors and opiates |
| TWI273659B (en) | 2002-07-17 | 2007-02-11 | Soitec Silicon On Insulator | Method of fabricating substrates, in particular for optics, electronics or optoelectronics |
| CN1245968C (zh) | 2002-10-09 | 2006-03-22 | 新疆特丰药业股份有限公司 | 一种萘普生钠缓释片剂的制备方法 |
| EP1587499A1 (en) | 2003-01-31 | 2005-10-26 | Elan Pharma International Limited | Nanoparticulate topiramate formulations |
| JP2007524596A (ja) * | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
| EP1727520A2 (en) | 2003-12-09 | 2006-12-06 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| DE102006056458A1 (de) * | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| WO2008085674A1 (en) | 2007-01-04 | 2008-07-17 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions comprising celecoxib co-crystals |
| US20080031950A1 (en) * | 2007-04-27 | 2008-02-07 | Nectid Inc. | Novel anelgesic combination |
| EP2022778A1 (en) * | 2007-08-07 | 2009-02-11 | Laboratorios del Dr. Esteve S.A. | A crystalline form of (R,R)-tramadol-(S)-naproxene salt |
| CA2724877C (en) | 2008-05-20 | 2016-09-13 | Neurogesx, Inc. | Water-soluble acetaminophen analogs |
| US8906948B2 (en) | 2008-09-06 | 2014-12-09 | Bionevia, LLC | Choline cocrystal of epalrestat |
| EP2177215A1 (en) * | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| EP2311446A1 (en) | 2009-10-16 | 2011-04-20 | Laboratorios Del. Dr. Esteve, S.A. | Compositions comprising Tramadol and Celecoxib in the treatment of pain |
| NZ598353A (en) | 2009-10-16 | 2014-01-31 | Esteve Labor Dr | Co-crystals of tramadol and coxibs |
| ES2402112T3 (es) * | 2009-10-16 | 2013-04-29 | Laboratorios Del Dr. Esteve, S.A. | Cocristales de tramadol y coxibs |
| WO2011140305A2 (en) * | 2010-05-07 | 2011-11-10 | Carefusion 2200, Inc. | Method of producing pleurodesis |
| EP2392319A1 (en) * | 2010-06-04 | 2011-12-07 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions of co-crystals of tramadol and coxibs |
| CA3137381A1 (en) * | 2019-05-14 | 2020-11-19 | Esteve Pharmaceuticals, S.A. | Use of co-crystals of tramadol and celecoxib for treating pain while reducing the abuse liability of tramadol |
-
2008
- 2008-10-17 EP EP20080384012 patent/EP2177215A1/en not_active Withdrawn
-
2009
- 2009-10-16 CN CN200980141056.6A patent/CN102186465B/zh not_active Expired - Fee Related
- 2009-10-16 PL PL09736862T patent/PL2349238T3/pl unknown
- 2009-10-16 JP JP2011531401A patent/JP5645830B2/ja not_active Expired - Fee Related
- 2009-10-16 RU RU2011119608/04A patent/RU2599717C2/ru active
- 2009-10-16 LT LTEP09736862.5T patent/LT2349238T/lt unknown
- 2009-10-16 HU HUE09736862A patent/HUE030976T2/en unknown
- 2009-10-16 DK DK09736862.5T patent/DK2349238T3/en active
- 2009-10-16 BR BRPI0920358-3A patent/BRPI0920358A2/pt not_active Application Discontinuation
- 2009-10-16 PT PT97368625T patent/PT2349238T/pt unknown
- 2009-10-16 ES ES09736862.5T patent/ES2603962T3/es active Active
- 2009-10-16 AU AU2009304235A patent/AU2009304235B2/en not_active Ceased
- 2009-10-16 CA CA2737754A patent/CA2737754C/en active Active
- 2009-10-16 WO PCT/EP2009/007451 patent/WO2010043412A1/en active Application Filing
- 2009-10-16 EP EP09736862.5A patent/EP2349238B1/en active Active
- 2009-10-16 KR KR1020117010637A patent/KR101679400B1/ko active IP Right Grant
- 2009-10-16 NZ NZ591873A patent/NZ591873A/xx not_active IP Right Cessation
- 2009-10-16 MX MX2011003612A patent/MX336318B/es unknown
- 2009-10-16 US US13/124,027 patent/US20110257134A1/en not_active Abandoned
- 2009-10-16 SI SI200931565A patent/SI2349238T1/sl unknown
-
2010
- 2010-04-19 MY MYPI2012000675A patent/MY156285A/en unknown
- 2010-04-19 US US13/395,021 patent/US8598152B2/en active Active
- 2010-04-19 IN IN1435DEN2012 patent/IN2012DN01435A/en unknown
- 2010-04-19 UA UAA201205792A patent/UA109534C2/uk unknown
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2011
- 2011-03-17 IL IL211785A patent/IL211785A/en active IP Right Grant
- 2011-04-13 ZA ZA2011/02762A patent/ZA201102762B/en unknown
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2013
- 2013-10-29 US US14/066,127 patent/US9012440B2/en active Active
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2014
- 2014-07-07 US US14/324,448 patent/US9393220B2/en active Active
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2015
- 2015-03-23 US US14/665,060 patent/US20150196504A1/en not_active Abandoned
- 2015-03-23 US US14/665,055 patent/US20150196503A1/en not_active Abandoned
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2016
- 2016-07-12 US US15/207,694 patent/US10238668B2/en active Active
- 2016-08-09 US US15/231,915 patent/US10245276B2/en active Active
- 2016-11-18 HR HRP20161526TT patent/HRP20161526T1/hr unknown
- 2016-11-22 CY CY20161101201T patent/CY1118374T1/el unknown
- 2016-11-30 SM SM201600439T patent/SMT201600439B/it unknown
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2019
- 2019-02-14 US US16/275,437 patent/US10548909B2/en active Active
- 2019-12-19 US US16/720,574 patent/US11478488B2/en active Active
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