PL1954321T3 - Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego - Google Patents

Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego

Info

Publication number
PL1954321T3
PL1954321T3 PL06824360T PL06824360T PL1954321T3 PL 1954321 T3 PL1954321 T3 PL 1954321T3 PL 06824360 T PL06824360 T PL 06824360T PL 06824360 T PL06824360 T PL 06824360T PL 1954321 T3 PL1954321 T3 PL 1954321T3
Authority
PL
Poland
Prior art keywords
dnp
metal ion
paramagnetic metal
dynamic nuclear
trityl radical
Prior art date
Application number
PL06824360T
Other languages
English (en)
Polish (pl)
Inventor
Mikkel Thaning
Rolf Servin
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20055681A external-priority patent/NO20055681D0/no
Priority claimed from NO20055705A external-priority patent/NO20055705D0/no
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL1954321T3 publication Critical patent/PL1954321T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
PL06824360T 2005-12-01 2006-12-01 Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego PL1954321T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NO20055681A NO20055681D0 (no) 2005-12-01 2005-12-01 Method of dynamic nuclear polarisation
NO20055705A NO20055705D0 (no) 2005-12-02 2005-12-02 Method of dynamic nuclear polarisation
NO20063119 2006-07-05
EP06824360A EP1954321B1 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
PCT/NO2006/000449 WO2007064226A2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Publications (1)

Publication Number Publication Date
PL1954321T3 true PL1954321T3 (pl) 2012-04-30

Family

ID=38092667

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06824360T PL1954321T3 (pl) 2005-12-01 2006-12-01 Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego

Country Status (10)

Country Link
US (1) US8951502B2 (https=)
EP (1) EP1954321B1 (https=)
JP (1) JP5475995B2 (https=)
KR (2) KR20130116383A (https=)
AT (1) ATE534407T1 (https=)
AU (1) AU2006321057B2 (https=)
CA (1) CA2628539C (https=)
ES (1) ES2375089T3 (https=)
PL (1) PL1954321T3 (https=)
WO (1) WO2007064226A2 (https=)

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WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
KR101858269B1 (ko) 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제
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WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
EP2847591A1 (en) 2012-05-07 2015-03-18 Albeda Innovation ApS Intra-operative cancer diagnosis based on a hyperpolarized marker
EP2972441B1 (en) 2013-03-14 2016-11-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
US20160296645A1 (en) 2013-07-01 2016-10-13 Bracco Imaging S.P.A Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
EP2891500B1 (en) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity
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CN120574245B (zh) * 2025-08-04 2025-12-02 中国科学院精密测量科学与技术创新研究院 一种含氟三苯甲基自由基化合物及其制备方法和应用

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Also Published As

Publication number Publication date
AU2006321057A1 (en) 2007-06-07
WO2007064226A2 (en) 2007-06-07
ATE534407T1 (de) 2011-12-15
JP5475995B2 (ja) 2014-04-16
KR20080072692A (ko) 2008-08-06
EP1954321A2 (en) 2008-08-13
EP1954321B1 (en) 2011-11-23
CA2628539C (en) 2014-04-29
JP2009517688A (ja) 2009-04-30
CA2628539A1 (en) 2007-06-07
KR20130116383A (ko) 2013-10-23
US20080260649A1 (en) 2008-10-23
ES2375089T3 (es) 2012-02-24
KR101372173B1 (ko) 2014-03-07
US8951502B2 (en) 2015-02-10
AU2006321057B2 (en) 2012-11-01
WO2007064226A3 (en) 2007-10-18

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