AU2006321057B2 - Method of dynamic nuclear polarisation (DNP) using a trityl radical and a paramagnetic metal ion - Google Patents

Method of dynamic nuclear polarisation (DNP) using a trityl radical and a paramagnetic metal ion Download PDF

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Publication number
AU2006321057B2
AU2006321057B2 AU2006321057A AU2006321057A AU2006321057B2 AU 2006321057 B2 AU2006321057 B2 AU 2006321057B2 AU 2006321057 A AU2006321057 A AU 2006321057A AU 2006321057 A AU2006321057 A AU 2006321057A AU 2006321057 B2 AU2006321057 B2 AU 2006321057B2
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AU
Australia
Prior art keywords
composition
sample
polarisation
trityl radical
hyperpolarised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006321057A
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English (en)
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AU2006321057A1 (en
Inventor
Rolf Servin
Mikkel Thaning
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GE Healthcare AS
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GE Healthcare AS
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Filing date
Publication date
Priority claimed from NO20055681A external-priority patent/NO20055681D0/no
Priority claimed from NO20055705A external-priority patent/NO20055705D0/no
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of AU2006321057A1 publication Critical patent/AU2006321057A1/en
Application granted granted Critical
Publication of AU2006321057B2 publication Critical patent/AU2006321057B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AU2006321057A 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (DNP) using a trityl radical and a paramagnetic metal ion Ceased AU2006321057B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
NO20055681 2005-12-01
NO20055681A NO20055681D0 (no) 2005-12-01 2005-12-01 Method of dynamic nuclear polarisation
NO20055705 2005-12-02
NO20055705A NO20055705D0 (no) 2005-12-02 2005-12-02 Method of dynamic nuclear polarisation
NO20063119 2006-07-05
NO20063119 2006-07-05
PCT/NO2006/000449 WO2007064226A2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Publications (2)

Publication Number Publication Date
AU2006321057A1 AU2006321057A1 (en) 2007-06-07
AU2006321057B2 true AU2006321057B2 (en) 2012-11-01

Family

ID=38092667

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006321057A Ceased AU2006321057B2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (DNP) using a trityl radical and a paramagnetic metal ion

Country Status (10)

Country Link
US (1) US8951502B2 (https=)
EP (1) EP1954321B1 (https=)
JP (1) JP5475995B2 (https=)
KR (2) KR20130116383A (https=)
AT (1) ATE534407T1 (https=)
AU (1) AU2006321057B2 (https=)
CA (1) CA2628539C (https=)
ES (1) ES2375089T3 (https=)
PL (1) PL1954321T3 (https=)
WO (1) WO2007064226A2 (https=)

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JP2011511775A (ja) * 2008-02-04 2011-04-14 ジーイー・ヘルスケア・リミテッド 過分極１３ｃ−アラニンを含むｍｒ造影剤、又は画像媒体、及びそのような画像媒体を使用する画像検査法
WO2009150211A1 (en) * 2008-06-13 2009-12-17 Ge Healthcare Limited Dnp polariser and method of producing a hyperpolarised selected material
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US8697034B2 (en) * 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
SG179067A1 (en) 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
EP2494918B1 (en) * 2009-10-29 2015-08-19 Kyushu University, National University Corporation Method for detecting endogenous biomolecules
EP2348327B1 (en) 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
KR101858269B1 (ko) 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제
US20140328766A1 (en) * 2010-08-24 2014-11-06 Ge Healthcare Limited Composition and method for generating a metabolic profile using 13c-mr detection
US9738686B2 (en) 2011-07-18 2017-08-22 The Trustees of the California State University Electron spin labeled ice binding compounds used for carrying paramagnetic centers for dynamic nuclear polarization
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
EP2847591A1 (en) 2012-05-07 2015-03-18 Albeda Innovation ApS Intra-operative cancer diagnosis based on a hyperpolarized marker
EP2972441B1 (en) 2013-03-14 2016-11-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
US20160296645A1 (en) 2013-07-01 2016-10-13 Bracco Imaging S.P.A Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
EP2891500B1 (en) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
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CN120574245B (zh) * 2025-08-04 2025-12-02 中国科学院精密测量科学与技术创新研究院 一种含氟三苯甲基自由基化合物及其制备方法和应用

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Also Published As

Publication number Publication date
AU2006321057A1 (en) 2007-06-07
WO2007064226A2 (en) 2007-06-07
ATE534407T1 (de) 2011-12-15
JP5475995B2 (ja) 2014-04-16
KR20080072692A (ko) 2008-08-06
EP1954321A2 (en) 2008-08-13
EP1954321B1 (en) 2011-11-23
CA2628539C (en) 2014-04-29
JP2009517688A (ja) 2009-04-30
CA2628539A1 (en) 2007-06-07
KR20130116383A (ko) 2013-10-23
US20080260649A1 (en) 2008-10-23
ES2375089T3 (es) 2012-02-24
KR101372173B1 (ko) 2014-03-07
US8951502B2 (en) 2015-02-10
PL1954321T3 (pl) 2012-04-30
WO2007064226A3 (en) 2007-10-18

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired