JP5475995B2 - 動的核分極（ｄｎｐ）法 - Google Patents

動的核分極（ｄｎｐ）法 Download PDF

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Publication number
JP5475995B2
JP5475995B2 JP2008543224A JP2008543224A JP5475995B2 JP 5475995 B2 JP5475995 B2 JP 5475995B2 JP 2008543224 A JP2008543224 A JP 2008543224A JP 2008543224 A JP2008543224 A JP 2008543224A JP 5475995 B2 JP5475995 B2 JP 5475995B2
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sample
composition
polarization
pyruvate
radical
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Japanese (ja)
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JP2009517688A5 (https=
JP2009517688A (ja
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サニング，ミッケル
セルヴィン，ロルフ
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ジーイー・ヘルスケア・アクスイェ・セルスカプ
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Priority claimed from NO20055681A external-priority patent/NO20055681D0/no
Priority claimed from NO20055705A external-priority patent/NO20055705D0/no
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Publication of JP2009517688A5 publication Critical patent/JP2009517688A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
JP2008543224A 2005-12-01 2006-12-01 動的核分極（ｄｎｐ）法 Expired - Fee Related JP5475995B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
NO20055681 2005-12-01
NO20055681A NO20055681D0 (no) 2005-12-01 2005-12-01 Method of dynamic nuclear polarisation
NO20055705A NO20055705D0 (no) 2005-12-02 2005-12-02 Method of dynamic nuclear polarisation
NO20055705 2005-12-02
NO20063119 2006-07-05
NO20063119 2006-07-05
PCT/NO2006/000449 WO2007064226A2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Publications (3)

Publication Number Publication Date
JP2009517688A JP2009517688A (ja) 2009-04-30
JP2009517688A5 JP2009517688A5 (https=) 2012-08-23
JP5475995B2 true JP5475995B2 (ja) 2014-04-16

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JP2008543224A Expired - Fee Related JP5475995B2 (ja) 2005-12-01 2006-12-01 動的核分極（ｄｎｐ）法

Country Status (10)

Country Link
US (1) US8951502B2 (https=)
EP (1) EP1954321B1 (https=)
JP (1) JP5475995B2 (https=)
KR (2) KR20130116383A (https=)
AT (1) ATE534407T1 (https=)
AU (1) AU2006321057B2 (https=)
CA (1) CA2628539C (https=)
ES (1) ES2375089T3 (https=)
PL (1) PL1954321T3 (https=)
WO (1) WO2007064226A2 (https=)

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EP2348327B1 (en) 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 過分極基質の製造方法およびｍｒｉのための方法
JP5879333B2 (ja) 2010-05-03 2016-03-08 ジーイー・ヘルスケア・リミテッド Ｌｄｈ活性を決定するための過分極乳酸塩造影剤
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US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
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Also Published As

Publication number Publication date
US20080260649A1 (en) 2008-10-23
KR20080072692A (ko) 2008-08-06
ATE534407T1 (de) 2011-12-15
AU2006321057A1 (en) 2007-06-07
EP1954321B1 (en) 2011-11-23
PL1954321T3 (pl) 2012-04-30
ES2375089T3 (es) 2012-02-24
KR101372173B1 (ko) 2014-03-07
AU2006321057B2 (en) 2012-11-01
EP1954321A2 (en) 2008-08-13
CA2628539A1 (en) 2007-06-07
JP2009517688A (ja) 2009-04-30
WO2007064226A3 (en) 2007-10-18
KR20130116383A (ko) 2013-10-23
CA2628539C (en) 2014-04-29
WO2007064226A2 (en) 2007-06-07
US8951502B2 (en) 2015-02-10

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