KR20130116383A - 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵 분극화 방법 - Google Patents

트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵 분극화 방법 Download PDF

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Publication number
KR20130116383A
KR20130116383A KR1020137025889A KR20137025889A KR20130116383A KR 20130116383 A KR20130116383 A KR 20130116383A KR 1020137025889 A KR1020137025889 A KR 1020137025889A KR 20137025889 A KR20137025889 A KR 20137025889A KR 20130116383 A KR20130116383 A KR 20130116383A
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KR
South Korea
Prior art keywords
composition
sample
paramagnetic metal
metal ions
polarization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020137025889A
Other languages
English (en)
Korean (ko)
Inventor
미켈 타닝
롤프 세르빈
Original Assignee
지이 헬스케어 에이에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20055681A external-priority patent/NO20055681D0/no
Priority claimed from NO20055705A external-priority patent/NO20055705D0/no
Application filed by 지이 헬스케어 에이에스 filed Critical 지이 헬스케어 에이에스
Publication of KR20130116383A publication Critical patent/KR20130116383A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
KR1020137025889A 2005-12-01 2006-12-01 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵 분극화 방법 Ceased KR20130116383A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
NO20055681 2005-12-01
NO20055681A NO20055681D0 (no) 2005-12-01 2005-12-01 Method of dynamic nuclear polarisation
NO20055705 2005-12-02
NO20055705A NO20055705D0 (no) 2005-12-02 2005-12-02 Method of dynamic nuclear polarisation
NO20063119 2006-07-05
NO20063119 2006-07-05
PCT/NO2006/000449 WO2007064226A2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020087013049A Division KR101372173B1 (ko) 2005-12-01 2006-12-01 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵분극화 방법

Publications (1)

Publication Number Publication Date
KR20130116383A true KR20130116383A (ko) 2013-10-23

Family

ID=38092667

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020137025889A Ceased KR20130116383A (ko) 2005-12-01 2006-12-01 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵 분극화 방법
KR1020087013049A Expired - Fee Related KR101372173B1 (ko) 2005-12-01 2006-12-01 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵분극화 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020087013049A Expired - Fee Related KR101372173B1 (ko) 2005-12-01 2006-12-01 트리틸 라디칼 및 상자성 금속 이온을 사용하는 동적 핵분극화 방법

Country Status (10)

Country Link
US (1) US8951502B2 (https=)
EP (1) EP1954321B1 (https=)
JP (1) JP5475995B2 (https=)
KR (2) KR20130116383A (https=)
AT (1) ATE534407T1 (https=)
AU (1) AU2006321057B2 (https=)
CA (1) CA2628539C (https=)
ES (1) ES2375089T3 (https=)
PL (1) PL1954321T3 (https=)
WO (1) WO2007064226A2 (https=)

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WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
EP2847591A1 (en) 2012-05-07 2015-03-18 Albeda Innovation ApS Intra-operative cancer diagnosis based on a hyperpolarized marker
EP2972441B1 (en) 2013-03-14 2016-11-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
US20160296645A1 (en) 2013-07-01 2016-10-13 Bracco Imaging S.P.A Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
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Also Published As

Publication number Publication date
AU2006321057A1 (en) 2007-06-07
WO2007064226A2 (en) 2007-06-07
ATE534407T1 (de) 2011-12-15
JP5475995B2 (ja) 2014-04-16
KR20080072692A (ko) 2008-08-06
EP1954321A2 (en) 2008-08-13
EP1954321B1 (en) 2011-11-23
CA2628539C (en) 2014-04-29
JP2009517688A (ja) 2009-04-30
CA2628539A1 (en) 2007-06-07
US20080260649A1 (en) 2008-10-23
ES2375089T3 (es) 2012-02-24
KR101372173B1 (ko) 2014-03-07
US8951502B2 (en) 2015-02-10
AU2006321057B2 (en) 2012-11-01
PL1954321T3 (pl) 2012-04-30
WO2007064226A3 (en) 2007-10-18

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