PL1663194T3 - Zastosowanie SAHA do leczenia międzybłoniaka - Google Patents

Zastosowanie SAHA do leczenia międzybłoniaka

Info

Publication number
PL1663194T3
PL1663194T3 PL04782425T PL04782425T PL1663194T3 PL 1663194 T3 PL1663194 T3 PL 1663194T3 PL 04782425 T PL04782425 T PL 04782425T PL 04782425 T PL04782425 T PL 04782425T PL 1663194 T3 PL1663194 T3 PL 1663194T3
Authority
PL
Poland
Prior art keywords
pharmaceutical compositions
present
mesothelioma
saha
methods
Prior art date
Application number
PL04782425T
Other languages
English (en)
Inventor
Nicholas G Bacopoulos
Judy H Chiao
Thomas A Miller
Carolyn M Paradise
Victoria M Richon
Original Assignee
Merck Hdac Res Llc
Sloan Kettering Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/650,025 external-priority patent/US7148257B2/en
Priority claimed from US10/665,079 external-priority patent/US20040127523A1/en
Application filed by Merck Hdac Res Llc, Sloan Kettering Inst Cancer Res filed Critical Merck Hdac Res Llc
Publication of PL1663194T3 publication Critical patent/PL1663194T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Electrotherapy Devices (AREA)
PL04782425T 2003-08-26 2004-08-26 Zastosowanie SAHA do leczenia międzybłoniaka PL1663194T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/650,025 US7148257B2 (en) 2002-03-04 2003-08-26 Methods of treating mesothelioma with suberoylanilide hydroxamic acid
US10/665,079 US20040127523A1 (en) 2002-03-04 2003-09-16 Methods of treating cancer with HDAC inhibitors
PCT/US2004/027943 WO2005018578A2 (en) 2003-08-26 2004-08-26 Method of treating cancer with hdac inhibitors
EP04782425A EP1663194B1 (en) 2003-08-26 2004-08-26 Use of SAHA for treating mesothelioma

Publications (1)

Publication Number Publication Date
PL1663194T3 true PL1663194T3 (pl) 2011-01-31

Family

ID=34556614

Family Applications (2)

Application Number Title Priority Date Filing Date
PL379887A PL379887A1 (pl) 2003-08-26 2004-08-26 Sposób leczenia raka inhibitorami HDAC
PL04782425T PL1663194T3 (pl) 2003-08-26 2004-08-26 Zastosowanie SAHA do leczenia międzybłoniaka

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL379887A PL379887A1 (pl) 2003-08-26 2004-08-26 Sposób leczenia raka inhibitorami HDAC

Country Status (23)

Country Link
US (1) US20090012175A1 (pl)
EP (2) EP2201947A3 (pl)
JP (2) JP4338734B2 (pl)
KR (1) KR100924737B1 (pl)
CN (1) CN102188415A (pl)
AT (1) ATE462426T1 (pl)
AU (1) AU2004266169B9 (pl)
BR (1) BRPI0413826A (pl)
CA (1) CA2535806C (pl)
DE (1) DE602004026321D1 (pl)
DK (1) DK1663194T3 (pl)
EC (1) ECSP066452A (pl)
ES (1) ES2345775T3 (pl)
HR (1) HRP20060080A2 (pl)
IL (1) IL173846A0 (pl)
MA (1) MA28209A1 (pl)
NO (1) NO328575B1 (pl)
NZ (2) NZ560485A (pl)
PL (2) PL379887A1 (pl)
PT (1) PT1663194E (pl)
RU (1) RU2356547C2 (pl)
SI (1) SI1663194T1 (pl)
WO (1) WO2005018578A2 (pl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US20040132825A1 (en) * 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
NZ535578A (en) * 2002-03-04 2008-03-28 Merck Hdac Res Llc Methods of inducing terminal differentiation
US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
BR0309280A (pt) * 2002-04-15 2005-02-22 Sloan Kettering Inst Cancer Terapia de combinação para o tratamento de câncer
WO2004089293A2 (en) 2003-04-01 2004-10-21 Memorial Sloan-Kettering Cancer Center Hydroxamic acid compounds and methods of use thereof
US7901675B2 (en) * 2004-10-13 2011-03-08 U.S. Department Of Veterans Affairs Method of using coenzyme Q10 to treat Huntington's disease
US20060135612A1 (en) * 2004-12-17 2006-06-22 U.S. Department Of Veterans Affairs Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
NZ589276A (en) 2005-02-03 2012-06-29 Topotarget Uk Ltd Combination therapies using hdac inhibitors and erlotinib (tarceva)
EP3354265A1 (en) 2005-03-22 2018-08-01 President and Fellows of Harvard College Treatment of solid tumors
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
GB0509225D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
CA2606598C (en) 2005-05-13 2014-12-23 Topotarget Uk Limited Pharmaceutical formulations of hdac inhibitors
TWI415603B (zh) 2005-05-20 2013-11-21 Merck Sharp & Dohme 1,8-辛二醯基苯胺羥胺酸(suberoylanilide hydroxamic acid)之調配物及其製配方法
BRPI0613429A2 (pt) 2005-07-14 2009-02-10 Takeda San Diego Inc inibidores de histona desacetilase
GB0518720D0 (en) * 2005-09-14 2005-10-19 Hamlet Pharma Ab Therapeutic combination
AU2006311829B8 (en) * 2005-11-04 2013-02-21 Merck Sharp & Dohme Corp. Methods of treating cancers with SAHA, Carboplatin, and Paclitaxel and other combination therapies
WO2007056243A2 (en) * 2005-11-04 2007-05-18 Merck & Co. Inc. Methods of treating cancers with saha and fluorouracil and other combination therapies
CN101325955A (zh) * 2005-11-04 2008-12-17 默克公司 用saha和培美曲塞治疗癌症的方法
WO2007054719A2 (en) * 2005-11-10 2007-05-18 Topotarget Uk Limited Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent
BRPI0707826B1 (pt) 2006-02-14 2022-04-19 Dana-Farber Cancer Institute, Inc. Compostos inibidores de histona desacetilase, composição farmacêutica e uso dos referidos compostos
US8222423B2 (en) 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
US20100137239A1 (en) 2006-04-24 2010-06-03 Gloucester Pharmaceuticals Gemcitabine combination therapy
CA2654540C (en) 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
WO2007146730A2 (en) 2006-06-08 2007-12-21 Gloucester Pharmaceuticals Deacetylase inhibitor therapy
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
KR20090087013A (ko) 2006-10-30 2009-08-14 크로마 데러퓨릭스 리미티드 히스톤 탈아세틸효소의 억제제로서 히드록사메이트
CA2667348A1 (en) * 2006-11-03 2008-05-15 University Of Maryland, Baltimore Methods of using saha and bortezomib for treating multiple myeloma
CN101801994A (zh) 2006-12-29 2010-08-11 格洛斯特制药公司 制备Romidepsin
WO2009040517A2 (en) * 2007-09-25 2009-04-02 Topotarget Uk Limited Methods of synthesis of certain hydroxamic acid compounds
WO2009064300A1 (en) * 2007-11-15 2009-05-22 The Johns Hopkins University Combinations of hdac inhibitors and cytokines/growth factors
CA2717207A1 (en) * 2008-03-07 2009-09-11 Topotarget A/S Methods of treatment employing prolonged continuous infusion of belinostat
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
EP2349985A2 (en) 2008-10-15 2011-08-03 Generics [UK] Limited Process for the preparation of vorinostat
CA2744448A1 (en) 2008-11-26 2010-06-03 Vinayak Gore Polymorphs
GB0900555D0 (en) * 2009-01-14 2009-02-11 Topotarget As New methods
GB0903480D0 (en) 2009-02-27 2009-04-08 Chroma Therapeutics Ltd Enzyme Inhibitors
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
US20130102477A1 (en) 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
KR20130092557A (ko) 2010-07-12 2013-08-20 셀진 코포레이션 로미뎁신 고체 형태 및 그의 용도
RU2765155C2 (ru) 2010-09-10 2022-01-26 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
CN102846611A (zh) * 2011-09-24 2013-01-02 复旦大学 斯克瑞泰Scriptaid在制备治疗创伤性脑损伤疾病药物中的用途
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
MX353929B (es) 2012-10-15 2018-02-02 Epizyme Inc Compuestos de benceno sustituidos.
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
CN103169807A (zh) * 2013-04-11 2013-06-26 太仓市胜舟生物技术有限公司 一种中西组合药物在制药中的应用
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
WO2015190700A1 (ko) * 2014-06-11 2015-12-17 성균관대학교산학협력단 패혈증 예방 또는 치료용 약학적 조성물
CN117797149A (zh) * 2018-11-20 2024-04-02 深圳微芯生物科技股份有限公司 西达本胺联合r-chop的应用及联合药物

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS61176523A (ja) * 1985-01-30 1986-08-08 Teruhiko Beppu 制癌剤
US5055608A (en) 1988-11-14 1991-10-08 Sloan-Kettering Institute For Cancer Research Novel potent inducers of thermal differentiation and method of use thereof
US5175191A (en) 1988-11-14 1992-12-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5608108A (en) 1988-11-14 1997-03-04 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
USRE38506E1 (en) * 1991-10-04 2004-04-20 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5700811A (en) 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5635532A (en) * 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
WO1997011366A1 (en) 1995-09-20 1997-03-27 Merck & Co., Inc. Histone deacetylase as target for antiprotozoal agents
US6030961A (en) 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US6043389A (en) * 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US6387673B1 (en) 1997-05-01 2002-05-14 The Salk Institute For Biological Studies Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
US6231880B1 (en) * 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
US6262116B1 (en) * 1998-01-23 2001-07-17 Sloan-Kettering Institute For Cancer Research Transcription therapy for cancers
AUPP505798A0 (en) 1998-08-04 1998-08-27 Fujisawa Pharmaceutical Co., Ltd. Novel compound fr225497 substance
CN1330660A (zh) 1998-10-13 2002-01-09 藤泽药品工业株式会社 环四肽化合物及其用途
JP2003500052A (ja) 1999-05-03 2003-01-07 メチルジーン インコーポレイテッド ヒストン脱アセチル酵素の抑制
EP1231919B1 (en) * 1999-09-08 2015-09-30 Sloan-Kettering Institute For Cancer Research Derivatives of 1-amino-1-(hetero)arylaminocarbonyl-6-hydroxyaminocarbonylhexane useful in the treatment of tumors
EP1233958B1 (en) 1999-11-23 2011-06-29 MethylGene Inc. Inhibitors of histone deacetylase
JP2003528074A (ja) 2000-03-24 2003-09-24 メチルジーン インコーポレイテッド ヒストン脱アセチル化酵素の阻害剤
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
WO2002022133A1 (en) * 2000-09-12 2002-03-21 Virginia Commonwealth University Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents
AU9013101A (en) 2000-09-29 2002-04-22 Prolifix Ltd Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors
AU2002243231A1 (en) * 2000-11-21 2002-07-24 Wake Forest University Method of treating autoimmune diseases
AR035659A1 (es) 2000-12-07 2004-06-23 Hoffmann La Roche Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
WO2002102323A2 (en) * 2001-06-14 2002-12-27 Bristol-Myers Squibb Company Novel human histone deacetylases
ITMI20011733A1 (it) * 2001-08-07 2003-02-07 Italfarmaco Spa Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
US20040132643A1 (en) * 2002-01-09 2004-07-08 Fojo Antonio Tito Histone deacelylase inhibitors in diagnosis and treatment of thyroid neoplasms
EP1482962A4 (en) * 2002-02-15 2009-12-23 Sloan Kettering Inst Cancer METHOD OF TREATING THIOREDOXIN-MEDIATED DISEASES (TRX)
US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US20060276547A1 (en) * 2002-03-04 2006-12-07 Bacopoulos Nicholas G Methods of treating cancer with HDAC inhibitors
US20040132825A1 (en) * 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
NZ535578A (en) * 2002-03-04 2008-03-28 Merck Hdac Res Llc Methods of inducing terminal differentiation
US7148257B2 (en) * 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
BR0309280A (pt) * 2002-04-15 2005-02-22 Sloan Kettering Inst Cancer Terapia de combinação para o tratamento de câncer
CA2506504A1 (en) * 2002-11-20 2004-06-03 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
WO2004089293A2 (en) * 2003-04-01 2004-10-21 Memorial Sloan-Kettering Cancer Center Hydroxamic acid compounds and methods of use thereof
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis

Also Published As

Publication number Publication date
PT1663194E (pt) 2010-07-06
NZ545935A (en) 2009-02-28
WO2005018578A2 (en) 2005-03-03
AU2004266169A1 (en) 2005-03-03
KR20070029617A (ko) 2007-03-14
IL173846A0 (en) 2006-07-05
RU2356547C2 (ru) 2009-05-27
JP4338734B2 (ja) 2009-10-07
ATE462426T1 (de) 2010-04-15
MA28209A1 (fr) 2006-10-02
NO328575B1 (no) 2010-03-22
EP1663194A2 (en) 2006-06-07
NO20061348L (no) 2006-05-23
JP4914411B2 (ja) 2012-04-11
DE602004026321D1 (de) 2010-05-12
JP2007518694A (ja) 2007-07-12
KR100924737B1 (ko) 2009-11-04
CN102188415A (zh) 2011-09-21
AU2004266169B2 (en) 2007-05-03
CA2535806A1 (en) 2005-03-03
RU2006109467A (ru) 2007-10-10
AU2004266169B9 (en) 2007-05-10
PL379887A1 (pl) 2006-11-27
ECSP066452A (es) 2006-09-18
EP2201947A2 (en) 2010-06-30
EP2201947A3 (en) 2010-08-11
AU2004266169A2 (en) 2006-04-06
EP1663194A4 (en) 2007-09-19
DK1663194T3 (da) 2010-07-19
HRP20060080A2 (en) 2006-07-31
CA2535806C (en) 2009-02-17
EP1663194B1 (en) 2010-03-31
JP2009073834A (ja) 2009-04-09
ES2345775T3 (es) 2010-10-01
NZ560485A (en) 2009-03-31
WO2005018578A3 (en) 2005-05-12
BRPI0413826A (pt) 2006-10-24
US20090012175A1 (en) 2009-01-08
SI1663194T1 (sl) 2010-08-31

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