PL1663194T3 - Zastosowanie SAHA do leczenia międzybłoniaka - Google Patents
Zastosowanie SAHA do leczenia międzybłoniakaInfo
- Publication number
- PL1663194T3 PL1663194T3 PL04782425T PL04782425T PL1663194T3 PL 1663194 T3 PL1663194 T3 PL 1663194T3 PL 04782425 T PL04782425 T PL 04782425T PL 04782425 T PL04782425 T PL 04782425T PL 1663194 T3 PL1663194 T3 PL 1663194T3
- Authority
- PL
- Poland
- Prior art keywords
- pharmaceutical compositions
- present
- mesothelioma
- saha
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Prostheses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/650,025 US7148257B2 (en) | 2002-03-04 | 2003-08-26 | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
US10/665,079 US20040127523A1 (en) | 2002-03-04 | 2003-09-16 | Methods of treating cancer with HDAC inhibitors |
PCT/US2004/027943 WO2005018578A2 (en) | 2003-08-26 | 2004-08-26 | Method of treating cancer with hdac inhibitors |
EP04782425A EP1663194B1 (en) | 2003-08-26 | 2004-08-26 | Use of SAHA for treating mesothelioma |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1663194T3 true PL1663194T3 (pl) | 2011-01-31 |
Family
ID=34556614
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL379887A PL379887A1 (pl) | 2003-08-26 | 2004-08-26 | Sposób leczenia raka inhibitorami HDAC |
PL04782425T PL1663194T3 (pl) | 2003-08-26 | 2004-08-26 | Zastosowanie SAHA do leczenia międzybłoniaka |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL379887A PL379887A1 (pl) | 2003-08-26 | 2004-08-26 | Sposób leczenia raka inhibitorami HDAC |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090012175A1 (pl) |
EP (2) | EP2201947A3 (pl) |
JP (2) | JP4338734B2 (pl) |
KR (1) | KR100924737B1 (pl) |
CN (1) | CN102188415A (pl) |
AT (1) | ATE462426T1 (pl) |
AU (1) | AU2004266169B9 (pl) |
BR (1) | BRPI0413826A (pl) |
CA (1) | CA2535806C (pl) |
DE (1) | DE602004026321D1 (pl) |
DK (1) | DK1663194T3 (pl) |
EC (1) | ECSP066452A (pl) |
ES (1) | ES2345775T3 (pl) |
HR (1) | HRP20060080A2 (pl) |
IL (1) | IL173846A0 (pl) |
MA (1) | MA28209A1 (pl) |
NO (1) | NO328575B1 (pl) |
NZ (2) | NZ560485A (pl) |
PL (2) | PL379887A1 (pl) |
PT (1) | PT1663194E (pl) |
RU (1) | RU2356547C2 (pl) |
SI (1) | SI1663194T1 (pl) |
WO (1) | WO2005018578A2 (pl) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
NZ535578A (en) * | 2002-03-04 | 2008-03-28 | Merck Hdac Res Llc | Methods of inducing terminal differentiation |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
BR0309280A (pt) * | 2002-04-15 | 2005-02-22 | Sloan Kettering Inst Cancer | Terapia de combinação para o tratamento de câncer |
WO2004089293A2 (en) | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
US7901675B2 (en) * | 2004-10-13 | 2011-03-08 | U.S. Department Of Veterans Affairs | Method of using coenzyme Q10 to treat Huntington's disease |
US20060135612A1 (en) * | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
NZ589276A (en) | 2005-02-03 | 2012-06-29 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors and erlotinib (tarceva) |
EP3354265A1 (en) | 2005-03-22 | 2018-08-01 | President and Fellows of Harvard College | Treatment of solid tumors |
GB0509223D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
GB0509225D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
CA2606598C (en) | 2005-05-13 | 2014-12-23 | Topotarget Uk Limited | Pharmaceutical formulations of hdac inhibitors |
TWI415603B (zh) | 2005-05-20 | 2013-11-21 | Merck Sharp & Dohme | 1,8-辛二醯基苯胺羥胺酸(suberoylanilide hydroxamic acid)之調配物及其製配方法 |
BRPI0613429A2 (pt) | 2005-07-14 | 2009-02-10 | Takeda San Diego Inc | inibidores de histona desacetilase |
GB0518720D0 (en) * | 2005-09-14 | 2005-10-19 | Hamlet Pharma Ab | Therapeutic combination |
AU2006311829B8 (en) * | 2005-11-04 | 2013-02-21 | Merck Sharp & Dohme Corp. | Methods of treating cancers with SAHA, Carboplatin, and Paclitaxel and other combination therapies |
WO2007056243A2 (en) * | 2005-11-04 | 2007-05-18 | Merck & Co. Inc. | Methods of treating cancers with saha and fluorouracil and other combination therapies |
CN101325955A (zh) * | 2005-11-04 | 2008-12-17 | 默克公司 | 用saha和培美曲塞治疗癌症的方法 |
WO2007054719A2 (en) * | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
BRPI0707826B1 (pt) | 2006-02-14 | 2022-04-19 | Dana-Farber Cancer Institute, Inc. | Compostos inibidores de histona desacetilase, composição farmacêutica e uso dos referidos compostos |
US8222423B2 (en) | 2006-02-14 | 2012-07-17 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
US20100137239A1 (en) | 2006-04-24 | 2010-06-03 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
CA2654540C (en) | 2006-05-03 | 2017-01-17 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
WO2007146730A2 (en) | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
KR20090087013A (ko) | 2006-10-30 | 2009-08-14 | 크로마 데러퓨릭스 리미티드 | 히스톤 탈아세틸효소의 억제제로서 히드록사메이트 |
CA2667348A1 (en) * | 2006-11-03 | 2008-05-15 | University Of Maryland, Baltimore | Methods of using saha and bortezomib for treating multiple myeloma |
CN101801994A (zh) | 2006-12-29 | 2010-08-11 | 格洛斯特制药公司 | 制备Romidepsin |
WO2009040517A2 (en) * | 2007-09-25 | 2009-04-02 | Topotarget Uk Limited | Methods of synthesis of certain hydroxamic acid compounds |
WO2009064300A1 (en) * | 2007-11-15 | 2009-05-22 | The Johns Hopkins University | Combinations of hdac inhibitors and cytokines/growth factors |
CA2717207A1 (en) * | 2008-03-07 | 2009-09-11 | Topotarget A/S | Methods of treatment employing prolonged continuous infusion of belinostat |
RU2515611C2 (ru) | 2008-07-23 | 2014-05-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Ингибиторы деацетилазы и их применение |
EP2349985A2 (en) | 2008-10-15 | 2011-08-03 | Generics [UK] Limited | Process for the preparation of vorinostat |
CA2744448A1 (en) | 2008-11-26 | 2010-06-03 | Vinayak Gore | Polymorphs |
GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
US20130102477A1 (en) | 2010-06-23 | 2013-04-25 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
KR20130092557A (ko) | 2010-07-12 | 2013-08-20 | 셀진 코포레이션 | 로미뎁신 고체 형태 및 그의 용도 |
RU2765155C2 (ru) | 2010-09-10 | 2022-01-26 | Эпизайм, Инк. | Ингибиторы ezh2 человека и способы их применения |
US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
CN102846611A (zh) * | 2011-09-24 | 2013-01-02 | 复旦大学 | 斯克瑞泰Scriptaid在制备治疗创伤性脑损伤疾病药物中的用途 |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
MX353929B (es) | 2012-10-15 | 2018-02-02 | Epizyme Inc | Compuestos de benceno sustituidos. |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
CN103169807A (zh) * | 2013-04-11 | 2013-06-26 | 太仓市胜舟生物技术有限公司 | 一种中西组合药物在制药中的应用 |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
WO2015190700A1 (ko) * | 2014-06-11 | 2015-12-17 | 성균관대학교산학협력단 | 패혈증 예방 또는 치료용 약학적 조성물 |
CN117797149A (zh) * | 2018-11-20 | 2024-04-02 | 深圳微芯生物科技股份有限公司 | 西达本胺联合r-chop的应用及联合药物 |
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PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
WO2002022133A1 (en) * | 2000-09-12 | 2002-03-21 | Virginia Commonwealth University | Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents |
AU9013101A (en) | 2000-09-29 | 2002-04-22 | Prolifix Ltd | Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors |
AU2002243231A1 (en) * | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
AR035659A1 (es) | 2000-12-07 | 2004-06-23 | Hoffmann La Roche | Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos |
US6495719B2 (en) * | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
WO2002102323A2 (en) * | 2001-06-14 | 2002-12-27 | Bristol-Myers Squibb Company | Novel human histone deacetylases |
ITMI20011733A1 (it) * | 2001-08-07 | 2003-02-07 | Italfarmaco Spa | Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc |
US20040132643A1 (en) * | 2002-01-09 | 2004-07-08 | Fojo Antonio Tito | Histone deacelylase inhibitors in diagnosis and treatment of thyroid neoplasms |
EP1482962A4 (en) * | 2002-02-15 | 2009-12-23 | Sloan Kettering Inst Cancer | METHOD OF TREATING THIOREDOXIN-MEDIATED DISEASES (TRX) |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
US20060276547A1 (en) * | 2002-03-04 | 2006-12-07 | Bacopoulos Nicholas G | Methods of treating cancer with HDAC inhibitors |
US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
NZ535578A (en) * | 2002-03-04 | 2008-03-28 | Merck Hdac Res Llc | Methods of inducing terminal differentiation |
US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
BR0309280A (pt) * | 2002-04-15 | 2005-02-22 | Sloan Kettering Inst Cancer | Terapia de combinação para o tratamento de câncer |
CA2506504A1 (en) * | 2002-11-20 | 2004-06-03 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
WO2004089293A2 (en) * | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
-
2004
- 2004-08-26 CN CN201110072778XA patent/CN102188415A/zh active Pending
- 2004-08-26 KR KR1020067003748A patent/KR100924737B1/ko not_active IP Right Cessation
- 2004-08-26 PL PL379887A patent/PL379887A1/pl unknown
- 2004-08-26 PT PT04782425T patent/PT1663194E/pt unknown
- 2004-08-26 JP JP2006524891A patent/JP4338734B2/ja not_active Expired - Fee Related
- 2004-08-26 AT AT04782425T patent/ATE462426T1/de active
- 2004-08-26 SI SI200431448T patent/SI1663194T1/sl unknown
- 2004-08-26 DE DE602004026321T patent/DE602004026321D1/de not_active Expired - Lifetime
- 2004-08-26 WO PCT/US2004/027943 patent/WO2005018578A2/en active IP Right Grant
- 2004-08-26 DK DK04782425.5T patent/DK1663194T3/da active
- 2004-08-26 CA CA002535806A patent/CA2535806C/en not_active Expired - Fee Related
- 2004-08-26 RU RU2006109467/14A patent/RU2356547C2/ru not_active IP Right Cessation
- 2004-08-26 BR BRPI0413826-0A patent/BRPI0413826A/pt not_active IP Right Cessation
- 2004-08-26 PL PL04782425T patent/PL1663194T3/pl unknown
- 2004-08-26 NZ NZ560485A patent/NZ560485A/en not_active IP Right Cessation
- 2004-08-26 ES ES04782425T patent/ES2345775T3/es not_active Expired - Lifetime
- 2004-08-26 AU AU2004266169A patent/AU2004266169B9/en not_active Expired
- 2004-08-26 NZ NZ54593504A patent/NZ545935A/xx not_active IP Right Cessation
- 2004-08-26 EP EP10158245A patent/EP2201947A3/en not_active Withdrawn
- 2004-08-26 EP EP04782425A patent/EP1663194B1/en not_active Expired - Lifetime
-
2006
- 2006-02-21 IL IL173846A patent/IL173846A0/en unknown
- 2006-02-23 MA MA28833A patent/MA28209A1/fr unknown
- 2006-02-23 HR HR20060080A patent/HRP20060080A2/xx not_active Application Discontinuation
- 2006-03-23 EC EC2006006452A patent/ECSP066452A/es unknown
- 2006-03-24 NO NO20061348A patent/NO328575B1/no not_active IP Right Cessation
-
2008
- 2008-07-08 US US12/217,843 patent/US20090012175A1/en not_active Abandoned
- 2008-09-11 JP JP2008232889A patent/JP4914411B2/ja not_active Expired - Fee Related
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