ECSP066452A - Métodos para el tratamiento del cáncer con inhibidores de hdac - Google Patents

Métodos para el tratamiento del cáncer con inhibidores de hdac

Info

Publication number
ECSP066452A
ECSP066452A EC2006006452A ECSP066452A ECSP066452A EC SP066452 A ECSP066452 A EC SP066452A EC 2006006452 A EC2006006452 A EC 2006006452A EC SP066452 A ECSP066452 A EC SP066452A EC SP066452 A ECSP066452 A EC SP066452A
Authority
EC
Ecuador
Prior art keywords
methods
hdac inhibitors
pharmaceutical compositions
present
mesothelioma
Prior art date
Application number
EC2006006452A
Other languages
English (en)
Inventor
Victoria M Richon
Nicholas G Bacopoulos
Judy H Chiao
Thomas A Miller
Carolyn M Paradise
Original Assignee
Aton Pharma Inc
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/650,025 external-priority patent/US7148257B2/en
Priority claimed from US10/665,079 external-priority patent/US20040127523A1/en
Application filed by Aton Pharma Inc, Sloan Kettering Inst Cancer filed Critical Aton Pharma Inc
Publication of ECSP066452A publication Critical patent/ECSP066452A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Electrotherapy Devices (AREA)

Abstract

La presente invención se refiere a métodos para el tratamiento de cánceres, por ej., mesotelioma o linfoma. Más específicamente, la presente invención se refiere a métodos para el tratamiento del mesotelioma o del linfoma difuso de células B grandes (DLBCL, por sus siglas en inglés), por medio de la administración de composiciones farmacéuticas que comprenden inhibidores de HDAC, por ej., ácido hidroxámico suberoilanilida (SAHA, por sus siglas en inglés). Las formulaciones orales de las composiciones farmacéuticas tienen perfiles farmacocinéticos favorables, tales como biodisponibilidad alta, y sorprendentemente generan altos niveles sanguíneos de los compuestos activos durante un período prolongado. La presente invención además provee un régimen de dosificación diaria seguro de estas composiciones farmacéuticas, el cual es fácil de seguir y resulta en una cantidad terapéuticamente efectiva de los inhibidores de HDAC in vivo.
EC2006006452A 2003-08-26 2006-03-23 Métodos para el tratamiento del cáncer con inhibidores de hdac ECSP066452A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/650,025 US7148257B2 (en) 2002-03-04 2003-08-26 Methods of treating mesothelioma with suberoylanilide hydroxamic acid
US10/665,079 US20040127523A1 (en) 2002-03-04 2003-09-16 Methods of treating cancer with HDAC inhibitors

Publications (1)

Publication Number Publication Date
ECSP066452A true ECSP066452A (es) 2006-09-18

Family

ID=34556614

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006452A ECSP066452A (es) 2003-08-26 2006-03-23 Métodos para el tratamiento del cáncer con inhibidores de hdac

Country Status (23)

Country Link
US (1) US20090012175A1 (es)
EP (2) EP1663194B1 (es)
JP (2) JP4338734B2 (es)
KR (1) KR100924737B1 (es)
CN (1) CN102188415A (es)
AT (1) ATE462426T1 (es)
AU (1) AU2004266169B9 (es)
BR (1) BRPI0413826A (es)
CA (1) CA2535806C (es)
DE (1) DE602004026321D1 (es)
DK (1) DK1663194T3 (es)
EC (1) ECSP066452A (es)
ES (1) ES2345775T3 (es)
HR (1) HRP20060080A2 (es)
IL (1) IL173846A0 (es)
MA (1) MA28209A1 (es)
NO (1) NO328575B1 (es)
NZ (2) NZ560485A (es)
PL (2) PL379887A1 (es)
PT (1) PT1663194E (es)
RU (1) RU2356547C2 (es)
SI (1) SI1663194T1 (es)
WO (1) WO2005018578A2 (es)

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Also Published As

Publication number Publication date
BRPI0413826A (pt) 2006-10-24
NZ545935A (en) 2009-02-28
SI1663194T1 (sl) 2010-08-31
JP2009073834A (ja) 2009-04-09
ES2345775T3 (es) 2010-10-01
EP2201947A2 (en) 2010-06-30
EP2201947A3 (en) 2010-08-11
AU2004266169A1 (en) 2005-03-03
JP2007518694A (ja) 2007-07-12
AU2004266169B9 (en) 2007-05-10
NZ560485A (en) 2009-03-31
RU2356547C2 (ru) 2009-05-27
CA2535806A1 (en) 2005-03-03
CN102188415A (zh) 2011-09-21
MA28209A1 (fr) 2006-10-02
AU2004266169A2 (en) 2006-04-06
DK1663194T3 (da) 2010-07-19
DE602004026321D1 (de) 2010-05-12
PL379887A1 (pl) 2006-11-27
KR20070029617A (ko) 2007-03-14
EP1663194A2 (en) 2006-06-07
EP1663194A4 (en) 2007-09-19
JP4338734B2 (ja) 2009-10-07
HRP20060080A2 (en) 2006-07-31
RU2006109467A (ru) 2007-10-10
NO328575B1 (no) 2010-03-22
IL173846A0 (en) 2006-07-05
AU2004266169B2 (en) 2007-05-03
KR100924737B1 (ko) 2009-11-04
PL1663194T3 (pl) 2011-01-31
JP4914411B2 (ja) 2012-04-11
US20090012175A1 (en) 2009-01-08
CA2535806C (en) 2009-02-17
PT1663194E (pt) 2010-07-06
WO2005018578A3 (en) 2005-05-12
NO20061348L (no) 2006-05-23
EP1663194B1 (en) 2010-03-31
WO2005018578A2 (en) 2005-03-03
ATE462426T1 (de) 2010-04-15

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