MA28209A1 - Procede pour traiter le cancer au moyen d'inhibiteurs d'hdac - Google Patents

Procede pour traiter le cancer au moyen d'inhibiteurs d'hdac

Info

Publication number
MA28209A1
MA28209A1 MA28833A MA28833A MA28209A1 MA 28209 A1 MA28209 A1 MA 28209A1 MA 28833 A MA28833 A MA 28833A MA 28833 A MA28833 A MA 28833A MA 28209 A1 MA28209 A1 MA 28209A1
Authority
MA
Morocco
Prior art keywords
hdac inhibitors
pharmaceutical compositions
present
methods
mesothelioma
Prior art date
Application number
MA28833A
Other languages
English (en)
Inventor
Nicholas G Bacopoulos
Judy H Chiao
Thomas A Miller
Carolyn M Paradise
Victoria M Richon
Original Assignee
Sloan Kettering Inst Cancer
Merck Hdac Res Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/650,025 external-priority patent/US7148257B2/en
Priority claimed from US10/665,079 external-priority patent/US20040127523A1/en
Application filed by Sloan Kettering Inst Cancer, Merck Hdac Res Llc filed Critical Sloan Kettering Inst Cancer
Publication of MA28209A1 publication Critical patent/MA28209A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Prostheses (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention se rapporte à des procédés permettant de traiter des cancers, par exemple des mésothéliomes ou des lymphomes. Cette invention concerne de manière plus spécifique des procédés permettant de traiter des mésothéliomes ou des lymphomes B diffus à grandes cellules (DLBCL), par administration de compositions pharmaceutiques comprenant des inhibiteurs d'HDAC, par exemple de l'acide hydroxamique suberoylanilide (SAHA). Les formulations orales des compositions pharmaceutiques possèdent des profils pharmacocinétiques favorables: ils présentent une biodisponibilité élevée et entraînent, de manière surprenante, des concentrations élevées des composés actifs dans le sang sur un laps de temps étendu. La présente invention concerne également une posologie quotidienne sûre desdites compositions pharmaceutiques, qui est simple à appliquer et permet d'obtenir une quantité d'inhibiteurs d'HDAC thérapeutiquement efficace in vivo.
MA28833A 2003-08-26 2006-02-23 Procede pour traiter le cancer au moyen d'inhibiteurs d'hdac MA28209A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/650,025 US7148257B2 (en) 2002-03-04 2003-08-26 Methods of treating mesothelioma with suberoylanilide hydroxamic acid
US10/665,079 US20040127523A1 (en) 2002-03-04 2003-09-16 Methods of treating cancer with HDAC inhibitors

Publications (1)

Publication Number Publication Date
MA28209A1 true MA28209A1 (fr) 2006-10-02

Family

ID=34556614

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28833A MA28209A1 (fr) 2003-08-26 2006-02-23 Procede pour traiter le cancer au moyen d'inhibiteurs d'hdac

Country Status (23)

Country Link
US (1) US20090012175A1 (fr)
EP (2) EP1663194B1 (fr)
JP (2) JP4338734B2 (fr)
KR (1) KR100924737B1 (fr)
CN (1) CN102188415A (fr)
AT (1) ATE462426T1 (fr)
AU (1) AU2004266169B9 (fr)
BR (1) BRPI0413826A (fr)
CA (1) CA2535806C (fr)
DE (1) DE602004026321D1 (fr)
DK (1) DK1663194T3 (fr)
EC (1) ECSP066452A (fr)
ES (1) ES2345775T3 (fr)
HR (1) HRP20060080A2 (fr)
IL (1) IL173846A0 (fr)
MA (1) MA28209A1 (fr)
NO (1) NO328575B1 (fr)
NZ (2) NZ560485A (fr)
PL (2) PL379887A1 (fr)
PT (1) PT1663194E (fr)
RU (1) RU2356547C2 (fr)
SI (1) SI1663194T1 (fr)
WO (1) WO2005018578A2 (fr)

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Also Published As

Publication number Publication date
SI1663194T1 (sl) 2010-08-31
PL379887A1 (pl) 2006-11-27
DK1663194T3 (da) 2010-07-19
KR20070029617A (ko) 2007-03-14
AU2004266169B9 (en) 2007-05-10
DE602004026321D1 (de) 2010-05-12
JP2007518694A (ja) 2007-07-12
ATE462426T1 (de) 2010-04-15
BRPI0413826A (pt) 2006-10-24
ECSP066452A (es) 2006-09-18
NO20061348L (no) 2006-05-23
JP4338734B2 (ja) 2009-10-07
AU2004266169B2 (en) 2007-05-03
ES2345775T3 (es) 2010-10-01
RU2006109467A (ru) 2007-10-10
EP2201947A2 (fr) 2010-06-30
EP2201947A3 (fr) 2010-08-11
WO2005018578A3 (fr) 2005-05-12
EP1663194A2 (fr) 2006-06-07
JP2009073834A (ja) 2009-04-09
CA2535806A1 (fr) 2005-03-03
NZ560485A (en) 2009-03-31
NZ545935A (en) 2009-02-28
IL173846A0 (en) 2006-07-05
AU2004266169A2 (en) 2006-04-06
KR100924737B1 (ko) 2009-11-04
JP4914411B2 (ja) 2012-04-11
EP1663194A4 (fr) 2007-09-19
NO328575B1 (no) 2010-03-22
PL1663194T3 (pl) 2011-01-31
PT1663194E (pt) 2010-07-06
HRP20060080A2 (en) 2006-07-31
US20090012175A1 (en) 2009-01-08
EP1663194B1 (fr) 2010-03-31
AU2004266169A1 (en) 2005-03-03
RU2356547C2 (ru) 2009-05-27
CA2535806C (fr) 2009-02-17
CN102188415A (zh) 2011-09-21
WO2005018578A2 (fr) 2005-03-03

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