PL165470B1 - S ro d e k do p ieleg n acji jam y ustnej p rzeciw dzialajacy pow staw aniu plytki n azeb n ej PL PL PL PL - Google Patents
S ro d e k do p ieleg n acji jam y ustnej p rzeciw dzialajacy pow staw aniu plytki n azeb n ej PL PL PL PLInfo
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- PL165470B1 PL165470B1 PL89283117A PL28311789A PL165470B1 PL 165470 B1 PL165470 B1 PL 165470B1 PL 89283117 A PL89283117 A PL 89283117A PL 28311789 A PL28311789 A PL 28311789A PL 165470 B1 PL165470 B1 PL 165470B1
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- PL
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- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 239000000551 dentifrice Substances 0.000 claims abstract description 85
- 239000004599 antimicrobial Substances 0.000 claims abstract description 50
- -1 alkyl radical Chemical class 0.000 claims abstract description 49
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 125000002091 cationic group Chemical group 0.000 claims abstract description 16
- 239000000499 gel Substances 0.000 claims abstract description 15
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 239000002324 mouth wash Substances 0.000 claims abstract description 12
- 229940051866 mouthwash Drugs 0.000 claims abstract description 10
- 229920000388 Polyphosphate Polymers 0.000 claims abstract description 8
- 239000001205 polyphosphate Substances 0.000 claims abstract description 8
- 235000011176 polyphosphates Nutrition 0.000 claims abstract description 8
- 125000002252 acyl group Chemical group 0.000 claims abstract description 6
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 6
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims abstract description 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 5
- 125000003118 aryl group Chemical group 0.000 claims abstract description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 5
- 208000006558 Dental Calculus Diseases 0.000 claims abstract description 4
- 230000002882 anti-plaque Effects 0.000 claims abstract description 4
- 229940112822 chewing gum Drugs 0.000 claims abstract description 4
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 4
- 239000007937 lozenge Substances 0.000 claims abstract description 4
- 125000000962 organic group Chemical group 0.000 claims abstract description 4
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 4
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 3
- 239000002553 antibacterial enhancer Substances 0.000 claims abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 79
- 239000003795 chemical substances by application Substances 0.000 claims description 79
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 35
- 238000005498 polishing Methods 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- 210000003296 saliva Anatomy 0.000 claims description 30
- 229920001577 copolymer Polymers 0.000 claims description 29
- 239000002253 acid Substances 0.000 claims description 24
- 239000000377 silicon dioxide Substances 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 19
- 239000004094 surface-active agent Substances 0.000 claims description 19
- 230000000845 anti-microbial effect Effects 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 239000000178 monomer Substances 0.000 claims description 15
- 239000003921 oil Substances 0.000 claims description 15
- 235000019198 oils Nutrition 0.000 claims description 15
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 14
- 238000012423 maintenance Methods 0.000 claims description 11
- 239000002562 thickening agent Substances 0.000 claims description 11
- 239000000606 toothpaste Substances 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 229940034610 toothpaste Drugs 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- PGKQTZHDCHKDQK-UHFFFAOYSA-N 2-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C=CC1=CC=CC=C1 PGKQTZHDCHKDQK-UHFFFAOYSA-N 0.000 claims description 8
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 8
- 231100000252 nontoxic Toxicity 0.000 claims description 8
- 230000003000 nontoxic effect Effects 0.000 claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 7
- 239000001506 calcium phosphate Substances 0.000 claims description 7
- 239000003623 enhancer Substances 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 7
- 230000007935 neutral effect Effects 0.000 claims description 7
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 5
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 5
- 150000008064 anhydrides Chemical class 0.000 claims description 5
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 5
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 5
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 5
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims description 4
- 150000003460 sulfonic acids Chemical class 0.000 claims description 4
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
- 229940072049 amyl acetate Drugs 0.000 claims description 3
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 claims description 3
- 229920006318 anionic polymer Polymers 0.000 claims description 3
- 229960002903 benzyl benzoate Drugs 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 210000004195 gingiva Anatomy 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 claims description 3
- 229940051250 hexylene glycol Drugs 0.000 claims description 3
- 150000002989 phenols Chemical class 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims description 2
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 2
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 2
- UVGZJJKEELPWRH-JSCKKFHOSA-M potassium (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate Chemical compound [K+].O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O UVGZJJKEELPWRH-JSCKKFHOSA-M 0.000 claims description 2
- 235000019983 sodium metaphosphate Nutrition 0.000 claims description 2
- 230000003381 solubilizing effect Effects 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000012178 vegetable wax Substances 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 239000011976 maleic acid Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 claims 1
- 230000003389 potentiating effect Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 abstract description 13
- 230000002708 enhancing effect Effects 0.000 abstract description 9
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract description 3
- 239000006072 paste Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 230000002378 acidificating effect Effects 0.000 abstract description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 77
- 229960003500 triclosan Drugs 0.000 description 76
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 30
- 229920005646 polycarboxylate Polymers 0.000 description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 23
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 21
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 21
- 239000000600 sorbitol Substances 0.000 description 21
- 239000011734 sodium Substances 0.000 description 19
- 229910052708 sodium Inorganic materials 0.000 description 18
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 17
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 16
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 16
- 238000010521 absorption reaction Methods 0.000 description 16
- 239000000243 solution Substances 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 125000000129 anionic group Chemical group 0.000 description 15
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 14
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 14
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 14
- 239000003146 anticoagulant agent Substances 0.000 description 12
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 11
- 230000000702 anti-platelet effect Effects 0.000 description 11
- 210000002919 epithelial cell Anatomy 0.000 description 11
- 239000000796 flavoring agent Substances 0.000 description 10
- 239000003906 humectant Substances 0.000 description 10
- 210000000214 mouth Anatomy 0.000 description 10
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 10
- 229910052783 alkali metal Inorganic materials 0.000 description 9
- 235000019634 flavors Nutrition 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 229960003742 phenol Drugs 0.000 description 9
- 239000011775 sodium fluoride Substances 0.000 description 9
- 235000013024 sodium fluoride Nutrition 0.000 description 9
- 229920002125 Sokalan® Polymers 0.000 description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 8
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- 239000012071 phase Substances 0.000 description 8
- 229960000414 sodium fluoride Drugs 0.000 description 8
- 210000004872 soft tissue Anatomy 0.000 description 8
- 150000001340 alkali metals Chemical class 0.000 description 7
- 239000008375 oral care agent Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 6
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 6
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 6
- 239000005770 Eugenol Substances 0.000 description 6
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 6
- 239000005844 Thymol Substances 0.000 description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 description 6
- 229960002217 eugenol Drugs 0.000 description 6
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 6
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 6
- 229960000790 thymol Drugs 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- PQSXNIMHIHYFEE-UHFFFAOYSA-N 4-(1-phenylethyl)benzene-1,3-diol Chemical compound C=1C=C(O)C=C(O)C=1C(C)C1=CC=CC=C1 PQSXNIMHIHYFEE-UHFFFAOYSA-N 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 229940127218 antiplatelet drug Drugs 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 229940106025 phenylethyl resorcinol Drugs 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 4
- 235000010234 sodium benzoate Nutrition 0.000 description 4
- 239000004299 sodium benzoate Substances 0.000 description 4
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 description 4
- UPXZHXVOMCGZDS-UHFFFAOYSA-N 2-phenylbenzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1C1=CC=CC=C1 UPXZHXVOMCGZDS-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
- SRIJLARXVRHZKD-UHFFFAOYSA-N OP(O)=O.C=CC1=CC=CC=C1 Chemical compound OP(O)=O.C=CC1=CC=CC=C1 SRIJLARXVRHZKD-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 230000006502 antiplatelets effects Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 239000007859 condensation product Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 229920006037 cross link polymer Polymers 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 3
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- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004862 thiobutyl group Chemical group 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical class [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- KVSKGMLNBAPGKH-UHFFFAOYSA-N tribromosalicylanilide Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 KVSKGMLNBAPGKH-UHFFFAOYSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ZDJAFJYWBILBIP-UHFFFAOYSA-K trisodium methane phosphate Chemical compound P(=O)([O-])([O-])[O-].[Na+].C.[Na+].[Na+] ZDJAFJYWBILBIP-UHFFFAOYSA-K 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/291,712 US4894220A (en) | 1987-01-30 | 1988-12-29 | Antibacterial antiplaque oral composition |
| US39860589A | 1989-08-25 | 1989-08-25 | |
| US39966989A | 1989-08-25 | 1989-08-25 | |
| US39860689A | 1989-08-25 | 1989-08-25 | |
| US07/398,592 US5188821A (en) | 1987-01-30 | 1989-08-25 | Antibacterial antiplaque oral composition mouthwash or liquid dentifrice |
| US07/398,566 US5032386A (en) | 1988-12-29 | 1989-08-25 | Antiplaque antibacterial oral composition |
| US41068289A | 1989-09-21 | 1989-09-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL283117A1 PL283117A1 (en) | 1991-02-11 |
| PL165470B1 true PL165470B1 (pl) | 1994-12-30 |
Family
ID=27569612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL89283117A PL165470B1 (pl) | 1988-12-29 | 1989-12-29 | S ro d e k do p ieleg n acji jam y ustnej p rzeciw dzialajacy pow staw aniu plytki n azeb n ej PL PL PL PL |
Country Status (31)
| Country | Link |
|---|---|
| JP (1) | JP2708134B2 (sv) |
| CN (1) | CN1048867C (sv) |
| AT (1) | AT397765B (sv) |
| AU (1) | AU625379B2 (sv) |
| BR (1) | BR8906866A (sv) |
| CH (1) | CH679639A5 (sv) |
| DE (1) | DE3942643B4 (sv) |
| DK (1) | DK175071B1 (sv) |
| DZ (2) | DZ1382A1 (sv) |
| FI (1) | FI100691B (sv) |
| FR (2) | FR2641186B1 (sv) |
| GB (3) | GB2227660B (sv) |
| GR (1) | GR1004463B (sv) |
| HK (3) | HK154796A (sv) |
| HU (1) | HU212183B (sv) |
| IE (1) | IE65326B1 (sv) |
| IL (1) | IL92692A0 (sv) |
| IT (1) | IT1237483B (sv) |
| LU (1) | LU87650A1 (sv) |
| MA (1) | MA21712A1 (sv) |
| MX (1) | MX173741B (sv) |
| MY (1) | MY105879A (sv) |
| NL (1) | NL194716C (sv) |
| NO (1) | NO179503C (sv) |
| NZ (1) | NZ231813A (sv) |
| OA (1) | OA09253A (sv) |
| PL (1) | PL165470B1 (sv) |
| PT (1) | PT92734B (sv) |
| SE (2) | SE507731C2 (sv) |
| SK (1) | SK751289A3 (sv) |
| ZW (1) | ZW17289A1 (sv) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256401A (en) * | 1987-01-30 | 1993-10-26 | Colgate-Palmolive Company | Antibacterial antiplaque mouthwash composition |
| US5334375A (en) * | 1988-12-29 | 1994-08-02 | Colgate Palmolive Company | Antibacterial antiplaque oral composition |
| SE512333C2 (sv) * | 1989-08-25 | 2000-02-28 | Colgate Palmolive Co | Antibakteriell oral komposition med plack- och tandstensbegränsande verkan |
| AU637777B2 (en) * | 1989-08-25 | 1993-06-10 | Colgate-Palmolive Company, The | Antibacterial antiplaque oral composition containing novel styrene-phosphonic acid copolymer |
| WO1992010992A1 (en) * | 1990-12-19 | 1992-07-09 | The Procter & Gamble Company | Oral compositions effective against plaque and gingivitis |
| US5094844A (en) * | 1990-12-20 | 1992-03-10 | Colgate-Palmolive Company | Anticalculus oral composition |
| US5385729A (en) * | 1991-08-01 | 1995-01-31 | Colgate Palmolive Company | Viscoelastic personal care composition |
| US5252313A (en) * | 1991-12-20 | 1993-10-12 | Colgate-Palmolive Company | Visually clear gel dentifrice |
| US5192533A (en) * | 1992-03-25 | 1993-03-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Nonirritating antitartar and antiplaque oral compositions |
| NZ247712A (en) * | 1992-06-19 | 1995-04-27 | Colgate Palmolive Co | Oral composition comprising an anti-bacterial compound, a water-insoluble biodegradable polymer, and an organic solvent |
| CA2177680C (en) * | 1993-12-29 | 2000-12-05 | Lori Ann Bacca | Tartar control dentifrice composition containing thymol |
| US5462728A (en) * | 1994-04-05 | 1995-10-31 | Blank; Izhak | Pharmaceutical compositions |
| JP3494739B2 (ja) * | 1995-02-13 | 2004-02-09 | 株式会社ジーシー | 歯科用グラスアイオノマーセメント用歯面処理剤 |
| AU2612999A (en) * | 1997-12-18 | 1999-07-12 | Gibbs, Christopher David | Oral care composition |
| KR100384103B1 (ko) * | 1998-04-02 | 2003-10-08 | 주식회사 태평양 | 트리클로산을함유한구강용조성물 |
| US6241972B1 (en) | 1999-02-19 | 2001-06-05 | Block Drug Company, Inc. | Oral care formulation for the treatment of sensitivity teeth |
| DE10051955A1 (de) * | 2000-10-20 | 2002-05-02 | Wella Ag | Haarbehandlungsmittel in Form eines festen und formstabilen Gels |
| AU2002216059A1 (en) | 2000-12-15 | 2002-06-24 | Joiner, Andrew | Oral bleaching composition |
| BR0116831A (pt) | 2001-01-16 | 2004-02-03 | Unilever Nv | Composição oral e seu uso |
| EP1413589A4 (en) * | 2001-07-13 | 2006-06-07 | Kao Corp | ORAL POLYMERS AND ORAL COMPOSITIONS |
| US6912826B2 (en) | 2002-10-07 | 2005-07-05 | Zoran Momich | Carrier loading cartoner |
| US7846422B2 (en) | 2003-08-04 | 2010-12-07 | Kao Corporation | Method for prevention or treatment of periodontal diseases and composition for an oral cavity |
| US20060024245A1 (en) * | 2004-07-29 | 2006-02-02 | Cadbury Adams, Llc. | Tooth whitening compositions and delivery systems therefor |
| US8974772B2 (en) | 2004-12-28 | 2015-03-10 | Colgate-Palmolive Company | Two phase toothpaste composition |
| CN102036649A (zh) * | 2008-02-08 | 2011-04-27 | 高露洁-棕榄公司 | 精氨酸盐及其治疗口腔疾病的用途 |
| WO2010114546A1 (en) * | 2009-04-02 | 2010-10-07 | Colgate-Palmolive Company | Dentifrice composition |
| EP2467121B1 (en) | 2009-08-19 | 2016-08-31 | Unilever PLC | Delivery system |
| WO2011109919A1 (en) | 2010-03-09 | 2011-09-15 | Unilever Plc | Stable oral care compositions |
| JP2013532684A (ja) * | 2010-07-29 | 2013-08-19 | コルゲート・パーモリブ・カンパニー | モクレン由来抗細菌剤に基づくリン酸非含有オーラルケア組成物 |
| BR112013004354B8 (pt) | 2010-09-10 | 2018-10-23 | Unilever Nv | ativo de partícula compósita e método de para produzir o ativo de partícula compósita |
| CN107582413A (zh) | 2010-09-10 | 2018-01-16 | 荷兰联合利华有限公司 | 有益于牙齿的口腔护理组合物 |
| EP2699217B1 (en) | 2011-04-18 | 2018-01-24 | Unilever N.V. | Tooth remineralizing oral care compositions |
| CN107690327B (zh) | 2015-06-05 | 2022-05-17 | 联合利华知识产权控股有限公司 | 口腔护理装置 |
| WO2016192923A1 (en) | 2015-06-05 | 2016-12-08 | Unilever Plc | Oral care device |
| CN107743386A (zh) | 2015-06-05 | 2018-02-27 | 荷兰联合利华有限公司 | 口腔护理装置 |
| EP3222326A1 (en) | 2016-03-23 | 2017-09-27 | Unilever PLC | Toothpaste composition |
| EP3295921A1 (en) | 2016-09-14 | 2018-03-21 | Unilever PLC | Use of oral care composition |
| GB201811065D0 (en) * | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
| EP3849507A1 (en) | 2018-09-12 | 2021-07-21 | Unilever Global Ip Limited | Oral care composition |
| WO2020212159A1 (en) | 2019-04-17 | 2020-10-22 | Unilever Plc | Oral care product |
| EP3888621A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care device |
| EP3888619A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care device |
| EP3888620A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
| EP3888622A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
| EP3888623A1 (en) | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3429963A (en) * | 1964-06-09 | 1969-02-25 | Colgate Palmolive Co | Dental preparation containing polymeric polyelectrolyte |
| US3629477A (en) * | 1966-08-08 | 1971-12-21 | Geigy Chem Corp | Halogenated diphenyether-containing compositions and control of pests therewith |
| ZA717486B (en) * | 1970-11-19 | 1973-06-27 | Colgate Palmolive Co | Treatment of teeth |
| US3897548A (en) * | 1973-04-09 | 1975-07-29 | Indiana University Foundation | Oral compositions for retarding the formation of dental plaque and methods of utilization thereof |
| US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| US4342857A (en) * | 1980-12-31 | 1982-08-03 | Colgate-Palmolive Company | Antigingivitis composition comprising vinyl phosphonic acid/vinyl phosphonyl fluoride copolymer |
| JPS5988416A (ja) * | 1982-11-15 | 1984-05-22 | ジヨンソン・エンド・ジヨンソン・プロダクツ・インコ−ポレ−テツド | 口腔衛生組成物 |
| DE3445695A1 (de) * | 1983-12-28 | 1985-07-11 | Colgate-Palmolive Co., New York, N.Y. | Mittel zur oral-dentalen anwendung gegen plaque und gingivitis |
| GB8411841D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
| GB8526093D0 (en) * | 1985-10-22 | 1985-11-27 | Beecham Group Plc | Composition |
| GB8615534D0 (en) * | 1986-06-25 | 1986-07-30 | Beecham Group Plc | Composition |
| JPH0772125B2 (ja) * | 1986-08-29 | 1995-08-02 | ライオン株式会社 | 口腔用組成物 |
| IN168400B (sv) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co | |
| SE8904179L (sv) * | 1988-12-29 | 1990-06-30 | Colgate Palmolive Co | Foerpackade orala anti-plaquekompositioner |
| SE512333C2 (sv) * | 1989-08-25 | 2000-02-28 | Colgate Palmolive Co | Antibakteriell oral komposition med plack- och tandstensbegränsande verkan |
-
1989
- 1989-12-12 SE SE8904180A patent/SE507731C2/sv unknown
- 1989-12-13 AU AU46769/89A patent/AU625379B2/en not_active Expired
- 1989-12-13 IL IL92692A patent/IL92692A0/xx not_active IP Right Cessation
- 1989-12-15 NZ NZ231813A patent/NZ231813A/en unknown
- 1989-12-20 MX MX018805A patent/MX173741B/es unknown
- 1989-12-21 GR GR890100853A patent/GR1004463B/el not_active IP Right Cessation
- 1989-12-21 GB GB8928878A patent/GB2227660B/en not_active Expired - Lifetime
- 1989-12-21 ZW ZW172/89A patent/ZW17289A1/xx unknown
- 1989-12-22 DE DE3942643A patent/DE3942643B4/de not_active Expired - Lifetime
- 1989-12-22 IT IT04869489A patent/IT1237483B/it active IP Right Grant
- 1989-12-25 DZ DZ890197A patent/DZ1382A1/fr active
- 1989-12-26 MA MA21974A patent/MA21712A1/fr unknown
- 1989-12-27 CH CH4685/89A patent/CH679639A5/de not_active IP Right Cessation
- 1989-12-27 MY MYPI89001861A patent/MY105879A/en unknown
- 1989-12-27 PT PT92734A patent/PT92734B/pt not_active IP Right Cessation
- 1989-12-28 NO NO895310A patent/NO179503C/no not_active IP Right Cessation
- 1989-12-28 HU HU896808A patent/HU212183B/hu unknown
- 1989-12-28 CN CN89109648A patent/CN1048867C/zh not_active Expired - Fee Related
- 1989-12-28 DK DK198906709A patent/DK175071B1/da not_active IP Right Cessation
- 1989-12-28 IE IE419589A patent/IE65326B1/en not_active IP Right Cessation
- 1989-12-28 FI FI896316A patent/FI100691B/sv active IP Right Grant
- 1989-12-28 SK SK7512-89A patent/SK751289A3/sk not_active IP Right Cessation
- 1989-12-28 FR FR8917373A patent/FR2641186B1/fr not_active Expired - Lifetime
- 1989-12-29 NL NL8903187A patent/NL194716C/nl not_active IP Right Cessation
- 1989-12-29 LU LU87650A patent/LU87650A1/fr unknown
- 1989-12-29 OA OA59716A patent/OA09253A/xx unknown
- 1989-12-29 PL PL89283117A patent/PL165470B1/pl unknown
- 1989-12-29 BR BR898906866A patent/BR8906866A/pt not_active Application Discontinuation
- 1989-12-29 AT AT0296889A patent/AT397765B/de not_active IP Right Cessation
-
1990
- 1990-01-04 JP JP2000211A patent/JP2708134B2/ja not_active Expired - Lifetime
-
1992
- 1992-08-07 GB GB9216778A patent/GB2257362B/en not_active Expired - Lifetime
- 1992-10-13 FR FR9212240A patent/FR2681529B1/fr not_active Expired - Lifetime
- 1992-12-03 GB GB9225278A patent/GB2259856B/en not_active Expired - Lifetime
-
1993
- 1993-06-23 DZ DZ930077A patent/DZ1699A1/fr active
-
1996
- 1996-08-15 HK HK154796A patent/HK154796A/xx not_active IP Right Cessation
- 1996-08-15 HK HK154996A patent/HK154996A/xx not_active IP Right Cessation
- 1996-08-15 HK HK154896A patent/HK154896A/xx not_active IP Right Cessation
-
1997
- 1997-10-09 SE SE9703681A patent/SE510832C2/sv unknown
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