CN107690327B - 口腔护理装置 - Google Patents
口腔护理装置 Download PDFInfo
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- CN107690327B CN107690327B CN201680032922.8A CN201680032922A CN107690327B CN 107690327 B CN107690327 B CN 107690327B CN 201680032922 A CN201680032922 A CN 201680032922A CN 107690327 B CN107690327 B CN 107690327B
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- composition
- teeth
- calcium
- phosphate
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- 239000000203 mixture Substances 0.000 claims abstract description 73
- 239000011575 calcium Substances 0.000 claims abstract description 26
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 23
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 14
- 239000010452 phosphate Substances 0.000 claims abstract description 14
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 14
- 230000002087 whitening effect Effects 0.000 claims abstract description 13
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 14
- 229910052918 calcium silicate Inorganic materials 0.000 claims description 14
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 14
- 239000000378 calcium silicate Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000001488 sodium phosphate Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 6
- 239000004408 titanium dioxide Substances 0.000 claims description 6
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 6
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 6
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 6
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 4
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 4
- 239000002250 absorbent Substances 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 claims description 2
- 229960005069 calcium Drugs 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 235000012241 calcium silicate Nutrition 0.000 description 12
- 239000004744 fabric Substances 0.000 description 9
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- 239000000047 product Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000000834 fixative Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
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- 229920001285 xanthan gum Polymers 0.000 description 4
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- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
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- 239000000377 silicon dioxide Substances 0.000 description 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 229960003563 calcium carbonate Drugs 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 229960002816 potassium chloride Drugs 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
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- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
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- 108010035532 Collagen Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
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Abstract
本发明公开了一种口腔护理试剂盒，其包含：i)施加装置，ii)第一非水性组合物，其包含增白组分和水不溶性和/或微溶性钙源；和(iii)第二组合物，其包含磷酸盐源，其中所述第二组合物在产品使用之前与所述第一组合物分开储存，其中，所述第一和第二组合物被调整以顺序施加至所述施加装置，所述装置然后置于牙齿表面15以持续接触。
Description
技术领域
本发明涉及用于牙齿再矿化和增白的口腔护理产品。
背景技术
牙齿是功能上和美观上均重要的。需要有坚硬健康且表现为洁白且光泽的牙齿。
牙齿增白条状物被视为是获得洁白牙齿的便捷途径。
如US 5879691和US 6893629中所公开的，其中活性增白剂是过氧化氢的增白条状物。
然而，存在用以使牙齿增白和强化的简单有效方法的需求。
发明内容
因此，本发明涉及口腔护理试剂盒，其包含：
i)施加装置，所述施加装置适于被置于牙齿表面上以持续接触；
ii)第一非水性组合物，其包含增白组分和水不溶性和/或微溶性钙源；和
(iii)第二组合物，其包含磷酸盐源；
其中，所述第二组合物在产品使用之前与所述第一组合物分开储存，并且其中，所述第一和第二组合物被调整以顺序施加至所述施加装置。
本发明还涉及美容增白牙齿的方法，其包括如下步骤：
i)选择施加装置；
ii)将包含增白组分和水不溶性和/或微溶性钙源的第一非水性组合物施加至所述施加装置的表面；
iii)随后，将包含磷酸盐源的第二组合物施加至所述第一组合物所施加至的施加装置的相同的表面；
iv)将所述装置iii)置于牙齿上以持续接触。
具体实施方式
本发明的递送装置优选是柔性的，更优选所述装置包含口腔可接受的柔性材料条状物。该条状物的表面能够被施加到牙齿表面。
优选地，该装置具有足够长度的伸长形状，以当抵靠使用者牙齿的前表面放置时，其延伸跨过多颗牙齿，并且该伸长形状具有足够宽度，其至少从牙齿的牙龈线延伸到牙齿的牙冠。该伸长形状使得对于后续应用的需求以及覆盖使用者所有牙齿的时间最小化。
在进一步的实施方式中，该条状物使得当抵靠使用者牙齿的前表面放置其延伸跨过多颗牙齿时，其可以是足够的，并且该条状物具有足够宽度，使得其至少从牙齿的前牙龈线延伸到牙齿的牙冠以及延伸到使用者牙齿后面的牙龈线，从而实现牙龈线上方的牙齿的全部覆盖。
优选地，该施加装置形状是矩形。
优选的是，所述装置，优选地条状物，是由吸收性材料形成，更优选地，所述装置(优选条状物)是由水溶性、水不溶性或能水合的聚合物或其它材料，例如其它聚合物(例如聚丙烯、聚乙烯等)和纤维素形成的织物，最优选地，所述天然纤维是混纺棉。
如果是条状物，所述施加条状物具有大于0.001mm的厚度和优选小于2.5mm的厚度是优选的。
本发明的第一组合物包含水不溶性和/或微溶性钙源。本文所使用的可溶和不可溶性钙源是指水中钙源的溶解性。“可溶”意指溶于水得到在室温下具有至少0.1摩尔每升浓度的溶液的源。“不可溶”意指溶于水得到在室温下具有小于0.001摩尔每升浓度的溶液的源。因此，“微溶”被定义为意指溶于水得到在室温下具有大于0.001摩尔每升且室温下小于0.1摩尔每升浓度的溶液的源。本文所使用的“基本上不含”意指小于1.5％，优选小于1.0％，且最优选0.0至0.75重量％，基于口腔护理组合物的总重量，并包括其中包含的所有范围。适用于本发明的钙源仅被限制到可以在口腔中使用的程度。在优选实施方式中，所应用的钙源不溶或微溶于水，但最优选的是，不溶于水。
可以用于本发明的钙源的类型的示例性实例包括例如磷酸钙(即，添加的)，葡糖酸钙、氧化钙、乳酸钙、碳酸钙、氢氧化钙、硫酸钙、羧甲基纤维素钙、藻酸钙、柠檬酸的钙盐、硅酸钙，它们的混合物等。在优选实施方式中，钙源是硅酸钙。在更优选的实施方式中，所使用硅酸钙是(CaSiO3)，其中该硅酸钙以商品名Microcal ET由Ineos Silicas Ltd市售。
在又一优选实施方式中，钙源是不溶性硅酸钙，其以在共同拥有的申请公开号2008/015117中所述的复合材料氧化钙-二氧化硅(CaO-SiO2)存在。
当应用硅酸钙复合材料时，钙与硅的比(Ca:Si)可以是1:10至3:1。Ca:Si比优选1:5至2:1，更优选1:3至2:1，最优选约1:2至2:1。硅酸钙可包括硅酸一钙、硅酸二钙或硅酸三钙，其中钙与硅的比(Ca:Si)应当理解为原子比。
本发明中应用的钙源可以处于结晶或无定形状态，且优选地，该钙源处于无定形状态。在通常优选的实施方式中，钙源处于介孔状态，即，该钙源是具有1纳米至50微米直径的孔的材料。通常优选的是介孔硅酸钙(MCS)。
可以用于本发明的MCS可以通过将钙盐、氧化硅前体(如硅酸盐)和结构导向剂组合以产生适用于煅烧的固体而制成。在前述共同拥有的申请公开号WO 2008/015117中描述了可以制造适用于本发明的MCS的方法的更详细描述。
作为本发明的第二层存在的组合物中的钙源的量典型地为口腔护理组合物的0.1至50％，优选1至30％，且最优选5至20重量％，基于口腔护理组合物的总重量，且包括其中包含的所有范围。
第一组合物是非水性的，即，所述组合物包括小于所述总第一组合物的1wt％的水，优选小于0.5wt％的水。
本发明的第一组合物包含增白源，优选二氧化钛。二氧化钛的优选形式是硅酸钙涂覆的TiO2。WO 2012/031786和WO 2012/031785中公开了硅酸钙包覆的二氧化钛的优选形式的实例。
优选地，二氧化钛的含量是第二层的1-30重量％或更优选5-20重量％。
第二组合物包括磷酸盐源。可用于本发明的磷酸盐源仅被限制到可在适用于口腔中的组合物中使用的程度。适用于本发明的磷酸盐源的类型的示例性实例包括磷酸一钠、磷酸二氢钠、磷酸氢二钠、焦磷酸钠、焦磷酸四钠、三聚磷酸钠、六偏磷酸钠、磷酸二氢钾、磷酸三钠、磷酸三钾，它们的混合物等。磷酸盐源优选为水溶性的磷酸盐源。
典型地，磷酸盐源占用于第三层的组合物的0.5至15％，优选2至12％，最优选4至9重量％，基于第三层的组合物的总重量且包括其中包含的所有范围。在优选实施方式中，所使用的磷酸盐源是使得口腔护理组合物具有5.5至8、优选6至7.5，最优选约中性的pH的磷酸盐源。在最优选的实施方式中，所使用磷酸盐源是以1:4至4:1、优选1:3至3:1，最优选1:2至2:1(包括其中包含的所有比率)的磷酸三钠与磷酸二氢一钠重量比的磷酸三钠和磷酸二氢一钠。
优选的是，第二组合物包括含水基质，即，该组合物包含大于浆液组合物的50wt％的水，更优选大于70wt％。
本文所述层的口腔护理组合物可包括本领域常用的成分，诸如：
■抗菌剂，例如，三氯生、氯己定，铜-、锌-和亚锡盐诸如柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸锌钠以及焦磷酸亚锡，血根碱提取物，甲硝唑，季铵化合物诸如氯化十六烷基吡啶；双胍，诸如氯己定二葡糖酸盐、海克替啶、奥替尼啶、阿来西定；和卤代双酚化合物，诸如2,2′-亚甲基双-(4-氯-6-溴苯酚)；
■抗炎剂，诸如布洛芬、氟比洛芬、阿司匹林、吲哚美辛等；
■抗龋剂，如三偏磷酸钠和酪蛋白；
■牙斑缓冲剂，诸如脲、乳酸钙、甘油磷酸钙和聚丙烯酸酯；
■维生素诸如维生素A、C和E；
■植物提取物；
■脱敏剂，例如，柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾以及硝酸钾；
■抗牙石剂，例如，碱金属焦磷酸盐、包含次磷酸盐的聚合物、有机膦酸盐以及磷酰柠檬酸盐等；
■生物分子，例如，细菌素、抗体、酶等；
■香料，例如薄荷油和绿薄荷油；
■蛋白质材料诸如胶原；
■防腐剂；
■乳浊剂；
■着色剂，如FD&C蓝、黄和/或红色染料/着色剂；
■pH调节剂；
■甜味剂；
■表面活性剂，诸如阴离子、阳离子和两性离子或两性表面活性剂(例如，月桂基硫酸钠、十二烷基苯磺酸钠)；
■颗粒研磨材料，诸如二氧化硅磨料、氧化铝、碳酸钙、硅酸锆、聚甲基丙烯酸甲酯、磷酸二钙、焦磷酸钙、羟磷灰石、三偏磷酸盐、不溶性六偏磷酸盐以及聚集颗粒研磨材料；
■氟化物源，如氟化钠、氟化亚锡、单氟磷酸钠、氟化锌铵、氟化锡铵、氟化钙，氟化钴铵或它们的混合物；
■还可以包括能够增强活性成分诸如抗微生物剂的递送的聚合物。这些聚合物的实例是聚乙烯基甲基醚与马来酸酐的共聚物以及其他类似的增强递送的聚合物，例如DE-A03,942,643中描述的那些；用以缓冲口腔护理组合物的pH和离子强度的缓冲液和盐；且
■可以包括的其他任选组分是，例如漂白剂诸如过氧化物，例如过氧二磷酸钾，泡腾体系诸如碳酸氢钠/柠檬酸体系，变色体系等。
本领域常用的这些成分通常和共同地占口腔护理组合物的小于20重量％，且优选0.0至15重量％，最优选口腔护理组合物的约0.01至约12重量％，包括其中包含的所有范围。
适合的载体湿润剂优选用于本发明的口腔护理组合物，且它们包括例如，甘油、山梨醇、丙二醇、双丙甘醇、双甘油、三醋精、矿物油、聚乙二醇(优选PEG-400)、链烷二醇如丁二醇和己二醇、乙醇、戊二醇或它们的混合物。在任何情况下，该载体湿润剂应该是基本不含水的，且优选无水的。例如，该载体湿润剂可以以固态使用，由此甘油是优选的载体湿润剂。这种载体尤其适用于第二层所用的组合物。
载体湿润剂用于占据组合物的其余部分高达100％，且其以口腔护理组合物的10至90重量％的范围存在。优选地，载体湿润剂占口腔护理组合物的25至80％，最优选45至70重量％，基于口腔护理组合物的总重量且包括其中包含的所有范围。
在最终涂覆的装置应用至牙齿之前，优选的是第一背衬层的厚度大于0.001mm，优选小于2.5mm厚，包含第二组合物的第二层小于约1mm厚，优选小于约0.5mm厚，更优选从约0.001至约0.3mm厚，第三层(如果存在)小于约1mm厚，优选小于约0.5mm厚，更优选从约0.001至约0.3mm厚。
在本发明的替代模式中，组合物被基质吸收，不存在层。
用于本发明的层中的组合物通过制备口腔护理配制物的传统方法制备。所述方法包括在中等剪切和大气压力下混合各成分。
使用方式
本发明提供了一种增白和再矿化牙齿的方法。所述方法包括将如上所述的第一组合物施加至施加装置的表面的步骤，随后将第二组合物施加至相同的表面。将装置置于牙齿上使得所述装置的处理表面持续与牙齿接触。在本发明的上下文中，持续接触是指在去除之前产品优选驻留在牙齿上1至30分钟，优选约5至10分钟。
优选地，在连续数天期间，除了常规刷牙(优选一天至少两次)外，本发明的口腔护理产品的应用每天进行一次。
典型地，该装置与本发明的口腔护理组合物一起使用(约两周至一个月的时间段)将实现牙齿上0.5至20微米、优选0.75至5微米的新羟磷灰石层(包括其中包含的所有范围)。
现在本发明将通过下面的非限制性实施例进行说明：
实施例
通过将1.9L水加入玻璃烧杯来制备模拟的口腔液。在连续搅拌下依次加入以下材料，从而允许每个化学品有充足的时间在加入下一个之前完全溶解。氯化钠16.07g、碳酸氢钠0.7g、氯化钾0.448g、磷酸氢钾2.56g、氯化镁六水合物0.622g、1M盐酸40ml、氯化钙0.1998g以及硫酸钠0.1434g。使用饱和的TRIS缓冲液将pH调节到7.0，使用容量瓶将总体积补充至2L。
出于研究目的获得和根据Human Tissue Act知情同意获得的，从人类提取的门牙和前磨牙，使用如下方法被置于塑料试管中。试管被切割为大约15mm高。将商购定色剂(Simplex Rapid)按照制造商的说明以2份粉末比1份液体混合。然后，试管被所得溶液完全填满，并静置约10分钟以使定色剂部分沉淀。此时，一个牙根被完全浸渍在定色剂中，使得牙齿的唇侧接近位于试管的前部。定色剂的完全固化在20分钟之后实现。任何暴露的牙本质用清澈的指甲油密封。牙齿储存于水中以防止脱水。
通过混合如下制备第一配制物
| 成分 | ％w/w |
| 甘油 | 69.9 |
| 硅酸钙 | 20.0 |
| 硅酸钙涂覆的TiO2 | 10.0 |
| 黄原胶 | 0.1 |
| 总计 | 100 |
将水和黄原胶加入Esco-Labor 1L混合容器，在65℃下搅拌30分钟，以分散黄原胶。一旦黄原胶被完全分散，缓慢加入剩余的粉末并混合以除去任何团块。
通过混合如下制备第二配制物
配方和加工：用于滴管的活化剂溶液
| 成分 | ％w/w |
| 水 | 95.1 |
| 磷酸三钠 | 1.63 |
| 磷酸一钠 | 1.37 |
| 纤维素胶 | 1.0 |
| 乙基己基甘油 | 0.3 |
| 苯甲醇 | 0.3 |
| 苯氧基乙醇 | 0.3 |
| 总共 | 100 |
将水加入至Esco-Labor 1L混合容器中，随后是Sensiva SC 50、乙氧基乙醇和苯甲醇，混合并分散。随后，通过容器盖中的开口缓慢加入SCMC至容器，混合并分散。
实施例A
通过以50:50重量比单独地混合第一和第二配制物来制备产品浆料。将7g混合物施加至一片10×3.5cm的针织棉织物，制备两个样品。对每个样品，加入5颗人类牙齿，并在37℃下将织物包裹在牙齿样本的周围30分钟。在从织物除去样品后，在40ml水中冲洗并温和地混合1分钟。然后，在模拟口腔液中温育样品5小时。施加过程总共重复5次。经由色度计测试基线处以及条状物应用和温育之后的颜色。将L*a*b*颜色参数转换成WIO白度指数以允许样品之间的比较。颜色变化表示为ΔWIO＝WIO(浆料应用)-WIO(基线)。
实施例1
将7g第二配制物施加至两片10×3.5cm的针织棉织物，并使得在室温下浸渍织物4小时。在使用前即刻，利用移液管将3.5g第一配制物施加至每个织物样品，并用刮刀均匀铺展。对每个样品，加入5颗人类牙齿，并在37℃下将织物包裹在牙齿样本的周围30分钟。在从织物除去样品后，在40ml水中冲洗并温和地混合1分钟。然后，在模拟口腔液中温育样品5小时。施加过程总共重复5次。经由色度计测试基线处以及条状物应用和温育之后的颜色。将L*a*b*颜色参数转换成WIO白度指数以允许样品之间的比较。颜色变化表示为ΔWIO＝WIO(浆料应用)-WIO(基线)。
| 1应用 | 3应用 | 5应用 | |
| 实施例A | 4.75±0.69 | 5.53±1.41 | 16.42±3.31 |
| 实施例1 | 6.11±1.59 | 9.36±1.43 | 18.66±3.43 |
实施例证实了顺序施加组合物至装置(条状物)并将所述条状物施加至牙齿比形成组合物的预混物，施加条状物并将装置施加至牙齿更有效。
Claims (3)
1.美容增白牙齿的方法，其包括如下步骤：
i)选择施加装置，所述施加装置是柔性的和是矩形的；
ii)将包含磷酸盐源的第二组合物施加至所述施加装置的表面，所述第二组合物的磷酸盐源是磷酸三钠和磷酸二氢钠的混合物，其中所述磷酸三钠和磷酸二氢钠的重量比为1:2至2:1，并且所述磷酸盐源占所述第二组合物的4至9重量％；
iii)随后，将包含增白组分和水不溶性和/或微溶性钙源的非水性组合物施加至所述第二组合物所施加至的所述施加装置的相同的表面，所述水不溶性和/或微溶性钙源是硅酸钙，所述非水性组合物的增白组分是被硅酸钙涂覆的二氧化钛，其中，所述钙源占所述非水性组合物的5至20重量％，所述二氧化钛占所述非水性组合物的5至20重量％；
iv)将所述装置处理的表面iii)置于牙齿上以持续接触1至30分钟。
2.如权利要求1所述的方法，其中，所述施加装置具有如下长度的伸长形状，当抵靠使用者牙齿的前表面放置时，延伸跨过多颗牙齿，并且该伸长形状具有如下宽度，以至少从牙齿的牙龈线延伸到牙齿的牙冠。
3.如权利要求1或2所述的方法，其中，从吸收性材料形成所述装置。
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| WO2008017203A1 (en) | 2006-08-01 | 2008-02-14 | Unilever Plc | Biomaterials, their preparation and use |
| CN107308010A (zh) | 2010-09-10 | 2017-11-03 | 荷兰联合利华有限公司 | 复合颗粒活性物及其制造方法 |
| JP2016529300A (ja) * | 2013-09-10 | 2016-09-23 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 口腔ケア組成物 |
-
2016
- 2016-05-05 US US15/572,949 patent/US20180140520A1/en not_active Abandoned
- 2016-05-05 BR BR112017023500-5A patent/BR112017023500B1/pt active IP Right Grant
- 2016-05-05 CN CN201680032922.8A patent/CN107690327B/zh active Active
- 2016-05-05 EP EP16722610.9A patent/EP3302350B1/en active Active
- 2016-05-05 EA EA201792166A patent/EA035881B1/ru not_active IP Right Cessation
- 2016-05-05 WO PCT/EP2016/060126 patent/WO2016192925A1/en active Application Filing
-
2017
- 2017-11-09 PH PH12017502039A patent/PH12017502039A1/en unknown
- 2017-12-04 CL CL2017003084A patent/CL2017003084A1/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
| CN1231596A (zh) * | 1996-09-27 | 1999-10-13 | 埃纳梅隆公司 | 经过改进的用于牙齿再矿化以及防止牙齿发生脱矿质作用的产品及方法 |
| CN101600443A (zh) * | 2006-12-05 | 2009-12-09 | 荷兰联合利华有限公司 | 口腔护理产品 |
| WO2012031786A2 (en) * | 2010-09-10 | 2012-03-15 | Unilever Plc | Oral care compositions for benefiting teeth |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201792166A1 (ru) | 2018-05-31 |
| BR112017023500A2 (pt) | 2018-07-31 |
| US20180140520A1 (en) | 2018-05-24 |
| BR112017023500B1 (pt) | 2022-11-16 |
| WO2016192925A1 (en) | 2016-12-08 |
| EP3302350A1 (en) | 2018-04-11 |
| CN107690327A (zh) | 2018-02-13 |
| PH12017502039A1 (en) | 2018-04-23 |
| EA035881B1 (ru) | 2020-08-26 |
| CL2017003084A1 (es) | 2018-05-11 |
| EP3302350B1 (en) | 2022-07-20 |
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