PL1633365T3 - Makrocykliczne pochodne chinazoliny jako środki przeciwproliferacyjne - Google Patents
Makrocykliczne pochodne chinazoliny jako środki przeciwproliferacyjneInfo
- Publication number
- PL1633365T3 PL1633365T3 PL04739341T PL04739341T PL1633365T3 PL 1633365 T3 PL1633365 T3 PL 1633365T3 PL 04739341 T PL04739341 T PL 04739341T PL 04739341 T PL04739341 T PL 04739341T PL 1633365 T3 PL1633365 T3 PL 1633365T3
- Authority
- PL
- Poland
- Prior art keywords
- antiproliferative agents
- quinazoline derivatives
- macrocyclic quinazoline
- macrocyclic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0305723 | 2003-05-27 | ||
| EP0310266 | 2003-09-15 | ||
| EP0351061 | 2003-12-18 | ||
| PCT/EP2004/005621 WO2004105765A1 (en) | 2003-05-27 | 2004-05-25 | Macrocyclic quinazoline derivatives as antiproliferative agents |
| EP04739341A EP1633365B1 (en) | 2003-05-27 | 2004-05-25 | Macrocyclic quinazoline derivatives as antiproliferative agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1633365T3 true PL1633365T3 (pl) | 2012-07-31 |
Family
ID=33493782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04739341T PL1633365T3 (pl) | 2003-05-27 | 2004-05-25 | Makrocykliczne pochodne chinazoliny jako środki przeciwproliferacyjne |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US7648975B2 (pl) |
| EP (2) | EP2305687A1 (pl) |
| JP (1) | JP4887151B2 (pl) |
| KR (1) | KR101143878B1 (pl) |
| CN (1) | CN102718775B (pl) |
| AR (2) | AR045687A1 (pl) |
| AT (1) | ATE544454T1 (pl) |
| AU (1) | AU2004243487B2 (pl) |
| BR (1) | BRPI0410714B8 (pl) |
| CA (1) | CA2525214C (pl) |
| CL (1) | CL2004001267A1 (pl) |
| CO (1) | CO5640038A2 (pl) |
| CY (1) | CY1113002T1 (pl) |
| DK (1) | DK1633365T3 (pl) |
| EA (1) | EA009064B1 (pl) |
| ES (1) | ES2381976T3 (pl) |
| HK (1) | HK1176350A1 (pl) |
| HR (1) | HRP20120351T1 (pl) |
| IL (3) | IL172154A0 (pl) |
| IS (1) | IS3030B (pl) |
| JO (1) | JO2785B1 (pl) |
| MX (1) | MXPA05012762A (pl) |
| MY (1) | MY148633A (pl) |
| NO (1) | NO334209B1 (pl) |
| NZ (1) | NZ544154A (pl) |
| PA (1) | PA8603801A1 (pl) |
| PL (1) | PL1633365T3 (pl) |
| PT (1) | PT1633365E (pl) |
| SI (1) | SI1633365T1 (pl) |
| TW (3) | TWI379835B (pl) |
| UA (1) | UA84010C2 (pl) |
| WO (1) | WO2004105765A1 (pl) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| WO2005048953A2 (en) * | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Amide derivatives as kinase modulators |
| CA2549869C (en) | 2003-12-18 | 2015-05-05 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents |
| NZ547795A (en) | 2003-12-18 | 2009-07-31 | Janssen Pharmaceutica Nv | 3-Cyano-quinoline derivatives with antiproliferative activity |
| JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| MY169441A (en) | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| BRPI0606905B1 (pt) | 2005-02-23 | 2021-06-01 | Shionogi & Co., Ltd. | Derivados de quinazolina tendo atividade inibitória de tirosina cinase e composição farmacêutica que os compreende |
| GB0509227D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| ES2330789T3 (es) * | 2005-06-30 | 2009-12-15 | Janssen Pharmaceutica Nv | Anilino-piridinotriazinas ciclicas como inhibidores de gsk-3. |
| BRPI0714211B8 (pt) * | 2006-07-13 | 2021-05-25 | Janssen Pharmaceutica Nv | derivados de mtki quinazolina, sua utilização e composição farmacêutica que os compreende |
| JP2009242240A (ja) * | 2006-08-04 | 2009-10-22 | Mebiopharm Co Ltd | 含ホウ素キナゾリン誘導体 |
| SG174774A1 (en) | 2006-09-11 | 2011-10-28 | Curis Inc | Quinazoline based egfr inhibitors containing a zinc binding moiety |
| CA2662587C (en) * | 2006-09-11 | 2013-08-06 | Curis, Inc. | Quinazoline based egfr inhibitors |
| US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CA2664145A1 (en) * | 2006-10-27 | 2008-05-02 | Janssen Pharmaceutica Nv | Use of a mt kinase inhibitor for treating or preventing brain cancer |
| WO2008049904A2 (en) * | 2006-10-27 | 2008-05-02 | Janssen Pharmaceutica Nv | Use of mtki 1 for treating or preventing bone cancer |
| EP2089710B1 (en) | 2006-10-27 | 2014-10-01 | Janssen Pharmaceutica NV | A method for pharmacologically profiling compounds |
| MX2009004436A (es) * | 2006-10-27 | 2009-05-22 | Janssen Pharmaceutica Nv | Derivados de quinazolina macrociclicos como inhibidores del factor de crecimiento endotelial vascular r3. |
| EP2123627B1 (en) * | 2007-01-19 | 2013-11-20 | Ube Industries, Ltd. | Process for producing aromatic amine having aralkyloxy or heteroaralkyloxy group |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US8318731B2 (en) | 2007-07-27 | 2012-11-27 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| US8119616B2 (en) | 2007-09-10 | 2012-02-21 | Curis, Inc. | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CL2008003384A1 (es) * | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
| US8426430B2 (en) | 2008-06-30 | 2013-04-23 | Hutchison Medipharma Enterprises Limited | Quinazoline derivatives |
| WO2010033941A1 (en) | 2008-09-22 | 2010-03-25 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
| US8513263B2 (en) | 2008-10-22 | 2013-08-20 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors |
| US8765727B2 (en) | 2009-01-23 | 2014-07-01 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| TWI406853B (zh) * | 2010-04-07 | 2013-09-01 | Dev Center Biotechnology | Ｅｇｆｒ與ｖｅｇｆｒ－２雙重抑制劑及其用途與製法 |
| CN102971322B (zh) | 2010-05-20 | 2016-02-17 | 阵列生物制药公司 | 作为trk激酶抑制剂的大环化合物 |
| WO2013126015A1 (en) | 2012-02-23 | 2013-08-29 | N. V. Nutricia | Composition comprising non- digestible oligosaccharides |
| WO2013132376A1 (en) * | 2012-03-06 | 2013-09-12 | Pfizer Inc. | Macrocyclic derivatives for the treatment of proliferative diseases |
| CN104513253A (zh) * | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
| CN108892661B (zh) * | 2014-02-07 | 2023-03-14 | 艾克赛特赫拉制药有限责任公司 | 治疗化合物和组合物 |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| HRP20230271T1 (hr) | 2014-11-16 | 2023-06-09 | Array Biopharma, Inc. | Kristalni oblik (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamid hidrogen sulfata |
| JP6740354B2 (ja) | 2015-10-05 | 2020-08-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法 |
| RU2744852C2 (ru) | 2015-10-26 | 2021-03-16 | Локсо Онколоджи, Инк. | Точечные мутации в устойчивых к ингибитору trk злокачественных опухолях и связанные с ними способы |
| AU2017226878B2 (en) * | 2016-02-29 | 2020-07-23 | Oncodesign Precision Medicine (OPM) | Radiolabeled macrocyclic EGFR inhibitor |
| SG11201808559PA (en) | 2016-04-04 | 2018-10-30 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| SI3800189T1 (sl) | 2016-05-18 | 2023-11-30 | Loxo Oncology, Inc. | Priprava (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo (1,5-a)pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| FI3720438T3 (fi) * | 2017-12-07 | 2023-09-01 | Amplyx Pharmaceuticals Inc | Heterosykli-substituoidut pyridiinistä johdetut antifungaaliset aineet |
| EP3810115B1 (en) | 2018-06-25 | 2024-07-17 | Basilea Pharmaceutica International AG, Allschwil | Pyridine derivatives substituted by heterocyclic ring and amino group |
| US20230159556A1 (en) * | 2020-04-20 | 2023-05-25 | Tenova Pharmaceuticals Inc. | Novel protein kinase inhibitors |
| CA3240907A1 (en) | 2021-12-16 | 2023-06-22 | Xiaohu S. OUYANG | Inhibitors of met kinase |
| WO2024017258A1 (zh) * | 2022-07-19 | 2024-01-25 | 百极弘烨(南通)医药科技有限公司 | Egfr小分子抑制剂、含其的药物组合物及其用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE558251A (pl) * | 1956-06-11 | |||
| DE2423536A1 (de) * | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US4066772A (en) * | 1975-07-21 | 1978-01-03 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
| NZ181256A (en) * | 1975-07-21 | 1978-04-28 | Janssen Pharmaceutica Nv | 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives |
| US4110333A (en) | 1976-05-17 | 1978-08-29 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
| US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US6344459B1 (en) | 1996-04-12 | 2002-02-05 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| AU761552B2 (en) * | 1998-10-01 | 2003-06-05 | Astrazeneca Ab | Chemical compounds |
| FR2809400B1 (fr) * | 2000-05-25 | 2004-04-09 | Inst Francais Du Petrole | Materiaux comportant des groupements organiques contenant du soufre et du phosphore lie par l'intermediaire d'atomes d'oxygenes a un oxyde mineral |
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| GB2446974B (en) * | 2006-04-13 | 2009-01-14 | Siemens Magnet Technology Ltd | A solenoidal magnet structure |
-
2004
- 2004-05-24 PA PA20048603801A patent/PA8603801A1/es unknown
- 2004-05-24 JO JO200466A patent/JO2785B1/en active
- 2004-05-25 WO PCT/EP2004/005621 patent/WO2004105765A1/en active Application Filing
- 2004-05-25 EP EP10192741A patent/EP2305687A1/en not_active Withdrawn
- 2004-05-25 CL CL200401267A patent/CL2004001267A1/es unknown
- 2004-05-25 EP EP04739341A patent/EP1633365B1/en not_active Expired - Lifetime
- 2004-05-25 CA CA2525214A patent/CA2525214C/en not_active Expired - Lifetime
- 2004-05-25 MY MYPI20042004A patent/MY148633A/en unknown
- 2004-05-25 PT PT04739341T patent/PT1633365E/pt unknown
- 2004-05-25 BR BRPI0410714A patent/BRPI0410714B8/pt not_active Application Discontinuation
- 2004-05-25 AT AT04739341T patent/ATE544454T1/de active
- 2004-05-25 KR KR1020057022189A patent/KR101143878B1/ko active IP Right Grant
- 2004-05-25 CN CN201210144221.7A patent/CN102718775B/zh not_active Expired - Lifetime
- 2004-05-25 UA UAA200510181A patent/UA84010C2/ru unknown
- 2004-05-25 JP JP2006529915A patent/JP4887151B2/ja not_active Expired - Lifetime
- 2004-05-25 NZ NZ544154A patent/NZ544154A/en unknown
- 2004-05-25 ES ES04739341T patent/ES2381976T3/es not_active Expired - Lifetime
- 2004-05-25 DK DK04739341.8T patent/DK1633365T3/da active
- 2004-05-25 AU AU2004243487A patent/AU2004243487B2/en not_active Expired
- 2004-05-25 EA EA200501866A patent/EA009064B1/ru unknown
- 2004-05-25 US US10/558,007 patent/US7648975B2/en active Active
- 2004-05-25 PL PL04739341T patent/PL1633365T3/pl unknown
- 2004-05-25 MX MXPA05012762A patent/MXPA05012762A/es active IP Right Grant
- 2004-05-25 SI SI200431864T patent/SI1633365T1/sl unknown
- 2004-05-26 AR ARP040101806A patent/AR045687A1/es active IP Right Grant
- 2004-05-26 TW TW093114851A patent/TWI379835B/zh not_active IP Right Cessation
- 2004-05-26 TW TW101115205A patent/TWI468397B/zh not_active IP Right Cessation
- 2004-05-26 TW TW101115204A patent/TWI468372B/zh not_active IP Right Cessation
-
2005
- 2005-10-14 IS IS8077A patent/IS3030B/is unknown
- 2005-11-24 IL IL172154A patent/IL172154A0/en active IP Right Grant
- 2005-11-24 CO CO05119403A patent/CO5640038A2/es active IP Right Grant
- 2005-12-27 NO NO20056196A patent/NO334209B1/no unknown
-
2009
- 2009-11-24 US US12/624,637 patent/US8394786B2/en active Active
-
2012
- 2012-04-19 HR HRP20120351TT patent/HRP20120351T1/hr unknown
- 2012-05-08 CY CY20121100428T patent/CY1113002T1/el unknown
-
2013
- 2013-01-18 US US13/744,878 patent/US9273013B2/en not_active Expired - Lifetime
- 2013-03-12 HK HK13103104.2A patent/HK1176350A1/zh not_active IP Right Cessation
- 2013-08-15 AR ARP130102897A patent/AR092137A2/es unknown
-
2014
- 2014-06-10 IL IL233046A patent/IL233046A0/en active IP Right Grant
- 2014-06-10 IL IL233045A patent/IL233045B/en active IP Right Grant
-
2016
- 2016-01-21 US US15/003,124 patent/US20160207938A1/en not_active Abandoned
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