PL135044B1 - Method of obtaining novel derivatives of benzodiazepine - Google Patents
Method of obtaining novel derivatives of benzodiazepine Download PDFInfo
- Publication number
- PL135044B1 PL135044B1 PL1980231270A PL23127080A PL135044B1 PL 135044 B1 PL135044 B1 PL 135044B1 PL 1980231270 A PL1980231270 A PL 1980231270A PL 23127080 A PL23127080 A PL 23127080A PL 135044 B1 PL135044 B1 PL 135044B1
- Authority
- PL
- Poland
- Prior art keywords
- formula
- carbon atoms
- compounds
- alkyl radical
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7935846 | 1979-10-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL231270A1 PL231270A1 (enExample) | 1981-12-23 |
| PL135044B1 true PL135044B1 (en) | 1985-09-30 |
Family
ID=10508540
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1980231270A PL135044B1 (en) | 1979-10-16 | 1980-10-15 | Method of obtaining novel derivatives of benzodiazepine |
| PL1980227306A PL126824B1 (en) | 1979-10-16 | 1980-10-15 | Method of obtaining new derivatives of benzodiazepine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1980227306A PL126824B1 (en) | 1979-10-16 | 1980-10-15 | Method of obtaining new derivatives of benzodiazepine |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US4404137A (enExample) |
| EP (1) | EP0027390B1 (enExample) |
| JP (1) | JPS5663987A (enExample) |
| KR (2) | KR850000471B1 (enExample) |
| AR (2) | AR228041A1 (enExample) |
| AT (1) | AT373889B (enExample) |
| AU (1) | AU538500B2 (enExample) |
| BE (1) | BE885729A (enExample) |
| BG (2) | BG34907A3 (enExample) |
| CA (1) | CA1159056A (enExample) |
| CH (1) | CH646700A5 (enExample) |
| CS (1) | CS244409B2 (enExample) |
| DD (1) | DD153692A5 (enExample) |
| DE (1) | DE3068706D1 (enExample) |
| DK (1) | DK437480A (enExample) |
| ES (1) | ES8106905A1 (enExample) |
| FI (1) | FI67550C (enExample) |
| FR (1) | FR2467851A1 (enExample) |
| GB (1) | GB8327127D0 (enExample) |
| GR (1) | GR70720B (enExample) |
| HU (1) | HU182213B (enExample) |
| IE (1) | IE50358B1 (enExample) |
| IL (1) | IL61264A (enExample) |
| IT (1) | IT1143047B (enExample) |
| LU (1) | LU82853A1 (enExample) |
| MX (1) | MX6233E (enExample) |
| NZ (1) | NZ195248A (enExample) |
| PH (2) | PH16288A (enExample) |
| PL (2) | PL135044B1 (enExample) |
| PT (1) | PT71913B (enExample) |
| RO (2) | RO85822B (enExample) |
| YU (1) | YU261580A (enExample) |
| ZA (1) | ZA806342B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404137A (en) * | 1979-10-16 | 1983-09-13 | Lilly Industries Limited | Pyrazolo [3,4-b][1,5]benzodiazepine compounds |
| US4431589A (en) * | 1980-12-11 | 1984-02-14 | Lilly House | Benzodiazepine compounds and their use as pharmaceuticals |
| US4596799A (en) * | 1985-01-29 | 1986-06-24 | Ciba-Geigy Corporation | 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines |
| TW219896B (enExample) * | 1988-07-07 | 1994-02-01 | Duphar Int Res | |
| GB8819059D0 (en) * | 1988-08-11 | 1988-09-14 | Lilly Industries Ltd | Benzodiazepine compounds & their use as pharmaceuticals |
| US5637584A (en) * | 1995-03-24 | 1997-06-10 | Eli Lilly And Company | Solvate of olanzapine |
| US5631250A (en) * | 1995-03-24 | 1997-05-20 | Eli Lilly And Company | Process and solvate of 2-methyl-thieno-benzodiazepine |
| NZ541014A (en) * | 2003-01-23 | 2008-05-30 | Acadia Pharm Inc | Use of N-desmethylclozapine to treat schizophrenia while increasing the level of activity of a muscarinic receptor |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| SI1696931T1 (sl) * | 2003-12-22 | 2009-08-31 | Acadia Pharm Inc | Amino substituirani diaril(a,d)cikloheptenski analogi kot muskarinski agonisti in postopki za zdravljenje nevropsihiatričnih motenj |
| WO2006001866A2 (en) * | 2004-04-01 | 2006-01-05 | Acadia Pharmaceuticals Inc. | Crystalline forms of n-desmethylclozapine |
| US20070105836A1 (en) * | 2005-10-31 | 2007-05-10 | Lars Pettersson | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| JP5438482B2 (ja) * | 2009-12-03 | 2014-03-12 | Ｊｕｋｉ株式会社 | ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450694A (en) * | 1966-02-23 | 1969-06-17 | Abbott Lab | Substituted benzoxazepines and benzothiazepines |
| US3758479A (en) * | 1967-03-22 | 1973-09-11 | Sandoz Ag | Nitro and sulphamoyl substituted dibenzodiazepines |
| DE1795183B1 (de) * | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel |
| CA918659A (en) * | 1969-07-31 | 1973-01-09 | Yoshitomi Pharmaceutical Industries | 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines |
| US4172831A (en) * | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
| US4115568A (en) * | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
| US3951981A (en) * | 1975-02-24 | 1976-04-20 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US3953430A (en) * | 1975-02-24 | 1976-04-27 | American Cyanamid Company | Substituted benzodiazepin-10-ones and method of use |
| DE2707270A1 (de) * | 1977-02-19 | 1978-08-24 | Hoechst Ag | Pyrazolo-diazepine und verfahren zu ihrer herstellung |
| DE2707269A1 (de) * | 1977-02-19 | 1978-08-24 | Hoechst Ag | Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung |
| US4097597A (en) * | 1977-02-23 | 1978-06-27 | Abbott Laboratories | Dibenzo b,e! 1,4!diazepines |
| IT7851496A0 (it) * | 1977-10-31 | 1978-10-13 | Sandoz Ag | Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica |
| CH643263A5 (de) * | 1979-05-11 | 1984-05-30 | Sandoz Ag | Benzodiazepine, ihre herstellung und verwendung. |
| EP0023707B1 (de) * | 1979-08-03 | 1986-04-30 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte Tetraazatricyclen, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel |
| US4404137A (en) * | 1979-10-16 | 1983-09-13 | Lilly Industries Limited | Pyrazolo [3,4-b][1,5]benzodiazepine compounds |
-
1980
- 1980-10-02 US US06/193,200 patent/US4404137A/en not_active Expired - Lifetime
- 1980-10-11 GR GR63138A patent/GR70720B/el unknown
- 1980-10-13 FR FR8021823A patent/FR2467851A1/fr active Granted
- 1980-10-13 NZ NZ195248A patent/NZ195248A/xx unknown
- 1980-10-13 RO RO108967A patent/RO85822B/ro unknown
- 1980-10-13 CS CS806938A patent/CS244409B2/cs unknown
- 1980-10-13 IL IL61264A patent/IL61264A/xx unknown
- 1980-10-13 RO RO102349A patent/RO81351B/ro unknown
- 1980-10-13 PH PH24717A patent/PH16288A/en unknown
- 1980-10-13 YU YU02615/80A patent/YU261580A/xx unknown
- 1980-10-13 MX MX809093U patent/MX6233E/es unknown
- 1980-10-14 AU AU63252/80A patent/AU538500B2/en not_active Ceased
- 1980-10-14 CA CA000362328A patent/CA1159056A/en not_active Expired
- 1980-10-14 CH CH763980A patent/CH646700A5/fr not_active IP Right Cessation
- 1980-10-14 IT IT49899/80A patent/IT1143047B/it active
- 1980-10-14 AT AT0510180A patent/AT373889B/de not_active IP Right Cessation
- 1980-10-14 PT PT71913A patent/PT71913B/pt unknown
- 1980-10-15 FI FI803253A patent/FI67550C/fi not_active IP Right Cessation
- 1980-10-15 HU HU802502A patent/HU182213B/hu not_active IP Right Cessation
- 1980-10-15 ES ES495948A patent/ES8106905A1/es not_active Expired
- 1980-10-15 ZA ZA00806342A patent/ZA806342B/xx unknown
- 1980-10-15 EP EP80303649A patent/EP0027390B1/en not_active Expired
- 1980-10-15 KR KR1019800003960A patent/KR850000471B1/ko not_active Expired
- 1980-10-15 LU LU82853A patent/LU82853A1/fr unknown
- 1980-10-15 DD DD80224618A patent/DD153692A5/de unknown
- 1980-10-15 JP JP14423180A patent/JPS5663987A/ja active Pending
- 1980-10-15 PL PL1980231270A patent/PL135044B1/pl unknown
- 1980-10-15 PL PL1980227306A patent/PL126824B1/pl unknown
- 1980-10-15 DE DE8080303649T patent/DE3068706D1/de not_active Expired
- 1980-10-15 BG BG049366A patent/BG34907A3/xx unknown
- 1980-10-15 BE BE6/47291A patent/BE885729A/fr not_active IP Right Cessation
- 1980-10-15 DK DK437480A patent/DK437480A/da not_active Application Discontinuation
- 1980-10-15 IE IE2135/80A patent/IE50358B1/en unknown
- 1980-10-15 BG BG057344A patent/BG35042A3/xx unknown
- 1980-10-16 AR AR282893A patent/AR228041A1/es active
-
1982
- 1982-07-21 AR AR290034A patent/AR228101A1/es active
- 1982-07-28 PH PH27643A patent/PH17759A/en unknown
- 1982-09-29 US US06/426,580 patent/US4486591A/en not_active Expired - Fee Related
-
1983
- 1983-10-11 GB GB838327127A patent/GB8327127D0/en active Pending
-
1984
- 1984-07-24 KR KR1019840004388A patent/KR850000472B1/ko not_active Expired
- 1984-08-06 US US06/638,181 patent/US4542131A/en not_active Expired - Fee Related
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