PL119715B1 - Process for preparing novel 6-keto-7-dimethylaminomethylen-decahydroquinolinesekagidrokhinolinov - Google Patents

Process for preparing novel 6-keto-7-dimethylaminomethylen-decahydroquinolinesekagidrokhinolinov

Info

Publication number
PL119715B1
PL119715B1 PL1979225531A PL22553179A PL119715B1 PL 119715 B1 PL119715 B1 PL 119715B1 PL 1979225531 A PL1979225531 A PL 1979225531A PL 22553179 A PL22553179 A PL 22553179A PL 119715 B1 PL119715 B1 PL 119715B1
Authority
PL
Poland
Prior art keywords
group
formula
keto
carbon atoms
compound
Prior art date
Application number
PL1979225531A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL119715B1 publication Critical patent/PL119715B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
PL1979225531A 1979-01-22 1979-06-29 Process for preparing novel 6-keto-7-dimethylaminomethylen-decahydroquinolinesekagidrokhinolinov PL119715B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US506179A 1979-01-22 1979-01-22
US06/031,641 US4198415A (en) 1979-01-22 1979-04-19 Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines

Publications (1)

Publication Number Publication Date
PL119715B1 true PL119715B1 (en) 1982-01-30

Family

ID=26673868

Family Applications (4)

Application Number Title Priority Date Filing Date
PL1979225531A PL119715B1 (en) 1979-01-22 1979-06-29 Process for preparing novel 6-keto-7-dimethylaminomethylen-decahydroquinolinesekagidrokhinolinov
PL1979225532A PL120037B1 (en) 1979-01-22 1979-06-29 Process for preparing novel 6-ketodecahydroquinolines
PL1979225533A PL119785B1 (en) 1979-01-22 1979-06-29 Method of manufacture of novel 6-hydroxydecahydroquinolines
PL1979216719A PL122153B1 (en) 1979-01-22 1979-06-29 Process for preparing novel octahydropyrazolo-/3,4-g/ quinolinesnov

Family Applications After (3)

Application Number Title Priority Date Filing Date
PL1979225532A PL120037B1 (en) 1979-01-22 1979-06-29 Process for preparing novel 6-ketodecahydroquinolines
PL1979225533A PL119785B1 (en) 1979-01-22 1979-06-29 Method of manufacture of novel 6-hydroxydecahydroquinolines
PL1979216719A PL122153B1 (en) 1979-01-22 1979-06-29 Process for preparing novel octahydropyrazolo-/3,4-g/ quinolinesnov

Country Status (25)

Country Link
US (1) US4198415A (enExample)
EP (2) EP0013787B1 (enExample)
AT (1) AT371819B (enExample)
AU (1) AU528076B2 (enExample)
CA (1) CA1136140A (enExample)
CH (3) CH644377A5 (enExample)
DD (5) DD148517A5 (enExample)
DE (2) DE2966951D1 (enExample)
DK (1) DK268879A (enExample)
EG (1) EG14696A (enExample)
ES (4) ES482089A1 (enExample)
FI (1) FI65247C (enExample)
FR (5) FR2446832A1 (enExample)
GB (4) GB2040915B (enExample)
GR (1) GR72516B (enExample)
IE (1) IE48394B1 (enExample)
IL (1) IL57668A (enExample)
LU (1) LU81439A1 (enExample)
MY (1) MY8500683A (enExample)
NZ (2) NZ190835A (enExample)
PH (3) PH14909A (enExample)
PL (4) PL119715B1 (enExample)
PT (1) PT69829A (enExample)
RO (2) RO77563A (enExample)
ZA (1) ZA793243B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65269A0 (en) * 1981-03-24 1982-05-31 Lilly Co Eli 6-substituted hexahydroindazolo or hexahydroisoindolo isoquinolines
US4540787A (en) * 1982-06-03 1985-09-10 Eli Lilly And Company Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines
US4567266A (en) * 1982-11-03 1986-01-28 Eli Lilly And Company Method of preparing octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines
US4471121A (en) * 1982-11-03 1984-09-11 Eli Lilly And Company Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof
US4468401A (en) * 1982-11-03 1984-08-28 Eli Lilly And Company Method of blocking peripheral norepinephrine release
ES8504174A1 (es) * 1982-11-03 1985-04-16 Lilly Co Eli Un procedimiento para la preparacion de derivados de pirazolo-quinolinas.
US4647667A (en) * 1982-11-03 1987-03-03 Eli Lilly And Company Octa- and deca-hydroquinoline intermediates
DE3373468D1 (de) * 1983-06-03 1987-10-15 Lilly Co Eli Trans-dl-1-alkyl-6-alkoxyoctahydroquinolines
US4626591A (en) * 1983-08-10 1986-12-02 Eli Lilly And Company Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines
IL73001A0 (en) * 1983-09-26 1984-12-31 Lilly Co Eli Improvements in and relating to 6-oxodecahydroquinolines
US4521421A (en) * 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
US4528290A (en) * 1984-01-30 1985-07-09 Eli Lilly And Company Stimulating dopamine D-1 receptors
CA1270488A (en) * 1983-09-26 1990-06-19 John M. Schaus Pyrazole-ring alkylated pyrazoloquinolines and intermediates
IL72730A (en) * 1983-09-26 1987-10-30 Lilly Co Eli Octahydro-2-pyrimido(4,5-g)quinolinamines,their preparation and pharmaceutical compositions containing them
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
US4507478A (en) * 1983-09-26 1985-03-26 Eli Lilly And Company 2-Mercaptopyrimidohexahydroquinolines and related compounds
US4587351A (en) * 1984-04-18 1986-05-06 Eli Lilly And Company Synthesis of ketones with calcium hypochlorite
US4689415A (en) * 1984-04-18 1987-08-25 Eli Lilly And Company Trans octahydroquinoline intermediate
US4537893A (en) * 1984-04-27 1985-08-27 Eli Lilly And Company Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors
GR851895B (enExample) * 1984-08-02 1985-12-03 Lilly Co Eli
US4600777A (en) * 1984-08-02 1986-07-15 Eli Lilly And Company Method of preparing 1-alkyl-7-oxodecahydroquinolines, and cis(±) and tran(±)isomers so prepared
GR851893B (enExample) * 1984-08-03 1985-12-03 Lilly Co Eli
US4537964A (en) * 1984-08-03 1985-08-27 Eli Lilly And Company Method of preparing permissibly-substituted 1H(and 2H)pyrazolo[3,4-g]quinolines; pyrimido[4,5,g]quinolines; thiazolo[4,5,g]quinolines and intermediates therefore
US4537965A (en) * 1984-08-03 1985-08-27 Eli Lilly And Company Method of preparing 4aR,8aR-5-permissibly substituted-6-oxo-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines, useful as intermediates
US4587336A (en) * 1984-08-15 1986-05-06 Eli Lilly And Company Partially hydrogenated intermediate pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
US4552956A (en) * 1984-08-15 1985-11-12 Eli Lilly And Company Partially hydrogenated pyrazolo, pyrimido and thiazolo[1,4]benzoxazines
FR2578254B1 (fr) * 1985-03-01 1987-03-06 Roussel Uclaf Nouveaux derives de la pyrazolobenzoxazine, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant, et des intermediaires
US4595754A (en) * 1985-03-04 1986-06-17 Eli Lilly And Company Process for preparing cis N-alkylperhydroquinolines
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4622398A (en) * 1985-06-24 1986-11-11 Eli Lilly And Company Dialkylaminotetrahydroquinazoline
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
US5134143A (en) * 1986-06-16 1992-07-28 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US4977160A (en) * 1986-06-16 1990-12-11 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US4762843A (en) * 1986-09-15 1988-08-09 Warner-Lambert Company Hetero [f] fused carbocyclic pyridines as dopaminergic agents
US5006525A (en) * 1989-07-24 1991-04-09 Eli Lilly And Company Dopamine agonists method
US5057515A (en) * 1989-07-24 1991-10-15 Eli Lilly And Company Method for agonizing a dopamine receptor
US4939259A (en) * 1989-07-24 1990-07-03 Eli Lilly And Company 2-oxo-pyrido[2,3-g]quinoline derivatives
US4977149A (en) * 1989-07-24 1990-12-11 Eli Lilly And Company Pyridoquinoline dopamine agonists, compositions and use
JPH0772175B2 (ja) * 1990-09-28 1995-08-02 フアイザー・インコーポレイテツド 窒素含有非芳香族複素環の縮合環類似体
US5416090A (en) * 1991-01-31 1995-05-16 Eli Lilly And Company Method of treating inflammation
US20030212085A1 (en) * 2001-04-17 2003-11-13 Mccall Robert B. Treatment of fibromyalgia and chronic fatigue syndrome
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
CN115768772A (zh) 2020-04-03 2023-03-07 弗特克斯药品有限公司 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1抗胰蛋白酶调节剂的吡喃并[4,3-b]L吲哚衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084165A (en) * 1959-05-21 1963-04-02 Bayer Ag Quinone derivatives and processes for producing the same
US3600393A (en) * 1969-03-03 1971-08-17 Aldrich Chem Co Inc Dialkylamino alkylamino pyrazolo (3,4b) quinolines
US3859291A (en) * 1973-10-01 1975-01-07 Morton Norwich Products Inc 9-(p-anisidino)-7-methyl-(1h)-pyrazolo(3,4-f)quinoline
US4028381A (en) * 1975-05-05 1977-06-07 Ciba-Geigy Corporation Pyrazolobenzazepines

Also Published As

Publication number Publication date
EP0013787A1 (en) 1980-08-06
FR2446834A1 (fr) 1980-08-14
RO77563A (ro) 1981-11-04
CH644377A5 (fr) 1984-07-31
ZA793243B (en) 1981-02-25
GB2040915B (en) 1983-05-11
DE2966951D1 (en) 1984-06-07
GB2092579A (en) 1982-08-18
DD144670A5 (de) 1980-10-29
FR2446832B1 (enExample) 1983-08-05
GR72516B (enExample) 1983-11-16
DD148517A5 (de) 1981-05-27
US4198415A (en) 1980-04-15
AU4844579A (en) 1980-07-31
FR2446822B1 (enExample) 1981-10-02
FR2446820A1 (fr) 1980-08-14
PL119785B1 (en) 1982-01-30
EP0013787B1 (en) 1984-05-02
PL122153B1 (en) 1982-06-30
GB2092580A (en) 1982-08-18
PL120037B1 (en) 1982-02-27
IL57668A (en) 1983-06-15
GB2092581A (en) 1982-08-18
DD148339A5 (de) 1981-05-20
ES482091A1 (es) 1980-04-01
DE2966945D1 (de) 1984-05-30
DD148518A5 (de) 1981-05-27
PH14909A (en) 1982-01-29
FR2446834B1 (enExample) 1982-03-05
ES482087A1 (es) 1980-04-01
GB2040915A (en) 1980-09-03
MY8500683A (en) 1985-12-31
DD148340A5 (de) 1981-05-20
EP0050881B1 (en) 1984-04-25
LU81439A1 (fr) 1979-09-12
DK268879A (da) 1980-07-23
NZ201279A (en) 1984-07-06
CH644607A5 (fr) 1984-08-15
PH14908A (en) 1982-01-29
CH644365A5 (fr) 1984-07-31
RO82159A (ro) 1983-07-07
IL57668A0 (en) 1979-10-31
EP0050881A1 (en) 1982-05-05
RO82159B (ro) 1983-06-30
FI65247B (fi) 1983-12-30
ES482090A1 (es) 1980-04-01
ATA452479A (de) 1982-12-15
FR2446822A1 (fr) 1980-08-14
IE48394B1 (en) 1985-01-09
FR2446832A1 (fr) 1980-08-14
NZ190835A (en) 1984-07-06
EG14696A (en) 1986-09-30
CA1136140A (en) 1982-11-23
GB2092580B (en) 1983-08-03
FI65247C (fi) 1984-04-10
AU528076B2 (en) 1983-04-14
AT371819B (de) 1983-08-10
PT69829A (en) 1979-07-01
FI792046A7 (fi) 1980-07-23
PL216719A1 (enExample) 1980-06-16
FR2446821A1 (fr) 1980-08-14
ES482089A1 (es) 1980-08-01
IE791209L (en) 1980-07-22
PH14991A (en) 1982-03-12

Similar Documents

Publication Publication Date Title
PL119715B1 (en) Process for preparing novel 6-keto-7-dimethylaminomethylen-decahydroquinolinesekagidrokhinolinov
USRE32518E (en) Camptothecin derivatives
US4778891A (en) Certain pyrano (3,4-f)-indolizine derivatives
CA2112129C (en) Oxazolidine derivative and pharmaceutically acceptable salt thereof
KR920010048B1 (ko) 광학 활성 피리도벤즈옥사진 유도체 및 이의 중간체의 제조방법
EP0200739B1 (en) Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A (en) Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
SU508193A3 (ru) Способ получени -(метоксиметил-фурилметил)-6,7-бензоморфанов или-морфинанов
SU651704A3 (ru) Способ получени производных дибензоциклогептена, рацемических или оптически активных, или их солей
WO1992018507A1 (en) Anti-tumor and anti-psoriatic agents
CN1082509C (zh) 从马比木分离的喜树碱骨架化合物及其作为新药物及治疗剂的合成子的用途
JP2991348B2 (ja) ７−（ジフェニルメチル）オキシ−９ａ−メトキシマイトサン並びにその製造及び使用
DE2700234A1 (de) Organische verbindungen und verfahren zu deren herstellung
KR840002068B1 (ko) 1-치환된-3-에톡시카보닐-6-옥소 데카하이드로퀴놀린의 제조방법
O'Malley et al. Regiocontrolled reactions of 7-desacetylforskolin. 2. Synthesis of 6-and 7-carbamate derivatives
US4668822A (en) Method for preparing (+)S-2--hydroxy-2-methyl-hexanoic acid
SU576043A3 (ru) Способ получени -оксиметил-2-нитроимидазола
CS227014B2 (cs) Způsob přípravy derivátů dekahydrochinolinu
US5202334A (en) Pyrazolo[1,5-a]pyridine compounds, and production and use thereof
US4921978A (en) Process for the preparation of a macrolide compound
IE48396B1 (en) 6(oxo-or hydroxy-)decahydroquinolines
CA1243021A (en) Tricyclic quinoline derivatives
EP0139265A2 (en) Imidazolidine prostaglandins
US4390703A (en) Intermediates for the resolution of some interphenylene-9-thia-11-oxo-12-azaprostanoic acids
HU179080B (en) Process for producing new 1,4-dithiepino-square bracket-2,3-c-square bracket closed-pyrrole derivatives