PH27437A - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
PH27437A
PH27437A PH37977A PH37977A PH27437A PH 27437 A PH27437 A PH 27437A PH 37977 A PH37977 A PH 37977A PH 37977 A PH37977 A PH 37977A PH 27437 A PH27437 A PH 27437A
Authority
PH
Philippines
Prior art keywords
phenyl
lower alkyl
alkyl
alkoxy
formula
Prior art date
Application number
PH37977A
Other languages
English (en)
Inventor
Terence James Ward
Janet Christine White
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878730193A external-priority patent/GB8730193D0/en
Priority claimed from GB888819728A external-priority patent/GB8819728D0/en
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of PH27437A publication Critical patent/PH27437A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH37977A 1987-12-24 1988-12-23 Heterocyclic compounds PH27437A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878730193A GB8730193D0 (en) 1987-12-24 1987-12-24 Heterocyclic compounds
GB888819728A GB8819728D0 (en) 1988-08-19 1988-08-19 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
PH27437A true PH27437A (en) 1993-07-02

Family

ID=26293248

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37977A PH27437A (en) 1987-12-24 1988-12-23 Heterocyclic compounds

Country Status (18)

Country Link
US (2) US4983600A (sv)
EP (2) EP0361629B1 (sv)
JP (1) JP2588265B2 (sv)
KR (1) KR970009588B1 (sv)
AT (2) ATE67200T1 (sv)
AU (1) AU611976B2 (sv)
CA (1) CA1334095C (sv)
DE (2) DE3864807D1 (sv)
DK (2) DK710488A (sv)
ES (2) ES2053959T3 (sv)
FI (1) FI95031C (sv)
GB (1) GB2213816B (sv)
GR (1) GR3002701T3 (sv)
HU (1) HU204267B (sv)
IE (2) IE62231B1 (sv)
IL (1) IL88644A (sv)
PH (1) PH27437A (sv)
PT (1) PT89286B (sv)

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GB8922622D0 (en) * 1989-10-07 1989-11-22 Wyeth John & Brother Ltd Aroylureas
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DE4009565A1 (de) * 1990-03-24 1991-09-26 Merck Patent Gmbh Indolderivate
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US5140023A (en) * 1990-04-27 1992-08-18 G. D. Searle & Co. Azatetracycle compounds
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US5227377A (en) * 1991-03-07 1993-07-13 G. D. Searle & Co. Meso-azacyclic amides of certain bicyclic carboxylic acids
US5516782A (en) * 1991-03-07 1996-05-14 G. D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
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GB9217629D0 (en) * 1992-08-19 1992-09-30 Wyeth John & Brother Ltd Aroylureas
GB2269747B (en) * 1992-08-19 1996-06-05 Wyeth John & Brother Ltd Aroyl-ureas as pharmaceuticals, particularly 5-ht3 antagonists
GB9224144D0 (en) * 1992-11-18 1993-01-06 Erba Carlo Spa Phenyl-imidazolidinone derivatives and process for their preparation
GB9314174D0 (en) * 1993-07-08 1993-08-18 American Home Prod 5-ht3-antagonists
CA2249410C (en) * 1996-03-20 2007-06-12 Wake Forest University Sigma-2 receptors as biomarkers of tumor cell proliferation
US6676925B1 (en) * 1996-03-20 2004-01-13 Wake Forest University Sigma-2 receptors as biomarkers of tumor cell proliferation
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6669925B1 (en) 2000-04-27 2003-12-30 Wake Forest University Sigma-2 receptors as biomarkers of tumor cell proliferation
AU2001282873A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6479510B2 (en) 2000-08-18 2002-11-12 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
AU2001282875A1 (en) 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
JP2005504058A (ja) 2001-08-24 2005-02-10 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 疾患の治療のための置換ヘテロアリール−７−アザ［２．２．１］ビシクロヘプタン
EP1419162A1 (en) * 2001-08-24 2004-05-19 Pharmacia &amp; Upjohn Company Substituted-aryl 7-aza 2.2.1]bicycloheptanes for the treatment of disease
CA2460075A1 (en) * 2001-09-12 2003-03-20 Donn Gregory Wishka Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases
IL160884A0 (en) 2001-10-02 2004-08-31 Upjohn Co Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
CA2464194A1 (en) * 2001-10-26 2003-05-08 Pharmacia & Upjohn Company N-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists
MXPA04004464A (es) * 2001-11-08 2004-08-11 Upjohn Co Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
BR0214016A (pt) 2001-11-09 2004-10-13 Upjohn Co Compostos azabicìclico-fenil-fundido heterocìclicos e seu uso como ligandos alfa 7 nachr
BR0307714A (pt) 2002-02-15 2005-02-09 Upjohn Co Benzoilamidas substituìdas com azabiciclo e tioamidas para tratamento de distúrbios relacionados ao cns
AU2003217275A1 (en) * 2002-02-19 2003-09-09 Pharmacia And Upjohn Company Azabicyclic compounds for the treatment of disease
AU2003219690A1 (en) * 2002-02-19 2003-09-09 Pharmacia And Upjohn Company Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
EP1478646A1 (en) * 2002-02-20 2004-11-24 PHARMACIA &amp; UPJOHN COMPANY Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
EP1542999A1 (en) * 2002-08-01 2005-06-22 Pharmacia & Upjohn Company LLC 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
CA2503786A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases
JPWO2005099698A1 (ja) * 2004-04-15 2008-03-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定化された４−アミノ−５−クロロ−Ｎ−［（１Ｒ，３ｒ，５Ｓ）−８−メチル−８−アザビシクロ［３．２．１］オクタ−３−イル］−２−［１−メチルブタ−２−インイルオキシ］ベンズアミド含有組成物
CR20190034A (es) 2011-03-18 2019-05-20 Genzyme Corp INHIBIDORES DE GLUCOSILCERAMIDA SINTASA (Divisional 2013-0471)
JOP20130273B1 (ar) 2012-09-11 2021-08-17 Genzyme Corp مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
CA3186766A1 (en) 2020-07-24 2022-01-27 Danielle Combessis Pharmaceutical compositions comprising venglustat

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Also Published As

Publication number Publication date
GB2213816B (en) 1991-05-08
HUT53101A (en) 1990-09-28
EP0323077B1 (en) 1991-09-11
DE3850255T2 (de) 1994-09-22
KR970009588B1 (ko) 1997-06-14
GB2213816A (en) 1989-08-23
PT89286B (pt) 1994-11-30
PT89286A (pt) 1989-12-29
DK710488A (da) 1989-06-25
HU204267B (en) 1991-12-30
ES2053959T3 (es) 1994-08-01
ATE107304T1 (de) 1994-07-15
DE3850255D1 (de) 1994-07-21
ATE67200T1 (de) 1991-09-15
EP0361629B1 (en) 1994-06-15
IE883661L (en) 1989-05-24
DK82793A (da) 1993-07-08
DE3864807D1 (de) 1991-10-17
AU2670288A (en) 1989-06-29
CA1334095C (en) 1995-01-24
FI885917A (sv) 1989-06-25
GB8829164D0 (en) 1989-01-25
US4983600A (en) 1991-01-08
FI95031C (sv) 1995-12-11
DK710488D0 (da) 1988-12-20
IL88644A0 (en) 1989-07-31
EP0361629A2 (en) 1990-04-04
JPH01203365A (ja) 1989-08-16
EP0361629A3 (en) 1990-06-13
IE881029L (en) 1989-06-24
KR890009923A (ko) 1989-08-04
US5106843A (en) 1992-04-21
EP0323077A1 (en) 1989-07-05
IL88644A (en) 1993-05-13
IE62231B1 (en) 1995-01-11
FI95031B (sv) 1995-08-31
GR3002701T3 (en) 1993-01-25
ES2051867T3 (es) 1994-07-01
DK82793D0 (da) 1993-07-08
IE63474B1 (en) 1995-04-19
AU611976B2 (en) 1991-06-27
JP2588265B2 (ja) 1997-03-05

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