PH27118A - Anticonvulsant compounds - Google Patents
Anticonvulsant compounds Download PDFInfo
- Publication number
- PH27118A PH27118A PH40399A PH40399A PH27118A PH 27118 A PH27118 A PH 27118A PH 40399 A PH40399 A PH 40399A PH 40399 A PH40399 A PH 40399A PH 27118 A PH27118 A PH 27118A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- difluoro
- pharmaceutically
- formula
- alpyridine
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 56
- 239000001961 anticonvulsive agent Substances 0.000 title description 9
- 229960003965 antiepileptics Drugs 0.000 title description 7
- 230000001773 anti-convulsant effect Effects 0.000 title description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000008194 pharmaceutical composition Chemical class 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 150000001412 amines Chemical class 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- PQIOSYKVBBWRRI-UHFFFAOYSA-N methylphosphonyl difluoride Chemical group CP(F)(F)=O PQIOSYKVBBWRRI-UHFFFAOYSA-N 0.000 claims description 4
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 abstract 1
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- 150000003230 pyrimidines Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 208000014155 speech-language disorder-1 Diseases 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 description 1
- 150000008523 triazolopyridines Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898909136A GB8909136D0 (en) | 1989-04-21 | 1989-04-21 | Anticonvulsant pyridines and analogues thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27118A true PH27118A (en) | 1993-03-16 |
Family
ID=10655494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH40399A PH27118A (en) | 1989-04-21 | 1990-04-19 | Anticonvulsant compounds |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0399653B1 (de) |
| JP (1) | JP2865367B2 (de) |
| KR (1) | KR0183972B1 (de) |
| AT (1) | ATE113046T1 (de) |
| CA (1) | CA2015047A1 (de) |
| CY (1) | CY2003B1 (de) |
| DD (1) | DD293823A5 (de) |
| DE (1) | DE69013396T2 (de) |
| DK (1) | DK0399653T3 (de) |
| ES (1) | ES2062351T3 (de) |
| FI (1) | FI93448C (de) |
| GB (1) | GB8909136D0 (de) |
| HK (1) | HK78397A (de) |
| HU (2) | HU206210B (de) |
| IE (1) | IE67335B1 (de) |
| IL (1) | IL94150A (de) |
| LV (1) | LV5780B4 (de) |
| NZ (1) | NZ233404A (de) |
| PH (1) | PH27118A (de) |
| PT (1) | PT93822B (de) |
| ZA (1) | ZA903021B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU755855B2 (en) * | 1998-06-16 | 2002-12-19 | Merck Sharp & Dohme Limited | Triazolo-pyridine derivatives as ligands for GABA receptors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929812A (en) * | 1974-05-20 | 1975-12-30 | Squibb & Sons Inc | Derivatives of 1H-triazolo {8 4,5-c{9 pyridine-7-carboxylic acids and esters |
| EP0288431B1 (de) * | 1987-04-07 | 1992-08-19 | Ciba-Geigy Ag | 3H-1,2,3-Triazolo[4,5-d]pyrimidine |
-
1989
- 1989-04-21 GB GB898909136A patent/GB8909136D0/en active Pending
-
1990
- 1990-04-19 PH PH40399A patent/PH27118A/en unknown
- 1990-04-20 JP JP2105156A patent/JP2865367B2/ja not_active Expired - Lifetime
- 1990-04-20 DE DE69013396T patent/DE69013396T2/de not_active Expired - Fee Related
- 1990-04-20 EP EP90304271A patent/EP0399653B1/de not_active Expired - Lifetime
- 1990-04-20 AT AT90304271T patent/ATE113046T1/de not_active IP Right Cessation
- 1990-04-20 DD DD90339946A patent/DD293823A5/de not_active IP Right Cessation
- 1990-04-20 ES ES90304271T patent/ES2062351T3/es not_active Expired - Lifetime
- 1990-04-20 FI FI901981A patent/FI93448C/fi not_active IP Right Cessation
- 1990-04-20 IL IL9415090A patent/IL94150A/en not_active IP Right Cessation
- 1990-04-20 CA CA002015047A patent/CA2015047A1/en not_active Abandoned
- 1990-04-20 NZ NZ233404A patent/NZ233404A/en unknown
- 1990-04-20 IE IE140990A patent/IE67335B1/en not_active IP Right Cessation
- 1990-04-20 KR KR1019900005523A patent/KR0183972B1/ko not_active IP Right Cessation
- 1990-04-20 DK DK90304271.1T patent/DK0399653T3/da active
- 1990-04-20 PT PT93822A patent/PT93822B/pt not_active IP Right Cessation
- 1990-04-20 ZA ZA903021A patent/ZA903021B/xx unknown
- 1990-04-20 HU HU902502A patent/HU206210B/hu not_active IP Right Cessation
-
1995
- 1995-05-11 HU HU95P/P00126P patent/HU211137A9/hu unknown
-
1996
- 1996-07-17 LV LV960252A patent/LV5780B4/xx unknown
-
1997
- 1997-06-12 HK HK78397A patent/HK78397A/xx not_active IP Right Cessation
-
1998
- 1998-04-30 CY CY9802003A patent/CY2003B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR0183972B1 (ko) | 1999-05-01 |
| FI901981A0 (fi) | 1990-04-20 |
| AU626409B2 (en) | 1992-07-30 |
| HU902502D0 (en) | 1990-08-28 |
| IE901409L (en) | 1990-10-21 |
| NZ233404A (en) | 1992-08-26 |
| GB8909136D0 (en) | 1989-06-07 |
| LV5780A4 (lv) | 1996-12-20 |
| HU206210B (en) | 1992-09-28 |
| DE69013396D1 (de) | 1994-11-24 |
| EP0399653A1 (de) | 1990-11-28 |
| DK0399653T3 (da) | 1994-11-14 |
| FI93448B (fi) | 1994-12-30 |
| PT93822B (pt) | 1996-09-30 |
| CY2003B1 (en) | 1998-04-30 |
| EP0399653B1 (de) | 1994-10-19 |
| KR900016208A (ko) | 1990-11-12 |
| AU5372290A (en) | 1990-10-25 |
| IE67335B1 (en) | 1996-03-20 |
| CA2015047A1 (en) | 1990-10-21 |
| LV5780B4 (lv) | 1997-04-20 |
| ES2062351T3 (es) | 1994-12-16 |
| HU211137A9 (en) | 1995-10-30 |
| ATE113046T1 (de) | 1994-11-15 |
| IL94150A (en) | 1994-02-27 |
| IL94150A0 (en) | 1991-01-31 |
| PT93822A (pt) | 1990-11-20 |
| HUT53905A (en) | 1990-12-28 |
| HK78397A (en) | 1997-06-20 |
| DE69013396T2 (de) | 1995-05-04 |
| JP2865367B2 (ja) | 1999-03-08 |
| JPH02292286A (ja) | 1990-12-03 |
| FI93448C (fi) | 1995-04-10 |
| ZA903021B (en) | 1991-12-24 |
| DD293823A5 (de) | 1991-09-12 |
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