PH26374A - Extraction and purification on an anticoagulant principle from the South American leech haementeria ghilianii - Google Patents
Extraction and purification on an anticoagulant principle from the South American leech haementeria ghilianii Download PDFInfo
- Publication number
- PH26374A PH26374A PH38801A PH38801A PH26374A PH 26374 A PH26374 A PH 26374A PH 38801 A PH38801 A PH 38801A PH 38801 A PH38801 A PH 38801A PH 26374 A PH26374 A PH 26374A
- Authority
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- Philippines
- Prior art keywords
- factor
- activity
- anticoagulant
- resin
- ghilianii
- Prior art date
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- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/207,415 US4832849A (en) | 1988-06-16 | 1988-06-16 | Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26374A true PH26374A (en) | 1992-06-01 |
Family
ID=22770459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH38801A PH26374A (en) | 1988-06-16 | 1989-06-15 | Extraction and purification on an anticoagulant principle from the South American leech haementeria ghilianii |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4832849A (ko) |
| EP (1) | EP0346894B1 (ko) |
| JP (1) | JPH02138300A (ko) |
| KR (1) | KR910000171A (ko) |
| CN (1) | CN1034335C (ko) |
| AR (1) | AR244702A1 (ko) |
| AT (1) | ATE118013T1 (ko) |
| AU (1) | AU621124B2 (ko) |
| CA (1) | CA1335666C (ko) |
| DE (1) | DE68920915T2 (ko) |
| DK (1) | DK295589A (ko) |
| ES (1) | ES2070145T3 (ko) |
| FI (1) | FI94487C (ko) |
| GR (1) | GR3015946T3 (ko) |
| HU (1) | HU205149B (ko) |
| IE (1) | IE61363B1 (ko) |
| IL (1) | IL90573A (ko) |
| NO (1) | NO178717C (ko) |
| NZ (1) | NZ229503A (ko) |
| PH (1) | PH26374A (ko) |
| PT (1) | PT90861B (ko) |
| ZA (1) | ZA894394B (ko) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385885A (en) * | 1988-01-15 | 1995-01-31 | Gasic; Gregory P. | Inhibition of smooth muscle cell proliferation by antistasin and tick anticoagulant peptide |
| DE3819078A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie |
| IL86856A0 (en) * | 1988-06-24 | 1988-11-30 | Yissum Res Dev Co | Bovine xa factor and pharmaceutical compositions containing the same |
| US5120537A (en) * | 1989-06-14 | 1992-06-09 | Oklahoma Medical Research Foundation | Factor xa based anticoagulant compositions |
| AU624962B2 (en) * | 1989-06-20 | 1992-06-25 | Merrell Dow Pharmaceuticals Inc. | Ghilanten: antimetastatic principle from the south american leech, haementeria ghilanii |
| US5239058A (en) * | 1989-09-07 | 1993-08-24 | Merck & Co., Inc. | Proteins having anticoagulant properties |
| US5328997A (en) * | 1989-09-07 | 1994-07-12 | Merck & Co., Inc. | Processes for making proteins having anticoagulant properties |
| US5192747A (en) * | 1989-10-03 | 1993-03-09 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
| DE4001238A1 (de) * | 1990-01-18 | 1991-07-25 | Basf Ag | Verfahren zur anreicherung bzw. reinigung von biomolekuelen |
| EP0444441B1 (en) * | 1990-03-01 | 1996-09-25 | Hewlett-Packard Company | Minimizing eluate band widths in liquid chromatography |
| GB9007879D0 (en) * | 1990-04-06 | 1990-06-06 | Biopharm Ltd | Treatment of thrombotic events |
| US5189019A (en) * | 1990-04-23 | 1993-02-23 | Merck & Co., Inc. | Antistasin derived anticoagulant protein |
| CA2047527A1 (en) * | 1990-07-24 | 1992-01-25 | Christopher Dunwiddie | Method for administering a therapeutic anticoagulant |
| CA2052486A1 (en) * | 1990-10-09 | 1992-04-10 | Thomas M. Connolly | Protein for inhibiting collagen-stimulated platelet aggregation |
| GB9022040D0 (en) * | 1990-10-10 | 1990-11-21 | Biopharm Ltd | Platelet adhesion inhibitor |
| DE4234921A1 (de) * | 1992-10-16 | 1994-04-21 | Basf Ag | Neues, die Gerinnungszeit des Blutes verlängerndes Protein aus dem Landblutegel Haemadipsa sylestris |
| DE69429858D1 (de) * | 1993-04-09 | 2002-03-21 | Bio Technology General Corp | Herstellung eines rekombinanten inhibitors des faktors xa des blutegels hirudo medicinalis |
| US5863534A (en) * | 1993-04-09 | 1999-01-26 | Bio-Technology General Corp. | Polypeptide having factor Xa inhibitory method of reducing blood coagulation with a novel polypeptide having factor Xa inhibitory activity |
| IL109259A0 (en) * | 1993-04-09 | 1994-07-31 | Bio Technology General Corp | Novel polypeptide having factor Xa inhibitory activity |
| US7005510B1 (en) * | 1993-06-23 | 2006-02-28 | Beckman Instruments, Inc. | Recombinant DNase B derived from Streptococcus pyogenes |
| CN1057911C (zh) * | 1994-08-30 | 2000-11-01 | 中国人民解放军264医院 | 治疗心血管病的中药及其制作方法 |
| KR0141651B1 (ko) * | 1994-09-07 | 1998-06-15 | 강재헌 | 금속이온 친화성 크로마토그라피를 이용한 히루딘의 정제방법 |
| CN1089006C (zh) * | 1999-08-13 | 2002-08-14 | 中国科学院生态环境研究中心 | 一种从茶叶提取活化的凝血因子十抑制组分（ati）方法 |
| US7927612B2 (en) * | 2000-01-19 | 2011-04-19 | Baofa Yu | Combinations and methods for treating neoplasms |
| CN100405060C (zh) * | 2006-01-24 | 2008-07-23 | 李振国 | 一种水蛭指纹图谱的建立方法和水蛭药材的鉴别方法 |
| CN101138634A (zh) | 2006-09-07 | 2008-03-12 | 于保法 | 用于治疗肿瘤的组合物 |
| CN101412726B (zh) * | 2007-10-15 | 2011-05-11 | 南京中医药大学 | 杂环类化合物 |
| MX2010008655A (es) * | 2008-02-06 | 2010-10-06 | Biocon Ltd | Un metodo para purificar un peptido. |
| US8790711B2 (en) | 2012-09-17 | 2014-07-29 | Biopep Solutions, Inc. | Treating diabetes with a whole, leech saliva extract |
| KR101341289B1 (ko) * | 2013-07-09 | 2013-12-12 | 한선대 | 거머리 타액의 채취방법 |
| SG11201704175WA (en) | 2014-11-26 | 2017-06-29 | Baofa Yu | Hapten-enhanced chemoimmunotherapy by ultra-minimum incision personalized intratumoral chemoimmunotherapy |
| CN105349601A (zh) * | 2015-11-17 | 2016-02-24 | 常熟理工学院 | 一种具有抗菌活性的水蛭多肽锌螯合物的制备方法 |
| CN105890960A (zh) * | 2016-05-06 | 2016-08-24 | 同济大学 | 一种蛋白质预分离方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300383A (en) * | 1963-10-15 | 1967-01-24 | Dresden Arzneimittel | Hirudine from leeches and process for recovery thereof |
| US3432596A (en) * | 1967-10-13 | 1969-03-11 | Dresden Arzneimittel | Method for producing highly pure hirudine |
| US4390630A (en) * | 1980-10-28 | 1983-06-28 | The Regents Of The University Of California | Hementin--a fibrinolytic agent |
| US4588587A (en) * | 1983-03-01 | 1986-05-13 | Pennsylvania Hospital | Method of treatment to inhibit metastasis |
| IL83912A (en) * | 1986-09-18 | 1993-05-13 | Pennsylvania Hospital | Protein having anticoagulant and antimetastatic properties |
-
1988
- 1988-06-16 US US07/207,415 patent/US4832849A/en not_active Expired - Fee Related
-
1989
- 1989-06-09 AR AR89314122A patent/AR244702A1/es active
- 1989-06-09 ZA ZA894394A patent/ZA894394B/xx unknown
- 1989-06-12 NZ NZ229503A patent/NZ229503A/xx unknown
- 1989-06-12 IL IL9057389A patent/IL90573A/en not_active IP Right Cessation
- 1989-06-13 AU AU36343/89A patent/AU621124B2/en not_active Ceased
- 1989-06-14 PT PT90861A patent/PT90861B/pt not_active IP Right Cessation
- 1989-06-14 HU HU893085A patent/HU205149B/hu not_active IP Right Cessation
- 1989-06-15 CN CN89104078A patent/CN1034335C/zh not_active Expired - Fee Related
- 1989-06-15 KR KR1019890008232A patent/KR910000171A/ko not_active Application Discontinuation
- 1989-06-15 ES ES89110877T patent/ES2070145T3/es not_active Expired - Lifetime
- 1989-06-15 IE IE194189A patent/IE61363B1/en not_active IP Right Cessation
- 1989-06-15 PH PH38801A patent/PH26374A/en unknown
- 1989-06-15 DK DK295589A patent/DK295589A/da not_active Application Discontinuation
- 1989-06-15 EP EP89110877A patent/EP0346894B1/en not_active Expired - Lifetime
- 1989-06-15 FI FI892947A patent/FI94487C/fi not_active IP Right Cessation
- 1989-06-15 NO NO892498A patent/NO178717C/no unknown
- 1989-06-15 DE DE68920915T patent/DE68920915T2/de not_active Expired - Fee Related
- 1989-06-15 AT AT89110877T patent/ATE118013T1/de not_active IP Right Cessation
- 1989-06-15 CA CA000602960A patent/CA1335666C/en not_active Expired - Fee Related
- 1989-06-16 JP JP1152461A patent/JPH02138300A/ja active Pending
-
1995
- 1995-04-27 GR GR950401060T patent/GR3015946T3/el unknown
Also Published As
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