PH24182A - Hydroxamic acid based collagenase inhibitors - Google Patents
Hydroxamic acid based collagenase inhibitorsInfo
- Publication number
- PH24182A PH24182A PH34231A PH34231A PH24182A PH 24182 A PH24182 A PH 24182A PH 34231 A PH34231 A PH 34231A PH 34231 A PH34231 A PH 34231A PH 24182 A PH24182 A PH 24182A
- Authority
- PH
- Philippines
- Prior art keywords
- hydroxamic acid
- acid based
- collagenase inhibitors
- based collagenase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/774,491 US4599361A (en) | 1985-09-10 | 1985-09-10 | Hydroxamic acid based collagenase inhibitors |
US06/880,130 US4743587A (en) | 1985-09-10 | 1986-07-07 | Hydroxamic acid based collagenase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PH24182A true PH24182A (en) | 1990-03-22 |
Family
ID=27118893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH34231A PH24182A (en) | 1985-09-10 | 1986-09-08 | Hydroxamic acid based collagenase inhibitors |
Country Status (14)
Country | Link |
---|---|
US (1) | US4743587A (ja) |
EP (1) | EP0214639B1 (ja) |
JP (1) | JPH0764800B2 (ja) |
CA (1) | CA1329397C (ja) |
DE (1) | DE3671891D1 (ja) |
DK (1) | DK169029B1 (ja) |
FI (1) | FI84472C (ja) |
GR (1) | GR862286B (ja) |
IE (1) | IE58770B1 (ja) |
IL (1) | IL79971A (ja) |
NO (1) | NO164092C (ja) |
NZ (1) | NZ217491A (ja) |
PH (1) | PH24182A (ja) |
PT (1) | PT83328B (ja) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0225292A3 (en) * | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Certain n-substituted butyramide derivatives |
US5166212A (en) * | 1985-12-06 | 1992-11-24 | Ciba-Geigy Corporation | Certain n-substituted butyramide derivatives |
US4939299A (en) * | 1986-12-04 | 1990-07-03 | Monsanto Company | Succinyl dihydroxamic acids |
FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
US5686422A (en) * | 1987-03-17 | 1997-11-11 | Research Corporation Technologies, Inc. | Synthetic inhibitors of mammalian collagenase |
JP2573006B2 (ja) * | 1987-12-17 | 1997-01-16 | 富士薬品工業株式会社 | 新規なヒドロキサム酸誘導体 |
GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
GB8919251D0 (en) * | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
JPH06509791A (ja) * | 1990-01-25 | 1994-11-02 | チルドレンズ ホスピタル | 血管形成抑制のための方法と組成物 |
US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
US5239078A (en) * | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
US5114953A (en) * | 1990-11-21 | 1992-05-19 | University Of Florida | Treatment for tissue ulceration |
US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
CA2073513A1 (en) * | 1990-12-03 | 1992-06-04 | John Robert Porter | Peptidyl derivatives |
US5889058A (en) * | 1990-12-03 | 1999-03-30 | Celltech Limited | Peptidyl derivatives |
CA2058797A1 (en) * | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
WO1992022523A2 (en) * | 1991-06-14 | 1992-12-23 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
US5530161A (en) * | 1991-07-08 | 1996-06-25 | British Bio-Technology Limited | Hydroxamic acid based collagenase inhibitors |
JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
GB9211706D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
GB9211707D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
AU666727B2 (en) * | 1992-06-25 | 1996-02-22 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives |
GB9220845D0 (en) * | 1992-10-03 | 1992-11-18 | British Bio Technology | Vasoactive peptide inhibition |
US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5403824A (en) * | 1993-03-19 | 1995-04-04 | The Procter & Gamble Company | Methods for the treatment of osteoporosis |
DE69414396T2 (de) * | 1993-08-09 | 1999-07-15 | Kanebo Ltd | Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten |
GB9501737D0 (en) * | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
ATE181055T1 (de) * | 1994-05-28 | 1999-06-15 | British Biotech Pharm | Succinyl hydroxamsäure-, n-formyl-n-hydroxy- aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease- inhibitoren |
GB9411088D0 (en) * | 1994-06-03 | 1994-07-27 | Hoffmann La Roche | Hydroxylamine derivatives |
US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
GB9601041D0 (en) * | 1996-01-17 | 1996-03-20 | Smithkline Beecham Plc | Novel compounds |
GB2324528B (en) * | 1996-09-10 | 2000-07-26 | British Biotech Pharm | Cytostatic hydroxamic acid derivatives |
EP0911319A1 (en) * | 1997-09-01 | 1999-04-28 | Roche Diagnostics GmbH | Malonic acid based matrix metalloproteinase inhibitors |
GB9804504D0 (en) | 1998-03-03 | 1998-04-29 | Leo Pharm Prod Ltd | Matrix metalloproteinase inhibitors |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
US6696456B1 (en) | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
US6797820B2 (en) | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
AU2001245862A1 (en) * | 2000-03-21 | 2001-10-03 | The Procter & Gamble Company | Difluorobutyric acid metalloprotease inhibitors |
RU2245876C2 (ru) * | 2000-03-21 | 2005-02-10 | Дзе Проктер Энд Гэмбл Компани | Производные сульфонамидов и фармацевтическая композиция на их основе |
CA2403778A1 (en) * | 2000-03-21 | 2001-09-27 | The Procter & Gamble Company | Carbocyclic side chain containing metalloprotease inhibitors |
US20030229113A1 (en) * | 2000-03-24 | 2003-12-11 | Koji Hashimoto | Keratinocyte growth inhibitors and hydroxamic acid derivatives |
ES2369498T3 (es) | 2003-04-04 | 2011-12-01 | Yeda Research And Development Co., Ltd. | Anticuerpos para inhibir la actividad de mmp-2 y mmp-9. |
US20060112494A1 (en) * | 2004-12-01 | 2006-06-01 | David Oppong | Method of protecting an animal skin product from metalloproteinase activity |
GB0722484D0 (en) * | 2007-11-15 | 2007-12-27 | Ucl Business Plc | Solid compositions |
GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
EA201101672A1 (ru) | 2009-05-28 | 2012-06-29 | Новартис Аг | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина |
BRPI1011657A2 (pt) | 2009-05-28 | 2019-04-16 | Novartis Ag | derivados aminopropiônicos substituídos como inibidores de neprilisina |
EP3216805A1 (en) | 2010-01-27 | 2017-09-13 | Yeda Research and Development Co. Ltd | Antibodies that inhibit metalloproteins |
CN103370337B (zh) | 2010-10-28 | 2015-12-09 | 耶达研究及发展有限公司 | 用于产生针对金属酶的抗体的方法 |
LT2956464T (lt) | 2013-02-14 | 2018-07-10 | Novartis Ag | Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai |
CN105008337B (zh) | 2013-02-14 | 2017-08-04 | 诺华股份有限公司 | 具有改善的体内功效的作为nep抑制剂的取代的联苯基丁酸衍生物 |
IL264768A (en) | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
US3471476A (en) * | 1964-05-18 | 1969-10-07 | Tino Gaeumann | Trihydroxamic acids |
US4077998A (en) * | 1975-10-28 | 1978-03-07 | Morton-Norwich Products, Inc. | Phthaloyl amino acid hydroxamic acids |
US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
US4028401A (en) * | 1976-07-01 | 1977-06-07 | Morton-Norwich Products, Inc. | (Substituted)ureidoacetohydroxamic acids |
NZ201010A (en) * | 1981-06-19 | 1986-02-21 | Ciba Geigy Ag | The treatment of inflammation diseases using desferrioxamine |
FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
US4419365A (en) * | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
-
1986
- 1986-07-07 US US06/880,130 patent/US4743587A/en not_active Expired - Lifetime
- 1986-09-08 DK DK427686A patent/DK169029B1/da not_active IP Right Cessation
- 1986-09-08 PT PT83328A patent/PT83328B/pt unknown
- 1986-09-08 NO NO863581A patent/NO164092C/no not_active IP Right Cessation
- 1986-09-08 FI FI863607A patent/FI84472C/fi not_active IP Right Cessation
- 1986-09-08 IL IL79971A patent/IL79971A/xx not_active IP Right Cessation
- 1986-09-08 CA CA000517713A patent/CA1329397C/en not_active Expired - Fee Related
- 1986-09-08 EP EP86112386A patent/EP0214639B1/en not_active Expired - Lifetime
- 1986-09-08 DE DE8686112386T patent/DE3671891D1/de not_active Expired - Lifetime
- 1986-09-08 GR GR862286A patent/GR862286B/el unknown
- 1986-09-08 NZ NZ217491A patent/NZ217491A/xx unknown
- 1986-09-08 PH PH34231A patent/PH24182A/en unknown
- 1986-09-09 IE IE240486A patent/IE58770B1/en not_active IP Right Cessation
- 1986-09-09 JP JP61212539A patent/JPH0764800B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IE862404L (en) | 1987-03-10 |
NZ217491A (en) | 1989-10-27 |
IE58770B1 (en) | 1993-11-03 |
US4743587A (en) | 1988-05-10 |
AU588362B2 (en) | 1989-09-14 |
JPH0764800B2 (ja) | 1995-07-12 |
AU6240886A (en) | 1987-03-12 |
DK427686A (da) | 1987-03-11 |
FI863607A (fi) | 1987-03-11 |
NO863581D0 (no) | 1986-09-08 |
PT83328A (pt) | 1986-10-01 |
EP0214639A3 (en) | 1988-02-17 |
FI84472B (fi) | 1991-08-30 |
PT83328B (pt) | 1988-07-29 |
FI863607A0 (fi) | 1986-09-08 |
EP0214639B1 (en) | 1990-06-13 |
IL79971A (en) | 1990-11-05 |
DE3671891D1 (de) | 1990-07-19 |
NO164092C (no) | 1990-08-29 |
DK427686D0 (da) | 1986-09-08 |
DK169029B1 (da) | 1994-08-01 |
GR862286B (en) | 1987-01-12 |
FI84472C (fi) | 1991-12-10 |
NO164092B (no) | 1990-05-21 |
EP0214639A2 (en) | 1987-03-18 |
IL79971A0 (en) | 1986-12-31 |
CA1329397C (en) | 1994-05-10 |
NO863581L (no) | 1987-03-11 |
JPS62103052A (ja) | 1987-05-13 |
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