PH22321A - Isoxazoles and furan derivatives, their preparation and use as antiviral agents - Google Patents

Isoxazoles and furan derivatives, their preparation and use as antiviral agents

Info

Publication number
PH22321A
PH22321A PH33948A PH33948A PH22321A PH 22321 A PH22321 A PH 22321A PH 33948 A PH33948 A PH 33948A PH 33948 A PH33948 A PH 33948A PH 22321 A PH22321 A PH 22321A
Authority
PH
Philippines
Prior art keywords
isoxazoles
preparation
antiviral agents
furan derivatives
furan
Prior art date
Application number
PH33948A
Other languages
English (en)
Inventor
Guy Dominic Diana
Carabateas Philip Michael
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of PH22321A publication Critical patent/PH22321A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
PH33948A 1985-07-02 1986-06-25 Isoxazoles and furan derivatives, their preparation and use as antiviral agents PH22321A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75134885A 1985-07-02 1985-07-02

Publications (1)

Publication Number Publication Date
PH22321A true PH22321A (en) 1988-07-29

Family

ID=25021592

Family Applications (2)

Application Number Title Priority Date Filing Date
PH33947A PH23197A (en) 1985-07-02 1986-06-25 Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents
PH33948A PH22321A (en) 1985-07-02 1986-06-25 Isoxazoles and furan derivatives, their preparation and use as antiviral agents

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PH33947A PH23197A (en) 1985-07-02 1986-06-25 Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents

Country Status (21)

Country Link
EP (2) EP0207453B1 (ko)
JP (2) JPH0768242B2 (ko)
KR (2) KR900001314B1 (ko)
AR (4) AR241705A1 (ko)
AT (2) ATE107645T1 (ko)
AU (2) AU589190B2 (ko)
CA (2) CA1280753C (ko)
DE (3) DE3689924D1 (ko)
DK (2) DK171275B1 (ko)
ES (5) ES8802518A1 (ko)
FI (2) FI862795A (ko)
GR (2) GR861695B (ko)
IE (2) IE59755B1 (ko)
IL (2) IL79309A (ko)
MX (4) MX2954A (ko)
MY (1) MY102908A (ko)
NO (2) NO164977C (ko)
NZ (1) NZ216678A (ko)
PH (2) PH23197A (ko)
PT (2) PT82891B (ko)
ZA (2) ZA864873B (ko)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US5051437A (en) * 1986-06-24 1991-09-24 Sterling Drug Inc. Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
GB8807275D0 (en) * 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
ES2141076T3 (es) 1988-09-01 2000-03-16 Bayer Ag Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5110821A (en) * 1989-08-18 1992-05-05 Sterling Drug Inc. 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
EP0468257B1 (en) * 1990-07-20 1999-09-01 Bayer Corporation Multimeric form of human rhinovirus receptor protein
IT1247509B (it) * 1991-04-19 1994-12-17 Univ Cagliari Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5514781A (en) * 1994-04-11 1996-05-07 Bayer Corporation Use of azoles as virucidal agents in solutions of biologically active proteins
US5514679A (en) * 1994-05-13 1996-05-07 Sterling Winthrop Inc. Therapeutic phenoxyalklpyridazines and intermediates therefor
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
WO2005005423A1 (en) 2003-07-02 2005-01-20 F. Hoffmann-La Roche Ag Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators
EP1866293A1 (en) 2005-03-31 2007-12-19 UCB Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
JP2012532102A (ja) * 2009-06-30 2012-12-13 シガ・テクノロジーズ・インコーポレーテッド デングウイルス感染の治療法および予防法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
NZ209209A (en) * 1983-08-29 1988-02-12 Sterling Drug Inc Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans

Also Published As

Publication number Publication date
JPS6216479A (ja) 1987-01-24
AU5945786A (en) 1987-01-08
DE3686677T2 (de) 1993-03-11
DE3689924T4 (de) 1995-05-11
AR242573A1 (es) 1993-04-30
ATE107645T1 (de) 1994-07-15
ES557778A0 (es) 1988-04-01
FI85021C (fi) 1992-02-25
DE3689924T2 (de) 1995-01-19
IE861724L (en) 1987-01-02
AU589190B2 (en) 1989-10-05
CA1280753C (en) 1991-02-26
IE861723L (en) 1987-01-02
IE59755B1 (en) 1994-03-23
FI85021B (fi) 1991-11-15
EP0207454A2 (en) 1987-01-07
DE3689924D1 (de) 1994-07-28
DK312986D0 (da) 1986-07-01
GR861697B (en) 1986-11-04
EP0207453A3 (en) 1988-11-23
IE66234B1 (en) 1995-12-13
NO165023B (no) 1990-09-03
IL79309A (en) 1990-11-29
FI862795A (fi) 1987-01-03
PT82892A (pt) 1987-01-26
FI862794A (fi) 1987-01-03
EP0207453B1 (en) 1994-06-22
MX2954A (es) 1993-11-01
NO862651L (no) 1987-01-05
IL79308A (en) 1991-01-31
DK173467B1 (da) 2000-12-04
NO862650L (no) 1987-01-05
PT82892B (pt) 1994-09-30
PH23197A (en) 1989-05-29
NO862650D0 (no) 1986-07-01
AU587622B2 (en) 1989-08-24
MX9100029A (es) 1993-01-01
DK171275B1 (da) 1996-08-19
ES8801651A1 (es) 1988-02-16
ZA864873B (en) 1987-02-25
MX9100033A (es) 1993-01-01
JPH0819128B2 (ja) 1996-02-28
NZ216678A (en) 1989-10-27
PT82891A (en) 1986-08-01
DK313086A (da) 1987-01-03
AU5945686A (en) 1987-01-08
ATE80397T1 (de) 1992-09-15
DK312986A (da) 1987-01-03
ES557779A0 (es) 1988-02-16
EP0207454B1 (en) 1992-09-09
KR870001202A (ko) 1987-03-12
KR900001314B1 (ko) 1990-03-08
AR242572A1 (es) 1993-04-30
ES557780A0 (es) 1988-02-16
GR861695B (en) 1986-11-04
NO862651D0 (no) 1986-07-01
JPS6216480A (ja) 1987-01-24
DE3686677D1 (de) 1992-10-15
CA1299176C (en) 1992-04-21
NO164977B (no) 1990-08-27
IL79309A0 (en) 1986-10-31
ZA864872B (en) 1987-02-25
ES8802153A1 (es) 1988-04-01
NO165023C (no) 1990-12-12
MX9100032A (es) 1993-01-01
KR870001205A (ko) 1987-03-12
IL79308A0 (en) 1986-10-31
ES556812A0 (es) 1988-07-01
MY102908A (en) 1993-03-31
ES8801649A1 (es) 1988-02-16
NO164977C (no) 1990-12-05
FI862795A0 (fi) 1986-07-01
JPH0768242B2 (ja) 1995-07-26
AR244686A1 (es) 1993-11-30
ES556811A0 (es) 1988-07-01
EP0207454A3 (en) 1988-08-10
FI862794A0 (fi) 1986-07-01
AR241705A1 (es) 1992-11-30
DK313086D0 (da) 1986-07-01
ES8802517A1 (es) 1988-07-01
PT82891B (pt) 1988-05-27
EP0207453A2 (en) 1987-01-07
KR900001315B1 (ko) 1990-03-08
ES8802518A1 (es) 1988-07-01

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