PE20191475A1 - (aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas - Google Patents

(aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas

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Publication number
PE20191475A1
PE20191475A1 PE2019001334A PE2019001334A PE20191475A1 PE 20191475 A1 PE20191475 A1 PE 20191475A1 PE 2019001334 A PE2019001334 A PE 2019001334A PE 2019001334 A PE2019001334 A PE 2019001334A PE 20191475 A1 PE20191475 A1 PE 20191475A1
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PE
Peru
Prior art keywords
halogen
alkyl
benzothiophen
sulfonamides
indol
Prior art date
Application number
PE2019001334A
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English (en)
Inventor
Christa E Mueller
Cecile Pegurier
Michael Louis Robert Deligny
Ali El-Tayeb
Joerg Hockemeyer
Marie Ledecq
Joel Mercier
Laurent Provins
Nader M Boshta
Sanjay Bhattaral
Vigneshwaran Namasivayam
Mario Funke
Lukas Schwach
Sabrina Gollos
LAUFENBERG Daniel VON
Anais Barre
Original Assignee
Ucb Pharma Gmbh
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Publication date
Application filed by Ucb Pharma Gmbh filed Critical Ucb Pharma Gmbh
Publication of PE20191475A1 publication Critical patent/PE20191475A1/es

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    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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Abstract

La presente invencion se refiere a compuestos de sulfonamida de formula I-2, donde X1 es N o CR7; X2 es NH, S u O; X3 es N o CR12; R2 es H, halogeno o metoxi; R4 es H, metoxi o halogeno; R5 es H, halogeno, CN, alquilo C1-C6, entre otros; R6 es H, OH, CN, nitro, halogeno, entre otros; R7 es H, halogeno, CN, nitro, entre otros; R8 es H, alquilo C1-C6, alcoxi C1-C6, entre otros; R9 es H, halogeno, azido, CN, entre otros; R10 es H, halogeno, alquilo C1-C6, amino, entre otros; R11 es H, CN, azido, entre otros; R12 es H, alquilo C1-C6, halogeno, entre otros. Dichos compuestos son moduladores de los receptores acoplados a la proteina G (GPR), en especifico GPR17 y son utiles para tratar o prevenir una variedad de enfermedades del SNC y otras enfermedades, en particular para prevenir y tratar enfermedades o trastornos mielinizantes
PE2019001334A 2016-12-28 2017-12-27 (aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas PE20191475A1 (es)

Applications Claiming Priority (2)

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EP16207137 2016-12-28
PCT/EP2017/084602 WO2018122232A1 (en) 2016-12-28 2017-12-27 (aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides

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EP (1) EP3562820A1 (es)
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AU (2) AU2017387695B2 (es)
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