CL2019001660A1 - (aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas. - Google Patents

(aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas.

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Publication number
CL2019001660A1
CL2019001660A1 CL2019001660A CL2019001660A CL2019001660A1 CL 2019001660 A1 CL2019001660 A1 CL 2019001660A1 CL 2019001660 A CL2019001660 A CL 2019001660A CL 2019001660 A CL2019001660 A CL 2019001660A CL 2019001660 A1 CL2019001660 A1 CL 2019001660A1
Authority
CL
Chile
Prior art keywords
benzothiophen
sulfonamides
benzofuran
aza
indole
Prior art date
Application number
CL2019001660A
Other languages
English (en)
Inventor
Christa E Mueller
Cécile Pegurier
Michael Louis Robert Deligny
Ali El-Tayeb
Joerg Hockemeyer
Marie Ledecq
Joël Mercier
Laurent Provins
Nader M Boshta
Sanjay Bhattarai
Vigneshwaran Namasivayam
Mario Funke
Lukas Schwach
Sabrina Gollos
LAUFENBERG Daniel VON
Anaïs Barré
Original Assignee
Ucb Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Gmbh filed Critical Ucb Pharma Gmbh
Publication of CL2019001660A1 publication Critical patent/CL2019001660A1/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D493/04—Ortho-condensed systems

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE SULFONAMIDA CON PROPIEDADES MODULADORAS DE GPR17, QUE SON ÚTILES PARA TRATAR O PREVENIR UNA VARIEDAD DE ENFERMEDADES DEL SNC Y OTRAS ENFERMEDADES, EN PARTICULAR PARA PREVENIR Y TRATAR ENFERMEDADES O TRASTORNOS MIELINIZANTES.
CL2019001660A 2016-12-28 2019-06-17 (aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas. CL2019001660A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16207137 2016-12-28

Publications (1)

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CL2019001660A1 true CL2019001660A1 (es) 2019-10-25

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CL2019001660A CL2019001660A1 (es) 2016-12-28 2019-06-17 (aza)indol-, benzotiofen, y benzofuran-3-sulfonamidas.

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US (4) US11345662B2 (es)
EP (1) EP3562820A1 (es)
JP (2) JP6946436B2 (es)
KR (1) KR102537100B1 (es)
CN (3) CN116283712A (es)
AR (1) AR110592A1 (es)
AU (2) AU2017387695B2 (es)
BR (1) BR112019012550A2 (es)
CA (1) CA3045244A1 (es)
CL (1) CL2019001660A1 (es)
CO (1) CO2019007829A2 (es)
CR (1) CR20190287A (es)
EA (1) EA201991553A1 (es)
EC (1) ECSP19044183A (es)
IL (2) IL295047A (es)
MX (1) MX2019006190A (es)
NZ (1) NZ753651A (es)
PE (1) PE20191475A1 (es)
PH (1) PH12019501095A1 (es)
RU (1) RU2767904C2 (es)
TN (1) TN2019000165A1 (es)
TW (1) TWI754702B (es)
UA (1) UA127890C2 (es)
UY (1) UY37554A (es)
WO (1) WO2018122232A1 (es)
ZA (1) ZA201903466B (es)

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TWI754702B (zh) * 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類
WO2019204816A1 (en) * 2018-04-20 2019-10-24 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers
EP3584244A1 (en) * 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides
EP3847154A1 (en) * 2018-09-03 2021-07-14 F. Hoffmann-La Roche AG Carboxamide and sulfonamide derivatives useful as tead modulators
CN110128422B (zh) * 2019-01-04 2022-03-18 金凯(辽宁)生命科技股份有限公司 5-甲氧基-7-氮杂吲哚的合成方法
GB201903671D0 (en) * 2019-03-18 2019-05-01 Univ Edinburgh Small molecule photosensitizers for photodynamic therapy
WO2020254289A1 (en) 2019-06-17 2020-12-24 Ucb Pharma Gmbh N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis
CN112375027B (zh) * 2020-12-07 2023-03-31 中国药科大学 吲哚磺酰胺类衍生物及其医药用途
CN112266328B (zh) * 2020-12-09 2023-11-03 郑州萃智医药科技有限公司 3-氟-4-硝基苯甲醛的合成路线及制备方法
PE20240125A1 (es) 2021-02-26 2024-01-22 Hoffmann La Roche Derivados novedosos de pirimidin-2-il sulfonamida
AU2022285899A1 (en) * 2021-06-04 2023-12-14 Rewind Therapeutics Nv 3-pyrrolylsulfonamide compounds as gpr17 antagonists
CN114276319B (zh) * 2022-01-06 2023-11-03 滁州学院 一种劳拉替尼中间体的合成方法
CN114315741B (zh) * 2022-01-19 2023-09-12 贵州医科大学 一种硫代化合物及其制备方法与应用
WO2024017856A1 (en) 2022-07-20 2024-01-25 F. Hoffmann-La Roche Ag Novel isoquinolinone, pyrrolopyridinone and thienopyridinone sulfonamide derivatives
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