EA201991553A1 - (аза)индол-, бензотиофен- и бензофуран-3-сульфонамиды - Google Patents

(аза)индол-, бензотиофен- и бензофуран-3-сульфонамиды

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Publication number
EA201991553A1
EA201991553A1 EA201991553A EA201991553A EA201991553A1 EA 201991553 A1 EA201991553 A1 EA 201991553A1 EA 201991553 A EA201991553 A EA 201991553A EA 201991553 A EA201991553 A EA 201991553A EA 201991553 A1 EA201991553 A1 EA 201991553A1
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EA
Eurasian Patent Office
Prior art keywords
benzotiophen
sulfonamides
indol
benzofuran
aza
Prior art date
Application number
EA201991553A
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English (en)
Inventor
Криста Э. Мюллер
Сесиль Пегюрье
Микаэль Луи Робер Делиньи
Али Эль-Тайеб
Йёрг Хоккемайер
Мари Ледек
Жоэль Мерсье
Лоран Провен
Надер М. Бошта
Санджай Бхаттарай
Вигнешваран Намасиваям
Марио Функе
Лукас Швах
Забрина Голлос
Даниэль Фон Лауфенберг
Анаис Барре
Original Assignee
Юсб Фарма Гмбх
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Publication date
Application filed by Юсб Фарма Гмбх filed Critical Юсб Фарма Гмбх
Publication of EA201991553A1 publication Critical patent/EA201991553A1/ru

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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Abstract

Настоящее изобретение относится к соединениям сульфонамида, обладающим способностью модулировать GPR17, которые являются полезными для лечения или предупреждения различных заболеваний ЦНС и других болезней, особенно для предупреждения и лечения нарушений миелинизации или связанных с ними заболеваний.
EA201991553A 2016-12-28 2017-12-27 (аза)индол-, бензотиофен- и бензофуран-3-сульфонамиды EA201991553A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16207137 2016-12-28
PCT/EP2017/084602 WO2018122232A1 (en) 2016-12-28 2017-12-27 (aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides

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EA201991553A1 true EA201991553A1 (ru) 2020-01-09

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US (4) US11345662B2 (ru)
EP (1) EP3562820A1 (ru)
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KR (1) KR102537100B1 (ru)
CN (3) CN116283712A (ru)
AR (1) AR110592A1 (ru)
AU (2) AU2017387695B2 (ru)
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CL (1) CL2019001660A1 (ru)
CO (1) CO2019007829A2 (ru)
CR (1) CR20190287A (ru)
EA (1) EA201991553A1 (ru)
EC (1) ECSP19044183A (ru)
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TWI754702B (zh) * 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類
WO2019204816A1 (en) * 2018-04-20 2019-10-24 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers
TW202016088A (zh) 2018-06-19 2020-05-01 德商Ｕｃｂ製藥有限公司 吡啶基及吡基-（氮）吲哚磺醯胺
EP3584244A1 (en) * 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides
EP3847154A1 (en) * 2018-09-03 2021-07-14 F. Hoffmann-La Roche AG Carboxamide and sulfonamide derivatives useful as tead modulators
CN110128422B (zh) * 2019-01-04 2022-03-18 金凯(辽宁)生命科技股份有限公司 5-甲氧基-7-氮杂吲哚的合成方法
GB201903671D0 (en) * 2019-03-18 2019-05-01 Univ Edinburgh Small molecule photosensitizers for photodynamic therapy
WO2020254289A1 (en) 2019-06-17 2020-12-24 Ucb Pharma Gmbh N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis
CN112375027B (zh) * 2020-12-07 2023-03-31 中国药科大学 吲哚磺酰胺类衍生物及其医药用途
CN112266328B (zh) * 2020-12-09 2023-11-03 郑州萃智医药科技有限公司 3-氟-4-硝基苯甲醛的合成路线及制备方法
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