BR112018075597A2 - derivados de carbamato de 2-amino-4-(amino substituído)fenila fluorado - Google Patents

derivados de carbamato de 2-amino-4-(amino substituído)fenila fluorado

Info

Publication number
BR112018075597A2
BR112018075597A2 BR112018075597-4A BR112018075597A BR112018075597A2 BR 112018075597 A2 BR112018075597 A2 BR 112018075597A2 BR 112018075597 A BR112018075597 A BR 112018075597A BR 112018075597 A2 BR112018075597 A2 BR 112018075597A2
Authority
BR
Brazil
Prior art keywords
amino
phenyl carbamate
carbamate derivatives
fluorinated phenyl
substituted amino
Prior art date
Application number
BR112018075597-4A
Other languages
English (en)
Inventor
D. Edwards Scott
C. Askew Ben
Furuya Takeru
Original Assignee
Scifluor Life Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scifluor Life Sciences, Inc. filed Critical Scifluor Life Sciences, Inc.
Publication of BR112018075597A2 publication Critical patent/BR112018075597A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Abstract

o pedido refere-se a derivados de carbamato de 2-amino-4-(amino substituído)fenila, ou solvatos ou sais farmaceuticamente aceitáveis dos mesmos, como moduladores de canal de potássio kcnq2/3, e métodos para seus usos.
BR112018075597-4A 2016-06-10 2017-06-09 derivados de carbamato de 2-amino-4-(amino substituído)fenila fluorado BR112018075597A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662348481P 2016-06-10 2016-06-10
US62/348,481 2016-06-10
PCT/US2017/036802 WO2017214539A1 (en) 2016-06-10 2017-06-09 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives

Publications (1)

Publication Number Publication Date
BR112018075597A2 true BR112018075597A2 (pt) 2019-03-26

Family

ID=60572305

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018075597-4A BR112018075597A2 (pt) 2016-06-10 2017-06-09 derivados de carbamato de 2-amino-4-(amino substituído)fenila fluorado

Country Status (12)

Country Link
US (2) US20170355679A1 (pt)
EP (1) EP3468947A4 (pt)
JP (1) JP2019518754A (pt)
KR (1) KR20190008411A (pt)
CN (1) CN109641836A (pt)
AU (1) AU2017278093B8 (pt)
BR (1) BR112018075597A2 (pt)
CA (1) CA3023340A1 (pt)
IL (1) IL262855A (pt)
MX (1) MX2018015251A (pt)
RU (1) RU2018147263A (pt)
WO (1) WO2017214539A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2018147263A (ru) 2016-06-10 2020-07-10 Сайфлуор Лайф Сайенсиз, Инк Фторированные 2-амино-4-(замещенные амино)фенилкарбаматные производные
AU2018384803A1 (en) * 2017-12-13 2020-06-25 Scifluor Life Sciences, Inc. Fluorinated 4-(substituted amino)phenyl carbamate derivatives
UY38540A (es) 2019-01-14 2020-08-31 Pi Industries Ltd Compuestos de fenilamidina 3-sustituida, preparación y uso
AR124167A1 (es) 2020-11-30 2023-02-22 Pi Industries Ltd Una nueva composición agroquímica que comprende compuestos de fenilamidina 3-sustituidos
CA3214084A1 (en) * 2021-03-19 2022-09-22 Xyzagen, Inc. Prodrugs of kv7 channel openers
EP4074696A4 (en) * 2021-10-27 2024-01-31 Shanghai Zhimeng Biopharma Inc POTASSIUM CHANNEL REGULATOR COMPOUND, PRODUCTION AND USE THEREOF
CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
TW202333693A (zh) * 2021-12-31 2023-09-01 大陸商上海翰森生物醫藥科技有限公司 苯并哌啶衍生物調節劑、其製備方法和應用
CN116478068A (zh) * 2022-01-14 2023-07-25 中国科学院上海药物研究所 一种高选择性kcnq4钾通道激动剂、其制备方法和用途
CN116535353A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
WO2024067819A1 (zh) * 2022-09-30 2024-04-04 上海翰森生物医药科技有限公司 含哌啶多环类衍生物调节剂、其制备方法和应用

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GB9915414D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
WO2002001970A2 (en) 2000-06-30 2002-01-10 Fmc Corporation Steam injection heater and method
WO2003106454A1 (en) * 2002-06-12 2003-12-24 Orchid Chemicals & Pharmaceuticals Ltd 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
US8790623B2 (en) 2005-01-18 2014-07-29 Il'Oreal Composition for treating keratin fibers, comprising at least one aromatic alcohol, at least one aromatic carboxylic acid, and at least one protecting agent
CN101563085A (zh) * 2006-08-23 2009-10-21 威朗国际制药公司 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺的衍生物
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WO2016077724A1 (en) * 2014-11-13 2016-05-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education (2-amino-4(arylamino)phenyl) carbamates
RU2018147263A (ru) 2016-06-10 2020-07-10 Сайфлуор Лайф Сайенсиз, Инк Фторированные 2-амино-4-(замещенные амино)фенилкарбаматные производные
AU2018384803A1 (en) 2017-12-13 2020-06-25 Scifluor Life Sciences, Inc. Fluorinated 4-(substituted amino)phenyl carbamate derivatives

Also Published As

Publication number Publication date
IL262855A (en) 2018-12-31
AU2017278093B2 (en) 2021-12-16
JP2019518754A (ja) 2019-07-04
RU2018147263A (ru) 2020-07-10
EP3468947A4 (en) 2020-01-08
CA3023340A1 (en) 2017-12-14
AU2017278093A1 (en) 2018-11-22
WO2017214539A1 (en) 2017-12-14
AU2017278093B8 (en) 2021-12-23
US11858900B2 (en) 2024-01-02
US20170355679A1 (en) 2017-12-14
MX2018015251A (es) 2019-04-25
EP3468947A1 (en) 2019-04-17
US20210309612A1 (en) 2021-10-07
CN109641836A (zh) 2019-04-16
KR20190008411A (ko) 2019-01-23

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]