PE20191467A1 - Metodo para tratar o mejorar trastornos metabolicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del peptido inhibidor gastrico (gipr) - Google Patents

Metodo para tratar o mejorar trastornos metabolicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del peptido inhibidor gastrico (gipr)

Info

Publication number
PE20191467A1
PE20191467A1 PE2019001431A PE2019001431A PE20191467A1 PE 20191467 A1 PE20191467 A1 PE 20191467A1 PE 2019001431 A PE2019001431 A PE 2019001431A PE 2019001431 A PE2019001431 A PE 2019001431A PE 20191467 A1 PE20191467 A1 PE 20191467A1
Authority
PE
Peru
Prior art keywords
glp
gipr
receptor
antagonists
treat
Prior art date
Application number
PE2019001431A
Other languages
English (en)
Spanish (es)
Inventor
Chawita Netirojjanakul
Yuan Cheng
Jerry Ryan Holder
Bin Wu
James R Falsey
Bradley J Herberich
Kelvin Sham
Leslie P Miranda
Shu-Chen Lu
Murielle M Veniant-Ellison
Shanaka Stanislaus
Junming Yie
Jing Xu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61832572&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20191467(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PE20191467A1 publication Critical patent/PE20191467A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6847—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a hormone or a hormone-releasing or -inhibiting factor
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Peptides Or Proteins (AREA)
PE2019001431A 2017-01-17 2018-01-16 Metodo para tratar o mejorar trastornos metabolicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del peptido inhibidor gastrico (gipr) PE20191467A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762447332P 2017-01-17 2017-01-17
PCT/US2018/013918 WO2018136440A1 (en) 2017-01-17 2018-01-16 Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)

Publications (1)

Publication Number Publication Date
PE20191467A1 true PE20191467A1 (es) 2019-10-16

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Application Number Title Priority Date Filing Date
PE2019001431A PE20191467A1 (es) 2017-01-17 2018-01-16 Metodo para tratar o mejorar trastornos metabolicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del peptido inhibidor gastrico (gipr)
PE2024001525A PE20250777A1 (es) 2017-01-17 2018-01-16 Metodo para tratar o mejorar trastornos metabolicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del peptido inhibidor gastrico (gipr)

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PE2024001525A PE20250777A1 (es) 2017-01-17 2018-01-16 Metodo para tratar o mejorar trastornos metabolicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del peptido inhibidor gastrico (gipr)

Country Status (38)

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US (3) US10905772B2 (enExample)
EP (2) EP3570885B1 (enExample)
JP (3) JP7175899B2 (enExample)
KR (3) KR102781241B1 (enExample)
CN (2) CN118079021A (enExample)
AR (1) AR110751A1 (enExample)
AU (2) AU2018210858B2 (enExample)
BR (1) BR112019014588A2 (enExample)
CA (1) CA3049023A1 (enExample)
CL (1) CL2019001963A1 (enExample)
CO (1) CO2019007685A2 (enExample)
CR (2) CR20190380A (enExample)
DK (1) DK3570885T3 (enExample)
EA (1) EA201991721A1 (enExample)
ES (1) ES3009462T3 (enExample)
FI (1) FI3570885T3 (enExample)
HR (1) HRP20241563T1 (enExample)
HU (1) HUE069334T2 (enExample)
IL (2) IL267660B2 (enExample)
JO (1) JOP20190177A1 (enExample)
LT (1) LT3570885T (enExample)
MA (1) MA47314B1 (enExample)
MD (1) MD3570885T2 (enExample)
MX (2) MX2019008462A (enExample)
NZ (1) NZ754937A (enExample)
PE (2) PE20191467A1 (enExample)
PH (1) PH12019501656A1 (enExample)
PL (1) PL3570885T3 (enExample)
PT (1) PT3570885T (enExample)
RS (1) RS66291B1 (enExample)
SA (1) SA519402246B1 (enExample)
SG (1) SG11201906525SA (enExample)
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SM (1) SMT202400502T1 (enExample)
TW (1) TWI708613B (enExample)
UY (1) UY37568A (enExample)
WO (1) WO2018136440A1 (enExample)
ZA (1) ZA201904287B (enExample)

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CN120019167A (zh) * 2022-10-12 2025-05-16 首尔大学医院 利用gipr标记物的用于预测磺酰脲类依赖性的组合物及其预测方法
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