PE20191148A1 - Tratamiento de la migrana refractaria - Google Patents
Tratamiento de la migrana refractariaInfo
- Publication number
- PE20191148A1 PE20191148A1 PE2019000710A PE2019000710A PE20191148A1 PE 20191148 A1 PE20191148 A1 PE 20191148A1 PE 2019000710 A PE2019000710 A PE 2019000710A PE 2019000710 A PE2019000710 A PE 2019000710A PE 20191148 A1 PE20191148 A1 PE 20191148A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- monoclonal antibody
- refractory
- treatment
- migrana
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
Se refiere a un anticuerpo monoclonal humano o humanizado, en donde el anticuerpo monoclonal es un anticuerpo antagonista anti-CGRP, que comprende una CDRH1 segun la SEQ ID NO: 3; una CDRH2 segun la SEQ ID NO: 4; una CDRH3 segun la SEQ ID NO: 5; una CDRL1 segun la SEQ ID NO: 6; una CDRL2 segun la SEQ ID NO: 7; y una CDRL3 segun la SEQ ID NO: 8. Dicho anticuerpo monoclonal modula la via del peptido relacionado con el gen de la calcitonina (CGRP), y es util en el tratamiento preventivo de la migrana refractaria.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662399180P | 2016-09-23 | 2016-09-23 | |
US201762558557P | 2017-09-14 | 2017-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20191148A1 true PE20191148A1 (es) | 2019-09-02 |
Family
ID=60120094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2019000710A PE20191148A1 (es) | 2016-09-23 | 2017-09-22 | Tratamiento de la migrana refractaria |
Country Status (15)
Country | Link |
---|---|
US (6) | US10392434B2 (es) |
EP (1) | EP3515937A1 (es) |
JP (3) | JP6937368B2 (es) |
KR (2) | KR20220031944A (es) |
CN (1) | CN109952314A (es) |
AU (2) | AU2017331593B2 (es) |
BR (1) | BR112019005823A2 (es) |
CA (1) | CA3036632A1 (es) |
CL (1) | CL2019000760A1 (es) |
IL (1) | IL265343A (es) |
MX (1) | MX2019003337A (es) |
PE (1) | PE20191148A1 (es) |
SG (1) | SG10201913032TA (es) |
WO (1) | WO2018055574A1 (es) |
ZA (1) | ZA201901531B (es) |
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CA3036632A1 (en) | 2018-03-29 |
AU2017331593B2 (en) | 2022-04-28 |
AU2017331593A1 (en) | 2019-04-11 |
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JP6937368B2 (ja) | 2021-09-22 |
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US20230242631A1 (en) | 2023-08-03 |
AU2022206792A1 (en) | 2022-10-06 |
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US20200223911A1 (en) | 2020-07-16 |
US20210040190A1 (en) | 2021-02-11 |
JP2021185180A (ja) | 2021-12-09 |
WO2018055574A1 (en) | 2018-03-29 |
US20180127490A1 (en) | 2018-05-10 |
EP3515937A1 (en) | 2019-07-31 |
US20210040191A1 (en) | 2021-02-11 |
US10392434B2 (en) | 2019-08-27 |
SG10201913032TA (en) | 2020-02-27 |
ZA201901531B (en) | 2022-01-26 |
MX2019003337A (es) | 2019-09-26 |
BR112019005823A2 (pt) | 2019-06-25 |
CN109952314A (zh) | 2019-06-28 |
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