CO2020014727A2 - Anticuerpo anti proteína reguladora de señales alfa sirpαlfa - Google Patents
Anticuerpo anti proteína reguladora de señales alfa sirpαlfaInfo
- Publication number
- CO2020014727A2 CO2020014727A2 CONC2020/0014727A CO2020014727A CO2020014727A2 CO 2020014727 A2 CO2020014727 A2 CO 2020014727A2 CO 2020014727 A CO2020014727 A CO 2020014727A CO 2020014727 A2 CO2020014727 A2 CO 2020014727A2
- Authority
- CO
- Colombia
- Prior art keywords
- seq
- amino acid
- acid sequence
- heavy chain
- residue
- Prior art date
Links
- 102000034356 gene-regulatory proteins Human genes 0.000 title 1
- 108091006104 gene-regulatory proteins Proteins 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 abstract 2
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 abstract 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 2
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 abstract 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
RESUMEN La presente invención se relaciona con el problema de proporcionar: un anticuerpo anti-SIRPα que puede usarse como agente tumoral; y un agente anti-tumoral que contiene el anticuerpo como ingrediente activo. La presente invención es un anticuerpo capaz de unir específicamente a SIRPα humana para inhibir la unión entre SIRPα humana y CD47, anticuerpo contiene: (a) una CDRL1 de cadena ligera que consiste en una secuencia de aminoácidos representada en la SEC. ID NO.: 1; (b) una CDRL2 de cadena ligera que consiste en una secuencia de aminoácidos representada por la SEC. ID NO.: 2; (c) una CDRL3 de cadena ligera que consiste en una secuencia de aminoácidos representada en la SEC. ID NO.: 3; (d) una CDRH1 de cadena pesada que consiste en una secuencia de aminoácidos representada en la SEC. ID NO.: 4; (e) una CDRH2 de cadena pesada que comprende una secuencia de aminoácidos representada en la SEC. ID NO.: 5; y (f) una CDRH3 de cadena pesada que comprende una secuencia de aminoácidos representada en la SEC. ID NO.: 6, en donde una región constante en cadena pesada es una región constante en cadena pesada de IgG4 humana y un residuo de fenilalanina en la posición 234, un residuo de leucina en la posición 235 y un residuo de serina en la posición 228, numerada de acuerdo con el índice EU como en Kabat et al., se sustituyen por un residuo de alanina, un residuo de alanina y un residuo de prolina, respectivamente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018131116 | 2018-07-10 | ||
| PCT/JP2019/027114 WO2020013170A1 (ja) | 2018-07-10 | 2019-07-09 | 抗ＳＩＲＰα抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2020014727A2 true CO2020014727A2 (es) | 2020-12-21 |
Family
ID=69142391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2020/0014727A CO2020014727A2 (es) | 2018-07-10 | 2020-11-27 | Anticuerpo anti proteína reguladora de señales alfa sirpαlfa |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210155707A1 (es) |
| EP (1) | EP3822289A4 (es) |
| JP (2) | JP7368809B2 (es) |
| KR (1) | KR20210030267A (es) |
| CN (2) | CN117024593A (es) |
| AU (1) | AU2019302152A1 (es) |
| BR (1) | BR112020023322A2 (es) |
| CA (2) | CA3104462C (es) |
| CO (1) | CO2020014727A2 (es) |
| IL (1) | IL279321A (es) |
| MX (1) | MX2020013068A (es) |
| PH (1) | PH12021500002A1 (es) |
| SG (1) | SG11202012338QA (es) |
| TW (1) | TW202035449A (es) |
| WO (1) | WO2020013170A1 (es) |
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| JP7393342B2 (ja) | 2018-03-21 | 2023-12-06 | エーエルエックス オンコロジー インコーポレイテッド | シグナル調節タンパク質αに対する抗体及び使用方法 |
| CA3142513A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| EP4045083B1 (en) | 2019-10-18 | 2024-01-10 | Forty Seven, Inc. | Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia |
| CN114599392A (zh) | 2019-10-31 | 2022-06-07 | 四十七公司 | 基于抗cd47和抗cd20的血癌治疗 |
| JP2023509881A (ja) | 2019-12-24 | 2023-03-10 | カルナバイオサイエンス株式会社 | ジアシルグリセロールキナーゼ調節化合物 |
| CN117964757A (zh) | 2020-02-14 | 2024-05-03 | 吉利德科学公司 | 与ccr8结合的抗体和融合蛋白及其用途 |
| EP4245321A1 (en) | 2020-11-11 | 2023-09-20 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with anti-sirpalpha antibody |
| CN112574310B (zh) * | 2020-12-11 | 2023-05-05 | 浙江博锐生物制药有限公司 | 抗SIRPα抗体及其用途 |
| WO2022153195A1 (en) | 2021-01-13 | 2022-07-21 | Memorial Sloan Kettering Cancer Center | Anti-dll3 antibody-drug conjugate |
| EP4277664A1 (en) | 2021-01-13 | 2023-11-22 | Memorial Sloan Kettering Cancer Center | Antibody-pyrrolobenzodiazepine derivative conjugate |
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| AU2022284373A1 (en) | 2021-06-04 | 2024-01-04 | Boehringer Ingelheim International Gmbh | Anti-sirp-alpha antibodies |
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| KR20240025597A (ko) | 2021-06-29 | 2024-02-27 | 씨젠 인크. | 비푸코실화 항-cd70 항체 및 cd47 길항제의 조합으로 암을 치료하는 방법 |
| TW202330504A (zh) | 2021-10-28 | 2023-08-01 | 美商基利科學股份有限公司 | 嗒𠯤—３（２ｈ）—酮衍生物 |
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| WO2023122581A2 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
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| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
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| JOP20190009A1 (ar) * | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| US11779642B2 (en) * | 2016-12-09 | 2023-10-10 | Alector Llc | Anti-SIRP-alpha antibodies and methods of use thereof |
| EA201891882A1 (ru) * | 2017-02-17 | 2019-07-31 | Осе Иммьюнотерапьютикс | НОВЫЕ АНТИТЕЛА К SIRPa И ВАРИАНТЫ ИХ ТЕРАПЕВТИЧЕСКОГО ПРИМЕНЕНИЯ |
| JP2018131116A (ja) | 2017-02-17 | 2018-08-23 | いすゞ自動車株式会社 | ステップ取り付け構造 |
| MX2019012233A (es) | 2017-04-13 | 2020-01-14 | Aduro Biotech Holdings Europe Bv | Anticuerpos anti-sirpa. |
-
2019
- 2019-07-09 EP EP19833586.1A patent/EP3822289A4/en active Pending
- 2019-07-09 CA CA3104462A patent/CA3104462C/en active Active
- 2019-07-09 BR BR112020023322-6A patent/BR112020023322A2/pt unknown
- 2019-07-09 TW TW108124073A patent/TW202035449A/zh unknown
- 2019-07-09 KR KR1020207034952A patent/KR20210030267A/ko active Search and Examination
- 2019-07-09 WO PCT/JP2019/027114 patent/WO2020013170A1/ja unknown
- 2019-07-09 SG SG11202012338QA patent/SG11202012338QA/en unknown
- 2019-07-09 CA CA3219158A patent/CA3219158A1/en active Pending
- 2019-07-09 JP JP2020530192A patent/JP7368809B2/ja active Active
- 2019-07-09 CN CN202311201098.2A patent/CN117024593A/zh active Pending
- 2019-07-09 MX MX2020013068A patent/MX2020013068A/es unknown
- 2019-07-09 CN CN201980059246.7A patent/CN112673023B/zh active Active
- 2019-07-09 US US17/258,115 patent/US20210155707A1/en active Pending
- 2019-07-09 AU AU2019302152A patent/AU2019302152A1/en active Pending
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2020
- 2020-11-27 CO CONC2020/0014727A patent/CO2020014727A2/es unknown
- 2020-12-09 IL IL279321A patent/IL279321A/en unknown
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2021
- 2021-01-07 PH PH12021500002A patent/PH12021500002A1/en unknown
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2023
- 2023-10-04 JP JP2023172481A patent/JP2023168526A/ja active Pending
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| Publication number | Publication date |
|---|---|
| PH12021500002A1 (en) | 2021-09-13 |
| US20210155707A1 (en) | 2021-05-27 |
| CN112673023A (zh) | 2021-04-16 |
| IL279321A (en) | 2021-01-31 |
| CA3104462A1 (en) | 2020-01-16 |
| BR112020023322A2 (pt) | 2021-02-02 |
| MX2020013068A (es) | 2021-03-02 |
| CN112673023B (zh) | 2023-09-12 |
| WO2020013170A1 (ja) | 2020-01-16 |
| JP2023168526A (ja) | 2023-11-24 |
| EP3822289A1 (en) | 2021-05-19 |
| CN117024593A (zh) | 2023-11-10 |
| KR20210030267A (ko) | 2021-03-17 |
| AU2019302152A1 (en) | 2021-01-07 |
| JP7368809B2 (ja) | 2023-10-25 |
| EP3822289A4 (en) | 2022-04-13 |
| SG11202012338QA (en) | 2021-01-28 |
| CA3219158A1 (en) | 2020-01-16 |
| CA3104462C (en) | 2023-12-19 |
| TW202035449A (zh) | 2020-10-01 |
| JPWO2020013170A1 (ja) | 2021-07-15 |
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