PE20142042A1 - Forma termodinamicamente estable de una sal tosilato de sorafenib - Google Patents

Forma termodinamicamente estable de una sal tosilato de sorafenib

Info

Publication number
PE20142042A1
PE20142042A1 PE2014000731A PE2014000731A PE20142042A1 PE 20142042 A1 PE20142042 A1 PE 20142042A1 PE 2014000731 A PE2014000731 A PE 2014000731A PE 2014000731 A PE2014000731 A PE 2014000731A PE 20142042 A1 PE20142042 A1 PE 20142042A1
Authority
PE
Peru
Prior art keywords
salt
thermodynamically stable
stable form
tosilate
amino
Prior art date
Application number
PE2014000731A
Other languages
English (en)
Inventor
Alfons Grunenberg
Jana Lenz
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35482258&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142042(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of PE20142042A1 publication Critical patent/PE20142042A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Paper (AREA)
  • Catalysts (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicinal Preparation (AREA)

Abstract

REFERIDO A UN COMPUESTO TERMODINAMICAMENTE ESTABLE A TEMPERATURA AMBIENTE, DE LA SAL TOSILATO DE 4-{4-[({[4-CLORO-3-(TRIFLUOROMETIL) FENIL]AMINO}CARBONIL)AMINO]FENOXI}-N-METILPIRIDIN-2-CARBOXAMIDA. DICHO COMPUESTO MUESTRA EN LA DIFRACTOMETRIA DE RAYOS X EL PICO MAXIMO DE 2 THETA ANGULO DE 4.4, 10.7, 11.1, 11.4 ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, SIENDO UTIL EN EL TRATAMIENTO DE RETINOPATIA, ARTRITIS REUMATOIDEA, ENTRE OTRAS.
PE2014000731A 2004-09-29 2005-09-28 Forma termodinamicamente estable de una sal tosilato de sorafenib PE20142042A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04023130 2004-09-29

Publications (1)

Publication Number Publication Date
PE20142042A1 true PE20142042A1 (es) 2014-12-03

Family

ID=35482258

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2005001145A PE20060699A1 (es) 2004-09-29 2005-09-28 Forma termodinamicamente estable de una sal tosilato
PE2009001132A PE20100445A1 (es) 2004-09-29 2005-09-28 Forma termodinamicamente estable de una sal tosilato de sorafenib
PE2014000731A PE20142042A1 (es) 2004-09-29 2005-09-28 Forma termodinamicamente estable de una sal tosilato de sorafenib

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PE2005001145A PE20060699A1 (es) 2004-09-29 2005-09-28 Forma termodinamicamente estable de una sal tosilato
PE2009001132A PE20100445A1 (es) 2004-09-29 2005-09-28 Forma termodinamicamente estable de una sal tosilato de sorafenib

Country Status (33)

Country Link
US (1) US8877933B2 (es)
EP (1) EP1797038B1 (es)
JP (2) JP5215666B2 (es)
KR (4) KR20070058537A (es)
CN (1) CN101065360B (es)
AR (1) AR051301A1 (es)
AU (1) AU2005289100B2 (es)
BR (1) BRPI0515946A (es)
CA (1) CA2581843C (es)
CU (1) CU20070068A7 (es)
CY (1) CY1113598T1 (es)
DK (1) DK1797038T3 (es)
EC (1) ECSP077356A (es)
ES (1) ES2387812T3 (es)
GT (1) GT200500270A (es)
HK (1) HK1114605A1 (es)
HN (1) HN2005000722A (es)
HR (1) HRP20120662T1 (es)
IL (1) IL181734A (es)
MA (1) MA28880B1 (es)
MY (1) MY176929A (es)
NO (1) NO344272B1 (es)
NZ (1) NZ553804A (es)
PE (3) PE20060699A1 (es)
PL (1) PL1797038T3 (es)
PT (1) PT1797038E (es)
SG (1) SG155996A1 (es)
SI (1) SI1797038T1 (es)
TW (1) TWI382016B (es)
UA (1) UA91520C2 (es)
UY (1) UY29144A1 (es)
WO (1) WO2006034797A1 (es)
ZA (1) ZA200702510B (es)

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