PE20130283A1 - Cristal de compuesto de amida - Google Patents

Cristal de compuesto de amida

Info

Publication number
PE20130283A1
PE20130283A1 PE2012002427A PE2012002427A PE20130283A1 PE 20130283 A1 PE20130283 A1 PE 20130283A1 PE 2012002427 A PE2012002427 A PE 2012002427A PE 2012002427 A PE2012002427 A PE 2012002427A PE 20130283 A1 PE20130283 A1 PE 20130283A1
Authority
PE
Peru
Prior art keywords
amida
compound crystal
crystal
methoxibutyl
interplan
Prior art date
Application number
PE2012002427A
Other languages
English (en)
Inventor
Masato Kitayama
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20130283A1 publication Critical patent/PE20130283A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A UN CRISTAL DE CLORHIDRATO DE 1-(4-METOXIBUTIL)-N-(2-METILPROPIL)-N-[(3S,5R)-5-(MORFOLIN-4-ILCARBONIL)PIPERIDIN-3-IL]-1H-BENCIMIDAZOL-2-CARBOXAMIDA CON UN PATRON DE DIFRACCION DE RAYOS X DE POLVO CON CARACTERISTICAS PICO EN LOS ESPACIAMIENTOS INTERPLANOS (d) DE ALREDEDOR DE 26.43 ± 0.2, 7.62 ± 0.2, 4.32 ± 0.2, 3.08 ± 0.2, 2.59 ± 0.2 Y 2.33 ± 0.2 ANGSTROMS. DICHO CRISTAL ES INHIBIDOR DE RENINA SIENDO UTIL COMO AGENTE PROFILACTICO O TERAPEUTICO DE LA HIPERTENSION
PE2012002427A 2010-06-16 2011-06-15 Cristal de compuesto de amida PE20130283A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010137194 2010-06-16

Publications (1)

Publication Number Publication Date
PE20130283A1 true PE20130283A1 (es) 2013-03-25

Family

ID=45348277

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012002427A PE20130283A1 (es) 2010-06-16 2011-06-15 Cristal de compuesto de amida

Country Status (27)

Country Link
US (1) US9018374B2 (es)
EP (1) EP2583967B1 (es)
JP (1) JP5782438B2 (es)
KR (1) KR20130119903A (es)
CN (1) CN103068816B (es)
AU (1) AU2011266099B2 (es)
BR (1) BR112012032055B8 (es)
CA (1) CA2802483C (es)
CL (1) CL2012003526A1 (es)
CO (1) CO6670573A2 (es)
DO (1) DOP2012000313A (es)
EA (1) EA022094B1 (es)
EC (1) ECSP13012392A (es)
ES (1) ES2524896T3 (es)
GE (1) GEP20146195B (es)
HK (1) HK1179605A1 (es)
IL (1) IL223562A (es)
MA (1) MA34378B1 (es)
MX (1) MX2012014828A (es)
MY (1) MY163927A (es)
PE (1) PE20130283A1 (es)
SG (1) SG186223A1 (es)
TN (1) TN2012000589A1 (es)
TW (1) TWI511967B (es)
UA (1) UA108888C2 (es)
WO (1) WO2011158880A1 (es)
ZA (1) ZA201300065B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104781226A (zh) * 2012-02-14 2015-07-15 陶氏环球技术有限责任公司 非离子型表面活性剂组合物
WO2013122260A1 (en) 2012-02-15 2013-08-22 Takeda Pharmaceutical Company Limited Tablet
CN103831159B (zh) * 2014-01-20 2016-04-13 华润赛科药业有限责任公司 一种阿齐沙坦微粉化方法
US9878981B2 (en) * 2014-04-10 2018-01-30 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
GB2542876B (en) * 2015-04-20 2019-10-23 Johnson Matthey Plc Structure Directing Agent
CN107595853A (zh) * 2017-10-25 2018-01-19 桂林浩新科技服务有限公司 一种用于治疗高血压合并冠心病的药物组合物及其用途
CN107595842A (zh) * 2017-10-25 2018-01-19 桂林浩新科技服务有限公司 一种药物复方制剂及在制备治疗高血压合并冠心病的药物中的用途

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CN1072649C (zh) 1995-09-13 2001-10-10 武田药品工业株式会社 苯并氧杂吖庚因化合物,其生产方法和用途
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
WO2002006234A1 (fr) 2000-07-17 2002-01-24 Takeda Chemical Industries, Ltd. Derives de sulfonate, procede de production et utilisation de ces derives
US7342117B2 (en) 2001-10-30 2008-03-11 Astellas Pharma Inc. α-form or β-form crystal of acetanilide derivative
AU2003278600A1 (en) 2002-11-01 2004-05-25 Takeda Pharmaceutical Company Limited Agent for preventing or treating neuropathy
EP1559422B1 (en) 2002-11-08 2014-04-30 Takeda Pharmaceutical Company Limited Receptor function controlling agent
AU2003284596A1 (en) 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
JP3618341B2 (ja) * 2003-04-15 2005-02-09 山之内製薬株式会社 臭化物及びその結晶
EP1614686B1 (en) 2003-04-15 2014-05-07 Astellas Pharma Inc. Bromide and its crystal
WO2004106276A1 (ja) 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited 縮合環化合物
CA2527033A1 (en) 2003-06-18 2004-12-23 Astrazeneca Ab 2-substitued 5,6-diaryl-pyrazine derivatives as cb1 modulators
US7534887B2 (en) 2003-09-30 2009-05-19 Takeda Pharmaceutical Company Limited Thiazoline derivative and use of the same
US7820673B2 (en) 2003-12-17 2010-10-26 Takeda Pharmaceutical Company Limited Urea derivative, process for producing the same, and use
CA2551610A1 (en) 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
WO2005063725A1 (ja) 2003-12-26 2005-07-14 Takeda Pharmaceutical Company Limited フェニルプロパン酸誘導体
US7786165B2 (en) 2004-03-15 2010-08-31 Takeda Pharmaceutical Company Limited Aminophenylpropanoic acid derivative
WO2005095338A1 (ja) 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited アルコキシフェニルプロパン酸誘導体
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
CA2605778A1 (en) 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
JP5044398B2 (ja) 2005-06-09 2012-10-10 武田薬品工業株式会社 固形製剤
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
EP1911738A4 (en) 2005-07-29 2009-12-16 Takeda Pharmaceutical PHENOXYALKANSÄUREVERBINDUNG
EP1916234B1 (en) 2005-07-29 2014-11-12 Takeda Pharmaceutical Company Limited Cyclopropanecarboxylic acid compound
AU2006277231A1 (en) 2005-08-10 2007-02-15 Takeda Pharmaceutical Company Limited Therapeutic agent for diabetes
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
TWI354668B (en) 2006-06-27 2011-12-21 Takeda Pharmaceutical Fused cyclic compounds
WO2008047821A1 (fr) 2006-10-18 2008-04-24 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné
US7652133B2 (en) 2006-10-19 2010-01-26 Takeda Pharmaceutical Company Limited Indole compound
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
EP2118066A1 (en) 2007-02-09 2009-11-18 Takeda Pharmaceutical Company Limited Fused ring compounds as partial agonists of ppar-gamma
WO2008136428A1 (ja) 2007-04-27 2008-11-13 Takeda Pharmaceutical Company Limited 含窒素５員複素環化合物
WO2008156757A1 (en) 2007-06-19 2008-12-24 Takeda Pharmaceutical Company Limited Indazole compounds for activating glucokinase
JP2010229034A (ja) 2007-07-26 2010-10-14 Dainippon Sumitomo Pharma Co Ltd 二環性ピロール誘導体
US8466282B2 (en) 2008-06-19 2013-06-18 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP4901849B2 (ja) 2008-12-15 2012-03-21 バブコック日立株式会社 空気清浄機、及び分析室、並びに空気の浄化方法
US8642622B2 (en) 2010-06-16 2014-02-04 Bristol-Myers Squibb Company Piperidinyl compound as a modulator of chemokine receptor activity

Also Published As

Publication number Publication date
EP2583967A1 (en) 2013-04-24
SG186223A1 (en) 2013-01-30
MX2012014828A (es) 2013-02-27
ZA201300065B (en) 2014-03-26
EA201291453A1 (ru) 2013-05-30
TW201206914A (en) 2012-02-16
JP5782438B2 (ja) 2015-09-24
IL223562A (en) 2015-03-31
JPWO2011158880A1 (ja) 2013-08-19
KR20130119903A (ko) 2013-11-01
AU2011266099B2 (en) 2014-09-11
CN103068816A (zh) 2013-04-24
TWI511967B (zh) 2015-12-11
HK1179605A1 (en) 2013-10-04
EP2583967A4 (en) 2013-09-04
GEP20146195B (en) 2014-11-10
CA2802483A1 (en) 2011-12-22
BR112012032055B1 (pt) 2019-10-22
CO6670573A2 (es) 2013-05-15
AU2011266099A1 (en) 2013-01-24
BR112012032055B8 (pt) 2019-11-12
MA34378B1 (fr) 2013-07-03
US9018374B2 (en) 2015-04-28
DOP2012000313A (es) 2013-02-15
MY163927A (en) 2017-11-15
CL2012003526A1 (es) 2013-05-31
US20130090337A1 (en) 2013-04-11
CA2802483C (en) 2017-10-24
BR112012032055A2 (pt) 2016-11-08
EA022094B1 (ru) 2015-10-30
ECSP13012392A (es) 2013-03-28
TN2012000589A1 (en) 2014-04-01
UA108888C2 (xx) 2015-06-25
CN103068816B (zh) 2015-01-07
US20130252954A2 (en) 2013-09-26
EP2583967B1 (en) 2014-10-01
ES2524896T3 (es) 2014-12-15
WO2011158880A1 (ja) 2011-12-22

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Legal Events

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