ECSP13012392A - Cristal de compuesto de amida - Google Patents

Cristal de compuesto de amida

Info

Publication number
ECSP13012392A
ECSP13012392A ECSP13012392A ECSP13012392A EC SP13012392 A ECSP13012392 A EC SP13012392A EC SP13012392 A ECSP13012392 A EC SP13012392A EC SP13012392 A ECSP13012392 A EC SP13012392A
Authority
EC
Ecuador
Prior art keywords
crystal
amida
ylcarbonyl
methoxybutyl
morpholin
Prior art date
Application number
Other languages
English (en)
Inventor
Masato Kitayama
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of ECSP13012392A publication Critical patent/ECSP13012392A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se describe un cristal de clorhidrato de 1-(4-metoxibutil)-N-(2-metilpropil)-N-[(3S,5R)-5-(morfolin-4-ilcarbonil)piperidin-3-il]-1H-bencimidazol-2-carboxamida que tiene excelente actividad inhibitoria de renina que es útil como un conservador u otro agente terapéutico para tipos de disfunción de órganos y similares, que se derivan de alta presión sanguínea e hipertensión. El cristal de clorhidrato de 1-(4-metoxibutil)-N-(2-metilpropil)-N-[(3S,5R)-5-(morfolin-4-ilcarbonil)piperidin-3-il]-1H-bencimidazol-2-carboxamida tiene un patrón de difracción de rayos-X de polvo, en donde el espaciamiento de celosía (d) del patrón de difracción de rayos-X de polvo, tiene picos característicos que aparecen en los alrededores de 26.43 ± 0.2, 7.62 ± 0.2 y 4.32 ± 0.2 angstroms.
ECSP13012392 2010-06-16 2013-01-16 Cristal de compuesto de amida ECSP13012392A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010137194 2010-06-16

Publications (1)

Publication Number Publication Date
ECSP13012392A true ECSP13012392A (es) 2013-03-28

Family

ID=45348277

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012392 ECSP13012392A (es) 2010-06-16 2013-01-16 Cristal de compuesto de amida

Country Status (27)

Country Link
US (1) US9018374B2 (es)
EP (1) EP2583967B1 (es)
JP (1) JP5782438B2 (es)
KR (1) KR20130119903A (es)
CN (1) CN103068816B (es)
AU (1) AU2011266099B2 (es)
BR (1) BR112012032055B8 (es)
CA (1) CA2802483C (es)
CL (1) CL2012003526A1 (es)
CO (1) CO6670573A2 (es)
DO (1) DOP2012000313A (es)
EA (1) EA022094B1 (es)
EC (1) ECSP13012392A (es)
ES (1) ES2524896T3 (es)
GE (1) GEP20146195B (es)
HK (1) HK1179605A1 (es)
IL (1) IL223562A (es)
MA (1) MA34378B1 (es)
MX (1) MX2012014828A (es)
MY (1) MY163927A (es)
PE (1) PE20130283A1 (es)
SG (1) SG186223A1 (es)
TN (1) TN2012000589A1 (es)
TW (1) TWI511967B (es)
UA (1) UA108888C2 (es)
WO (1) WO2011158880A1 (es)
ZA (1) ZA201300065B (es)

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US9382192B2 (en) * 2012-02-14 2016-07-05 Dow Global Technologies Llc Nonionic surfactant compositions
JP6077555B2 (ja) * 2012-02-15 2017-02-08 武田薬品工業株式会社 錠剤
CN103831159B (zh) * 2014-01-20 2016-04-13 华润赛科药业有限责任公司 一种阿齐沙坦微粉化方法
US9878981B2 (en) * 2014-04-10 2018-01-30 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
GB2542876B (en) * 2015-04-20 2019-10-23 Johnson Matthey Plc Structure Directing Agent
CN107595842A (zh) * 2017-10-25 2018-01-19 桂林浩新科技服务有限公司 一种药物复方制剂及在制备治疗高血压合并冠心病的药物中的用途
CN107595853A (zh) * 2017-10-25 2018-01-19 桂林浩新科技服务有限公司 一种用于治疗高血压合并冠心病的药物组合物及其用途

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CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
AU2001269531A1 (en) 2000-07-17 2002-01-30 Takeda Chemical Industries Ltd. Sulfone derivatives, process for their production and use thereof
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EP1641779A1 (en) 2003-06-18 2006-04-05 AstraZeneca AB 2-substitued 5, 6-diaryl-pyrazine derivatives as cb1 modulator.
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TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
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EA200970746A1 (ru) 2007-02-09 2010-02-26 Такеда Фармасьютикал Компани Лимитед Конденсированные циклические соединения в качестве частичных агонистов ppar-гамма
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JP4901849B2 (ja) 2008-12-15 2012-03-21 バブコック日立株式会社 空気清浄機、及び分析室、並びに空気の浄化方法
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Also Published As

Publication number Publication date
CA2802483A1 (en) 2011-12-22
CN103068816A (zh) 2013-04-24
ES2524896T3 (es) 2014-12-15
TN2012000589A1 (en) 2014-04-01
JPWO2011158880A1 (ja) 2013-08-19
EA201291453A1 (ru) 2013-05-30
US20130252954A2 (en) 2013-09-26
EP2583967A4 (en) 2013-09-04
MY163927A (en) 2017-11-15
CA2802483C (en) 2017-10-24
CN103068816B (zh) 2015-01-07
EP2583967B1 (en) 2014-10-01
EP2583967A1 (en) 2013-04-24
WO2011158880A1 (ja) 2011-12-22
BR112012032055B8 (pt) 2019-11-12
TW201206914A (en) 2012-02-16
CL2012003526A1 (es) 2013-05-31
JP5782438B2 (ja) 2015-09-24
DOP2012000313A (es) 2013-02-15
GEP20146195B (en) 2014-11-10
BR112012032055A2 (pt) 2016-11-08
SG186223A1 (en) 2013-01-30
AU2011266099B2 (en) 2014-09-11
US20130090337A1 (en) 2013-04-11
UA108888C2 (xx) 2015-06-25
KR20130119903A (ko) 2013-11-01
MA34378B1 (fr) 2013-07-03
PE20130283A1 (es) 2013-03-25
IL223562A (en) 2015-03-31
CO6670573A2 (es) 2013-05-15
ZA201300065B (en) 2014-03-26
TWI511967B (zh) 2015-12-11
EA022094B1 (ru) 2015-10-30
BR112012032055B1 (pt) 2019-10-22
MX2012014828A (es) 2013-02-27
HK1179605A1 (en) 2013-10-04
AU2011266099A1 (en) 2013-01-24
US9018374B2 (en) 2015-04-28

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