PE20130179A1 - Nuevos derivados terciarios de 8-hidroxiquinolina-7-carboxamida - Google Patents
Nuevos derivados terciarios de 8-hidroxiquinolina-7-carboxamidaInfo
- Publication number
- PE20130179A1 PE20130179A1 PE2012000845A PE2012000845A PE20130179A1 PE 20130179 A1 PE20130179 A1 PE 20130179A1 PE 2012000845 A PE2012000845 A PE 2012000845A PE 2012000845 A PE2012000845 A PE 2012000845A PE 20130179 A1 PE20130179 A1 PE 20130179A1
- Authority
- PE
- Peru
- Prior art keywords
- carboxamide
- hydroxy
- hydroxyquinoline
- methyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R2 Y R3 SON INDEPENDIENTEMENTE ALQUILO C1-C6 CON LA CONDICION QUE AMBOS NO SEAN METILO, (CH2)n-CICLOALQUILO, (CH2)n-HETEROCICLO, (CH2)n-CN, ENTRE OTROS, O JUNTOS CON EL NITROGENO AL CUAL ESTAN UNIDOS FORMAN UN HETEROMONOCICLO DE 5 A 8 MIEMBROS QUE CONTIENE DE UNO A TRES HETEROATOMOS TALES COMO O Y S, O JUNTOS CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS FORMAN DIHIDROQUINOLINA SUSTITUIDA POR HALOGENO Y/O HIDROXI; n ES UN ENTERO DE 0 A 2. SON COMPUESTOS PREFERIDOS: 8-HIDROXI-N-METIL-N-FENETILQUINOLINA-7-CARBOXAMIDA; N-(FURAN-2-ILMETIL)-8-HIDROXI-N-METILQUINOLINA-7-CARBOXAMIDA; ENTRE OTROS. REFERIDO ADEMAS A UNA FORMULACION FARMACEUTICA. DICHO COMPUESTO ES UTIL PARA EL TRATAMIENTO Y/O PREVENCION DE INFECCIONES FUNGICAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09180902A EP2345643A1 (en) | 2009-12-29 | 2009-12-29 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20130179A1 true PE20130179A1 (es) | 2013-02-24 |
Family
ID=42026678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000845A PE20130179A1 (es) | 2009-12-29 | 2010-12-28 | Nuevos derivados terciarios de 8-hidroxiquinolina-7-carboxamida |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8729098B2 (es) |
| EP (2) | EP2345643A1 (es) |
| JP (1) | JP5808754B2 (es) |
| KR (1) | KR101666505B1 (es) |
| CN (2) | CN102686566A (es) |
| AU (1) | AU2010338267B2 (es) |
| BR (1) | BR112012015728A2 (es) |
| CA (1) | CA2783213C (es) |
| CL (1) | CL2012001757A1 (es) |
| CY (1) | CY1116493T1 (es) |
| DK (1) | DK2519505T3 (es) |
| DO (1) | DOP2012000186A (es) |
| EA (1) | EA025563B1 (es) |
| EC (1) | ECSP12012007A (es) |
| ES (1) | ES2540327T3 (es) |
| GE (1) | GEP20156244B (es) |
| GT (1) | GT201200216A (es) |
| HK (1) | HK1178526A1 (es) |
| HR (1) | HRP20150749T1 (es) |
| HU (1) | HUE027220T2 (es) |
| IL (1) | IL220427A (es) |
| MA (1) | MA33829B1 (es) |
| MX (1) | MX2012007748A (es) |
| MY (1) | MY161869A (es) |
| NI (1) | NI201200114A (es) |
| NZ (1) | NZ600788A (es) |
| PE (1) | PE20130179A1 (es) |
| PL (1) | PL2519505T3 (es) |
| PT (1) | PT2519505E (es) |
| RS (1) | RS54096B1 (es) |
| SG (1) | SG181586A1 (es) |
| SI (1) | SI2519505T1 (es) |
| SM (1) | SMT201500182B (es) |
| TN (1) | TN2012000320A1 (es) |
| UA (1) | UA107949C2 (es) |
| WO (1) | WO2011080264A1 (es) |
| ZA (1) | ZA201204347B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2345641A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | New secondary 8-hydroxyquinoline-7-carboxamide derivatives |
| EP2345642A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents |
| EP2817291A1 (en) * | 2012-02-24 | 2014-12-31 | F. Hoffmann-La Roche AG | Antiviral compounds |
| US9751838B2 (en) | 2012-10-02 | 2017-09-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Tetrahydroquinoline derivatives and their use as Epac inhibitors |
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| USD976093S1 (en) | 2020-09-22 | 2023-01-24 | Milwaukee Electric Tool Corporation | Staple collation |
| CN220302508U (zh) | 2020-09-22 | 2024-01-05 | 米沃奇电动工具公司 | 动力式紧固件驱动器及钉排 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US326328A (en) | 1885-09-15 | Broiler | ||
| US326330A (en) | 1885-09-15 | Harness-support | ||
| DE540842C (de) | 1930-08-06 | 1931-12-28 | Chinosol Fabrik Akt Ges | Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure |
| BR9604823A (pt) | 1995-04-08 | 1999-01-05 | Basf Ag | Processo para controlar funggs nocivos e pragas fúngicas mistura sinérgica adequada para controlar pragas fúngicas e uso de compostos |
| WO1997017973A1 (en) * | 1995-11-13 | 1997-05-22 | Smithkline Beecham Corporation | Hemoregulatory compounds |
| US6310211B1 (en) | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| BR9815377A (pt) * | 1997-09-30 | 2001-01-16 | Daiichi Pharmaceutical Co Ltda | Derivados de sulfonil |
| JP2001294572A (ja) * | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
| AU1152702A (en) | 2000-10-12 | 2002-04-22 | Merck & Co Inc | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| US6919351B2 (en) | 2000-10-12 | 2005-07-19 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors |
| ATE411292T1 (de) | 2001-03-01 | 2008-10-15 | Shionogi & Co | Stickstoffhaltige heteroarylverbindungen mit hiv- integrase inhibierender wirkung |
| US7358249B2 (en) | 2002-08-13 | 2008-04-15 | Shionogi & Co., Ltd. | Heterocyclic compounds having inhibitory activity against HIV integrase |
| WO2005033079A1 (ja) * | 2003-09-30 | 2005-04-14 | Eisai Co., Ltd. | ヘテロ環化合物を含有する新規な抗真菌剤 |
| FR2889192A1 (fr) * | 2005-07-27 | 2007-02-02 | Cytomics Systems Sa | Composes antifongiques, compositions contenant ces composes et leurs utilisations |
| AU2007276804A1 (en) * | 2006-07-26 | 2008-01-31 | Novartis Ag | Inhibitors of undecaprenyl pyrophosphate synthase |
| WO2009140215A2 (en) * | 2008-05-11 | 2009-11-19 | Geraghty, Erin | Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds |
| JP5114610B1 (ja) * | 2009-11-10 | 2013-01-09 | ファイザー・インク | Ｎ１−ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害薬 |
| AR079529A1 (es) * | 2009-12-18 | 2012-02-01 | Incyte Corp | Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k |
| EP2345642A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents |
| EP2345641A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | New secondary 8-hydroxyquinoline-7-carboxamide derivatives |
-
2009
- 2009-12-29 EP EP09180902A patent/EP2345643A1/en not_active Withdrawn
-
2010
- 2010-12-28 US US13/519,206 patent/US8729098B2/en not_active Expired - Fee Related
- 2010-12-28 BR BR112012015728A patent/BR112012015728A2/pt not_active IP Right Cessation
- 2010-12-28 MX MX2012007748A patent/MX2012007748A/es active IP Right Grant
- 2010-12-28 SG SG2012042289A patent/SG181586A1/en unknown
- 2010-12-28 CA CA2783213A patent/CA2783213C/en not_active Expired - Fee Related
- 2010-12-28 PE PE2012000845A patent/PE20130179A1/es not_active Application Discontinuation
- 2010-12-28 KR KR1020127019421A patent/KR101666505B1/ko active IP Right Grant
- 2010-12-28 PL PL10800763T patent/PL2519505T3/pl unknown
- 2010-12-28 GE GEAP201012809A patent/GEP20156244B/en unknown
- 2010-12-28 CN CN2010800600068A patent/CN102686566A/zh active Pending
- 2010-12-28 EP EP10800763.4A patent/EP2519505B1/en active Active
- 2010-12-28 CN CN201510660625.5A patent/CN105384685A/zh active Pending
- 2010-12-28 DK DK10800763.4T patent/DK2519505T3/en active
- 2010-12-28 JP JP2012546432A patent/JP5808754B2/ja not_active Expired - Fee Related
- 2010-12-28 HU HUE10800763A patent/HUE027220T2/hu unknown
- 2010-12-28 SI SI201030974T patent/SI2519505T1/sl unknown
- 2010-12-28 MY MYPI2012002959A patent/MY161869A/en unknown
- 2010-12-28 ES ES10800763.4T patent/ES2540327T3/es active Active
- 2010-12-28 AU AU2010338267A patent/AU2010338267B2/en not_active Ceased
- 2010-12-28 PT PT108007634T patent/PT2519505E/pt unknown
- 2010-12-28 UA UAA201207789A patent/UA107949C2/ru unknown
- 2010-12-28 WO PCT/EP2010/070790 patent/WO2011080264A1/en active Application Filing
- 2010-12-28 RS RS20150445A patent/RS54096B1/en unknown
- 2010-12-28 EA EA201270670A patent/EA025563B1/ru not_active IP Right Cessation
- 2010-12-28 NZ NZ600788A patent/NZ600788A/xx not_active IP Right Cessation
-
2012
- 2012-06-13 ZA ZA2012/04347A patent/ZA201204347B/en unknown
- 2012-06-14 IL IL220427A patent/IL220427A/en not_active IP Right Cessation
- 2012-06-15 MA MA34972A patent/MA33829B1/fr unknown
- 2012-06-22 TN TNP2012000320A patent/TN2012000320A1/en unknown
- 2012-06-25 GT GT201200216A patent/GT201200216A/es unknown
- 2012-06-26 CL CL2012001757A patent/CL2012001757A1/es unknown
- 2012-06-27 DO DO2012000186A patent/DOP2012000186A/es unknown
- 2012-06-28 NI NI201200114A patent/NI201200114A/es unknown
- 2012-06-28 EC ECSP12012007 patent/ECSP12012007A/es unknown
-
2013
- 2013-05-06 HK HK13105408.0A patent/HK1178526A1/xx not_active IP Right Cessation
-
2015
- 2015-07-08 HR HRP20150749TT patent/HRP20150749T1/hr unknown
- 2015-07-13 CY CY20151100609T patent/CY1116493T1/el unknown
- 2015-07-30 SM SM201500182T patent/SMT201500182B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |