MA33829B1 - Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations - Google Patents

Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations

Info

Publication number
MA33829B1
MA33829B1 MA34972A MA34972A MA33829B1 MA 33829 B1 MA33829 B1 MA 33829B1 MA 34972 A MA34972 A MA 34972A MA 34972 A MA34972 A MA 34972A MA 33829 B1 MA33829 B1 MA 33829B1
Authority
MA
Morocco
Prior art keywords
hydroxyquinoline
carboxamide derivatives
novel tertiary
compounds
candida
Prior art date
Application number
MA34972A
Other languages
Arabic (ar)
English (en)
Inventor
Stefania Gagliardi
Sordo Simone Del
Federico Mailland
Michela Legora
Original Assignee
Polichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42026678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33829(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem Sa filed Critical Polichem Sa
Publication of MA33829B1 publication Critical patent/MA33829B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cette invention concerne de nouveaux dérivés de 8-hydroxyquinoline- 7-carboxamide tertiaires de formule générale (i) et leurs sels pharmaceutiquement acceptables. Ces composés sont utiles en tant qu'agents antifongiques. Plus spécifiquement, ces composés ont été testés contre tricophyton rubrum, tricophyton mentagrophytes, aspergillus niger et scopulariopsis brevicaulis. Ils sont également actifs contre l'espèce candida, par exemple, candida albicans et candida glabrata.
MA34972A 2009-12-29 2012-06-15 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations MA33829B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09180902A EP2345643A1 (fr) 2009-12-29 2009-12-29 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations
PCT/EP2010/070790 WO2011080264A1 (fr) 2009-12-29 2010-12-28 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations

Publications (1)

Publication Number Publication Date
MA33829B1 true MA33829B1 (fr) 2012-12-03

Family

ID=42026678

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34972A MA33829B1 (fr) 2009-12-29 2012-06-15 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations

Country Status (37)

Country Link
US (1) US8729098B2 (fr)
EP (2) EP2345643A1 (fr)
JP (1) JP5808754B2 (fr)
KR (1) KR101666505B1 (fr)
CN (2) CN105384685A (fr)
AU (1) AU2010338267B2 (fr)
BR (1) BR112012015728A2 (fr)
CA (1) CA2783213C (fr)
CL (1) CL2012001757A1 (fr)
CY (1) CY1116493T1 (fr)
DK (1) DK2519505T3 (fr)
DO (1) DOP2012000186A (fr)
EA (1) EA025563B1 (fr)
EC (1) ECSP12012007A (fr)
ES (1) ES2540327T3 (fr)
GE (1) GEP20156244B (fr)
GT (1) GT201200216A (fr)
HK (1) HK1178526A1 (fr)
HR (1) HRP20150749T1 (fr)
HU (1) HUE027220T2 (fr)
IL (1) IL220427A (fr)
MA (1) MA33829B1 (fr)
MX (1) MX2012007748A (fr)
MY (1) MY161869A (fr)
NI (1) NI201200114A (fr)
NZ (1) NZ600788A (fr)
PE (1) PE20130179A1 (fr)
PL (1) PL2519505T3 (fr)
PT (1) PT2519505E (fr)
RS (1) RS54096B1 (fr)
SG (1) SG181586A1 (fr)
SI (1) SI2519505T1 (fr)
SM (1) SMT201500182B (fr)
TN (1) TN2012000320A1 (fr)
UA (1) UA107949C2 (fr)
WO (1) WO2011080264A1 (fr)
ZA (1) ZA201204347B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2345641A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaire
EP2345642A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques
MX2014009799A (es) * 2012-02-24 2014-09-08 Hoffmann La Roche Compuestos antivirales.
ES2749512T3 (es) 2012-10-02 2020-03-20 Inst Nat Sante Rech Med Derivados de tetrahidroquinolina y su uso como inhibidores de Epac
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
USD976093S1 (en) 2020-09-22 2023-01-24 Milwaukee Electric Tool Corporation Staple collation
WO2022066759A1 (fr) 2020-09-22 2022-03-31 Milwaukee Electric Tool Corporation Agrafe et regroupement d'agrafes

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US326330A (en) 1885-09-15 Harness-support
US326328A (en) 1885-09-15 Broiler
DE540842C (de) 1930-08-06 1931-12-28 Chinosol Fabrik Akt Ges Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure
NZ304327A (en) 1995-04-08 1999-02-25 Basf Ag Synergistic fungicidal compositions containing a quinoline derivative and a cytochrom b/c inhibitor
WO1997017973A1 (fr) * 1995-11-13 1997-05-22 Smithkline Beecham Corporation Composes hemoregulateurs
EP0927164A1 (fr) 1996-09-10 1999-07-07 PHARMACIA & UPJOHN COMPANY 8-hydroxyquinoleines 7-substituees utilisees comme agents antiviraux
DK1031563T3 (da) * 1997-09-30 2006-05-08 Daiichi Seiyaku Co Sulfonylderivater
JP2001294572A (ja) * 2000-02-09 2001-10-23 Dai Ichi Seiyaku Co Ltd 新規スルホニル誘導体
ATE430745T1 (de) 2000-10-12 2009-05-15 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
AU1532802A (en) 2000-10-12 2002-04-22 Merck & Co Inc Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
KR20030078958A (ko) 2001-03-01 2003-10-08 시오노기세이야쿠가부시키가이샤 Ｈｉｖ 인테그라제 저해 활성을 갖는 질소 함유의헤테로아릴 화합물
AU2003257822A1 (en) 2002-08-13 2004-04-30 Shionogi And Co., Ltd. Heterocyclic compound having hiv integrase inhibitory activity
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
FR2889192A1 (fr) * 2005-07-27 2007-02-02 Cytomics Systems Sa Composes antifongiques, compositions contenant ces composes et leurs utilisations
WO2008014307A2 (fr) * 2006-07-26 2008-01-31 Novartis Ag Inhibiteurs de l'undécaprényl pyrophosphate synthase
WO2009140215A2 (fr) * 2008-05-11 2009-11-19 Geraghty, Erin Procédé pour traiter des infections bactériennes résistant au médicament et d'autres infections par du clioquinol, de la phanquinone et des composés apparentés
ES2444543T3 (es) * 2009-11-10 2014-02-25 Pfizer Inc Inhibidores de la N1-pirazoloespirocetona acetil-CoA carboxilasa
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
EP2345642A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques
EP2345641A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaire

Also Published As

Publication number Publication date
SI2519505T1 (sl) 2015-08-31
KR101666505B1 (ko) 2016-10-14
PL2519505T3 (pl) 2015-11-30
TN2012000320A1 (en) 2013-12-12
CY1116493T1 (el) 2017-03-15
EP2519505B1 (fr) 2015-05-27
IL220427A (en) 2015-04-30
BR112012015728A2 (pt) 2019-09-24
CL2012001757A1 (es) 2013-03-22
NZ600788A (en) 2013-08-30
JP5808754B2 (ja) 2015-11-10
ZA201204347B (en) 2013-09-25
WO2011080264A1 (fr) 2011-07-07
NI201200114A (es) 2013-04-22
ES2540327T3 (es) 2015-07-09
UA107949C2 (en) 2015-03-10
CA2783213A1 (fr) 2011-07-07
DK2519505T3 (en) 2015-06-29
AU2010338267B2 (en) 2014-03-27
EA025563B1 (ru) 2017-01-30
KR20120101563A (ko) 2012-09-13
AU2010338267A1 (en) 2012-07-19
DOP2012000186A (es) 2013-01-15
PE20130179A1 (es) 2013-02-24
SG181586A1 (en) 2012-07-30
EA201270670A1 (ru) 2013-03-29
CN105384685A (zh) 2016-03-09
SMT201500182B (it) 2015-09-07
PT2519505E (pt) 2015-09-03
US8729098B2 (en) 2014-05-20
CN102686566A (zh) 2012-09-19
HRP20150749T1 (hr) 2015-08-14
RS54096B1 (en) 2015-10-30
EP2519505A1 (fr) 2012-11-07
JP2013515755A (ja) 2013-05-09
HUE027220T2 (hu) 2016-10-28
GEP20156244B (en) 2015-02-10
CA2783213C (fr) 2017-09-12
US20120309751A1 (en) 2012-12-06
EP2345643A1 (fr) 2011-07-20
AU2010338267A2 (en) 2012-07-26
MY161869A (en) 2017-05-15
GT201200216A (es) 2014-12-26
MX2012007748A (es) 2012-08-03
ECSP12012007A (es) 2012-08-31
HK1178526A1 (en) 2013-09-13

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