PE20120576A1 - Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion farmaceuticamente aceptable - Google Patents
Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion farmaceuticamente aceptableInfo
- Publication number
- PE20120576A1 PE20120576A1 PE2011000106A PE2011000106A PE20120576A1 PE 20120576 A1 PE20120576 A1 PE 20120576A1 PE 2011000106 A PE2011000106 A PE 2011000106A PE 2011000106 A PE2011000106 A PE 2011000106A PE 20120576 A1 PE20120576 A1 PE 20120576A1
- Authority
- PE
- Peru
- Prior art keywords
- ivabradine
- pharmaceutically acceptable
- substituted
- addition salts
- acceptable addition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN PROCEDIMIENTO DE SINTESIS DE IVABRADINA QUE COMPRENDE: A) SOMETER EL COMPUESTO DE FORMULA VI A LA ACCION DE UN TIOL EN UN DISOLVENTE ORGANICO PARA FORMAR EL HEMITIOACETAL RESPECTIVO; B) SOMETER A UNA REACCION DE CICLACION PARA DAR LUGAR AL COMPUESTO VIII, DONDE R ES ALQUILO LINEAL O RAMIFICADO, SUSTITUIDO O NO, OPCIONALMENTE PERFLUORADO, ARILO SUSTITUIDO O NO, BENCILO SUSTITUIDO O NO, ENTRE OTROS; C) SE SOMETE A UNA REACCION DE REDUCCION PARA DAR LUGAR A LA IVABRADINA, QUE PUEDE SER TRANSFORMADA EVENTUALMENTE EN SUS SALES DE ADICION A UN ACIDO FARMACEUTICAMENTE ACEPTABLE, ELEGIDO ENTRE LOS ACIDOS CLORHIDRICO, BROMHIDRICO, SULFURICO, FOSFORICO, ACETICO, TRIFLUOACETICO, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1000657A FR2956401B1 (fr) | 2010-02-17 | 2010-02-17 | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120576A1 true PE20120576A1 (es) | 2012-05-12 |
Family
ID=42133409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000106A PE20120576A1 (es) | 2010-02-17 | 2011-01-31 | Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion farmaceuticamente aceptable |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8278440B2 (es) |
| EP (1) | EP2364972B1 (es) |
| JP (1) | JP5306387B2 (es) |
| KR (1) | KR101310683B1 (es) |
| CN (3) | CN102161642B (es) |
| AR (1) | AR080178A1 (es) |
| AU (1) | AU2011200403B2 (es) |
| BR (1) | BRPI1100169A2 (es) |
| CA (1) | CA2731315C (es) |
| CL (1) | CL2011000297A1 (es) |
| CY (1) | CY1113338T1 (es) |
| DK (1) | DK2364972T3 (es) |
| EA (1) | EA019373B1 (es) |
| ES (1) | ES2396042T3 (es) |
| FR (1) | FR2956401B1 (es) |
| GE (1) | GEP20135737B (es) |
| HK (3) | HK1162021A1 (es) |
| HR (1) | HRP20120955T1 (es) |
| JO (1) | JO2854B1 (es) |
| MA (1) | MA32681B1 (es) |
| ME (1) | ME01464B (es) |
| MX (1) | MX2011001465A (es) |
| MY (1) | MY147697A (es) |
| NZ (1) | NZ590883A (es) |
| PE (1) | PE20120576A1 (es) |
| PL (1) | PL2364972T3 (es) |
| PT (1) | PT2364972E (es) |
| RS (1) | RS52529B (es) |
| SA (1) | SA111320199B1 (es) |
| SG (1) | SG173961A1 (es) |
| SI (1) | SI2364972T1 (es) |
| TW (1) | TWI395738B (es) |
| UA (1) | UA106208C2 (es) |
| UY (1) | UY33211A (es) |
| WO (1) | WO2011101558A1 (es) |
| ZA (1) | ZA201100964B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2950343B1 (fr) * | 2009-09-18 | 2011-11-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| CN102566619B (zh) * | 2012-02-07 | 2013-12-25 | 宁波市镇海华泰电器厂 | 噪声式水温控制装置 |
| FR2988720B1 (fr) * | 2012-03-27 | 2014-03-14 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| CN103848789B (zh) * | 2012-11-29 | 2016-05-18 | 江苏恒瑞医药股份有限公司 | 一种伊伐布雷定的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| AU2003239508A1 (en) * | 2002-05-21 | 2003-12-12 | Bristol-Myers Squibb Company | Indole compounds useful as impdh inhibitors |
| FR2868776B1 (fr) * | 2004-04-13 | 2008-04-18 | Servier Lab | Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| TW200817334A (en) * | 2005-02-07 | 2008-04-16 | Servier Lab | New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
| EP2097383B1 (en) * | 2006-11-30 | 2012-02-08 | Cadila Healthcare Limited | Process for preparation of ivabradine hydrochloride |
| CN101284813B (zh) * | 2007-04-12 | 2012-08-15 | 上海优拓医药科技有限公司 | 伊伐布雷定的制备方法 |
| JP5632279B2 (ja) * | 2007-05-30 | 2014-11-26 | アイエヌディー−スイフト ラボラトリーズ リミテッド | 塩酸イバブラジンの調製方法及びポリモルフ |
| CN101544605A (zh) * | 2008-03-24 | 2009-09-30 | 北京深蓝海生物医药科技有限公司 | 伊伐布雷定及其药学上可接受的加成盐的制备方法 |
| FR2932800B1 (fr) | 2008-06-20 | 2015-02-20 | Servier Lab | Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| WO2010072409A1 (en) | 2008-12-22 | 2010-07-01 | Krka, D. D., Novo Mesto | Process for preparation of ivabradine |
-
2010
- 2010-02-17 FR FR1000657A patent/FR2956401B1/fr not_active Expired - Fee Related
-
2011
- 2011-01-30 JO JO201130A patent/JO2854B1/en active
- 2011-01-31 UY UY33211A patent/UY33211A/es unknown
- 2011-01-31 SG SG2011006848A patent/SG173961A1/en unknown
- 2011-01-31 PE PE2011000106A patent/PE20120576A1/es active IP Right Grant
- 2011-01-31 MY MYPI2011000487A patent/MY147697A/en unknown
- 2011-01-31 AU AU2011200403A patent/AU2011200403B2/en not_active Ceased
- 2011-02-02 NZ NZ590883A patent/NZ590883A/en not_active IP Right Cessation
- 2011-02-07 ZA ZA2011/00964A patent/ZA201100964B/en unknown
- 2011-02-08 MX MX2011001465A patent/MX2011001465A/es active IP Right Grant
- 2011-02-09 CA CA2731315A patent/CA2731315C/fr not_active Expired - Fee Related
- 2011-02-11 CL CL2011000297A patent/CL2011000297A1/es unknown
- 2011-02-14 UA UAA201101721A patent/UA106208C2/ru unknown
- 2011-02-15 MA MA33624A patent/MA32681B1/fr unknown
- 2011-02-15 AR ARP110100451A patent/AR080178A1/es unknown
- 2011-02-15 GE GEAP201112105A patent/GEP20135737B/en unknown
- 2011-02-15 EA EA201100230A patent/EA019373B1/ru not_active IP Right Cessation
- 2011-02-15 US US12/931,961 patent/US8278440B2/en not_active Expired - Fee Related
- 2011-02-16 PT PT11290091T patent/PT2364972E/pt unknown
- 2011-02-16 DK DK11290091.5T patent/DK2364972T3/da active
- 2011-02-16 WO PCT/FR2011/000092 patent/WO2011101558A1/fr active Application Filing
- 2011-02-16 CN CN201110038835.2A patent/CN102161642B/zh not_active Expired - Fee Related
- 2011-02-16 CN CN201310167930.1A patent/CN103265491B/zh not_active Expired - Fee Related
- 2011-02-16 RS RS20120511A patent/RS52529B/en unknown
- 2011-02-16 EP EP11290091A patent/EP2364972B1/fr active Active
- 2011-02-16 CN CN201310168300.6A patent/CN103232360B/zh not_active Expired - Fee Related
- 2011-02-16 ES ES11290091T patent/ES2396042T3/es active Active
- 2011-02-16 SI SI201130005T patent/SI2364972T1/sl unknown
- 2011-02-16 SA SA111320199A patent/SA111320199B1/ar unknown
- 2011-02-16 ME MEP-2012-139A patent/ME01464B/me unknown
- 2011-02-16 PL PL11290091T patent/PL2364972T3/pl unknown
- 2011-02-16 TW TW100105145A patent/TWI395738B/zh not_active IP Right Cessation
- 2011-02-16 BR BRPI1100169-0A patent/BRPI1100169A2/pt not_active Application Discontinuation
- 2011-02-16 JP JP2011030786A patent/JP5306387B2/ja active Active
- 2011-02-17 KR KR1020110014201A patent/KR101310683B1/ko active IP Right Grant
-
2012
- 2012-02-23 HK HK12101805.9A patent/HK1162021A1/xx not_active IP Right Cessation
- 2012-11-13 CY CY20121101086T patent/CY1113338T1/el unknown
- 2012-11-21 HR HRP20120955AT patent/HRP20120955T1/hr unknown
-
2013
- 2013-09-16 HK HK13110667.6A patent/HK1183295A1/xx not_active IP Right Cessation
- 2013-09-25 HK HK13110938.9A patent/HK1183488A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |